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Receptor
PDB id Resolution Class Description Source Keywords
1XDS 2.3 Å EC: 1.-.-.- CRYSTAL STRUCTURE OF ACLACINOMYCIN-10-HYDROXYLASE (RDMB) IN COMPLEX WITH S-ADENOSYL-L-METHIONINE (SAM) AND 11-DEOXY- B ETA-RHODOMYCIN (DBRA) STREPTOMYCES PURPURASCENS ANTHRACYCLINE; HYDROXYLASE; S-ADENOSYL-L-METHIONINE; STREPTOMYCES; POLYKETIDE ANTIBIOTICS; DIVERGENT EVOLUTION STRUCTURAL PROTEOMICS IN EUROPE SPINE STRUCTURAL GENOMICSTRANSFERASE
Ref.: ACLACINOMYCIN 10-HYDROXYLASE IS A NOVEL SUBSTRATE-ASSISTED HYDROXYLASE REQUIRING S-ADENOSYL-L-METHIONINE AS COFACTOR J.BIOL.CHEM. V. 280 3636 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DRA A:5600;
B:9600;
Valid;
Valid;
none;
none;
submit data
769.831 C40 H51 N O14 CC[C@...
SAM A:5635;
B:9635;
Valid;
Valid;
none;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1XDS 2.3 Å EC: 1.-.-.- CRYSTAL STRUCTURE OF ACLACINOMYCIN-10-HYDROXYLASE (RDMB) IN COMPLEX WITH S-ADENOSYL-L-METHIONINE (SAM) AND 11-DEOXY- B ETA-RHODOMYCIN (DBRA) STREPTOMYCES PURPURASCENS ANTHRACYCLINE; HYDROXYLASE; S-ADENOSYL-L-METHIONINE; STREPTOMYCES; POLYKETIDE ANTIBIOTICS; DIVERGENT EVOLUTION STRUCTURAL PROTEOMICS IN EUROPE SPINE STRUCTURAL GENOMICSTRANSFERASE
Ref.: ACLACINOMYCIN 10-HYDROXYLASE IS A NOVEL SUBSTRATE-ASSISTED HYDROXYLASE REQUIRING S-ADENOSYL-L-METHIONINE AS COFACTOR J.BIOL.CHEM. V. 280 3636 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 318 families.
1 1XDS - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 280 families.
1 1XDS - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 1XDS - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: DRA; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 DRA 1 1
2 AKY 0.81203 0.967213
3 AKA 0.757576 0.967213
4 3VL 0.535714 0.95082
5 AKT 0.489209 0.934426
Ligand no: 2; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1XDS; Ligand: DRA; Similar sites found with APoc: 4
This union binding pocket(no: 1) in the query (biounit: 1xds.bio1) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 5ICE SAH 21.3068
2 3TKY N7I 25.8152
3 1KYZ FER 26.3014
4 3GXO MQA 36.3144
Pocket No.: 2; Query (leader) PDB : 1XDS; Ligand: SAM; Similar sites found with APoc: 681
