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Receptor
PDB id Resolution Class Description Source Keywords
1OLM 1.95 Å EC: 2.-.-.- SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED V ITAMIN E AND CHOLESTEROL BIOSYNTHESIS HOMO SAPIENS LIPID-BINDING PROTEIN CHOLESTEROL BIOSYNTHESIS OXIDIZED VITAMIN E LIPID-BINDING TRANSPORT TRANSCRIPTION REGULATION ACTIVATOR
Ref.: SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS J.MOL.BIOL. V. 332 759 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
VTQ A:1322;
C:1323;
E:1398;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
446.706 C29 H50 O3 CC1=C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1OLM 1.95 Å EC: 2.-.-.- SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED V ITAMIN E AND CHOLESTEROL BIOSYNTHESIS HOMO SAPIENS LIPID-BINDING PROTEIN CHOLESTEROL BIOSYNTHESIS OXIDIZED VITAMIN E LIPID-BINDING TRANSPORT TRANSCRIPTION REGULATION ACTIVATOR
Ref.: SUPERNATANT PROTEIN FACTOR IN COMPLEX WITH RRR-ALPHA-TOCOPHERYLQUINONE: A LINK BETWEEN OXIDIZED VITAMIN E AND CHOLESTEROL BIOSYNTHESIS J.MOL.BIOL. V. 332 759 2003
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 1OLM - VTQ C29 H50 O3 CC1=C(C(=O....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: VTQ; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 VTQ 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found with APoc: 388
This union binding pocket(no: 1) in the query (biounit: 1olm.bio3) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 3GF2 SAL None
3 4RJD TFP None
4 2C1Q BTN None
5 3KPE TM3 None
6 5N8V KZZ None
7 1ZED PNP 0.992556
8 5CXI 5TW 1.47783
9 2O1V ADP 1.48883
10 2WD7 VGD 1.49254
11 4V3I ASP LEU THR ARG PRO 1.55642
12 2HHP FLC 1.73697
13 5OSW DIU 1.73697
14 2VWA PTY 1.9802
15 6CGN DA 1.98511
16 3W5N RAM 1.98511
17 3NB0 G6P 1.98511
18 4OPC PGT 1.98511
19 4OPC FDA 1.98511
20 6CB2 OLC 2.04778
21 4MLO PAM 2.17391
22 3WUC GLC GAL 2.18978
23 5NBP BGC BGC BGC 2.20588
24 1IS3 LAT 2.22222
25 4IGQ OGA 2.22222
26 4OKD GLC GLC GLC 2.23325
27 5EGH PC 2.23325
28 5N87 N66 2.23642
29 1YYE 196 2.23881
30 2R5V HHH 2.2409
31 5IN3 G1P 2.24439
32 1YKD CMP 2.26131
33 1HV6 MAW MAV GCU 2.2792
34 5YJS SAL 2.30769
35 6CS8 F9Y 2.31023
36 2YFB SIN 2.32558
37 1OIJ AKG 2.32558
38 5C3R HMU 2.33236
39 5C3R AKG 2.33236
40 1JAY F42 2.35849
41 3WV6 GAL BGC 2.36486
42 4BCS BTN 2.4
43 1DMY AZM 2.41935
44 5O9W AKG 2.45232
