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Receptor
PDB id Resolution Class Description Source Keywords
1TL2 2 Å NON-ENZYME: BINDING TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHO TACHYPLEUS TRIDENTATUS ANIMAL LECTIN HORSESHOE CRAB N-ACETYLGLUCOSAMINE BETA-PROSUGAR BINDING PROTEIN
Ref.: TACHYLECTIN-2: CRYSTAL STRUCTURE OF A SPECIFIC GLCNAC/GALNAC-BINDING LECTIN INVOLVED IN THE INNATE HOST DEFENSE OF THE JAPANESE HORSESHOE CRAB TACHYPL TRIDENTATUS. EMBO J. V. 18 2313 1999
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NDG A:237;
A:238;
A:239;
A:240;
A:241;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
Kd = 51.28 uM
221.208 C8 H15 N O6 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1TL2 2 Å NON-ENZYME: BINDING TACHYLECTIN-2 FROM TACHYPLEUS TRIDENTATUS (JAPANESE HORSESHO TACHYPLEUS TRIDENTATUS ANIMAL LECTIN HORSESHOE CRAB N-ACETYLGLUCOSAMINE BETA-PROSUGAR BINDING PROTEIN
Ref.: TACHYLECTIN-2: CRYSTAL STRUCTURE OF A SPECIFIC GLCNAC/GALNAC-BINDING LECTIN INVOLVED IN THE INNATE HOST DEFENSE OF THE JAPANESE HORSESHOE CRAB TACHYPL TRIDENTATUS. EMBO J. V. 18 2313 1999
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 510 families.
1 1TL2 Kd = 51.28 uM NDG C8 H15 N O6 CC(=O)N[C@....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 391 families.
1 1TL2 Kd = 51.28 uM NDG C8 H15 N O6 CC(=O)N[C@....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 1TL2 Kd = 51.28 uM NDG C8 H15 N O6 CC(=O)N[C@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: NDG; Similar ligands found: 105
No: Ligand ECFP6 Tc MDL keys Tc
1 NGA 1 1
2 NAG 1 1
3 A2G 1 1
4 BM3 1 1
5 HSQ 1 1
6 NDG 1 1
7 BGN 0.638298 0.888889
8 SIZ 0.630435 0.906977
9 YX1 0.625 0.65
10 STZ 0.612245 0.65
11 4QY 0.591837 0.735849
12 BMX 0.591837 0.735849
13 16G 0.591837 0.735849
14 9C1 0.58 0.886364
15 SNG 0.5625 0.866667
16 NGS 0.54902 0.661017
17 NDG NAG 0.54386 0.833333
18 CBS 0.54386 0.833333
19 NAG GDL 0.54386 0.833333
20 CBS CBS 0.54386 0.833333
21 ASG 0.538462 0.661017
22 BG8 0.537037 0.906977
23 MAG 0.530612 0.909091
24 2F8 0.530612 0.909091
25 NDG GAL 0.517857 0.888889
26 NLC 0.517857 0.888889
27 GAL NDG 0.517857 0.888889
28 NAG A2G 0.517241 0.833333
29 4V5 0.517241 0.829787
30 NAG NGA 0.517241 0.833333
31 4UZ 0.508475 0.808511
32 NAG NAG NAG NAG NDG 0.508197 0.816327
33 NDG NAG NAG NAG 0.508197 0.816327
34 NAG NAG NDG 0.508197 0.816327
35 NAG NAG NDG NAG 0.508197 0.816327
36 CTO 0.508197 0.816327
37 NDG NAG NAG NDG 0.508197 0.816327
38 NAG NAG NAG NDG 0.508197 0.816327
39 NDG NAG NAG 0.508197 0.816327
40 NAG NAG NAG NAG NAG 0.508197 0.816327
41 NAG NAG NAG NAG NAG NAG 0.508197 0.816327
42 NAG NAG NAG NAG NAG NAG NAG NAG 0.508197 0.816327
43 MQG 0.5 0.698113
44 NBG 0.5 0.951219
45 GAL NGA 0.491228 0.888889
46 A2G GAL 0.491228 0.888889
47 GAL A2G 0.491228 0.888889
48 AMU 0.490909 0.930233
49 NG1 0.490566 0.754717
50 GN1 0.490566 0.754717
51 NAG GAL 0.474576 0.888889
52 GAL NAG 0.474576 0.888889
53 NAG FUC 0.474576 0.866667
54 NAG GAL NAG 0.455882 0.833333