This union binding pocket(no: 2) in the query (biounit: 1xds.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5A3B APR 0.990099
2 2RGO FAD 1.15321
3 2UYQ SAM 1.29032
4 1GPE FAD 1.3369
5 5MBX SP5 1.3369
6 5MBX FAD 1.3369
7 3OZ2 FAD 1.3369
8 2XVF FAD 1.3369
9 2XVE FAD 1.3369
10 4A0S NAP 1.3369
11 4BLW AMP 1.38408
12 4BLW SAH 1.38408
13 1H2B NAJ 1.39276
14 1ORR NAD 1.44092
15 3FZG SAM 1.5
16 2YY7 NAD 1.60256
17 4POO SAM 1.60428
18 2ZWI C5P 1.60858
19 1RLZ NAD 1.62602
20 1WVG APR 1.67131
21 1SB8 UD2 1.70455
22 1SB8 NAD 1.70455
23 3I6I NDP 1.7341
24 6DNT NAD 1.74419
25 6GAS FAD 1.81269
26 4EA7 COA 1.81818
27 4EA7 JB2 1.81818
28 2EFJ SAH 1.87166
29 4HXY NDP 1.87166
30 2ZJ1 ARJ 1.87166
31 2ZJ1 NAD 1.87166
32 5M67 ADE 1.87166
33 3NJ4 NAD 1.87166
34 3X0V FAD 1.87166
35 4ZNO SUC 1.87166
36 5M67 NAD 1.87166
37 5M67 3D1 1.87166
38 1RYI FAD 1.87166
39 1VKO NAD 1.87166
40 1C3X 8IG 1.8797
41 5XNC MTA 1.88679
42 5Z3I ADE 1.88679
43 3AB1 FAD 1.94444
44 2WPB ZZI 1.97368
45 1S7G APR 1.97628
46 1S7G NAD 1.97628
47 1R6D NAD 2.07715
48 1R6D DAU 2.07715
49 4GKV NAD 2.08333
50 1RJD SAM 2.09581
51 4MDH NAD 2.09581
52 3LZW NAP 2.10843
53 3LZW FAD 2.10843
54 6BQ6 TER 2.1148
55 3EVF GTA 2.13904
56 3EVF SAH 2.13904
57 5CUQ NSC 2.13904
58 3L9W AMP 2.13904
59 2P41 SAH 2.13904
60 3GCZ SAM 2.13904
61 3L9W GSH 2.13904
62 3HDY FDA 2.13904
63 3HDY GDU 2.13904
64 3HDY FAD 2.13904
65 3QVP FAD 2.13904
66 2HQM FAD 2.13904
67 5JJR SAH 2.13904
68 5OC1 FAD 2.13904
69 5MIT FAD 2.13904
70 5MIT NAP 2.13904
71 3KLJ FAD 2.13904
72 5HSA FAS 2.13904
73 1QAN SAH 2.13904
74 3K7M FAD 2.13904
75 3EYA FAD 2.13904
76 5FJN BE2 2.13904
77 5FJN FAD 2.13904
78 3AYI FAD 2.13904
79 3AYI HCI 2.13904
80 5BJX NAD 2.18579
81 5BJX UDP 2.18579
82 5BW4 SAM 2.24719
83 1YXM ADE 2.31023
84 6FA4 GNP 2.31214
85 4M37 SAH 2.33236
86 4M38 SAH 2.33236
87 3QJ4 FAD 2.33918
88 1XHL NDP 2.3569
89 4ZA2 NAD 2.37154
90 5JAQ NAI 2.40642
91 2WPF FAD 2.40642
92 2WPF WPF 2.40642
93 3G5S FAD 2.40642
94 1OC2 TDX 2.40642
95 1OC2 NAD 2.40642
96 5EB4 FAD 2.40642
97 4MO2 FDA 2.40642
98 4MO2 FAD 2.40642
99 1H82 FAD 2.40642
100 5KOX RFP 2.40642
101 5KOX FAD 2.40642
102 4EIP FAD 2.40642
103 1H82 GZZ 2.40642
