-->
Receptor
PDB id Resolution Class Description Source Keywords
1WG8 2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF A PREDICTED S-ADENOSYLMETHIONINE- DEPENDENT METHYLTRANSFERASE TT1512 FROM THERMUS T HERMOPHILUS HB8. THERMUS THERMOPHILUS S-ADENOSYL-METHYLTRANSFERASE MRAW THERMUS THERMOPHILUS RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI STRUCTURAL GENOMICS
Ref.: CRYSTAL STRUCTURE OF A PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE TT1512 FROM THERMUS THERMOPHILUS HB8 AT 2.0 ANG. RESOLUTION. TO BE PUBLISHED
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM A:3142;
B:3141;
Valid;
Valid;
none;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1WG8 2 Å EC: 2.1.1.- CRYSTAL STRUCTURE OF A PREDICTED S-ADENOSYLMETHIONINE- DEPENDENT METHYLTRANSFERASE TT1512 FROM THERMUS T HERMOPHILUS HB8. THERMUS THERMOPHILUS S-ADENOSYL-METHYLTRANSFERASE MRAW THERMUS THERMOPHILUS RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE RSGI STRUCTURAL GENOMICS
Ref.: CRYSTAL STRUCTURE OF A PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE TT1512 FROM THERMUS THERMOPHILUS HB8 AT 2.0 ANG. RESOLUTION. TO BE PUBLISHED
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 1WG8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 54 families.
1 1WG8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 47 families.
1 3TKA - SAM C15 H22 N6 O5 S C[S@@+](CC....
2 1M6Y - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 1N2X - SAM C15 H22 N6 O5 S C[S@@+](CC....
4 1WG8 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1WG8; Ligand: SAM; Similar sites found with APoc: 724
This union binding pocket(no: 1) in the query (biounit: 1wg8.bio1) has 26 residues
No: Leader PDB Ligand Sequence Similarity
1 5WHU SIA GAL GLC None
2 5C2N NAG None
3 1ORR NAD 1.05263
4 1SQL GUN 1.36986
5 2AOT SAH 1.40351
6 4RDH AMP 1.40351
7 4RDI ATP 1.40351
8 1JQD SAH 1.40351
9 5G3U FDA 1.40351
10 5G3U ITW 1.40351
11 1JQD HSM 1.40351
12 2DPM SAM 1.40845
13 4D79 ATP 1.44928
14 1VHW ADN 1.58103
15 4CQM NAP 1.63934
16 6FDF SAH 1.75439
17 5JJR SAH 1.75439
18 2P41 SAH 1.75439
19 2O07 SPD 1.75439
20 2O07 MTA 1.75439
21 3HDY FDA 1.75439
22 3HDY GDU 1.75439
23 3HDY FAD 1.75439
24 1ELI PYC 1.75439
25 4OPC FDA 1.75439
26 4OPC PGT 1.75439
27 1T5C ADP 1.75439
28 2Q1S NAI 1.75439
29 3EYA FAD 1.75439
30 1WUU GLA 1.75439
31 1GY8 NAD 1.75439
32 4FC7 COA 1.80505
33 4FC7 NAP 1.80505
