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Receptor
PDB id Resolution Class Description Source Keywords
1U2Z 2.2 Å EC: 2.1.1.43 CRYSTAL STRUCTURE OF HISTONE K79 METHYLTRANSFERASE DOT1P FROM YEAST SACCHAROMYCES CEREVISIAE HISTONE METHYLTRANSFERASE NUCLEOSOME
Ref.: STRUCTURE OF THE CONSERVED CORE OF THE YEAST DOT1P, A NUCLEOSOMAL HISTONE H3 LYSINE 79 METHYLTRANSFERASE J.BIOL.CHEM. V. 279 43296 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAH A:801;
B:802;
C:803;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
384.411 C14 H20 N6 O5 S c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1U2Z 2.2 Å EC: 2.1.1.43 CRYSTAL STRUCTURE OF HISTONE K79 METHYLTRANSFERASE DOT1P FROM YEAST SACCHAROMYCES CEREVISIAE HISTONE METHYLTRANSFERASE NUCLEOSOME
Ref.: STRUCTURE OF THE CONSERVED CORE OF THE YEAST DOT1P, A NUCLEOSOMAL HISTONE H3 LYSINE 79 METHYLTRANSFERASE J.BIOL.CHEM. V. 279 43296 2004
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 1U2Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 28 families.
1 1U2Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 22 families.
1 1U2Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAH; Similar ligands found: 211
No: Ligand ECFP6 Tc MDL keys Tc
1 SAH 1 1
2 5X8 0.759494 0.969697
3 A7D 0.734177 0.926471
4 TT8 0.709302 0.970588
5 DSH 0.692308 0.914286
6 SXZ 0.692308 0.916667
7 DTA 0.666667 0.857143
8 3DH 0.662338 0.869565
9 S8M 0.655556 0.901408
10 SFG 0.635294 0.954545
11 SA8 0.62069 0.915493
12 EEM 0.617977 0.890411
13 MTA 0.615385 0.869565
14 SAI 0.613636 0.955882
15 S7M 0.586957 0.916667
16 36A 0.586538 0.90411
17 K15 0.583333 0.878378
18 ADN 0.573333 0.84058
19 RAB 0.573333 0.84058
20 XYA 0.573333 0.84058
21 62X 0.572917 0.855263
22 5CD 0.571429 0.852941
23 0UM 0.5625 0.876712
24 5N5 0.558442 0.84058
25 A4D 0.551282 0.867647
26 SAM 0.537634 0.916667
27 SMM 0.536842 0.88
28 SSA 0.536842 0.712644
29 KB1 0.534653 0.902778
30 A5D 0.532609 0.857143
31 SIB 0.53125 0.928571
32 EP4 0.530864 0.819444
33 DSZ 0.530612 0.732558
34 GSU 0.53 0.752941
35 A 0.529412 0.763158
36 LMS 0.529412 0.694118
37 AMP 0.529412 0.763158
38 5CA 0.525773 0.712644
39 ME8 0.524752 0.8125
40 M2T 0.52439 0.821918
41 6RE 0.523256 0.824324
42 GJV 0.522727 0.813333
43 AAT 0.515789 0.863014
44 LSS 0.515152 0.696629
45 KAA 0.514852 0.727273
46 J7C 0.511364 0.835616
47 A5A 0.510417 0.697674
48 SON 0.505495 0.805195
49 SRP 0.505155 0.805195
50 F0P 0.504505 0.915493
51 54H 0.5 0.681818
52 VMS 0.5 0.681818
53 ADX 0.5 0.694118
54 CA0 0.5 0.769231
55 AMO 0.5 0.805195
56 5AL 0.5 0.779221
57 KH3 0.5 0.866667
58 NVA LMS 0.49505 0.707865