55 3YW 0.448276 0.930233
56 GLA GAL NAG 0.446154 0.888889
57 MAN BMA NAG 0.446154 0.888889
58 NGA GAL 0.428571 0.869565
59 FUC GAL NAG 0.426471 0.869565
60 GAL NAG FUC 0.426471 0.869565
61 DR2 0.426471 0.869565
62 NAG GAL FUC 0.426471 0.869565
63 NDG GAL FUC 0.426471 0.869565
64 FUC GAL NDG 0.426471 0.869565
65 FUL GAL NAG 0.426471 0.869565
66 G6S NAG 0.426471 0.645161
67 TNR 0.42623 0.833333
68 GYU 0.42623 0.740741
69 GAL NGA A2G 0.424242 0.833333
70 NAG BDP 0.421875 0.851064
71 NAG MBG 0.419355 0.851064
72 NGA GAL BGC 0.41791 0.888889
73 NAG NDG 0.415385 0.784314
74 NAG NAG 0.415385 0.784314
75 AZC 0.415094 0.795918
76 SN5 SN5 0.412698 0.705882
77 A2G MBG 0.412698 0.851064
78 MBG A2G 0.412698 0.851064
79 HS2 0.411765 0.8125
80 5AX 0.411765 0.866667
81 NAG MAN BMA 0.411765 0.888889
82 6ZC 0.409091 0.655738
83 LEC 0.409091 0.655738
84 TCG 0.408451 0.689655
85 GAL BGC NAG GAL 0.408451 0.888889
86 NAG MAN 0.40625 0.851064
87 WOO 0.404762 0.7
88 MAN 0.404762 0.7
89 GAL 0.404762 0.7
90 BGC 0.404762 0.7
91 BMA 0.404762 0.7
92 GLA 0.404762 0.7
93 ALL 0.404762 0.7
94 GLC 0.404762 0.7
95 GXL 0.404762 0.7
96 GIV 0.404762 0.7
97 NAG AMU 0.402778 0.8
98 NAG MUB 0.402778 0.8
99 NAG A2G GAL 0.402778 0.833333
100 A2G GAL FUC 0.4 0.869565
101 FUC GLA A2G 0.4 0.869565
102 DR3 0.4 0.869565
103 A2G GLA FUC 0.4 0.869565
104 NGA GAL FUC 0.4 0.869565
105 FUC GAL A2G 0.4 0.869565
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1TL2; Ligand: NDG; Similar sites found with APoc: 308
This union binding pocket(no: 1) in the query (biounit: 1tl2.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 1W4R TTP None
2 1N07 ADP None
3 1N07 FMN None
4 4E5N NAD None
5 1L5Y BEF None
6 4K4D HFQ None
7 3EHH ADP None
8 3MJH GTP 1.19048
9 1U7Z PMT 1.32743
10 3GF4 FAD 1.69492
11 3GF4 UPG 1.69492
12 5GT9 NAP 1.69492
13 2VCH UDP 1.69492
14 6DUB SAH 1.8018
15 5J60 FAD 2.11864
16 5GSN NAP 2.11864
17 5GSN MMZ 2.11864
18 3AYI HCI 2.11864
19 3AYI FAD 2.11864
20 5GSN FAD 2.11864
21 5JIC ADP 2.11864
22 5JIC N7E 2.11864
23 5O96 SAM 2.11864
24 4XQC 13D 2.11864
25 4XQC NAD 2.11864
26 2JAP NDP 2.11864
27 2Z5F A3P 2.11864
28 1YQS BSA 2.11864
29 5OVK NDP 2.11864
30 5OVL NAP 2.11864
31 3G5K BB2 2.18579
32 3WV8 ATP 2.29358
33 1COY FAD 2.54237
34 1GPE FAD 2.54237
35 2BHZ MAL 2.54237
36 4B9Q ATP 2.54237
37 5YSS NAD 2.54237
38 2H21 SAM 2.54237
39 1QO8 FAD 2.54237
40 1PJS SAH 2.54237
41 1KOL NAD 2.54237
42 5MGZ SAH 2.54237
43 5THQ NDP 2.54237
44 5ZI2 ADP 2.54237
45 5GZ9 MAN 2.54237
46 3JYN NDP 2.54237
47 1RP0 AHZ 2.54237
48 4MP8 NAD 2.54237
49 4MP8 MLI 2.54237
50 2QXL ATP 2.54237
51 2YBQ SAH 2.54237
52 1YKI NFZ 2.76498
53 3EWP APR 2.82486
54 5EE5 GTP 2.92398
55 4HA6 FAD 2.9661
56 5I60 67W 2.9661
57 3K7M FAD 2.9661
58 1X1T NAD 2.9661
59 1XA4 COA 2.9661
60 6B3V ANP 2.9661
61 6B3V 7DQ 2.9661
62 6F3M NAD 2.9661
63 2IXB A2G 2.9661
64 2IXB NAD 2.9661
65 4ONA UW1 2.9661
66 3HQ9 OXL 2.9661
67 4PW9 MSS 2.9661
68 5ERR ADP 2.9661
69 4NST ADP 2.9661
70 1AQU A3P 2.9661
71 4PPF FLC 2.9661
72 2Q1W NAD 2.9661
73 3S43 478 3.0303