34 3EVG SAH 1.81818
35 2XVM SAH 2.01005
36 3VSE SAH 2.10526
37 1F3L SAH 2.10526
38 1NW5 SAM 2.10526
39 4UCI SAM 2.10526
40 2PT9 2MH 2.10526
41 2PT9 S4M 2.10526
42 4M52 M52 2.10526
43 4YAC NAI 2.10526
44 4M52 FAD 2.10526
45 3UCL FAD 2.10526
46 3UCL CYH 2.10526
47 3UCL NAP 2.10526
48 2A8X FAD 2.10526
49 4YNU FAD 2.10526
50 4YNU LGC 2.10526
51 1V6A TRE 2.10526
52 1Q1R FAD 2.10526
53 2VVM FAD 2.10526
54 2VVL FAD 2.10526
55 1C0I FAD 2.10526
56 1C0I BE2 2.10526
57 1I2B USQ 2.10526
58 1I2B UPG 2.10526
59 1I2B NAD 2.10526
60 4HNN LYS 2.10526
61 5FPE 3TR 2.10526
62 2I7C AAT 2.12014
63 4GK9 MAN BMA MAN MAN MAN 2.15054
64 1HGX 5GP 2.18579
65 5OVK NDP 2.34375
66 2CHT TSA 2.3622
67 2PHT MAN MAN MAN 2.38095
68 1RTF BEN 2.38095
69 1Q8S MAN MMA 2.38095
70 1Q8O MAN MMA 2.38095
71 1Q8V MAN MAN 2.38095
72 2PHU MAN MAN 2.38095
73 3GEG NAD 2.42915
74 2UYQ SAM 2.45614
75 5Z3I ADE 2.45614
76 2RAB NAD 2.45614
77 2RAB FAD 2.45614
78 1BZL GCG 2.45614
79 3TKY SAH 2.45614
80 1BZL FAD 2.45614
81 4D04 FAD 2.45614
82 4D04 NAP 2.45614
83 4C3Y FAD 2.45614
84 2GN4 NDP 2.45614
85 1RSG FAD 2.45614
86 6FP4 E1T 2.45614
87 6FP4 FAD 2.45614
88 1YY5 FAD 2.45614
89 5J60 FAD 2.45614
90 5F8F SFG 2.45614
91 1E5Q SHR 2.45614
92 2GN4 UD1 2.45614
93 3X0V FAD 2.45614
94 5TTJ FAD 2.45614
95 4C3Y ANB 2.45614
96 5M90 JIF 2.45614
97 1UDB NAD 2.45614
98 1UDB UFG 2.45614
99 4XPQ FUL 2.45614
100 6F5W KG1 2.45614
101 1ZX5 LFR 2.45614
102 2RGJ FAD 2.45614
103 2WA2 SAM 2.53623
104 1XCL SAH 2.55319
105 1KYQ NAD 2.55474
106 5O4J 9KH 2.55474
107 5O4J PJL 2.55474
108 5O4J SAH 2.55474
109 3RKR NAP 2.67176
110 6ACS CIT 2.71318
111 2P3V SRT 2.73438
112 2WSB NAD 2.75591
113 5BSZ SAH 2.8
114 4KIB SAH 2.80702
115 1G55 SAH 2.80702
116 4KRG SAH 2.80702
117 5AHO TLA 2.80702
118 5KVA SAM 2.80702
119 5KOK SAH 2.80702
120 6ECU SAH 2.80702
121 6ECW SAH 2.80702
122 5X62 SAH 2.80702
123 4KGD FAD 2.80702
124 4KGD TDP 2.80702
125 1YQZ FAD 2.80702
126 1Y8Q ATP 2.80702
127 4MO2 FDA 2.80702
128 4REP FAD 2.80702
129 3F8D FAD 2.80702
130 4MO2 FAD 2.80702
131 4AP3 NAP 2.80702
132 4AP3 FAD 2.80702
133 5KOK S9T 2.80702
134 2Z3Y F2N 2.80702
135 1JS8 MAN MAN BMA 2.80702
136 2OG2 MLI 2.80702
137 5KOK R9T 2.80702
138 6C5B SAH 2.80702
139 2DKH FAD 2.80702
140 2DKH 3HB 2.80702
141 3GDN HBX 2.80702
142 3GDN FAD 2.80702
143 1E6E FAD 2.80702
144 1COY FAD 2.80702
145 2JB2 PHE 2.80702
146 2JB2 FAD 2.80702
147 2NPX FAD 2.80702
148 2NPX NAD 2.80702
