Receptor
PDB id Resolution Class Description Source Keywords
1OKK 2.05 Å NON-ENZYME: SIGNAL_HORMONE HOMO-HETERODIMERIC COMPLEX OF THE SRP GTPASES THERMUS AQUATICUS CELL CYCLE SIGNAL RECOGNITION/COMPLEX SRP FFH FTSY GTPASE MEMBRANE TARGETING SIGNAL SEQUENCE RECOGNITION
Ref.: HETERODIMERIC GTPASE CORE OF THE SRP TARGETING COMPLEX SCIENCE V. 303 373 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BZP A:1296;
A:1297;
Invalid;
Invalid;
none;
none;
submit data
130.145 C5 H10 N2 O2 C1CN(...
EDO D:1309;
D:1310;
D:1311;
D:1312;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
GCP A:1001;
D:1001;
Valid;
Valid;
none;
none;
submit data
521.208 C11 H18 N5 O13 P3 c1nc2...
MG A:1002;
D:1002;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
SO4 A:1298;
A:1299;
A:1300;
A:1301;
A:1302;
A:1303;
A:1304;
A:1305;
A:1306;
A:1307;
D:1308;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1RJ9 1.9 Å NON-ENZYME: SIGNAL_HORMONE STRUCTURE OF THE HETERODIMER OF THE CONSERVED GTPASE DOMAINS SIGNAL RECOGNITION PARTICLE (FFH) AND ITS RECEPTOR (FTSY) THERMUS AQUATICUS SRP-GTPASE DOMAIN HETERODIMER NUCLEOTIDE TWINNING PROTEINCOMPLEX PROTEIN TRANSPORT
Ref.: SUBSTRATE TWINNING ACTIVATES THE SIGNAL RECOGNITION PARTICLE AND ITS RECEPTOR NATURE V. 427 215 2004
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 1OKK - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
2 2J7P - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 2CNW - GDP ALF n/a n/a
4 1RJ9 - GCP C11 H18 N5 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GCP; Similar ligands found: 136
No: Ligand ECFP6 Tc MDL keys Tc
1 GCP 1 1
2 GP3 0.8375 0.948718
3 GDP 0.82716 0.973684
4 GNH 0.817073 0.961039
5 GP2 0.804878 0.987013
6 GTP 0.797619 0.973684
7 G1R 0.788235 0.961039
8 GSP 0.77907 0.925
9 GNP 0.77907 0.948718
10 5GP 0.765432 0.960526
11 G 0.765432 0.960526
12 G2P 0.758621 0.987013
13 GMV 0.755814 0.948718
14 G2R 0.736264 0.961538
15 Y9Z 0.715789 0.903614
16 GDP MG 0.704545 0.9
17 GAV 0.703297 0.936709
18 G3A 0.701031 0.948718
19 GDC 0.697917 0.936709
20 GDD 0.697917 0.936709
21 GKE 0.697917 0.936709
22 GDP BEF 0.696629 0.878049
23 ALF 5GP 0.696629 0.86747
24 G5P 0.693878 0.948718
25 GPG 0.691489 0.936709
26 GDR 0.690722 0.936709
27 GTG 0.690722 0.91358
28 GFB 0.690722 0.936709
29 GDP AF3 0.688172 0.86747
30 YGP 0.6875 0.879518
31 GCP G 0.684783 0.935897
32 6CK 0.683673 0.91358
33 GTP MG 0.673913 0.9
34 BEF GDP 0.673913 0.86747
35 GKD 0.67 0.936709
36 JB2 0.67 0.936709
37 GDX 0.663366 0.948718
38 GPD 0.663366 0.925926