74 3UWB BB2 3.24675
75 3IID APR 3.31754
76 5HSA FAS 3.38983
77 1C0I FAD 3.38983
78 1C0I BE2 3.38983
79 4GUT FAD 3.38983
80 4MO2 FAD 3.38983
81 3X0V FAD 3.38983
82 4MIG G3F 3.38983
83 4HSU FAD 3.38983
84 4N49 SAM 3.38983
85 4MO2 FDA 3.38983
86 4GUS FAD 3.38983
87 2WTX VDO 3.38983
88 5HTX ADP 3.38983
89 4FWE FAD 3.38983
90 6GNC FAD 3.38983
91 4J4H 1J1 3.38983
92 4J4H NAI 3.38983
93 6GAS FAD 3.38983
94 3LZW FAD 3.38983
95 2OO0 XAP 3.38983
96 3SJ7 NDP 3.38983
97 4ZG4 VO4 ADP 3.38983
98 5JF2 SF7 3.43137
99 3BIB PSF 3.44828
100 4EOX 0S5 3.44828
101 1QF5 RPL 3.81356
102 1QF5 GDP 3.81356
103 5B4T NAD 3.81356
104 5B4T 3HR 3.81356
105 1REO FAD 3.81356
106 5JBE GLC GLC GLC GLC GLC 3.81356
107 2IID PHE 3.81356
108 2IID FAD 3.81356
109 2IVD FAD 3.81356
110 4C3Y FAD 3.81356
111 4C3Y ANB 3.81356
112 4BNU 9KQ 3.81356
113 3GDN FAD 3.81356
114 1W78 ADP 3.81356
115 1XVV CCQ 3.81356
116 1PVN MZP 3.81356
117 3O26 NDP 3.81356
118 5TS5 FAD 3.81356
119 5B47 PYR 3.81356
120 5B47 TPP 3.81356
121 1W78 PD8 3.81356
122 3VPH OXM 3.81356
123 4IXH IMP 3.81356
124 5E9W SAH 3.81356
125 4DPL NAP 3.81356
126 5O98 NAP 3.81356
127 6A3J NAI 3.81356
128 1P1C SAH 4.0201
129 2J9C ATP 4.20168
130 6H3O FAD 4.23729
131 2Q7V FAD 4.23729
132 5THY SAH 4.23729
133 3U9Z ADP 4.23729
134 1P9B GDP 4.23729
135 5THZ SAH 4.23729
136 4M52 FAD 4.23729
137 4J7U NAP 4.23729
138 4J7U YTZ 4.23729
139 4D9M 0JO 4.23729
140 3MAG SAH 4.23729
141 2VJ8 HA2 4.23729
142 5KGS 6SR 4.23729
143 1Z6Z NAP 4.23729
144 1KXP ATP 4.23729
145 2A92 NAI 4.23729
146 1EZ0 NAP 4.23729
147 3MCT SAH 4.23729
148 5YPU ATP 4.23729
149 2VJM COA 4.23729
150 4PL8 ATP 4.23729
151 3HSS MLA 4.23729
152 3MN5 ATP 4.23729
153 1JG3 ADN 4.25532
154 5ZDN CDP 4.2654
155 2AMT 1AA 4.40252
156 5ZZB ATP 4.41176
157 5YEE ATP 4.41176
158 5E8J SAH 4.54545
159 1ZX5 LFR 4.66102
160 2C7G FAD 4.66102
161 2AE2 PTO 4.66102
162 3NTA COA 4.66102
163 1P0F NAP 4.66102
164 5OGX FAD 4.66102
165 3NTD COA 4.66102
166 3ICS COA 4.66102
167 2QZX IVA VAL VAL STA ALA STA 4.66102
168 3ICT COA 4.66102
169 4DEC UDP 4.66102
170 4DEC 3PG 4.66102
171 4O0L NDP 4.66102
172 1TU3 GNP 4.67836
173 1Z06 GNP 4.7619
174 3JVH HHV 4.91803
175 1JG9 GLC 5.08475
176 1KNR FAD 5.08475
177 2GMH FAD 5.08475
178 5ZYN FAD 5.08475
179 1V8B NAD 5.08475
180 5AHM IMP 5.08475
181 2F5Z FAD 5.08475
182 4R5M NAP 5.08475
183 4R5M 4NO 5.08475
184 3RNM FAD 5.08475
185 5U97 PIT 5.08475
186 1WG8 SAM 5.08475
187 5NMX FAD 5.08475
188 5UY8 8UM 5.08475
189 5UY8 AMZ 5.08475
190 5M58 SAH 5.21739
191 3C3N FMN 5.50847
192 5O4J 9KH 5.50847
193 5O4J SAH 5.50847
194 4Z24 FAD 5.50847
195 4X7R NTO 5.50847
196 4X7R 3YW 5.50847
197 4X7R UDP 5.50847
198 6CI9 NAP 5.50847
199 4UP3 FAD 5.50847
200 4W6Z 8ID 5.50847
201 1IZE IVA VAL VAL STA ALA STA 5.50847
202 4C8E C5P 5.50847
203 1S17 GNR 5.55556
204 3IWD M2T 5.88235
205 2R4J 13P 5.9322
206 2R4J FAD 5.9322
207 2E5V FAD 5.9322
208 5YB7 ORN 5.9322
209 5YB7 FAD 5.9322
210 6GAR FAD 5.9322
211 5TUZ SAM 5.9322
212 5TUZ 7L6 5.9322
213 4AUT FAD 5.9322
214 3AB1 FAD 5.9322
215 1LLU NAD 5.9322