59 AHX 0.49505 0.753086
60 TSB 0.494949 0.689655
61 53H 0.494949 0.674157
62 G5A 0.494737 0.712644
63 ABM 0.494382 0.74359
64 A2D 0.494382 0.74359
65 ZAS 0.494253 0.808219
66 A6D 0.490196 0.759494
67 8QN 0.49 0.779221
68 GEK 0.49 0.956522
69 GAP 0.489583 0.769231
70 AN2 0.48913 0.734177
71 A3S 0.48913 0.884058
72 S4M 0.488889 0.831169
73 SRA 0.488636 0.746835
74 LAD 0.485437 0.810127
75 52H 0.484848 0.674157
76 A12 0.483516 0.759494
77 BA3 0.483516 0.74359
78 AP2 0.483516 0.759494
79 NEC 0.483146 0.788732
80 AOC 0.483146 0.842857
81 Y3J 0.481481 0.768116
82 VRT 0.479167 0.861111
83 50T 0.478723 0.734177
84 B4P 0.478261 0.74359
85 ADP 0.478261 0.74359
86 5AS 0.478261 0.655556
87 AP5 0.478261 0.74359
88 A3N 0.477778 0.830986
89 YSA 0.476636 0.712644
90 XAH 0.476636 0.768293
91 0XU 0.473684 0.897059
92 AT4 0.473118 0.7375
93 WAQ 0.471154 0.807692
94 NSS 0.470588 0.712644
95 5AD 0.468354 0.791045
96 AU1 0.468085 0.725
97 M33 0.468085 0.734177
98 MAO 0.467391 0.797468
99 TXA 0.466667 0.759494
100 NB8 0.466667 0.775
101 A3G 0.466667 0.871429
102 3AM 0.465909 0.727273
103 DAL AMP 0.465347 0.779221
104 8X1 0.465347 0.707865
105 A3T 0.463158 0.842857
106 ATP 0.463158 0.74359
107 HEJ 0.463158 0.74359
108 ACP 0.463158 0.746835
109 7D7 0.4625 0.785714
110 LEU LMS 0.461538 0.688889
111 9ZA 0.460784 0.740741
112 9ZD 0.460784 0.740741
113 5FA 0.458333 0.74359
114 AQP 0.458333 0.74359
115 AR6 0.458333 0.766234
116 APC 0.458333 0.759494
117 APR 0.458333 0.766234
118 PRX 0.458333 0.746835
119 F2R 0.457627 0.75
120 IOT 0.456897 0.761905
121 4AD 0.456311 0.794872
122 PAJ 0.456311 0.722892
123 WSA 0.45614 0.72093
124 YAP 0.453704 0.794872
125 8PZ 0.453704 0.712644
126 FA5 0.453704 0.805195
127 ADP PO3 0.453608 0.763158
128 ADV 0.453608 0.782051
129 NVA 2AD 0.453608 0.849315
130 SAP 0.453608 0.728395
131 AGS 0.453608 0.728395
132 RBY 0.453608 0.782051
133 AD9 0.453608 0.725
134 PTJ 0.45283 0.731707
135 MHZ 0.452632 0.797468
136 00A 0.451923 0.740741
137 A3P 0.451613 0.74026
138 YLP 0.451327 0.771084
139 7MD 0.45045 0.768293
140 ALF ADP 0.45 0.707317
141 ADP ALF 0.45 0.707317
142 2VA 0.447917 0.819444
143 OOB 0.446602 0.779221
144 ANP 0.444444 0.725
145 T99 0.444444 0.7375
146 ACQ 0.444444 0.746835
147 TAT 0.444444 0.7375
148 P5A 0.443396 0.719101
149 7D5 0.443182 0.708861
150 A1R 0.442308 0.7625
151 YLC 0.439655 0.790123
152 2AM 0.438202 0.717949
153 DLL 0.438095 0.779221
154 ARG AMP 0.4375 0.759036
155 A22 0.436893 0.734177
156 D3Y 0.436893 0.859155
157 ATF 0.435644 0.716049
158 MYR AMP 0.435185 0.746988
159 80F 0.434426 0.75
160 SO8 0.434343 0.808219