104 3S5W FAD 2.40642
105 1U2Z SAH 2.40642
106 2Q28 ADP 2.40642
107 2WOX NDP 2.40642
108 2WME NAP 2.40642
109 1Z45 NAD 2.40642
110 3U31 NAD 2.41379
111 1NJR XYL 2.46479
112 5F7J ADE 2.5
113 2RH4 EMO 2.52708
114 1BXK NAD 2.53521
115 6EQS BV8 2.54545
116 5HJM MTA 2.55682
117 3RIY NAD 2.5641
118 6F9Q NAD 2.57353
119 6GAR FAD 2.5788
120 3QWI CUE 2.59259
121 3QWI NAP 2.59259
122 2EXX NAP 2.61438
123 5X62 SAH 2.6738
124 6C8R SAH 2.6738
125 2Q1W NAD 2.6738
126 1GET FAD 2.6738
127 1GET NAP 2.6738
128 2IVD FAD 2.6738
129 5J5Z FAD 2.6738
130 2EJU SAH 2.6738
131 2AQJ TRP 2.6738
132 2AQJ FAD 2.6738
133 6AIN FAD 2.6738
134 5X68 FAD 2.6738
135 3OND NAD 2.6738
136 3OND ADN 2.6738
137 6C8R EQV 2.6738
138 1W62 PYC 2.6738
139 2YX1 SFG 2.67857
140 3BGD SAH 2.69231
141 3BGD PM6 2.69231
142 3SJ7 NDP 2.77778
143 5OJ7 AR6 2.7972
144 2CFC NAD 2.8
145 4BUZ OAD 2.84553
146 4BUZ OCZ 2.84553
147 4BUZ NAD 2.84553
148 1YC5 NCA 2.84553
149 3LCV SAM 2.84698
150 1XKQ NDP 2.85714
151 5E72 SAM 2.89017
152 5O42 NAD 2.91971
153 5O42 9JW 2.91971
154 5O42 BGC 2.91971
155 5KOK SAH 2.94118
156 3VSE SAH 2.94118
157 1V59 FAD 2.94118
158 2V3V MGD 2.94118
159 4M52 FAD 2.94118
160 4HA6 FAD 2.94118
161 4M52 M52 2.94118
162 3GDN FAD 2.94118
163 3GDN HBX 2.94118
164 4RSL FAD 2.94118
165 2A8X FAD 2.94118
166 5EJ2 NAD 2.94118
167 4U7W NDP 2.94118
168 1V59 NAD 2.94118
169 1RM0 D6P 2.94118
170 1RM0 NAI 2.94118
171 4UCI SAM 2.94118
172 2QA1 FAD 2.94118
173 3NYC IAR 2.94118
174 3NYC FAD 2.94118
175 5KOK R9T 2.94118
176 5KOK S9T 2.94118
177 2EG5 SAH 2.95699
178 3LCC SAH 2.97872
179 6HOY TSN 2.98013
180 6HOY AR6 2.98013
181 2DTX BMA 3.0303
182 3ZG6 APR 3.04054
183 3GRU AMP 3.05085
184 1ZEM NAD 3.05344
185 4PIO AVI 3.09598
186 4PIO SAH 3.09598
187 5ZW3 SAH 3.11111
188 4RDI ATP 3.125
189 4RDH AMP 3.125
190 2WSB NAD 3.14961
191 3BJE URA 3.15186
192 3GU3 SAH 3.16901
193 3VC1 SAH 3.20513
194 3VC1 GST 3.20513
195 4PTN GXV 3.207
196 3NDJ SAH 3.20856
197 3NDJ JHZ 3.20856
198 4RPL FAD 3.20856
199 4RPL 3UC 3.20856
200 1ELI PYC 3.20856
201 1I2B UPG 3.20856
202 1I2B NAD 3.20856
203 1I2B USQ 3.20856
204 4OPC FDA 3.20856
205 4OPC PGT 3.20856
206 1Q9I FAD 3.20856
207 1Q9I TEO 3.20856
208 4MIG G3F 3.20856
209 2BD0 NAP 3.20856