216 4A62 ANP 5.9322
217 2RFI SAH 5.9322
218 3SWC SAH 5.9322
219 4QED NAP 5.9322
220 3NUG NAD 5.9322
221 4AX9 N5N 5.9322
222 3E3U NVC 6.09137
223 1SAY PYR 6.09418
224 3M6P BB2 6.21762
225 4CZG QH3 6.35593
226 4CZG ADP 6.35593
227 1I8T FAD 6.35593
228 5LJW ANP 6.35593
229 3QXY SAM 6.35593
230 3WQT ANP 6.35593
231 4EUE NAI 6.35593
232 4HXY NDP 6.35593
233 5ZBL AMP 6.40394
234 1ZUI SKM 6.54762
235 4K49 HFQ 6.61765
236 5YLT C7N 6.77966
237 5YLT SFG 6.77966
238 3RUV ANP 6.77966
239 5E1M SAH 6.77966
240 3M54 SAH 6.77966
241 2XTZ GSP 6.77966
242 4J8O SAH 6.77966
243 2H6T IVA VAL VAL STA ALA STA 6.77966
244 3ETG NDP 6.77966
245 3ETG GLU 6.77966
246 2F69 SAH 6.77966
247 1RQ5 CTT 6.77966
248 4FMU 0UM 6.77966
249 5WQP NAP 6.83761
250 4U8P UDP 7.20339
251 4ZRN NAD 7.20339
252 1Q19 APC 7.20339
253 3SJH LAR 7.40741
254 3SJH ATP 7.40741
255 1GZ4 ATP 7.62712
256 4JNE ATP 7.62712
257 1T9D P22 7.62712
258 4IV9 FAD 7.62712
259 4EHU ANP 7.62712
260 1JBW ACQ 7.62712
261 4K26 NDP 7.62712
262 4ZL4 4PK 7.62712
263 3G5S FAD 8.05085
264 5TUK FAD 8.05085
265 1O94 ADP 8.05085
266 1AE1 NAP 8.47458
267 1VL8 NAP 8.47458
268 1PFK ADP 8.47458
269 4C1Q SAH 8.57143
270 5XK9 DMA 8.62069
271 5XK9 GST 8.62069
272 3QFA FAD 8.62069
273 3VC3 C6P 8.72093
274 4USR FAD 8.8983
275 4RLQ 3SK 8.8983
276 1XG5 NAP 9.32203
277 3BXF 13P 9.32203
278 4P7U 1PS 9.82143
279 6EOF ADP 10.1695
280 6AU6 GDP 10.1695
281 1CS4 GSP 10.1695
282 4NVQ 2OD 10.5932
283 4NVQ SAH 10.5932
284 5T0K SAM 10.5932
285 5JIY SAM 10.5932
286 3CZ7 ACO 10.5932
287 6ASY ATP 11.0169
288 1SVM ATP 11.0169
289 5ERG SAM 11.4407
290 4ZLU ADP 11.4407
291 4ZLU 4PW 11.4407
292 2WOE AR6 11.8644
293 3DZ6 M8E 11.9403
294 6FHQ DE5 12.069
295 2PBD ATP 12.2302
296 4CQM NAP 12.2881
297 5EFQ ADP 12.7119
298 2GVC FAD 13.1356
299 1T3D CYS 13.1356
300 3KMT SAH 13.4454
301 4J56 FAD 14.0351
302 2Q3O FMN 14.4068
303 2FKA BEF 14.7287
304 6F97 FAD 14.8305
305 5LRT ADP 15.2542
306 4YSX FAD 17.3729
307 2A2C NG1 28.3898
308 2A2C ADP 28.3898
Pocket No.: 2; Query (leader) PDB : 1TL2; Ligand: NDG; Similar sites found with APoc: 171
This union binding pocket(no: 2) in the query (biounit: 1tl2.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 3LF0 ATP None
2 3U7S 017 None
3 3GD8 GOL 1.34529
4 3QDL FMN 1.42857
5 5TOW NAI 1.69492
6 5TOW ADN 1.69492
7 1UDB NAD 1.69492
8 1UDB UFG 1.69492
9 5I34 GDP 1.69492
10 2FXD DR7 2.0202
11 5JE0 SAH 2.11864
12 5JE0 AZ8 2.11864
13 4ZCC NAI 2.11864
14 4ZCC FAD 2.11864
15 1GQ2 NAP 2.11864
16 2YNC YNC 2.11864
17 4GKV NAD 2.11864
18 3LKZ SFG 2.11864
19 4E93 GUI 2.11864
20 4WGF HX2 2.43902
21 3KA2 2NC 2.46305
22 2C6Q IMP 2.54237
23 2C6Q NDP 2.54237
24 3W8X FAD 2.54237
25 1VHD NAP 2.54237
26 3WLE NAD 2.54237
27 3ICC NAP 2.54237
28 3EVG SAH 2.54237
29 5ZI2 NAD 2.54237
30 6GBC AMP 2.6087
31 1P9P SAH 2.68199
32 2PXX SAH 2.7907
33 6GNA FAD 2.9661
34 1YXM ADE 2.9661
35 2YG3 FAD 2.9661
36 4C2X NHW 2.9661
37 2BNF UTP 2.9661
38 2BNE U5P 2.9661
39 5WA0 MSS 2.9661
40 3LMS GLY 2.9661
41 4GNI ATP 2.9661
42 5HGZ ACO 2.9661
43 1KGZ PRP 2.9661
44 1G27 BB1 2.97619