45 4RFR RHN 2.46305
46 5V4R MGT 2.46914
47 2AXR ABL 2.48139
48 4J24 EST 2.5
49 4J26 EST 2.5
50 3OLL EST 2.5
51 4RYV ZEA 2.58065
52 4Y24 TD2 2.5974
53 3RDO BTN 2.61438
54 3TDV GDP 2.61438
55 1ULE GLA GAL NAG 2.66667
56 3X01 AMP 2.72953
57 5VRH OLB 2.72953
58 6B9T 2HE 2.72953
59 3UDZ ADP 2.72953
60 1OJK GLC BGC 2.73632
61 4P6X HCY 2.7451
62 1XMY ROL 2.76382
63 5HV0 AKG 2.76498
64 4NPL AKG 2.8
65 5A6N U7E 2.82686
66 1GQG DCD 2.85714
67 3TDC 0EU 2.88714
68 3NNT DQA 2.89855
69 3NV3 GAL NAG MAN 2.89855
70 4BTB PRO PRO PRO PRO PRO PRO PRO PRO PRO 2.92887
71 3B00 16A 2.94118
72 3OPT AKG 2.94906
73 3EW2 BTN 2.96296
74 2WW2 SWA 2.97767
75 3OYW TDG 2.98507
76 6AYH C3G 2.98507
77 1GZW GAL BGC 2.98507
78 4XJ7 ADE 2.99625
79 5I0U DCY 3
80 3FW3 ETS 3.00752
81 3ANK NG6 GCD 3.01508
82 5FYR INS 3.02013
83 3SCH TB6 3.0303
84 1ZZ7 S0H 3.0303
85 4DE3 DN8 3.04183
86 5KBE IPH 3.05677
87 6BR9 PGV 3.06407
88 6BR9 6OU 3.06407
89 3ZJQ NCA 3.07692
90 1SWG BTN 3.125
91 4FE2 AIR 3.13725
92 1Y7P RIP 3.13901
93 3G58 988 3.14961
94 4CNO 9PY 3.1746
95 5XJD 87L 3.18182
96 4F06 PHB 3.2345
97 3JUQ AKD 3.24324
98 3JUQ AJD 3.24324
99 4I90 CHT 3.30033
100 5AZC PGT 3.33333
101 5I8T LAC 3.35196
102 2GWH PCI 3.3557
103 3B1Q NOS 3.37423
104 2BCG GER 3.39806
105 4OJ8 AKG 3.41297
106 2HZQ STR 3.44828
107 1XZ3 ICF 3.44828
108 1TV5 N8E 3.47395
109 2PX6 DH9 3.48101
110 4N14 WR7 3.50318
111 6BMS PLM 3.51906
112 5K21 6QF 3.5461
113 4URG C2E 3.59281
114 4JH6 FCN 3.62319
115 5I8F ML1 3.63636
116 5EY0 GTP 3.64964
117 3MPB FRU 3.65854
118 1NX4 AKG 3.663
119 1NKI PPF 3.7037
120 5W0N UPU 3.72208
121 4EKQ NPO 3.74332
122 5TV6 PML 3.75
123 6BMM OLB 3.75427
124 3ZXE PGZ 3.7594
125 1K12 FUC 3.79747
126 4XU6 TDA 3.80952
127 2GBB CIT 3.84615
128 2BHW NEX 3.87931
129 3O01 DXC 3.8961
130 1FX8 BOG 3.91459
131 5X7Q GLC GLC GLC GLC GLC 3.97022
132 4RW3 IPD 3.97022
133 5JWP AKG 3.97727
134 2ET1 GLV 3.9801
135 2WA4 069 4.01146
136 2XUM OGA 4.01146
137 3P3N AKG 4.01146
138 3AQT RCO 4.08163
139 6FOF LAT 4.08163
140 4ZSI 4R1 4.09357
141 1TMX HGX 4.09556
142 2ZZV LAC 4.15512
143 2BP1 FLC 4.16667
144 4JZR 4JR 4.16667
145 2GQS C2R 4.21941
146 1OS7 AKG 4.24028
147 3B6C SDN 4.2735
148 1Y2F WAI 4.31655
149 3E2M E2M 4.32432
150 5XNA SHV 4.34783
151 3FS1 MYR 4.34783
152 1DTL BEP 4.34783
153 4QDF 30Q 4.35897
154 4QDC ASD 4.35897
155 4WGF HX2 4.39024
156 4DOO DAO 4.39024
157 3TL1 JRO 4.40252
158 6GNO XDI 4.44444