161 OAD 0.433962 0.769231
162 3UK 0.433962 0.769231
163 TAD 0.433628 0.765432
164 25A 0.432692 0.74359
165 6YZ 0.431373 0.746835
166 VO4 ADP 0.431373 0.734177
167 ADP VO4 0.431373 0.734177
168 9SN 0.431193 0.731707
169 TYM 0.431034 0.805195
170 B5V 0.429907 0.759494
171 PR8 0.429907 0.8
172 ADQ 0.428571 0.746835
173 YLB 0.42735 0.771084
174 9K8 0.425926 0.67033
175 1ZZ 0.425926 0.746988
176 FYA 0.425926 0.779221
177 3OD 0.425926 0.769231
178 PPS 0.425743 0.674419
179 MAP 0.423077 0.707317
180 A2P 0.421053 0.727273
181 4YB 0.421053 0.735632
182 9X8 0.420561 0.75
183 ADP BMA 0.420561 0.746835
184 TYR AMP 0.419643 0.794872
185 5SV 0.419048 0.731707
186 3NZ 0.416667 0.824324
187 YLA 0.416667 0.771084
188 8Q2 0.415254 0.688889
189 A3R 0.415094 0.7625
190 B5Y 0.414414 0.75
191 B5M 0.414414 0.75
192 48N 0.413793 0.753086
193 LPA AMP 0.413793 0.768293
194 AYB 0.413223 0.761905
195 ACK 0.413043 0.710526
196 QQY 0.413043 0.696203
197 BIS 0.412844 0.719512
198 JB6 0.412844 0.7625
199 PAP 0.41 0.730769
200 DQV 0.408696 0.75641
201 OVE 0.408602 0.7125
202 AMP DBH 0.40708 0.746835
203 4UV 0.40708 0.75
204 3AD 0.406977 0.852941
205 AF3 ADP 3PG 0.40678 0.743902
206 OMR 0.40678 0.738095
207 LAQ 0.405172 0.768293
208 A A 0.40367 0.74359
209 7C5 0.403509 0.789474
210 7MC 0.403361 0.75
211 4UU 0.4 0.75
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1U2Z; Ligand: SAH; Similar sites found with APoc: 567
This union binding pocket(no: 1) in the query (biounit: 1u2z.bio2) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3NKV GNP 1.14286
2 5U19 827 1.17302
3 5U19 SAH 1.17302
4 3ITJ CIT 1.18343
5 5XNC MTA 1.34771
6 1O8B ABF 1.36986
7 5DNK SAH 1.38568
8 4D04 FAD 1.38568
9 4D04 NAP 1.38568
10 3ICT ADP 1.38568
11 2AJ4 GLA 1.38568
12 3ICS ADP 1.38568
13 1PIE GLA 1.43198
14 5T67 JHZ 1.44231
15 5T67 SAH 1.44231
16 3NDJ JHZ 1.44231
17 3NDJ SAH 1.44231
18 3A27 SAM 1.47059
19 4NTD FAD 1.47059
20 5K0A FAD 1.51515
21 5BSZ SAH 1.6
22 4DCM SAM 1.6
23 1V59 NAD 1.61663
24 2JHP SAH 1.61663
25 1GPE FAD 1.61663
26 1V59 FAD 1.61663
27 1X87 NAD 1.61663
28 1GET NAP 1.61663
29 1GET FAD 1.61663
30 2WPF WPF 1.61663
31 2WPF FAD 1.61663
32 3AXB PRO 1.61663
33 3AXB FAD 1.61663
34 1QO8 FAD 1.61663
35 2C7G ODP 1.61663
36 1H82 FAD 1.61663
37 1H82 GZZ 1.61663
38 2C7G FAD 1.61663
39 3NUG NAD 1.61943
40 4WS6 WBU 1.68067
41 1SVK ALF GDP 1.69972
42 3LST SAH 1.72414
43 1RZM E4P 1.77515
44 4HXY NDP 1.82648
45 4KRG SAH 1.84758
46 4C2C ALA ALA ALA 1.84758
47 2RAB NAD 1.84758
48 2RAB FAD 1.84758
49 5D3U TRP 1.84758
50 2YG3 FAD 1.84758
51 4RLQ 3SK 1.84758
52 4C3Y FAD 1.84758
53 1LVL NAD 1.84758