45 2ZL4 ALA ALA ALA ALA 3.06122
46 2QQ0 ANP 3.26087
47 1JQ9 PHE LEU SER TYR LYS 3.30579
48 2YCH ATP 3.38983
49 1D8C SOR 3.38983
50 4JK3 NAD 3.38983
51 3NJ4 NAD 3.38983
52 3LU1 NAD 3.38983
53 1IG3 VIB 3.38983
54 1KYZ SAH 3.38983
55 3IWK NAD 3.38983
56 4Z87 5GP 3.38983
57 2IHU TP9 3.38983
58 5H7J GCP 3.38983
59 2ZTS ADP 3.58566
60 1LTH NAD 3.81356
61 2VVM FAD 3.81356
62 5MBX FAD 3.81356
63 5MBX SP5 3.81356
64 1OFD AKG 3.81356
65 3GDN HBX 3.81356
66 1OFD FMN 3.81356
67 4YKG FAD 3.81356
68 1DL5 SAH 3.81356
69 4NBU NAI 3.81356
70 2VVL FAD 3.81356
71 5ZBC FAD 3.81356
72 4UA3 COA 3.81356
73 3MWS 017 4.0404
74 2J9D ADP 4.20168
75 3NCQ ATP 4.20168
76 2J9D AMP 4.20168
77 4REP FAD 4.23729
78 1BW9 PPY 4.23729
79 1C1X HFA 4.23729
80 4Y30 SAH 4.23729
81 2Q97 ATP 4.23729
82 4CBU ATP 4.23729
83 2O07 SPD 4.23729
84 2O07 MTA 4.23729
85 2A42 ATP 4.23729
86 2V51 ATP 4.23729
87 4B1V ATP 4.23729
88 4PKI ATP 4.23729
89 2A40 ATP 4.23729
90 4B1X ATP 4.23729
91 2FF3 ATP 4.23729
92 4PKG ATP 4.23729
93 4B1W ATP 4.23729
94 1IBR GNP 4.62963
95 6H5E ANP 4.66102
96 3LM9 ADP 4.66102
97 5OBU ANP 4.66102
98 4CBX ATP 4.66102
99 2A9D MTE 4.66102
100 2XYA 7L4 4.94506
101 2NVA PL2 5.08475
102 1UAD GNP 5.14286
103 5FEU NAP 5.15464
104 4YRY FAD 5.50847
105 2WUF KEM 5.50847
106 1WA5 GTP 5.68182
107 3TNF GNP 5.74713
108 4LHW GNP 5.74713
109 2VBU CDP 5.88235
110 1YZN GNP 5.94595
111 3ZOK GLY 6.35593
112 2V7B BEZ 6.35593
113 4WZH FMN 6.35593
114 2CXG GLC GLC 6.35593
115 1LDN NAD 6.35593
116 6FTB M0E 6.66667
117 1N62 MCN 6.77966
118 2RGO FAD 6.77966
119 2RGH FAD 6.77966
120 4Z0G 5GP 6.77966
121 4USQ FAD 6.77966
122 3T1O GDP 7.07071
123 4USI ATP 7.14286
124 1H82 GZZ 7.20339
125 1H82 FAD 7.20339
126 4LGY ADP 7.20339
127 3VPB ADP 7.20339
128 3WGT QSC 7.62712
129 3WGT FAD 7.62712
130 5WKC TP9 7.62712
131 5WKC AUJ 7.62712
132 2PID YSA 7.62712
133 1UWK URO 8.05085
134 1UWK NAD 8.05085
135 3GJX GTP 8.05085
136 2BUP ATP 8.05085
137 2BUP ADP 8.05085
138 1X87 NAD 8.47458
139 3CTY FAD 8.47458
140 1FK8 NAD 8.8983
141 5ZZA ATP 9.09091
142 3MJY FMN 9.32203
143 3MJY IJZ 9.32203
144 5M67 3D1 9.74576
145 5M67 NAD 9.74576
146 3M1I GTP 10.4712
147 1ME8 RVP 10.5932
148 3WYF GTP 11.4407
149 1VQW FAD 13.1356
150 2GV8 FAD 13.1356
151 4OM8 NAD 13.1356
152 1YY5 FAD 14.4068
153 1RSG FAD 14.4068
154 3BC1 GNP 16.4103
155 4K81 GTP 18.7134
156 5O2T GSP 18.9349
157 5UWO GNP 25.8741
158 5UWS GNP 25.8741
159 5UWI GNP 25.8741
160 5UWR GNP 25.8741
161 5UWQ GNP 25.8741
162 5UWU GNP 25.8741
163 5UWW GNP 25.8741
164 5DI9 GNP 25.8741
165 5UWT GNP 25.8741
166 5DHF GNP 25.8741
167 5UWJ GNP 25.8741
168 6CIT GNP 25.8741
169 5DIF GNP 25.8741
170 5UWH GNP 27.2727
171 5UWP GNP 42.1053
Pocket No.: 3; Query (leader) PDB : 1TL2; Ligand: NDG; Similar sites found with APoc: 131
This union binding pocket(no: 3) in the query (biounit: 1tl2.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 4RF2 NAP 1.69492
2 1W5F G2P 1.69492
3 1UPT GTP 1.75439
4 4YNM SAM 1.76991
5 4KVG GTP 1.78571
6 5FFF NAP 2.11864
7 2JAH NDP 2.11864
8 4NBI D3Y 2.43902