149 6F7L FAD 2.80702
150 2C31 TZD 2.80702
151 2C31 ADP 2.80702
152 1E1M NAP 2.80702
153 1E1M FAD 2.80702
154 2V6G NAP 2.80702
155 4EUE NAI 2.80702
156 2Q28 ADP 2.80702
157 5X68 FAD 2.80702
158 1COY AND 2.80702
159 4MIG G3F 2.80702
160 2ZZV LAC 2.80702
161 3LU1 NAD 2.80702
162 3B9Q MLI 2.80702
163 5CX6 CDP 2.80702
164 5GWT SIN 2.8777
165 5GWT NAD 2.8777
166 1NW4 IMH 2.89855
167 1Z34 2FD 2.97872
168 1P1C SAH 3.01508
169 2ZL4 ALA ALA ALA ALA 3.06122
170 3WDM ADN 3.06513
171 3P2E SAH 3.11111
172 3GD8 GOL 3.13901
173 1KPG SAH 3.15789
174 5HJM MTA 3.15789
175 5E9W SAH 3.15789
176 1FP2 SAH 3.15789
177 1Q9I TEO 3.15789
178 1Q9I FAD 3.15789
179 5T67 JHZ 3.15789
180 5T67 SAH 3.15789
181 6GKV SAH 3.15789
182 3GD4 NAD 3.15789
183 3GD4 FAD 3.15789
184 5ZYN FAD 3.15789
185 4D7E FAD 3.15789
186 5YF1 8V0 3.15789
187 3CGD FAD 3.15789
188 5YF1 SFG 3.15789
189 3KLJ FAD 3.15789
190 3CGD COA 3.15789
191 4TQK NAG 3.15789
192 3AXB PRO 3.15789
193 3AXB FAD 3.15789
194 3NTD FAD 3.15789
195 5NMX FAD 3.15789
196 5NMX NAP 3.15789
197 1KNR FAD 3.15789
198 5WGR FAD 3.15789
199 1VDC FAD 3.15789
200 2Q0L FAD 3.15789
201 3CGD NAD 3.15789
202 3CGB FAD 3.15789
203 3NT6 FAD 3.15789
204 6EL3 NAP 3.15789
205 3NTA FAD 3.15789
206 4DA6 GA2 3.16206
207 4UHF BUA 3.19149
208 3VPB GLU 3.19149
209 3JWH SAH 3.22581
210 1QAN SAH 3.27869
211 4P86 5GP 3.27869
212 4P83 U5P 3.2967
213 6AR9 3L4 3.30882
214 5E1M PRO PRO LYS ARG ILE ALA 3.3195
215 5E1M SAH 3.3195
216 1BC5 SAH 3.34572
217 2W5P CL8 3.3557
218 3T7S SAM 3.35821
219 1MZV AMP 3.40426
220 3FZG SAM 3.5
221 3FPF TNA 3.50877
222 3FPF MTA 3.50877
223 4BLW SAH 3.50877
224 4N49 SAM 3.50877
225 6ECT SAM 3.50877
226 1U2Z SAH 3.50877
227 1TPY SAH 3.50877
228 4NTD FAD 3.50877
229 4BLW AMP 3.50877
230 3AB1 FAD 3.50877
231 5FWA J7C 3.50877
232 3MBI HSX 3.50877
233 5N0J FAD 3.50877
234 3E1T FAD 3.50877
235 5K0A FAD 3.50877
236 4USR FAD 3.50877
237 5MB4 NAG 3.50877
238 6GH9 MIX 3.50877
239 1OC2 TDX 3.50877
240 1OC2 NAD 3.50877
241 4ZVV NAD 3.50877
242 2WET FAD 3.50877
243 4AT0 FAD 3.50877
244 2C5A NAD 3.50877
245 2C5A GDC 3.50877
246 2JFV FLC 3.50877
247 4ZVV GN0 3.50877
248 5FTW SAH 3.51562
249 1NJR XYL 3.52113
250 5YJF SAH 3.52113
251 5YJF 8WO 3.52113
252 3GCZ SAM 3.5461
253 3LCV SAM 3.55872
254 3EVF SAH 3.61011
255 3EVF GTA 3.61011
256 1O5O U5P 3.61991
257 1X87 NAD 3.62976
258 5JE0 SAH 3.64372
259 5JE0 AZ8 3.64372
260 1XTT U5P 3.7037
261 2O66 FLC 3.7037