54 4C3Y ANB 1.84758
55 3LKZ SFG 1.86916
56 5K4W NAI 1.86916
57 5K4W THR 1.86916
58 3TKY SAH 1.90217
59 1BH2 GSP 1.90476
60 1U7T TDT 1.91571
61 1E3W NAD 1.91571
62 1E6W NAD 1.92308
63 3WMX NAD 1.95531
64 3R6K FUC GAL GLA 1.96721
65 2PHT MAN MAN MAN 1.98413
66 5N0J FAD 1.9943
67 2OBF SAH 2.07612
68 2OBF F83 2.07612
69 3M6W SAM 2.07852
70 1MO9 KPC 2.07852
71 1MO9 FAD 2.07852
72 2F6D ACR 2.07852
73 5H6S HDH 2.07852
74 1OIX GDP 2.09424
75 4D7E FAD 2.0979
76 5W7R SAH 2.0979
77 2WK1 SAH 2.12766
78 3FPZ AHZ 2.14724
79 1KYZ SAH 2.19178
80 1KYZ FER 2.19178
81 3T7S SAM 2.23881
82 4ONQ SFG 2.2409
83 1ZGA SAH 2.2409
84 5W7K SAH 2.24359
85 5CUQ NSC 2.24719
86 5BW4 SAM 2.24719
87 2GDZ NAD 2.24719
88 3LGS ADE 2.24719
89 3KVY URA 2.26537
90 3PFG TLO 2.28137
91 3PFG SAM 2.28137
92 1G60 SAM 2.30769
93 1UWK URO 2.30947
94 1UWK NAD 2.30947
95 3NKS FAD 2.30947
96 1ELI PYC 2.31362
97 5TWB FAD 2.32558
98 5OVK NDP 2.34375
99 1QZZ SAM 2.40642
100 1XDS SAM 2.40642
101 3GWZ SAH 2.43902
102 1KPG SAH 2.43902
103 3GXO SAH 2.43902
104 1RP0 AHZ 2.46479
105 4PIO SAH 2.47678
106 4PIO AVI 2.47678
107 3GCZ SAM 2.48227
108 1I9G SAM 2.5
109 3PT9 SAH 2.54042
110 3X0D SAH 2.54042
111 5FWA J7C 2.54042
112 4REP FAD 2.54042
113 4BV6 FAD 2.54042
114 2Q28 ADP 2.54042
115 3LCC SAH 2.55319
116 3A4T SFG 2.55474
117 5K7U SAM 2.5788
118 3CBG SAH 2.58621
119 1IY8 NAD 2.62172
120 1G55 SAH 2.62391
121 1PVN MZP 2.65957
122 2YX1 SFG 2.67857
123 1XSE NDP 2.71186
124 5FTW SAH 2.73438
125 3P9C SAH 2.74725
126 1ZBQ NAD 2.75229
127 1XTP SAI 2.75591
128 4RPL 3UC 2.75689
129 4RPL FAD 2.75689
130 4USR FAD 2.77008
131 1D4D FAD 2.77136
132 5TSH ADP 2.77136
133 1NAA ABL 2.77136
134 1NAA 6FA 2.77136
135 4B63 ORN 2.77136
136 4B63 FAD 2.77136
137 4B63 NAP 2.77136
138 3CH6 NAP 2.7972
139 3CH6 311 2.7972
140 6ECT SAM 2.80374
141 3G89 SAM 2.81124
142 3GF4 UPG 2.82051
143 1NW5 SAM 2.82132
144 1XKQ NDP 2.85714
145 5GWT SIN 2.8777
146 5GWT NAD 2.8777
147 6C8R EQV 2.90237
148 6C8R SAH 2.90237
149 5E1M SAH 2.90456
150 5E1M PRO PRO LYS ARG ILE ALA 2.90456
151 2GN4 NDP 2.90698
152 2GN4 UD1 2.90698
153 4M37 SAH 2.91545
154 4M38 SAH 2.91545
155 3FUU ADN 2.95203
156 1YXM ADE 2.9703
157 2PX8 SAH 2.97398
158 6FDF SAH 2.99401
159 5IL1 SAM 3
160 2HQM FAD 3.00231
161 4HA6 FAD 3.00231
162 3G2O SAM 3.01003
163 3FPF TNA 3.02013
164 3FPF MTA 3.02013
165 2Q7V FAD 3.07692
166 3H8V ATP 3.08219
167 3U31 NAD 3.10345
168 1TPY SAH 3.13589
169 3C6K SPD 3.14961
170 3C6K MTA 3.14961
171 5EEH P9P 3.19149
172 5EEH SAH 3.19149
173 5XLX SAH 3.19149
174 3MQ2 SAH 3.21101
175 3UVD MB3 3.22581
176 5WP5 SAH 3.23326
177 1PJS NAD 3.23326
178 3UOY FAD 3.23326