9 2GQT FAD 2.54237
10 1CT9 GLN 2.54237
11 4WHZ 3NL 2.54237
12 4NBT NAD 2.54237
13 4BUY F37 2.54237
14 4ZI2 GNP 2.63158
15 5SZH GNP 2.95567
16 1H5S TMP 2.9661
17 3FPF MTA 2.9661
18 3FPF TNA 2.9661
19 2GWH A3P 2.9661
20 5L53 NAP 2.9661
21 5W7R 9Z7 2.9661
22 5W7R SAH 2.9661
23 2VG1 FPP 3.07018
24 1OIX GDP 3.14136
25 4JDR FAD 3.38983
26 3VHE 42Q 3.38983
27 1QM5 PLP 3.38983
28 3WXB NDP 3.38983
29 2H6B 3C4 3.38983
30 4RDI ATP 3.38983
31 2ZIF SAM 3.38983
32 2WTX UDP 3.38983
33 1SOX MTE 3.38983
34 4RDH AMP 3.38983
35 4AG8 AXI 3.38983
36 3TN7 NJP 3.38983
37 2Z6J FMN 3.38983
38 2CUL FAD 3.44828
39 5VBC SAH 3.49345
40 2J4K U5P 3.53982
41 4OOP DUP 3.61446
42 2BFR ADP 3.64583
43 1ZCB GDP 3.81356
44 3FPZ AHZ 3.81356
45 1PS9 FAD 3.81356
46 3ZZH ARG 3.81356
47 3KLJ FAD 3.81356
48 5VN0 NAI 3.81356
49 5TCI MLI 3.81356
50 3KCC CMP 3.81356
51 4BGB ADP 3.81356
52 4M9Q GNP 3.96476
53 5LLT DND 4.22535
54 1OC2 NAD 4.23729
55 1OC2 TDX 4.23729
56 5GVH FMN 4.23729
57 2FXU ATP 4.23729
58 1YAG ATP 4.23729
59 2FF6 ATP 4.23729
60 3MN7 ATP 4.23729
61 1ON3 MCA 4.23729
62 2A3Z ATP 4.23729
63 3VGL ANP 4.23729
64 4EFH ADP 4.23729
65 3QVP FAD 4.66102
66 2AE2 NAP 4.66102
67 4D9C PMP 4.66102
68 1NJJ ORX 4.66102
69 4N9I PCG 4.7619
70 2W83 GTP 4.84848
71 2DTJ THR 5.05618
72 5UKL SIX 5.08475
73 3MGB PAP 5.08475
74 5AE2 FAD 5.08475
75 1LVL FAD 5.08475
76 4OXI GAP 5.08475
77 5EOW FAD 5.08475
78 1EM6 NBG 5.08475
79 3GD4 NAD 5.08475
80 2OKL BB2 5.40541
81 4DV8 0LX 5.50847
82 3GBR PRP 5.50847
83 3E5H GNP 5.61798
84 5XFV FMN 5.9322
85 1HSK FAD 5.9322
86 4H03 ATP 5.9322
87 4H03 LAR 5.9322
88 4XT8 NAP 5.9322
89 3HNA SAH 5.9322
90 4BAS GNP 6.03015
91 4TXJ THM 6.35593
92 4I4Z 2NE 6.35593
93 5TVI O8N 6.52174
94 2A5F GTP 6.73575
95 1GTE FAD 6.77966
96 2JK0 ASP 6.77966
97 1RZU ADP 6.77966
98 5LEF GTP 6.80628
99 4ZRN UPG 7.20339
100 1R6D NAD 7.20339
101 1XHC FAD 7.20339
102 2NVK FAD 7.20339
103 1SVK ALF GDP 7.62712
104 1BH2 GSP 7.62712
105 1Y3A GDP 7.62712
106 6CMJ F6J 7.62712
107 1FQK ALF 7.62712
108 4AU7 SAH 7.62712
109 1TAD ALF 7.62712
110 1TAD GDP 7.62712
111 3O9L LPN 7.83133
112 2PZM NAD 8.05085
113 2PZM UDP 8.05085
114 3ITJ FAD 8.05085
115 1J2J GTP 8.43373
116 1O3Y GTP 8.43373
117 4GOJ GNP 8.47458
118 6CZ7 MGD 9.32203
119 5HK9 64O 9.32203
120 6DNT NAD 9.74576
121 4OH4 ANP 9.74576
122 1PTR PRB 10
123 5O3Q CMP 10
124 4PO2 ASN ARG LEU LEU LEU THR GLY 10.2128
125 1FUT 2GP 10.3774
126 2J59 GTP 11.9048
127 2AJ4 ANP 13.1356
128 2C5L GTP 18.4971
129 1LFD GNP 19.1617
130 1NVV GNP 19.2771
131 1OFU GDP 24.3697
Pocket No.: 4; Query (leader) PDB : 1TL2; Ligand: NDG; Similar sites found with APoc: 176
This union binding pocket(no: 4) in the query (biounit: 1tl2.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 4UP5 94W None
2 3SUD SUE 0.985222
3 3P8N L4T 1.07527
4 5OBY ANP 1.27119
5 3VZS NAP 1.27119
6 1NFQ NAI 1.27119
7 1PNO NAP 1.66667
8 5VEG FMN 1.68539
9 1NJR XYL 1.69492
10 2Q2V NAD 1.69492
11 1L1E SAH 1.69492
12 6FA4 GNP 1.7341
13 3X1Z GNP 1.79641
14 1XS1 DUT 2.07254
15 4R0M FA5 2.11864
16 5AHS FAD 2.11864