159 5OLK DTP 4.4665
160 4WOE ADP 4.4665
161 4Z28 BTN 4.47761
162 5T9C G3P 4.47761
163 4OCT AKG 4.5045
164 6HDT BTN 4.51128
165 6G5Q EMZ 4.51128
166 5H9Q TD2 4.51613
167 5T7I LAT NAG GAL 4.51613
168 1I0B PEL 4.51807
169 1GVE CIT 4.58716
170 4JGP PYR 4.60829
171 1EYE PMM 4.64286
172 5LWY OLB 4.6729
173 5LX9 OLB 4.71464
174 2UW1 GVM 4.73373
175 2F7A BEZ 4.74138
176 1I82 BGC BGC 4.7619
177 2GC0 PAN 4.78723
178 4K55 H6P 4.83871
179 6EVN PRO PRO GLY PRO ALA GLY PRO PRO GLY 4.90196
180 1OBD ATP 4.90196
181 3T03 3T0 4.92958
182 2AGC DAO 4.93827
183 5HCN DAO 4.98084
184 5DXG EST 4.98084
185 5DX3 EST 4.98084
186 5WGQ EST 4.98084
187 5DXE EST 4.98084
188 5WGD EST 4.98084
189 1RTW MP5 5
190 2C91 TLA 5.02959
191 1GT4 UNA 5.03145
192 2QZO KN1 5.03876
193 5HYR EST 5.03876
194 2P4Y C03 5.05415
195 4MG8 27J 5.09804
196 4MGD 27N 5.09804
197 4MG9 27K 5.09804
198 4TUZ 36J 5.09804
199 4MGA 27L 5.09804
200 4MGB XDH 5.09804
201 3FUR Z12 5.14706
202 3UUA 0CZ 5.17928
203 4TV1 36M 5.17928
204 4QCK ASD 5.18135
205 5WBF LAC 5.18518
206 1R6N 434 5.21327
207 2WDQ CBE 5.21739
208 5TPV TYD 5.22876
209 4G7A AZM 5.24194
210 4DK7 0KS 5.26316
211 2I74 MAN MAN MAN MAN 5.29101
212 4EVQ PHB 5.33333
213 4QVX 3CQ 5.38922
214 5IUY BOG 5.45906
215 2XIB DFU 5.45906
216 3W54 RNB 5.47112
217 2VQ5 HBA 5.47264
218 5JSP DQY 5.47264
219 2ARC ARA 5.4878
220 3F8C HT1 5.55556
221 4ZU5 THM 5.55556
222 5Y02 MXN 5.60748
223 5Y02 HBX 5.60748
224 3RV5 DXC 5.61798
225 5GLT BGC GAL NAG GAL 5.6338
226 5W7B MYR 5.67376
227 2VAT COA 5.7072
228 5VNF VAL THR SER VAL VAL 5.73248
229 3IX9 MTX 5.78947
230 4V1F BQ1 5.81395
231 4J8T DOG 5.83942
232 4IAW LIZ 5.85106
233 4YLZ LAT NAG GAL 5.88235
234 3RGA LSB 6.00707
235 6AYI C3G 6.03015
236 1NSZ GLC 6.05187
237 5BVB DOG 6.06061
238 1OGX EQU 6.10687
239 2GN2 C5P 6.14035
240 5IM3 DTP 6.20347
241 1N8V BDD 6.25
242 4EKV BTN 6.28931
243 6BR8 PGV 6.34921
244 6BR8 6OU 6.34921
245 3P9T TCL 6.39269
246 1MH5 HAL 6.39269
247 1XIM XYL 6.61578
248 3KP6 SAL 6.62252
249 1NF8 BOG 6.76329
250 6GMN F4E 6.79012
251 4HDK 13X 6.85714
252 3VV1 GAL FUC 6.875
253 3W9R A8S 6.87831
254 4QM9 CYS 6.93642
255 4D52 GXL 6.98413
256 3L9R L9R 7.06714
257 5C9J DAO 7.07071
258 5WL1 CUY 7.07071
259 5WL1 D3D 7.07071
260 5U98 1KX 7.07071
261 5UC9 MYR 7.07965
262 3CF6 SP1 7.18563
263 5D3X 4IP 7.18563
264 1EWF PC1 7.19603
265 5O5Y GLC 7.19603
266 1OGZ EQU 7.2
267 3L1N PLM 7.2165
268 2HJ9 AI2 7.37463