262 1IY8 NAD 3.74532
263 2JKY 5GP 3.75587
264 1G60 SAM 3.84615
265 3S1S SAH 3.85965
266 6ARJ BW4 3.85965
267 5JGL SAM 3.85965
268 6ARJ SAH 3.85965
269 5DXA SFG 3.85965
270 5DX1 SFG 3.85965
271 5DX8 SFG 3.85965
272 4DCM SAM 3.85965
273 1V5F FAD 3.85965
274 1V5F TPP 3.85965
275 2BRY FAD 3.85965
276 4TXI FAD 3.85965
277 6C8R EQV 3.85965
278 6C8R SAH 3.85965
279 2GV8 FAD 3.85965
280 2GVC FAD 3.85965
281 5GSN NAP 3.85965
282 5GSN FAD 3.85965
283 1VQW FAD 3.85965
284 4PIO AVI 3.85965
285 3QJ4 FAD 3.85965
286 5TS5 FAD 3.85965
287 5KOX FAD 3.85965
288 5KOX RFP 3.85965
289 4PIO SAH 3.85965
290 4MOP 2H5 3.85965
291 5GSN MMZ 3.85965
292 5FJN BE2 3.85965
293 5FJN FAD 3.85965
294 6H3O FAD 3.85965
295 4K5S PM0 3.85965
296 4K5S FAD 3.85965
297 3S5W FAD 3.85965
298 4PLG OXM 3.85965
299 4PLG NAI 3.85965
300 6CI9 NAP 3.861
301 6F4W FMC 3.86266
302 4USI AKG 3.8961
303 1I9G SAM 3.92857
304 3H2B SAH 3.94089
305 6DUB SAH 4.05405
306 3N8K D1X 4.06977
307 1P19 IMP 4.0724
308 1KYZ SAH 4.21053
309 6IS0 SAH 4.21053
310 2IID FAD 4.21053
311 2IID PHE 4.21053
312 1TZJ A3B 4.21053
313 1I8T FAD 4.21053
314 4TM3 FAD 4.21053
315 5OC1 FAD 4.21053
316 4PLT NAI 4.21053
317 1FUR MLT 4.21053
318 1CZA GLC 4.21053
319 3GMB FAD 4.21053
320 5I39 FAD 4.21053
321 2QA1 FAD 4.21053
322 5JAQ NAI 4.21053
323 2Y6Q FAD 4.21053
324 2Y6Q I7T 4.21053
325 2QES ADE 4.21456
326 3LE7 ADE 4.21456
327 1ODJ GMP 4.25532
328 2JBH 5GP 4.44444
329 2PX8 SAH 4.46097
330 5CUQ NSC 4.49438
331 2EJU SAH 4.5614
332 3LKZ SFG 4.5614
333 6BQ6 TER 4.5614
334 2HQM FAD 4.5614
335 1GPE FAD 4.5614
336 4JDR FAD 4.5614
337 3G5S FAD 4.5614
338 1Z3C SA8 4.5614
339 5BUK FAD 4.5614
340 5EZ7 FAD 4.5614
341 3FG2 FAD 4.5614
342 2Z48 A2G 4.5614
343 5TUF TDC 4.5614
344 5TUF FAD 4.5614
345 4L2I FAD 4.56274
346 3DUV KDO 4.58015
347 3MQ2 SAH 4.58716
348 4R6W PC 4.65116
349 4R6W SAH 4.65116
350 2VT3 ATP 4.65116
351 5MGZ SAH 4.66102
352 1JG3 ADN 4.68085
353 2BZG SAH 4.74138
354 2VDV SAM 4.87805
355 4I5I 4I5 4.87805
356 4II2 ATP 4.90798
357 2ZIF SAM 4.91228
358 3MAG SAH 4.91228
359 3SQP FAD 4.91228
360 1FP1 SAH 4.91228
361 1YBH FAD 4.91228
362 3LAD FAD 4.91228
363 3MCT SAH 4.91228
364 5U8U FAD 4.91228
365 1PJS NAD 4.91228
366 3GF4 FAD 4.91228
367 5TWB FAD 4.91228
368 1FEC FAD 4.91228
369 3GF4 UPG 4.91228
370 1REO FAD 4.91228
371 5KJW 53C 4.91228
372 1JQ3 AAT 4.91228
373 4U8P UDP 4.91228
374 4U8P FDA 4.91228
375 2IVD FAD 4.91228
376 5JCA FAD 4.92958