17 5L4S 6KX 2.11864
18 5L4S NAP 2.11864
19 1H5Q NAP 2.11864
20 2YY7 NAD 2.11864
21 5AHS COA 2.11864
22 2D7C GTP 2.39521
23 3F9W SAH 2.40964
24 1D6S MET PLP 2.48447
25 1D6S PLP MET 2.48447
26 1COY AND 2.54237
27 3L4S NAD 2.54237
28 3L4S 3PG 2.54237
29 1U1F 183 2.54237
30 2VVT I24 2.54237
31 4MZU COA 2.54237
32 3WMX NAD 2.54237
33 2CFC NAD 2.54237
34 1GAD NAD 2.54237
35 3OID NDP 2.54237
36 4P6G 2FZ 2.65487
37 2GJN NIS 2.7439
38 1YZQ GNP 2.94118
39 2OBF F83 2.9661
40 3LCV SAM 2.9661
41 5BRT FAD 2.9661
42 3A28 NAD 2.9661
43 1VBJ NAP 2.9661
44 5LD5 NAD 2.9661
45 5JGL SAM 2.9661
46 4CTA ATP 2.9661
47 5B3A 0JO 2.9661
48 5AZC PGT 3.38983
49 3SIG AR6 3.38983
50 1N5D NDP 3.38983
51 6D6Y SAH 3.38983
52 3PC3 P1T 3.38983
53 1YKJ FAD 3.38983
54 1GEG NAD 3.38983
55 5CZY SAM 3.38983
56 4FE2 AIR 3.38983
57 4B2D SER 3.38983
58 2BD0 NAP 3.38983
59 5VA6 SAH 3.49345
60 5VAH SAH 3.49345
61 2UZH CDP 3.63636
62 1MO9 FAD 3.81356
63 1MO9 KPC 3.81356
64 4URF NAD 3.81356
65 3C1O NAP 3.81356
66 5K4W THR 3.81356
67 5K4W NAI 3.81356
68 3VIU ADP 3.81356
69 2ZXI FAD 3.81356
70 3LST SAH 3.81356
71 4L3L 5FI 3.81356
72 3H4V NAP 3.81356
73 1WPY BTN 3.82979
74 1VG8 GNP 3.86473
75 2HV8 GTP 4.06977
76 5CCM 4ZX 4.23729
77 5CCM SAM 4.23729
78 5Z21 OXM 4.23729
79 4MOP 2H5 4.23729
80 4B1V LAB 4.23729
81 2A8X FAD 4.23729
82 1VL0 NAI 4.23729
83 3JSX FAD 4.23729
84 3MN6 ATP 4.23729
85 2D1K ATP 4.23729
86 6ECW SAH 4.23729
87 3MN9 ATP 4.23729
88 1RM4 NDP 4.23729
89 5Z20 OXM 4.23729
90 2GQS C2R 4.23729
91 4NBW NAD 4.23729
92 2C7G ODP 4.66102
93 3QWI CUE 4.66102
94 3QWI NAP 4.66102
95 3LKF PC 4.66102
96 3H7U NAP 4.66102
97 4FN4 NAD 4.66102
98 3MVH WFE 4.66102
99 1RJW ETF 4.66102
100 1DJL NAP 4.83092
101 3JQ8 NAP 5.08475
102 3JQ9 NAP 5.08475
103 1HDG NAD 5.08475
104 3JQB NAP 5.08475
105 3JQG NAP 5.08475
106 4AT0 FAD 5.08475
107 3TKA SAM 5.08475
108 5T2U NAP 5.08475
109 3FSJ D7K 5.08475
110 6GNF QPS 5.08475
111 4ITU NAI 5.08475
112 3FRH SAH 5.13834
113 4YRY NAD 5.50847
114 3AFN NAP 5.50847
115 1BZL FAD 5.9322
116 3QV1 NAD 5.9322
117 3DLS ADP 5.9322
118 4Q9M 2ZW 5.9322
119 1FWM CB3 6.35593
120 4CU1 H4B 6.35593
121 3TG5 SAH 6.77966
122 5KJK SAM 6.77966
123 5KJK 6T1 6.77966
124 3S7D SAH 6.77966
125 3B20 NAD 6.77966
126 3TA2 ATP 6.77966
127 3ZTV ADN 6.77966
128 3B1J NAD 6.77966
129 3EAU NDP 7.20339
130 3EAU PDN 7.20339
131 4JTA NAP 7.20339
132 2Y8E GNP 7.26257
133 1WF3 GNP 7.62712
134 3SSO SAH 7.62712
135 5JBX COA 7.62712
136 3CIP ATP 8.05085
137 2PFC PLM 8.19672
138 3EWR APR 8.33333
139 2AHR NAP 8.47458
140 1B8U OAA 8.47458
141 1UDY CS8 8.8983
142 1PCA CIT 9.32203
143 5IL1 SAM 9.43396
144 1MT6 SAH 10.5932
145 3PPM JG1 10.5932
146 1CZR FMN 10.6509
147 2FP2 TSA 10.8434
148 2AG5 NAD 11.0169
149 1JA9 NDP 11.0169
150 4Q4K FMN 11.8644
151 3U4L ATP 12.1429
152 2PAV ATP 12.2302
153 5JCA FAD 13.1356
154 3A4V NAD 13.1356
155 3A4V PYR 13.1356
156 5WUW NAP 13.2404
157 2ZFZ ARG 13.9241
158 3GWZ SAH 15.2542
159 3GXO SAH 15.2542
160 6C2Z P1T 16.5254
161 1NBU PH2 17.6471
162 6D55 GNP 19.1617
163 6D5E GNP 19.1617
164 6D59 GNP 19.1617