269 4ZGM 32M 7.37705
270 3KFF XBT 7.40741
271 3KFF ZBT 7.40741
272 4P7X YCP 7.53425
273 4P7X AKG 7.53425
274 5FS0 5JC 7.58294
275 1T36 ORN 7.69231
276 1H2M OGA 7.69231
277 3WW2 SF6 7.8125
278 1HBK MYR 7.86517
279 4QXB OGA 7.90274
280 5FPN KYD 7.94045
281 1QFT HSM 8
282 4XDA RIB 8.09062
283 5YSN 5AD 8.13559
284 1T0S BML 8.13953
285 4LIT AKG 8.18859
286 1W6O LAT 8.20895
287 5H9P TD2 8.22785
288 3FAL REA 8.26446
289 2P7Q GG6 8.27068
290 4MA6 28E 8.28025
291 3WG3 A2G GAL NAG FUC 8.42697
292 2R0H CTO 8.53659
293 3PG7 PTY 8.59375
294 3AI3 SOE 8.74525
295 5X3R 7Y3 8.78049
296 3NJQ NJQ 8.80829
297 5OO5 UUA 8.87097
298 4UCC ZKW 8.933
299 6D5V FVY 8.98204
300 4A7W GTP 9.16667
301 4XCB AKG 9.1954
302 4F4S EFO 9.21053
303 6D61 4AA 9.23077
304 2QL9 CIT 9.24856
305 2OVD DAO 9.34066
306 2Z77 HE7 9.35252
307 2Z77 NCA 9.35252
308 5NLD LBT 9.35252
309 5LUN OGA 9.375
310 1XVB 3BR 9.41177
311 1I06 TZL 9.44444
312 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 9.52381
313 3RY9 1CA 9.6
314 5V3D FCN 9.65517
315 1A78 TDG 9.70149
316 1H2K OGA 9.7561
317 5O6Y 5YA 9.81308
318 1N5S ADL 9.82143
319 1ZOY UQ1 9.92064
320 5XJ7 87O 9.95025
321 1XX4 BAM 9.96169
322 3HUJ AGH 10.0478
323 1NU4 MLA 10.3093
324 4BJ8 BTN 10.3175
325 4JNJ BTN 10.4348
326 2HO2 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 10.5263
327 3QP8 HL0 10.8696
328 4DOL PLM 11.0599
329 2OMN IPH 11.0599
330 4OGQ 7PH 11.1111
331 4OGQ 1O2 11.1111
332 4OGQ UMQ 11.1111
333 3G08 FEE 11.1111
334 3RUG DB6 11.1111
335 3N9Q OGA 11.1663
336 4G86 BNT 11.2676
337 1J3R 6PG 11.5789
338 2Y69 CHD 11.6279
339 4J7Q B7N 11.7117
340 5X80 SAL 11.875
341 2WOR 2AN 12
342 3N7S 3N7 12.1739
343 4MA7 P2Z 12.2807
344 5CHR 4NC 12.4088
345 4YSX E23 12.4113
346 5UGW GSH 12.5714
347 4LOC OXM 12.6551
348 4GGZ BTN 13.0435
349 3RMK BML 13.253
350 4RHP PEF 13.617
351 4O4Z N2O 13.6364
352 3G4Q MCH 13.6986
353 3H22 B53 13.8047
354 4WVW SLT 13.8889
355 4V2O CLQ 14.6341
356 4ZU4 4TG 14.8649
357 5B09 4MX 15.3846
358 3N9P OGA 15.625
359 3E70 GDP 15.8537
360 5KAU RHQ 16.3636
361 5OCA 9QZ 16.6667
362 5AIG VPR 16.8
363 3KO0 TFP 16.8317
364 5N26 CPT 17.033
365 4XCP PLM 17.0588
366 5Z84 CHD 17.4312
367 5ZCO CHD 17.4312
368 5W97 CHD 17.4312
369 5ZCO PEK 17.4312
370 1Q23 FUA 17.8082
371 5TFZ 7BC 18
372 3KYQ DPV 18.0905
373 1ZEI CRS 18.8679
374 5MWE TCE 20
375 2QCX PF1 20.9125
376 5EZU MYR 21.3483
377 5KWY C3S 22.5564
378 5YZ2 AMP 22.9167