179 3UOY NAP 3.23326
180 4HAT GNP 3.24074
181 2ZFU SAH 3.25581
182 2PXX SAH 3.25581
183 4MO2 FDA 3.26087
184 4MO2 FAD 3.26087
185 4K26 SFF 3.26087
186 1R6D NAD 3.2641
187 4N49 SAM 3.27103
188 2P41 SAH 3.27869
189 4RVG SAM 3.28639
190 4RVG TYD 3.28639
191 1J71 THR ILE THR SER 3.29341
192 1JAY F42 3.30189
193 1V35 NAI 3.34347
194 4UCI SAM 3.37349
195 2XTZ GSP 3.38983
196 6GR0 F8W 3.44828
197 4BLW AMP 3.46021
198 5JGL SAM 3.46021
199 4BLW SAH 3.46021
200 4KRI SAH 3.4642
201 4AP3 NAP 3.4642
202 4AP3 FAD 3.4642
203 6F97 FAD 3.4642
204 4RDH AMP 3.47222
205 4RDI ATP 3.47222
206 2PWY SAH 3.48837
207 1WG8 SAM 3.50877
208 5FJN BE2 3.50877
209 5FJN FAD 3.50877
210 1NV8 SAM 3.52113
211 1NV8 MEQ 3.52113
212 1VE3 SAM 3.52423
213 5W7M SAH 3.52564
214 1GY8 NAD 3.52645
215 5FUB SAH 3.56083
216 3GJX GTP 3.56164
217 4EUE NAI 3.58852
218 5KVA SAM 3.59712
219 6DUB SAH 3.6036
220 4FC7 NAP 3.61011
221 4FC7 COA 3.61011
222 2O07 SPD 3.61842
223 2O07 MTA 3.61842
224 2WA2 SAM 3.62319
225 6GAS FAD 3.62538
226 5WP4 SAH 3.69515
227 1YY5 FAD 3.69515
228 2XVE FAD 3.69515
229 1VQW FAD 3.69515
230 3OFK SAH 3.7037
231 6GAR FAD 3.72493
232 1SQF SAM 3.7296
233 3C3Y SAH 3.79747
234 1ZEM NAD 3.81679
235 3SSO SAH 3.81862
236 1XCL SAH 3.82979
237 3WYG GTP 3.84615
238 2UYQ SAM 3.87097
239 1GTE FAD 3.9261
240 5J5Z FAD 3.9261
241 4TXI FAD 3.9261
242 2BRY FAD 3.9261
243 1FEC FAD 3.9261
244 2Q1S NAI 3.9261
245 3H2B SAH 3.94089
246 5KMS NAD 3.95062
247 1FP2 SAH 3.97727
248 3A25 SAM 3.98671
249 1FQK ALF 4
250 1TAD ALF 4.01235
251 1TAD GDP 4.01235
252 3DUW SAH 4.03587
253 2XYQ SAH 4.09836
254 1DKU AP2 4.10095
255 5DLY 5D7 4.13534
256 5DLY SAH 4.13534
257 3VSE SAH 4.15704
258 2JB2 FAD 4.15704
259 2JB2 PHE 4.15704
260 1COY FAD 4.15704
261 2HMT NAI 4.16667
262 2GAG NAD 4.19753
263 3LZW NAP 4.21687
264 3LZW FAD 4.21687
265 3BGD SAH 4.23077
266 3BGD PM6 4.23077
267 4Y9D NAI 4.2623
268 1LSS NAD 4.28571
269 2EG5 SAH 4.30108
270 2BZG SAH 4.31034
271 2WSB NAD 4.33071
272 3EVF SAH 4.33213
273 3EVF GTA 4.33213
274 3FRH SAH 4.34783
275 1VG8 GNP 4.34783
276 1F3L SAH 4.36137
277 4E70 N7I 4.38144
278 3SQP FAD 4.38799
279 4MOP 2H5 4.38799
280 5DM1 SAH 4.49438
281 5DM1 5D7 4.49438
282 4POO SAM 4.5
283 5F8F SFG 4.50928
284 1P1C SAH 4.52261
285 1ESW ACR 4.61894
286 4PNE SAH 4.63576
287 2IMG MLT 4.63576
288 2PT9 2MH 4.6729
289 2PT9 S4M 4.6729
290 2FFQ GSP 4.67836
291 2EFJ SAH 4.6875
292 6B92 SAH 4.7619
293 4LO2 GAL BGC 4.7619
294 1WUU GLA 4.7619
295 5MPT SAH 4.83092
296 4DMG SAM 4.83461
297 5HSA FAS 4.84988
298 5Z75 NAD 4.89297
299 3QPB URA 4.96454
300 3HVJ 705 4.97738
301 3ELW SAM 5
302 3ELW GP3 5