377 5JCA NDP 4.92958
378 3BGD SAH 5
379 3BGD PM6 5
380 2PWY SAH 5.03876
381 3C3Y SAH 5.06329
382 1TL2 NDG 5.08475
383 2RGO FAD 5.10708
384 3KU0 ADE 5.17928
385 4DVR 0LY 5.18868
386 3OZG SSI 5.2
387 3RFV 15L 5.24345
388 3RFV NAI 5.24345
389 5THY SAH 5.26316
390 5THZ SAH 5.26316
391 2YX1 SFG 5.26316
392 5MW4 5JU 5.26316
393 3LST SAH 5.26316
394 5GM1 SAH 5.26316
395 1RJW ETF 5.26316
396 3L9W GSH 5.26316
397 3L9W AMP 5.26316
398 1LVL FAD 5.26316
399 4J36 1HR 5.26316
400 5K4G ASP 5.26316
401 3LXD FAD 5.26316
402 4J36 FAD 5.26316
403 4HA6 FAD 5.26316
404 6DEN TP9 5.26316
405 6DEN FAD 5.26316
406 6DEN G8A 5.26316
407 1NAA 6FA 5.26316
408 1NAA ABL 5.26316
409 1LVL NAD 5.26316
410 1MUU NAD 5.26316
411 6AIN FAD 5.26316
412 5JE8 NAD 5.26316
413 2PZM UDP 5.26316
414 2PZM NAD 5.26316
415 1R6D NAD 5.26316
416 1R6D DAU 5.26316
417 3KP6 SAL 5.29801
418 1UAY ADN 5.3719
419 3U40 ADN 5.3719
420 3Q87 SAM 5.6
421 4KRI SAH 5.61404
422 5XNC MTA 5.61404
423 1GET FAD 5.61404
424 1GET NAP 5.61404
425 5BVA FAD 5.61404
426 3LZW NAP 5.61404
427 3LZW FAD 5.61404
428 1BW9 NAD 5.61404
429 5WKC FAD 5.61404
430 4CNK FAD 5.61404
431 4FWE FAD 5.61404
432 4NTC FAD 5.61404
433 1PN0 FAD 5.61404
434 1PN0 IPH 5.61404
435 1T9D FAD 5.61404
436 1T9D P25 5.61404
437 1MV8 NAD 5.61404
438 4ZCC NAI 5.61404
439 4ZCC FAD 5.61404
440 1T9D 1MM 5.61404
441 1T9D PYD 5.61404
442 4X9M FAD 5.61404
443 3OJO NAD 5.61404
444 6BWL NAD 5.61404
445 4GUS FAD 5.64516
446 4GUT FAD 5.64516
447 5XLX SAH 5.67376
448 6FA4 D1W 5.78035
449 1I4D GDP 5.80357
450 4X7Y SAH 5.83942
451 5VJN IR8 5.88235
452 1QB7 ADE 5.9322
453 5E72 SAM 5.96491
454 1UWK NAD 5.96491
455 1UWK URO 5.96491
456 6ER9 NAP 5.96491
457 6ER9 FAD 5.96491
458 2NVK FAD 5.96491
459 2CDU ADP 5.96491
460 3ICT ADP 5.96491
461 4TQG NDP 5.96491
462 1WD4 AHR 5.96491
463 3ICS ADP 5.96491
464 3ICS FAD 5.96491
465 3ICT FAD 5.96491
466 2CDU FAD 5.96491
467 3ICR FAD 5.96491
468 4B3J COA 5.96491
469 6F97 FAD 5.96491
470 2R4J FAD 5.96491
471 2R4J 13P 5.96491
472 1UXG NAD 5.96491
473 1UXG FUM 5.96491
474 4CP8 MLI 5.96491
475 3CTY FAD 5.96491
476 3QPB URA 6.02837
477 6A4R ASP 6.03774
478 2A14 SAH 6.08365
479 5W7K SAH 6.31579
480 4LWP SAH 6.31579
481 1MO9 FAD 6.31579
482 1MO9 KPC 6.31579
483 4RVG TYD 6.31579
484 4RVG SAM 6.31579
485 5J5Z FAD 6.31579
486 3RNM FAD 6.31579
487 6GAS FAD 6.31579
488 3FPZ AHZ 6.31579
489 3WGT QSC 6.31579
490 2AQJ FAD 6.31579
491 2AQJ TRP 6.31579