379 5NNT DPV 24.3243
380 5HUA FK5 26.9565
381 3HX3 RET 29.1139
382 3SAO NKN 33.75
383 1BHX ASP PHE GLU GLU ILE 40
384 3Q8G PEE 44.375
385 1AUA BOG 44.5946
386 1R5L VIV 45.8015
387 3W68 VIV 45.8647
388 3N9O OGA 47.0588
Pocket No.: 2; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found with APoc: 55
This union binding pocket(no: 2) in the query (biounit: 1olm.bio1) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 2FAH MLA 1.73697
2 1A8U BEZ 1.80505
3 2Y3S TIR 2.23325
4 5LXB 7A9 2.47934
5 3N75 G4P 2.48139
6 1U3R 338 2.48963
7 1OFZ FUC 2.5641
8 4B1M FRU FRU 2.7027
9 3LXI CAM 2.72953
10 1XM4 PIL 2.76382
11 6A63 LAT 2.89855
12 1SZ0 M6P 2.97767
13 2OVW CBI 2.97767
14 1WBI BTN 3.10078
15 1SGJ OAA 3.16901
16 1D6H COA 3.35917
17 6AC9 ANP 3.51351
18 1VYF OLA 3.7037
19 5J32 IPM 3.72208
20 3NNF AKG 3.77907
21 2GQR ADP 3.79747
22 2Y0I AKG 3.97727
23 5ML3 DL3 4.02685
24 3FRQ ERY 4.10256
25 2GQS ADP 4.21941
26 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 4.34783
27 5OES ADP 4.4665
28 4CPH LH4 4.51128
29 3T50 FMN 4.6875
30 4MG7 27H 5.09804
31 3UUD EST 5.17928
32 6EOZ 58K 5.19481
33 2YG2 S1P 5.23256
34 1E8G FAD 5.7072
35 1M0W ANP 5.95534
36 2HZL PYR 6.0274
37 5FPX GLY SER SER HIS HIS HIS HIS HIS 6.19469
38 5XQW 8EU 7.109
39 5UC4 83S 7.72727
40 1DZK PRZ 8.28025
41 5TZO 7V7 8.51064
42 2PSJ CEI 8.77743
43 4RLT FSE 8.84354
44 2WMC MGP 8.98876
45 5MOB A8S 9.48276
46 1QY1 PRZ 9.77011
47 2JIG PD2 9.82143
48 3ZW2 NAG GAL FUC 10.3448
49 2GTE VA 10.4839
50 5NC9 8SZ 10.5263
51 2BS5 BGC GAL FUC 12.2222
52 5TVI MYR 13.0435
53 2HFN FMN 15.6863
54 5KEW 6SB 21.2766
55 5BU3 4W9 22.8261
Pocket No.: 3; Query (leader) PDB : 1OLM; Ligand: VTQ; Similar sites found with APoc: 27
This union binding pocket(no: 3) in the query (biounit: 1olm.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 4UDB CV7 1.83824
2 5W75 SUC 2.04082
3 2Q1H AS4 2.4
4 5NTP 98E 2.52101
5 6A0S NDP 2.71084
6 4LSJ LSJ 2.71318
7 3B99 U51 2.97767
8 5A61 3PO 3.22581
9 4M26 AKG 3.84615
10 5YW0 SIN 4.08805
11 4EAX S12 4.16667
12 1OW4 2AN 4.65116
13 2QYK NPV 4.77612
14 2VFK AMP 4.87805
15 6MPT C30 4.8951
16 6EOZ AKG 5.19481
17 5X13 HC4 5.31915
18 3ZGJ RMN 5.66038
19 5U9J GER 5.91716
20 5MZI FYK 5.95534
21 5MZI FAD 5.95534
22 2UZ2 BTN 6.15385
23 1Y9Q MED 6.77083
24 1PU7 39A 7.33945
25 4X9D U5P 12.6761
26 5ZCO PGV 17.4312
27 2V5E SCR 35.6436
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