303 1EJ0 SAM 5
304 1GZ6 NAI 5.01567
305 3SJU NDP 5.01792
306 4GLL NAD 5.04451
307 1DL5 SAH 5.04732
308 5UWP GNP 5.06329
309 5UWI GNP 5.06329
310 6CIT GNP 5.06329
311 5DI9 GNP 5.06329
312 5DIF GNP 5.06329
313 5UWJ GNP 5.06329
314 5UWU GNP 5.06329
315 5UWW GNP 5.06329
316 5DHF GNP 5.06329
317 5UWH GNP 5.06329
318 5UWS GNP 5.06329
319 5UWO GNP 5.06329
320 2Z3Y F2N 5.08083
321 1ZK7 FAD 5.08083
322 1RJD SAM 5.08982
323 1FP1 SAH 5.10753
324 6GKV SAH 5.12821
325 3VYW SAM 5.19481
326 4IWN GEK 5.24017
327 3GEG NAD 5.26316
328 3GU3 SAH 5.28169
329 3HDY FDA 5.28967
330 3HDY GDU 5.28967
331 3HDY FAD 5.28967
332 2I7C AAT 5.30035
333 5WGR FAD 5.31178
334 5U8U FAD 5.31178
335 3RAB GNP 5.32544
336 3L9W AMP 5.32688
337 3L9W GSH 5.32688
338 5ZW3 SAH 5.33333
339 6ECU SAH 5.37975
340 2YVF FAD 5.39216
341 2YVF NAD 5.39216
342 1JQ3 AAT 5.40541
343 3BXO SAM 5.43933
344 1I8T FAD 5.44959
345 5BJX NAD 5.46448
346 5BJX UDP 5.46448
347 4X7Y SAH 5.47445
348 3DXY SAM 5.50459
349 5MGZ SAH 5.50847
350 4USQ FAD 5.54017
351 6D6Y SAH 5.54273
352 3LAD FAD 5.54273
353 6GFK SAH 5.57769
354 5LOG SAH 5.5794
355 1N2X SAM 5.64784
356 1CS4 GSP 5.66038
357 5FA5 MTA 5.72207
358 5GM1 SAH 5.72391
359 4YAC NAI 5.72391
360 1L3I SAH 5.72917
361 1IM8 SAI 5.7377
362 4CQM NAP 5.7377
363 6BQ6 TER 5.74018
364 3TNF GNP 5.74713
365 4LHW GNP 5.74713
366 3TKA SAM 5.76369
367 2ZWA SAH 5.77367
368 3P2E SAH 5.77778
369 1UAY ADN 5.78512
370 2H88 TEO 5.82524
371 4YMH SAH 5.83333
372 3AB1 FAD 5.83333
373 1EFV FAD 5.88235
374 1EFV AMP 5.88235
375 3SBD GNP 5.88235
376 3WYF GTP 5.93607
377 3M1I GTP 5.93607
378 1BC5 SAH 5.94796
379 4X60 SFG 6
380 4X60 3XV 6
381 5ULP KB1 6.00462
382 4GQB 0XU 6.10465
383 3O7W SAM 6.12245
384 1BDB NAD 6.13718
385 5X62 SAH 6.15764
386 1I1N SAH 6.19469
387 5FA8 SAM 6.21118
388 4OBW SAM 6.22568
389 4ITU NAI 6.23557
390 4ITU 1HS 6.23557
391 2ITM XUL 6.23557
392 5HJM MTA 6.25
393 4FZV SAM 6.27615
394 4FN4 NAD 6.29921
395 5UFN SAH 6.30252
396 5DX8 SFG 6.30372
397 6ARJ BW4 6.30372
398 6ARJ SAH 6.30372
399 5DXA SFG 6.30372
400 5DX1 SFG 6.30372
401 5DX0 SFG 6.30372
402 5DWQ SFG 6.30372
403 3BJE R1P 6.30372
404 5YF1 8V0 6.35359
405 5YF1 SFG 6.35359
406 4CNK FAD 6.39386
407 2ZIF SAM 6.39731
408 3Q87 SAM 6.4
409 5GWX SAM 6.46651
410 5GWX SAR 6.46651
411 3ZOK GLY 6.46651
412 2VDV SAM 6.50407
413 5O2T GSP 6.50888
414 5M58 SAH 6.52174
415 2XVM SAH 6.53266
416 1NXJ GLV 6.55738
417 1Y8Q ATP 6.6474
418 1NJR XYL 6.69014
419 2HNK SAH 6.69456
420 4RSL FAD 6.69746
421 1XHL NDP 6.73401
422 5ICE 2H4 6.81818
423 5ICE SAH 6.81818
424 2EWM NAD 6.82731
425 3MAG SAH 6.84039
426 4XUC 43G 6.88073
427 4XUC SAM 6.88073