492 3WGT FAD 6.31579
493 2ZXI FAD 6.31579
494 3IHG FAD 6.31579
495 2C7G FAD 6.31579
496 2C7G ODP 6.31579
497 2A92 NAI 6.31579
498 2YLN CYS 6.36042
499 5BW4 SAM 6.36704
500 3OU2 SAH 6.42202
501 5LOG SAH 6.43777
502 3PFG SAM 6.46388
503 3PFG TLO 6.46388
504 2DWU DGL 6.52174
505 3VYW SAM 6.66667
506 1L1E SAH 6.66667
507 4RSL FAD 6.66667
508 3UOY FAD 6.66667
509 3UOY NAP 6.66667
510 5BRT CH9 6.66667
511 5BRT FAD 6.66667
512 4DSG FAD 6.66667
513 4DSG UDP 6.66667
514 5BJX NAD 6.66667
515 5BJX UDP 6.66667
516 4BJZ FAD 6.66667
517 4BJZ P3A 6.66667
518 1VBO MAN 6.71141
519 4NEC SAH 6.81818
520 6FX2 FUC C4W NAG BMA MAN NAG GAL 6.97674
521 1SQF SAM 7.01754
522 4PNE SAH 7.01754
523 1XHC FAD 7.01754
524 4IV9 FAD 7.01754
525 3H8V ATP 7.01754
526 1XDS SAM 7.01754
527 5MIT NAP 7.01754
528 5MIT FAD 7.01754
529 1QZZ SAM 7.01754
530 5MBX SP5 7.01754
531 5MBX FAD 7.01754
532 3NYC IAR 7.01754
533 3NYC FAD 7.01754
534 1VE3 SAM 7.04846
535 2PS1 ORO 7.07965
536 4M1U A2G MBG 7.14286
537 1UPF URF 7.14286
538 5N53 8NB 7.17949
539 3PQC GDP 7.17949
540 6B92 SAH 7.36842
541 5WP4 SAH 7.36842
542 1V59 FAD 7.36842
543 2WPF FAD 7.36842
544 2WPF WPF 7.36842
545 1V59 NAD 7.36842
546 5JCM NAD 7.36842
547 5JCM ISD 7.36842
548 5JCM FAD 7.36842
549 5HSA FAS 7.36842
550 5MZI FYK 7.36842
551 5MZI FAD 7.36842
552 1DJN ADP 7.36842
553 5YJI SAH 7.39437
554 5YJI 8WO 7.39437
555 5D4V SAH 7.46269
556 5NC1 NAG 7.59494
557 4NBU NAI 7.6
558 3A25 SAM 7.6412
559 4YRY FAD 7.7193
560 4YRY NAD 7.7193
561 1LTH NAD 7.7193
562 1RP0 AHZ 7.74648
563 4JLS 3ZE 7.89474
564 2PXX SAH 7.90698
565 5O6Y 5YA 7.94393
566 4RL4 PPV 8.01887
567 4RPL 3UC 8.07018
568 4RPL FAD 8.07018
569 2XVF FAD 8.07018
570 2XVE FAD 8.07018
571 2GAG NAD 8.08081
572 5G3L SIA 8.08081
573 2GAG FAD 8.08081
574 2GAG FOA 8.08081
575 3HVJ 705 8.1448
576 3ACC 5GP 8.28729
577 6GFK SAH 8.36653
578 5ERG SAM 8.42105
579 5FUB SAH 8.42105
580 1D4D FAD 8.42105
581 3QVP FAD 8.42105
582 3ZNN 4WL 8.42105
583 3ZNN FAD 8.42105
584 3U31 NAD 8.42105
585 1Q0S SAH 8.49421
586 4YUW S4M 8.55263
587 4YUW 4JU 8.55263
588 1EFV AMP 8.62745
589 1EFV FAD 8.62745
590 4XUC 43G 8.7156
591 4XUC SAM 8.7156
592 4B63 FAD 8.77193
593 4B63 NAP 8.77193
594 4B63 ORN 8.77193
595 1H82 FAD 8.77193
596 1H82 GZZ 8.77193
597 5IL1 SAM 8.77193
598 5K7U SAM 8.77193
599 1SB8 UD2 8.77193
600 1SB8 NAD 8.77193
601 5UFN SAH 8.82353
602 5N5D SAM 8.84956
603 3C6K SPD 8.92388
604 3C6K MTA 8.92388