210 5JCM FAD 3.20856
211 5JCM NAD 3.20856
212 5JCM ISD 3.20856
213 2VVL FAD 3.20856
214 4LHD GLY 3.20856
215 2VVM FAD 3.20856
216 1V8B NAD 3.20856
217 2JHP SAH 3.20856
218 4AT0 FAD 3.20856
219 4TVD BGC 3.20856
220 2Q0L FAD 3.21543
221 3JWH SAH 3.22581
222 1RJW ETF 3.24484
223 1UDB UFG 3.25444
224 1UDB NAD 3.25444
225 4D79 ATP 3.26087
226 1X87 NAD 3.26679
227 1AE1 NAP 3.2967
228 5Y1G AKB 3.35366
229 5Y1G NAD 3.35366
230 6EL3 NAP 3.41207
231 4RVG TYD 3.47594
232 4RVG SAM 3.47594
233 3GF4 FAD 3.47594
234 2ZXI FAD 3.47594
235 3GF4 UPG 3.47594
236 2BRY FAD 3.47594
237 2IV2 MGD 3.47594
238 2R4J 13P 3.47594
239 2R4J FAD 3.47594
240 2Y6Q I7T 3.47594
241 2Y6Q FAD 3.47594
242 2JJQ SAH 3.47594
243 1TPY SAH 3.48432
244 5TWB FAD 3.48837
245 5FTW SAH 3.51562
246 5GWX SAM 3.52113
247 5GWX SAR 3.52113
248 3MB5 SAM 3.52941
249 1I8T FAD 3.54223
250 3FRH SAH 3.55731
251 3ZV6 4HB 3.55872
252 3ZV6 NAD 3.55872
253 4G5H UD7 3.58127
254 4G5H NAP 3.58127
255 1ZK4 NAP 3.58566
256 1ZK4 AC0 3.58566
257 3EVG SAH 3.63636
258 3FPZ AHZ 3.68098
259 4DCM SAM 3.73333
260 4TXI FAD 3.73984
261 5F8F SFG 3.74332
262 4AZW SAM 3.74332
263 5WGR FAD 3.74332
264 5U8U FAD 3.74332
265 6FP4 FAD 3.74332
266 6FP4 E1T 3.74332
267 3S1S SAH 3.74332
268 3LKZ SFG 3.74332
269 4JDR FAD 3.74332
270 5ULP KB1 3.74332
271 1T9D PYD 3.74332
272 1T9D P25 3.74332
273 1T9D 1MM 3.74332
274 1T9D FAD 3.74332
275 5WKC FAD 3.74332
276 2E5V FAD 3.74332
277 4A59 AMP 3.74332
278 2GMH FAD 3.74332
279 3H8V ATP 3.76712
280 1G55 SAH 3.79009
281 1LLU NAD 3.80117
282 1D4O NAP 3.80435
283 5W7M SAH 3.84615
284 4GLL NAD 3.85757
285 5JCA FAD 3.87324
286 2PWY SAH 3.87597
287 2BZG SAH 3.87931
288 5UWA 8ND 3.94089
289 3EWP APR 3.9548
290 2VDV SAM 4.01069
291 1GY8 NAD 4.01069
292 6F97 FAD 4.01069
293 2JB2 PHE 4.01069
294 2JB2 FAD 4.01069
295 2Q7V FAD 4.01069
296 2YG3 FAD 4.01069
297 6F3M NAD 4.01069
298 4USQ FAD 4.01069
299 1GTE FAD 4.01069
300 1LVL FAD 4.01069
301 1U1I NAD 4.01069
302 5BUK FAD 4.01069
303 2ZIF SAM 4.0404
304 6B92 SAH 4.08163
305 5WDR GNP 4.09357
306 2GUD MAN 4.09836
307 2NUO BGC 4.09836
308 2GUC MAN 4.09836
309 2GUD BMA 4.09836
310 2NU5 NAG 4.09836
311 2HYR BGC GLC 4.09836
312 2HYQ MAN MAN 4.09836
313 1KPG SAH 4.18118