39 GDP ALF 0.652632 0.86747
40 JB3 0.632075 0.925
41 GMP 0.62963 0.857143
42 NGD 0.626168 0.936709
43 G G 0.616162 0.911392
44 G3D 0.610526 0.960526
45 2MD 0.609091 0.870588
46 G4P 0.597938 0.960526
47 U2G 0.59633 0.91358
48 FEG 0.59633 0.880952
49 GDP 7MG 0.596154 0.888889
50 CAG 0.59292 0.860465
51 MGD 0.59292 0.870588
52 ZGP 0.590909 0.870588
53 0O2 0.59 0.960526
54 CG2 0.585586 0.91358
55 PGD 0.57265 0.902439
56 MD1 0.57265 0.892857
57 3GP 0.566667 0.922078
58 TPG 0.563025 0.842697
59 DBG 0.563025 0.925
60 FE9 0.550847 0.760417
61 ACP 0.548387 0.922078
62 GH3 0.54 0.973684
63 I2C FE2 CMO CMO 0.533898 0.791209
64 2GP 0.532609 0.935065
65 G4M 0.53125 0.860465
66 U A G G 0.529915 0.911392
67 GPX 0.529412 0.922078
68 DGI 0.525773 0.924051
69 G A A A 0.521368 0.9
70 IDP 0.520833 0.947368
71 DGT 0.52 0.924051
72 P1G 0.510417 0.873418
73 G1G 0.504132 0.902439
74 BGO 0.5 0.901235
75 G1R G1R 0.5 0.901235
76 PGD O 0.496 0.831461
77 ACQ 0.494949 0.922078
78 G G U 0.491071 0.911392
79 P2G 0.489583 0.860759
80 GGM 0.487395 0.879518
81 MGP 0.485149 0.936709
82 6G0 0.480392 0.936709
83 DG 0.479167 0.911392
84 DGP 0.479167 0.911392
85 GPC 0.47541 0.858824
86 G C 0.475 0.878049
87 4TC 0.470085 0.876543
88 IMP 0.46875 0.934211
89 GTA 0.464912 0.91358
90 G2Q 0.453704 0.961538
91 A2D 0.452632 0.871795
92 G G G C 0.452381 0.890244
93 G7M 0.44898 0.924051
94 APC G U 0.448 0.8875
95 U G A 0.445255 0.86747
96 SGP 0.444444 0.807229
97 BA3 0.443299 0.871795
98 G G G RPC 0.439024 0.853659
99 B4P 0.438776 0.871795
100 ADP 0.438776 0.896104
101 AP5 0.438776 0.871795
102 A G C C 0.4375 0.888889
103 ANP 0.436893 0.873418
104 G C C C 0.435115 0.901235
105 AN2 0.434343 0.884615
106 M33 0.43 0.860759
107 A12 0.428571 0.910256
108 AP2 0.428571 0.910256
109 A G U 0.427536 0.86747
110 PCG 0.427184 0.909091
111 35G 0.427184 0.909091
112 C2E 0.427184 0.897436
113 ATP 0.425743 0.896104
114 5GP 5GP 0.423077 0.860759
115 G U34 0.422764 0.86747
116 APR 0.421569 0.871795
117 AQP 0.421569 0.896104
118 AR6 0.421569 0.871795
119 5FA 0.421569 0.896104
120 SAP 0.417476 0.851852
121 AGS 0.417476 0.851852
122 AD9 0.417476 0.873418
123 UP5 0.416667 0.851852
124 CA0 0.415842 0.873418
125 ATF 0.415094 0.8625
126 A1R 0.409091 0.841463
127 01G 0.408696 0.880952
128 APC 0.407767 0.910256
129 DG DG 0.40708 0.86747
130 A4P 0.406504 0.848837
131 UCG 0.406015 0.888889
132 7DD 0.405941 0.883117
133 93A 0.405941 0.813953
134 6AD 0.40566 0.821429
135 ADX 0.401961 0.790698
136 AGO 0.401575 0.86747