605 3A27 SAM 9.12281
606 1GTE FAD 9.12281
607 4A6D SAM 9.12281
608 4EIP FAD 9.12281
609 6B3A SAM 9.12281
610 2HNK SAH 9.20502
611 3BXO SAM 9.20502
612 1LSS NAD 9.28571
613 3BPX SAL 9.45946
614 3PT9 SAH 9.47368
615 4BV6 FAD 9.47368
616 2E5V FAD 9.47368
617 3K7M FAD 9.47368
618 5EB4 FAD 9.47368
619 3DU4 KAP 9.47368
620 3HQP FDP 9.47368
621 4XFR CIT 9.47368
622 3QFA FAD 9.48276
623 5GWX SAR 9.50704
624 5GWX SAM 9.50704
625 1DQN IMU 9.56522
626 1VKF CIT 9.57447
627 4YMH SAH 9.58333
628 4YSX FAD 9.61539
629 4JNA FAD 9.70588
630 1DL5 SAH 9.82456
631 3QOX SAH 9.82456
632 4Y9D NAI 9.82456
633 6G5Q EMZ 9.82456
634 1L3I SAH 9.89583
635 3CTR MGP 9.90099
636 2JHP SAH 9.93789
637 4DZ1 DAL 10.0386
638 5DNK SAH 10.1754
639 1KPH SAH 10.1754
640 3GWZ SAH 10.1754
641 3GXO SAH 10.1754
642 5W7M SAH 10.1754
643 4XQC NAD 10.1754
644 2Q1W NAD 10.1754
645 4D5G TPP 10.5263
646 4D5G FAD 10.5263
647 1PS9 FAD 10.5263
648 4IF4 BEF 10.5769
649 1I1N SAH 10.6195
650 5ODQ FAD 10.7143
651 2FKA BEF 10.8527
652 2HMT NAI 11.1111
653 4AZW SAM 11.2281
654 4USQ FAD 11.2281
655 5E8J SAH 11.3636
656 5U19 827 11.5789
657 5U19 SAH 11.5789
658 5VN0 FAD 11.5789
659 5VN0 NAI 11.5789
660 1L5Y BEF 11.6129
661 1PZM 5GP 11.8483
662 2OBF SAH 11.9298
663 2OBF F83 11.9298
664 1ZGA SAH 11.9298
665 3BJE R1P 11.9298
666 5MPT SAH 12.0773
667 2Q7V FAD 12.2807
668 6GAR FAD 12.2807
669 3R51 MMA 12.5
670 3MB5 SAM 12.549
671 3AYI FAD 12.6316
672 3AYI HCI 12.6316
673 4KCT FDP 12.6316
674 3AD8 NAD 12.8079
675 3AD8 PYC 12.8079
676 3AD8 FAD 12.8079
677 3WV8 ATP 12.844
678 3ELW SAM 12.9825
679 3ELW GP3 12.9825
680 4Z24 FAD 12.9825
681 1ZK7 FAD 13.3333
682 4POO SAM 13.5
683 1R18 SAH 13.6564
684 2YG3 FAD 13.6842
685 2YVJ NAI 13.6842
686 2YVF FAD 13.6842
687 2YVF NAD 13.6842
688 5ULP KB1 13.806
689 1T26 GBD 14.0351
690 1T26 NAI 14.0351
691 4C2G ALA ALA ALA ALA 14.0351
692 5YEC ATP 14.2857
693 4YKG NAD 14.386
694 4YKG FAD 14.386
695 1FL2 FAD 14.386
696 6MJ7 ARG 14.5455
697 5FA8 SAM 14.9068
698 4J56 FAD 14.9123
699 4DMG SAM 15.0877
700 1O97 FAD 15.0877
701 1O97 AMP 15.0877
702 1O94 ADP 15.0877
703 3KIF GDL 15.0943
704 6F5Z SAH 15.1515
705 2F5Z FAD 15.625
706 3G2O SAM 15.7895
707 1QO8 FAD 15.7895
708 3DXY SAM 16.055
709 4EMI NAD 16.4912
710 4EMI FAD 16.4912
711 4EMJ FAD 16.4912
712 4GQB 0XU 18.1818
713 4OBW SAM 19.0661
714 5ZZ6 ADP 19.2308
715 5ZZ6 NAD 19.2308
716 5FA5 MTA 20
717 1DCP HBI 21.1538
718 5GVR LMR 21.3675