314 1KPH SAH 4.18118
315 1E3W NAD 4.21456
316 1E6W NAD 4.23077
317 4CS9 AMP 4.2328
318 1Q0S SAH 4.2471
319 5DLY 5D7 4.27807
320 5DLY SAH 4.27807
321 3DMH GMP 4.27807
322 1BZL GCG 4.27807
323 1BZL FAD 4.27807
324 5BVA FAD 4.27807
325 4YNU LGC 4.27807
326 4YNU FAD 4.27807
327 2NVK FAD 4.27807
328 4C3Y FAD 4.27807
329 4C3Y ANB 4.27807
330 3DMH SAM 4.27807
331 3LAD FAD 4.27807
332 2C5A NAD 4.27807
333 2C5A GDC 4.27807
334 4MOP 2H5 4.27807
335 1I9G SAM 4.28571
336 1COY AND 4.33925
337 1COY FAD 4.33925
338 1NW5 SAM 4.38871
339 1GZ6 NAI 4.38871
340 3A4V PYR 4.4164
341 3O7W SAM 4.42177
342 1I1N SAH 4.42478
343 2CDU FAD 4.42478
344 4QTU SAM 4.44444
345 3ML1 MGD 4.44444
346 3O03 NAP 4.46735
347 1V5F FAD 4.54545
348 1V5F TPP 4.54545
349 1YBH FAD 4.54545
350 3E1T FAD 4.54545
351 1G0N PHH 4.54545
352 1G0N NDP 4.54545
353 3A4T SFG 4.54545
354 1NAA ABL 4.54545
355 1NAA 6FA 4.54545
356 1E3I CXF 4.54545
357 1JPA ANP 4.54545
358 6BWL NAD 4.57317
359 2Y7P SAL 4.58716
360 1GR0 NAD 4.63215
361 4EMI FAD 4.63415
362 4EMJ FAD 4.63415
363 2GN4 NDP 4.65116
364 2GN4 UD1 4.65116
365 3OID NDP 4.65116
366 1XCL SAH 4.68085
367 1DUG GSH 4.70085
368 6GFK SAH 4.78088
369 5M58 SAH 4.78261
370 4ZRN UPG 4.80769
371 4ZRN NAD 4.80769
372 1UWK NAD 4.81283
373 1UWK URO 4.81283
374 4DMG SAM 4.81283
375 1EU1 MGD 4.81283
376 1E1M FAD 4.81283
377 1E1M NAP 4.81283
378 2HMT NAI 4.86111
379 5Z2L NDP 4.89796
380 1U7T TDT 4.98084
381 5OJI NAP 5
382 5OJI ISN 5
383 2XVM SAH 5.02513
384 5DNK SAH 5.08021
385 3PT9 SAH 5.08021
386 4KGD FAD 5.08021
387 4KGD TDP 5.08021
388 5BRT FAD 5.08021
389 5BRT CH9 5.08021
390 1YY5 FAD 5.08021
391 3RNM FAD 5.08021
392 1RSG FAD 5.08021
393 6DEN TP9 5.08021
394 6DEN FAD 5.08021
395 6DEN G8A 5.08021
396 3OFK SAH 5.09259
397 2IVF MGD 5.11364
398 2PXX SAH 5.11628
399 2ZFU SAH 5.11628
400 2VT3 ATP 5.11628
401 2PZM UDP 5.15152
402 2PZM NAD 5.15152
403 1ZBQ NAD 5.19878
404 6B3A SAM 5.21472
405 5YJI SAH 5.28169
406 5YJI 8WO 5.28169
407 4NTO 1PW 5.31401
408 3PFG TLO 5.32319
409 3PFG SAM 5.32319
410 1PR9 NAP 5.32787
411 3D3W NAP 5.32787
412 3ELW SAM 5.33333
413 3ELW GP3 5.33333
414 6D6Y SAH 5.34759
415 1KNR FAD 5.34759
416 2ZWA SAH 5.34759
417 5ZYN FAD 5.34759
418 4YMH SAH 5.34759