428 2FK8 SAM 6.91824
429 1KEW NAD 6.92521
430 5JJR SAH 6.92841
431 2C5L GTP 6.93642
432 1Q0S SAH 6.94981
433 6ECW SAH 6.98413
434 5WDR GNP 7.01754
435 4K81 GTP 7.01754
436 3MCT SAH 7.07071
437 1UAD GNP 7.07071
438 5N5D SAM 7.07965
439 6AU6 GDP 7.1618
440 3DDC GNP 7.22892
441 1NVV GNP 7.22892
442 5Z2M GTP 7.24638
443 6C5B SAH 7.33138
444 3OU2 SAH 7.33945
445 2YVJ FAD 7.33945
446 3MB5 SAM 7.45098
447 3FZG SAM 7.5
448 2JJQ SAH 7.52941
449 1V6A TRE 7.53012
450 1L1E SAH 7.66551
451 1QAN SAH 7.78689
452 6F5Z SAH 7.79221
453 2F5Z FAD 7.8125
454 4C4A SAH 7.85219
455 3GDH SAH 7.88382
456 5TQZ GLC 8
457 1KYQ NAD 8.0292
458 6DEN FAD 8.08314
459 6DEN TP9 8.08314
460 6DEN G8A 8.08314
461 4Y30 SAH 8.26211
462 4Y30 49L 8.26211
463 4JDR FAD 8.31409
464 4YJK URA 8.33333
465 5THY SAH 8.39506
466 3LCV SAM 8.54093
467 5JAQ NAI 8.62069
468 5THZ SAH 8.64198
469 1XFF GLU 8.75
470 3BBH SFG 8.78049
471 2ODE ALF GDP 9.21986
472 3EGI ADP 9.2233
473 3GD4 FAD 9.23787
474 3GD4 NAD 9.23787
475 2EJU SAH 9.25926
476 6CI9 NAP 9.26641
477 2A14 SAH 9.5057
478 1IBR GNP 9.52381
479 3AKK ADP 9.53846
480 5D63 FUC GLA GLA 9.55631
481 3S1S SAH 9.69977
482 3DMH SAM 9.71129
483 3DMH GMP 9.71129
484 1KPH SAH 9.7561
485 3TLJ SAH 9.91957
486 5ERG SAM 9.93072
487 4KIB SAH 10.084
488 5E72 SAM 10.1156
489 1R18 SAH 10.1322
490 4AZW SAM 10.1617
491 5O42 NAD 10.219
492 5O42 BGC 10.219
493 5O42 9JW 10.219
494 6FHQ DE5 10.3448
495 3RNM FAD 10.3448
496 6IS0 SAH 10.3926
497 4ZRN NAD 10.5769
498 4ZRN UPG 10.5769
499 4NEC SAH 10.6061
500 1JG3 ADN 10.6236
501 1WA5 GTP 10.6236
502 5KOK SAH 10.8312
503 5KOK S9T 10.8312
504 5KOK R9T 10.8312
505 4C2G ALA ALA ALA ALA 11.0855
506 4M73 SAH 11.276
507 4M73 M72 11.276
508 5FFF NAP 11.284
509 1JQD SAH 11.3014
510 2AOT SAH 11.3014
511 3JWH SAH 11.5207
512 2DPM SAM 11.6197
513 5NGZ 2BG 11.6751
514 5F2K SAH 11.6848
515 5F2K OCA 11.6848
516 1Z3C SA8 11.745
517 4JNA FAD 11.7647
518 1PN0 FAD 11.7783
519 1PN0 IPH 11.7783
520 3AD8 NAD 11.8227
521 2YY7 NAD 11.859
522 1WY7 SAH 12.0773
523 1VBO MAN MAN MAN 12.0805
524 1VBO MAN 12.0805
525 3ZV6 NAD 12.4555
526 3GRU AMP 12.5424
527 2NGR AF3 12.5654
528 2NXE SAM 12.5984
529 3CX8 GSP 12.8079
530 3EVG SAH 12.933
531 3U4C NDP 12.933
532 1ZQ9 SAM 12.9825
533 3I53 SAH 13.253
534 2HRL SIA GAL SIA BGC NGA CEQ 13.3858
535 2VVL FAD 13.3949
536 2VVM FAD 13.3949
537 1SQL GUN 13.6986
538 3VC1 GST 13.7821
539 3VC1 SAH 13.7821
540 5Y5Q DUT 13.7931
541 2RNF UM3 14.1667
542 4A6D SAM 14.4476
543 5E8J SAH 14.7436
544 5E9W SAH 14.7436
545 1KUJ MMA 15.0376
546 1ZC3 GNP 15.0442
547 4NBU NAI 15.2
548 4R6W PC 15.8915
549 4R6W SAH 15.8915