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1RJ9; Ligand: GCP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1rj9.bio1) has 55 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1RJ9; Ligand: GCP; Similar sites found: 121
This union binding pocket(no: 2) in the query (biounit: 1rj9.bio1) has 69 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1Z6T ADP 0.0002519 0.50055 2.63158
2 1G6O ADP 0.00002942 0.55746 2.66667
3 1TQ4 GDP 0.000009055 0.5576 3.28947
4 5VGR GDP 0.001605 0.46205 3.33333
5 1KA1 A3P 0.02311 0.41278 3.33333
6 4LO2 GAL BGC 0.04466 0.4046 3.37838
7 4R43 GDP 0.0008707 0.49445 4
8 1YTM ATP 0.001062 0.46239 4
9 1AZT GSP 0.00007868 0.40455 4
10 3PQC GDP 0.00009038 0.53315 4.10256
11 2NCD ADP 0.00007241 0.5702 4.27632
12 1SQ5 ADP 0.0002196 0.51961 4.54545
13 3BER AMP 0.003229 0.46473 4.81928
14 1VG8 GNP 0.00004666 0.4001 4.83092
15 2ZFI ADP 0.0002794 0.5202 5
16 1JQN DCO 0.01628 0.42408 5
17 3CV2 OXL 0.03789 0.42367 5
18 2WIC GNP 0.000004129 0.60761 5.24345
19 4P4T GDP 0.000007339 0.56777 5.26316
20 1TAD ALF 0.00007594 0.40447 5.26316
21 1TAD GDP 0.00007594 0.40447 5.26316
22 5H68 AGS 0.005287 0.40524 5.33333
23 1G7S GDP 0.00002266 0.56991 5.59211
24 1IWE IMP 0.0005134 0.45205 5.66667
25 4OHY ANP 0.0003789 0.47082 5.92105
26 1CS4 GSP 0.00009703 0.4845 6.22222
27 2BEK ATP 0.002646 0.40315 6.22568
28 1ZD9 GDP 0.00001225 0.55733 6.38298
29 4QOS ADP 0.0002401 0.51197 6.41509
30 4V0K GDP 0.00005734 0.50653 6.50888
31 2CBZ ATP 0.000003944 0.65442 6.75105
32 3U6B GDP 0.000002139 0.63953 6.85279
33 2BVN GNP 0.000003249 0.59789 6.87023
34 5HCN GCP 0.000000749 0.40072 6.89655
35 1GOJ ADP 0.00001474 0.61548 6.90789
36 1UPT GTP 0.000004117 0.40487 7.01754
37 1FQJ GDP 0.00005043 0.51353 7.14286
38 1FQJ ALF 0.02917 0.42482 7.14286
39 2DPY ADP 0.0001057 0.55636 7.23684
40 5IRR GSP 0.00007212 0.51129 7.23684
41 2ZTS ADP 0.00214 0.45214 7.23684
42 2FNA ADP 0.0004522 0.47529 7.33333
43 4BQS ADP 0.00003347 0.56828 7.38636
44 3BFX A3P 0.005367 0.43337 7.77027
45 1W7J ADP BEF 0.001979 0.4577 7.89474
46 1QF5 GDP 0.00005146 0.45749 7.89474
47 5FTB ANP 0.00009406 0.53228 8
48 5FHD ADP ALF 0.0002717 0.48963 8
49 3NHB ADP 0.0001442 0.5539 8.22368
50 3T34 GDP 0.00009453 0.50144 8.33333
51 1U4J MAN 0.04928 0.40637 8.47458
52 4BAS GNP 0.00001063 0.40244 8.54271
53 2G77 GDP 0.00002608 0.54768 8.55263
54 2G77 AF3 0.03582 0.41989 8.55263
55 4AG5 ADP 0.00001511 0.60778 8.66667
56 3EZ2 ADP 0.0004168 0.51723 8.66667
57 1GXU 2HP 0.00009542 0.55472 8.79121
58 4IEE AGS 0.0002509 0.52901 9