419 2IHK CSF 5.34759
420 1H0H MGD 5.34759
421 2AE2 NAP 5.38462
422 2AE2 PTO 5.38462
423 5W7K SAH 5.44872
424 3DXY SAM 5.50459
425 1P1C SAH 5.52764
426 1XXR MAN 5.59006
427 5T67 SAH 5.61497
428 5T67 JHZ 5.61497
429 3AD8 PYC 5.61497
430 3AD8 FAD 5.61497
431 2IID FAD 5.61497
432 2IID PHE 5.61497
433 1REO FAD 5.61497
434 5THY SAH 5.61497
435 1KEW NAD 5.61497
436 5THZ SAH 5.61497
437 5KMS FAD 5.61497
438 3AD8 NAD 5.61497
439 4USR FAD 5.61497
440 5DM1 5D7 5.61798
441 5DM1 SAH 5.61798
442 3R51 MMA 5.625
443 3A25 SAM 5.64784
444 6FDF SAH 5.68862
445 4L2I FAD 5.70342
446 2A14 SAH 5.70342
447 1R37 NAD 5.76369
448 3TKA SAM 5.76369
449 1NFQ NAI 5.76923
450 3P2E SAH 5.77778
451 1WY7 SAH 5.7971
452 5FWA J7C 5.88235
453 4N49 SAM 5.88235
454 3C6K SPD 5.88235
455 3C6K MTA 5.88235
456 1VL8 NAP 5.88235
457 5TS5 FAD 5.88235
458 5Y77 FAD 5.88235
459 1FL2 FAD 5.88235
460 4JNA FAD 5.88235
461 5FUB SAH 5.93472
462 5JWC FAD 5.9501
463 1H5Q NAP 6.03774
464 1XSE NDP 6.1017
465 3VC3 C6P 6.10465
466 4J56 FAD 6.14035
467 1Q1R FAD 6.14973
468 1JQD HSM 6.16438
469 2AOT SAH 6.16438
470 1JQD SAH 6.16438
471 2QQF A1R 6.16883
472 2OD9 A1R NCA 6.16883
473 3A27 SAM 6.25
474 5L95 AMP 6.25
475 5UFN SAH 6.30252
476 4W6Z 8ID 6.34006
477 5MGZ SAH 6.35593
478 1SZD APR 6.39731
479 3SSO SAH 6.41711
480 4LWP SAH 6.41711
481 4XQC 13D 6.41711
482 4XQC NAD 6.41711
483 3MQ2 SAH 6.42202
484 2YVJ FAD 6.42202
485 3G89 SAM 6.4257
486 1M2K APR 6.4257
487 3WDM ADN 6.51341
488 4CQM NAP 6.51341
489 5E5U MLT 6.53266
490 2FK8 SAM 6.60377
491 3FUU ADN 6.64207
492 3QOX SAH 6.68449
493 4KRG SAH 6.68449
494 1ZQ9 SAM 6.68449
495 3NKS FAD 6.68449
496 1TUU AMP 6.68449
497 1Z3C SA8 6.71141
498 6GKV SAH 6.83761
499 1ZK7 FAD 6.95187
500 1SQF SAM 6.95187
501 3NTA FAD 6.95187
502 3NTD FAD 6.95187
503 3NT6 FAD 6.95187
504 1WG8 SAM 7.01754
505 2NXE SAM 7.08661
506 2WK1 SAH 7.0922
507 2Q46 NAP 7.11462
508 1LSS NAD 7.14286
509 4C4A SAH 7.21925
510 1Y8Q ATP 7.21925
511 4II2 ATP 7.21925
512 1D4D FAD 7.21925
513 2PX8 SAH 7.21925
514 2C7G FAD 7.21925
515 2C7G ODP 7.21925
516 1TMO 2MD 7.21925
517 5JE0 SAH 7.28745
518 5JE0 AZ8 7.28745
519 5LW0 AR6 7.35931
520 3H2B SAH 7.38916
521 3LU1 NAD 7.41758
522 5YF1 SFG 7.45856
523 5YF1 8V0 7.45856