165 6D56 GNP 19.1617
166 6D5J GNP 19.1617
167 6BVM GNP 19.1617
168 6BVI GNP 19.1617
169 6BVK GNP 19.1617
170 6BVL GNP 19.1617
171 6D5L GNP 19.1617
172 6BVJ GNP 19.1617
173 6D5G GNP 19.1617
174 6D5H GNP 19.1617
175 6D5M GNP 19.1617
176 5HQ8 SAH 31.25
Pocket No.: 5; Query (leader) PDB : 1TL2; Ligand: NDG; Similar sites found with APoc: 120
This union binding pocket(no: 5) in the query (biounit: 1tl2.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 4DR9 BB2 None
2 3O7B SAH 0.847458
3 3KEE 30B 1.05263
4 5MTE BB2 1.45985
5 5H68 AGS 1.69492
6 1A27 NAP 1.69492
7 1GUA GNP 1.79641
8 5EP2 AZU 2.11864
9 2PK3 A2R 2.11864
10 5YU3 PRO 2.11864
11 5YU3 NAD 2.11864
12 4NTD FAD 2.11864
13 1H74 ADP 2.11864
14 2CDU ADP 2.11864
15 3EMY IVA VAL VAL STA ALA STA 2.54237
16 1YBH P22 2.54237
17 2XVF FAD 2.54237
18 4MO4 ACP 2.54237
19 3KO8 NAD 2.54237
20 1Z3C SA8 2.54237
21 5XDT MB3 2.54237
22 3AIA SAM 2.8436
23 5GG9 8GM 2.9661
24 2B4Q NAP 2.9661
25 1OLS TDP 2.9661
26 2RAB FAD 2.9661
27 5W8Q BU4 2.9661
28 3DOE GTP 3.0303
29 4KWI NAP 3.38983
30 4KWI 1TJ 3.38983
31 4QGE 35O 3.38983
32 3OIX FMN 3.38983
33 1BC5 SAH 3.81356
34 1X9I G6Q 3.81356
35 2H7C COA 3.81356
36 1DEK DGP 3.81356
37 4AVV CD 3.92157
38 3FV3 IVA VAL VAL STA ALA STA 4.23729
39 1D7O NAD 4.23729
40 1D7O TCL 4.23729
41 1ZFJ IMP 4.23729
42 1D4D FAD 4.23729
43 1IYK MYA 4.23729
44 1HXD BTN 4.23729
45 5CPR SAM 4.23729
46 1UYY BGC BGC 4.58015
47 2A14 SAH 4.66102
48 2B4R NAD 4.66102
49 2B4R AES 4.66102
50 3M2W L8I 4.66102
51 2E4U GLU 4.66102
52 1R2Q GNP 4.70588
53 4KAX GTP 4.73373
54 1NHX PEP 5.08475
55 1NHX FTB 5.08475
56 1WD4 AHR 5.08475
57 5YJI 8WO 5.08475
58 5YJI SAH 5.08475
59 1SJN DUP 5.29412
60 3TKI S25 5.50847
61 4ER2 IVA VAL VAL STA ALA STA 5.50847
62 5VJE GOS 5.50847
63 5EXT ADP 5.50847
64 5WDR GNP 5.84795
65 4NTC FAD 5.9322
66 1EB1 ZAL PRO MMO 5.9322
67 4LNU GTP 5.9322
68 3RYC GTP 5.9322
69 4HDO GNP 6.35593
70 4O1M NAD 6.35593
71 4N02 FNR 6.35593
72 4IDC NDP 6.35593
73 4IDC 1XX 6.35593
74 3RAB GNP 6.50888
75 4OSP NAP 6.77966
76 4N65 FMN 6.77966
77 2R75 01G 6.77966
78 3GYQ SAM 6.77966
79 5WQP NCA 6.83761
80 4C81 CDP 7.06522
81 1ZC3 GNP 7.07965
82 4RVU NDP 7.20339
83 2JHP SAH 7.20339
84 2CK3 ANP 7.20339
85 2FFQ GSP 7.60234
86 4K26 SFF 7.62712
87 3EYA TDP 7.62712
88 1E96 GTP 7.8125
89 5YJF 8WO 8.05085
90 5YJF SAH 8.05085
91 6G5J EM8 8.48485
92 6ASZ GLN THR ALA ARG M3L SER 8.69565
93 1OAA OAA 8.8983
94 3PCR GTP 8.8983
95 4P5E N6P 9.21053
96 5FPE 3TR 9.32203
97 2VDV SAM 9.32203
98 6B5Q PPI CZS 2KY MLY 1XY 9.33333
99 2V7Y ADP 9.74576
100 5EXW 7DT 10.1695
101 5EYK 5U5 10.1695
102 5ECP ATP 10.7623
103 5ECP JAA 10.7623
104 5ECP MET 10.7623
105 5AR0 GB8 11.0169
106 5XC5 GTP 11.3636
107 4HAT GNP 11.4286
108 3CQD ATP 11.8644
109 1I7M CG 11.9403
110 4WOP CTP 12
111 1KSH GDP 12.5
112 1M2O GNP 15.7895
113 2QTV GNP 16.3265
114 5OCG GNP 16.9312
115 3QLM PLM 16.9355
116 5BVA FAD 18.6441
117 6D5V GNP 19.1617
118 3DDC GNP 19.2771
119 3KUD GDP 19.2771
120 2UZI GTP 19.2771
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