59 2WJG GDP 0.00001999 0.57996 9.04255
60 1JI0 ATP 0.000102 0.55722 9.16667
61 1YZN GNP 0.00007905 0.49212 9.18919
62 3K7S R52 0.02538 0.41777 9.49721
63 4A7W GTP 0.04449 0.41074 9.53947
64 2VOH CIT 0.04287 0.42567 9.55414
65 4DKX GDP 0.000003196 0.62149 9.72222
66 2ODE ALF GDP 0.0001011 0.40203 9.92908
67 4M9Q GNP 0.00001296 0.54494 10.1322
68 3T12 GDP ALF 0.00006819 0.51239 10.6061
69 2WKQ GTP 0.0002378 0.48368 10.8553
70 5DI3 GNP 0.00001567 0.54122 11.3514
71 5BQ5 ADP BEF 0.0002875 0.50808 11.6402
72 3GJ8 GDP 0.000004174 0.60737 11.7647
73 1L2T ATP 0.004514 0.42394 11.9149
74 4J0Q GDP 0.000002306 0.63779 12
75 4NEC SAH 0.03221 0.40237 12.1212
76 3GJ0 GDP 0.000003879 0.6171 12.2172
77 2Y8E GNP 0.00009088 0.49362 12.2905
78 1GUA GNP 0.0001372 0.48205 12.3457
79 2CK3 ANP 0.00108 0.46608 12.8289
80 2CK3 ADP 0.001042 0.45524 12.8289
81 4NON GDP 0.0005906 0.45207 12.8289
82 3FKQ ATP 0.0003221 0.49544 12.8686
83 5J1J ANP 0.0000178 0.40151 13.6842
84 1WQ1 GDP 0.00009156 0.50205 13.8554
85 1WQ1 AF3 0.02677 0.4284 13.8554
86 5UFQ GNP 0.00002632 0.40232 13.8554
87 5UWQ GNP 0.0001173 0.48491 13.9241
88 5UWJ GNP 0.0001392 0.48178 13.9241
89 5JCP GDP ALF 0.0001079 0.51816 14.3333
90 4H1V GNP 0.00004251 0.53752 15
91 1WA5 GTP 0.0002418 0.45804 15.3409
92 1YRB GDP 0.000001316 0.4007 15.6489
93 4CVN ADP 0.00001086 0.61047 16.0584
94 2A5J GDP 0.000008659 0.58396 16.2304
95 2GJ8 ALF GDP 0.000033 0.50807 16.2791
96 2HF9 GSP 0.00006511 0.52866 16.3717
97 1XEX ATP 0.001664 0.43959 16.4835
98 4WZA ACP 0.001494 0.41491 17
99 4WZA ADP 0.001543 0.41441 17
100 1S9D GDP 0.000003197 0.61328 17.6829
101 1GP2 GDP 0.0001835 0.48867 18.3099
102 3N5C GDP 0.0000009495 0.64898 18.5185
103 3PCR GTP 0.00004192 0.51709 19.1358
104 5EE5 GTP 0.000005879 0.40605 19.883
105 1R4A GNP 0.000009579 0.40995 21.2121
106 5TAR GDP 0.00001681 0.56302 22.1622
107 1WDT GTP 0.00001183 0.55804 22.3684
108 3LXR GDP 0.0001153 0.52788 23.2432
109 4LC1 GDP 0.000001354 0.64094 23.6842
110 1M2O GNP 0.00003009 0.40155 24.2105
111 1TX4 ALF GDP 0.0004309 0.47223 24.2938
112 1J2J GTP 0.00003386 0.5212 24.4444
113 1QHH ATP 0.00454 0.45249 24.5509
114 4HI0 GDP 0.00002288 0.53908 24.6231
115 3MJH GTP 0.0001143 0.48936 26.7857
116 3QBT GNP 0.00006423 0.50006 27.5862
117 4LHW GNP 0.0001156 0.48914 27.5862
118 1Z2A GDP 0.0001512 0.4924 33.3333
119 1Z0J GTP 0.00005409 0.49905 33.8983
120 2BCG GDP 0.00004726 0.52983 35.9223
121 2OM2 GDP 0.00008879 0.51199 41.6667
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