550 4LWP SAH 16.3043
551 5SZH GNP 16.9935
552 4YUW 4JU 17.1053
553 4YUW S4M 17.1053
554 5YJI SAH 17.6056
555 5YJI 8WO 17.6056
556 5GVR LMR 18.3761
557 3G5K BB2 18.5792
558 5JE0 AZ8 20.6478
559 5JE0 SAH 20.6478
560 4QTU SAM 20.6731
561 5L95 AMP 23.75
562 2UZI GTP 29.8077
563 5UWT GNP 30.4348
564 5YJF SAH 36.2676
565 5YJF 8WO 36.2676
566 5UWR GNP 40.7407
567 5H67 ATP 42.7136
568 5UWQ GNP 50
Pocket No.: 2; Query (leader) PDB : 1U2Z; Ligand: SAH; Similar sites found with APoc: 79
This union binding pocket(no: 2) in the query (biounit: 1u2z.bio1) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 1RLZ NAD 1.35501
2 2V6G NAP 1.37363
3 3S5W FAD 1.38568
4 5WS9 AMP 1.38568
5 4MIG G3F 1.61663
6 3ZFD ANP 1.7094
7 2JC9 ADN 1.84758
8 4LH7 1X8 1.85759
9 1Q8O MAN MMA 1.98413
10 5MBX SP5 2.07852
11 5MBX FAD 2.07852
12 2Z3U CRR 2.11765
13 5EJ2 NAD 2.27273
14 3DUV KDO 2.29008
15 2Q1W NAD 2.4024
16 5A9A UTP 2.46914
17 1Q9I TEO 2.77136
18 1Q9I FAD 2.77136
19 1BZL GCG 2.77136
20 1BZL FAD 2.77136
21 6FP4 FAD 2.77136
22 2XVF FAD 2.80172
23 1ZCB GDP 3.03867
24 6GSZ BGC 3.23326
25 1RSG FAD 3.23326
26 4K26 NDP 3.26087
27 4BGB ADP 3.38462
28 1T9D FAD 3.4642
29 1T9D P25 3.4642
30 1T9D 1MM 3.4642
31 1T9D PYD 3.4642
32 5WKC FAD 3.4642
33 2Q0L FAD 3.53698
34 2GV8 FAD 3.69515
35 2GVC FAD 3.69515
36 1US5 GLU 3.82166
37 5KMS FAD 3.95062
38 4YRY FAD 3.98551
39 4JF5 FLC 4.11523
40 5TS5 FAD 4.15704
41 5WXU FLC 4.38799
42 2RGO FAD 4.38799
43 2IID PHE 4.38799
44 2IID FAD 4.38799
45 2PZM NAD 4.54545
46 2PZM UDP 4.54545
47 2XG5 EC5 4.62428
48 2XG5 EC2 4.62428
49 1GEG NAD 4.6875
50 5NMX FAD 4.94118
51 5NMX NAP 4.94118
52 5ARK UMP 5.97015
53 4YSX FAD 6.02837
54 2DTX BMA 6.06061
55 6EV2 BGC 6.45161
56 4YAG NAI 6.57439
57 6D5H GNP 7.18563
58 6D5M GNP 7.18563
59 6D5G GNP 7.18563
60 6D5V GNP 7.18563
61 6D5E GNP 7.18563
62 6BVJ GNP 7.18563
63 6D55 GNP 7.18563
64 6H3O FAD 7.3903
65 4ETZ C2E 7.40741
66 4HDO GNP 7.45342
67 5BVA FAD 7.57946
68 3KLJ FAD 7.79221
69 1YZN GNP 8.10811
70 4JX1 CAM 9.73451
71 1S7G APR 10.6719
72 2AOU CQA 11.3014
73 3ZV6 4HB 12.4555
74 2P3V SRT 13.2812
75 1VR0 3SL 13.7652
76 4KVG GTP 15.4762
77 1GUA GNP 15.5689
78 1E6E FAD 24.2188
79 4HDQ GNP 30.7692
Pocket No.: 3; Query (leader) PDB : 1U2Z; Ligand: SAH; Similar sites found with APoc: 9
This union binding pocket(no: 3) in the query (biounit: 1u2z.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3GD8 GOL 2.24215
2 3KVY R2B 2.26537
3 3GF4 FAD 2.82051
4 6EL3 NAP 3.67454
5 1JXN MFU 3.71901
6 4TQK NAG 3.94089
7 2CDU ADP 5.31178
8 1V7Z CRN 7.30769
9 2XOC ADP 14.1762
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