719 1XTP SAI 22.8346
720 4HSU FAD 23.3333
721 2ZFU SAH 28.8372
722 5DWQ SFG 35
723 5DX0 SFG 35
724 5L95 AMP 38.75
Pocket No.: 2; Query (leader) PDB : 1WG8; Ligand: SAM; Similar sites found with APoc: 101
This union binding pocket(no: 2) in the query (biounit: 1wg8.bio2) has 24 residues
No: Leader PDB Ligand Sequence Similarity
1 1PTR PRB None
2 1XSE NDP 1.40351
3 5DT6 GLU 1.49813
4 5YLF BGC 1.75439
5 1UP7 NAD 2.10526
6 3W68 PBU 2.25564
7 2DUR MAN MAN 2.37154
8 2PHR MAN MAN 2.38095
9 2PHW MAN MAN 2.38095
10 2PHF MAN MAN 2.38095
11 1Q8P MAN MMA 2.38095
12 2GND MAN MMA 2.38095
13 2GMM MAN MAN 2.38095
14 4G5H NAP 2.45614
15 4G5H UD7 2.45614
16 4YAG NAI 2.45614
17 3U4C NDP 2.4911
18 1RPN NDP 2.80702
19 5T52 A2G 2.89256
20 1JN2 SFP 2.95359
21 2RBK VN4 3.06513
22 1GEG NAD 3.125
23 2J5V PCA 3.15789
24 3OZ2 FAD 3.15789
25 6B2W AG2 3.15789
26 1SDW IYT 3.15789
27 1JNR FAD 3.15789
28 4UP4 GAL NAG 3.50877
29 5DF1 NAP 3.50877
30 5DF1 58X 3.50877
31 4HXY NDP 3.50877
32 2GMH FAD 3.50877
33 3I6B KDO 3.88889
34 2PZE ATP 3.93013
35 5F7J ADE 4.21053
36 5HXI FAD 4.21053
37 1GR0 NAD 4.21053
38 4ZRN UPG 4.21053
39 4ZRN NAD 4.21053
40 3KB6 LAC 4.21053
41 4PLT OXM 4.21053
42 3CT5 NAG NAG NAG 4.40252
43 2Z49 AMG 4.5614
44 2Z48 NGA 4.5614
45 3A4V NAD 4.5614
46 3A4V PYR 4.5614
47 3T31 DCQ 4.5614
48 3T31 FAD 4.5614
49 1VL8 NAP 4.86891
50 1RZM E4P 4.91228
51 3K56 IS3 5.26316
52 1V8K ANP 5.26316
53 6DNT NAD 5.26316
54 5ICE 2H4 5.26316
55 5ICE SAH 5.26316
56 5JWC FAD 5.61404
57 5LW0 AR6 5.61404
58 1C1X HFA 5.61404
59 1JQY A32 5.82524
60 5VJN ADE 5.88235
61 2B9W FAD 6.31579
62 5TQZ GLC 6.66667
63 5XHA FRU 7.01754
64 1YXM ADE 7.01754
65 6FHO FAD 7.01754
66 5O42 BGC 7.29927
67 5O42 9JW 7.29927
68 5O42 NAD 7.29927
69 5Y77 FAD 7.36842
70 4OJP MAL 7.36842
71 1RYI GOA 7.7193
72 1RYI FAD 7.7193
73 1K27 MTM 8.12721
74 1SOW NAD 8.42105
75 1M2K APR 8.43373
76 5KMS NAD 8.77193
77 5KMS FAD 8.77193
78 5XLS URA 8.96552
79 3NUG NAD 9.31174
80 2A8Y MTA 9.62963
81 1DJL NAP 10.1449
82 3FGZ BEF 10.1562
83 4XQC 13D 10.1754
84 3P9C SAH 10.5263
85 6AU6 GDP 10.8772
86 1D4O NAP 11.413
87 2OOR TXP 12.6437
88 5CIC 51R 12.963
89 2DT5 NAD 13.2701
90 1N7G NDP 13.6842
91 2YVJ FAD 13.6842
92 3ZV6 4HB 13.879
93 3ZV6 NAD 13.879
94 2PYY GLU 14.0351
95 4L6T GAL NGA GAL BGC SIA 14.2857
96 1PEA ACM 15.0877
97 5IN4 6CK 16.4912
98 5IN4 NAP 16.4912
99 5IN4 GDP 16.4912
100 2ZE3 AKG 16.7273
101 4NTX AMR 21.0084
APoc FAQ
Feedback