524 5MW4 5JU 7.48503
525 3TLJ SAH 7.48663
526 4TQG NDP 7.48663
527 1PN0 FAD 7.48663
528 1F3L SAH 7.48663
529 1PN0 IPH 7.48663
530 5ERG SAM 7.48663
531 3VYW SAM 7.48663
532 1RKX NAD 7.56302
533 1N2X SAM 7.6412
534 1FEC FAD 7.75401
535 3B9Q MLI 7.75401
536 5N5D SAM 7.75401
537 1E6E FAD 7.8125
538 5F2K OCA 7.88043
539 5F2K SAH 7.88043
540 2WA2 SAM 8.02139
541 1QO8 FAD 8.02139
542 5O4J SAH 8.0292
543 5O4J 9KH 8.0292
544 3FPF TNA 8.05369
545 3FPF MTA 8.05369
546 5LAU AR6 8.17308
547 1NV8 MEQ 8.28877
548 1NV8 SAM 8.28877
549 3X0D SAH 8.28877
550 5KVA SAM 8.28877
551 5L13 6ZE 8.28877
552 2OBF SAH 8.3045
553 2OBF F83 8.3045
554 1L1E SAH 8.36237
555 5BSZ SAH 8.4
556 2DKH 3HB 8.55615
557 2DKH FAD 8.55615
558 3HVJ 705 8.59729
559 4NEC SAH 8.71212
560 5FA5 MTA 8.71935
561 3EGI ADP 8.73786
562 2DPM SAM 8.80282
563 1G60 SAM 8.84615
564 5UAO FAD 9.09091
565 4RIF 3R2 9.09091
566 4X60 SFG 9.14286
567 4X60 3XV 9.14286
568 4GQB 0XU 9.30233
569 2O07 SPD 9.35829
570 2O07 MTA 9.35829
571 1JQ3 AAT 9.35829
572 2PT9 2MH 9.35829
573 2PT9 S4M 9.35829
574 2I7C AAT 9.35829
575 3RKR NAP 9.54198
576 5JGL SAM 9.68858
577 1VE3 SAM 9.69163
578 1EFV FAD 9.80392
579 1EFV AMP 9.80392
580 6F5Z SAH 9.83607
581 3T7S SAM 9.89305
582 1DL5 SAH 9.89305
583 5N0J FAD 10.2564
584 5XLX SAH 10.2837
585 4YUW 4JU 10.4278
586 4YUW S4M 10.4278
587 2NPX NAD 10.4278
588 2NPX FAD 10.4278
589 3OU2 SAH 10.5505
590 4EUE NAI 10.6952
591 4D5G TPP 10.6952
592 4D5G FAD 10.6952
593 4URF NAD 10.8871
594 3QFA FAD 11.2069
595 3BXO SAM 11.2299
596 1RPN NDP 11.2299
597 6DUB SAH 11.2613
598 3G2O SAM 11.3712
599 5E9W SAH 11.4973
600 1XTP SAI 11.4973
601 1ZX5 LFR 11.6667
602 3GFB NAD 11.7143
603 1NM5 NAP 11.8227
604 1NM5 NAD 11.8227
605 5MPT SAH 12.2995
606 2F5Z FAD 12.5
607 6ARJ BW4 12.6074
608 6ARJ SAH 12.6074
609 5DX1 SFG 12.6074
610 5DX8 SFG 12.6074
611 5DXA SFG 12.6074
612 5DWQ SFG 12.6074
613 5DX0 SFG 12.6074
614 6CI9 NAP 12.7413
615 4OBW SAM 12.8342
616 3DUW SAH 12.8342
617 4IWN GEK 13.1004
618 5OOH NAP 13.1068
619 5OOH 9ZZ 13.1068
620 6FLZ MMA 13.1944
621 4XUC 43G 13.3028
622 4XUC SAM 13.3028
623 1EJ0 SAM 13.3333
624 5WP5 SAH 13.369
625 4R6W PC 13.6364
626 4R6W SAH 13.6364
627 1BC5 SAH 13.7546
628 5WP4 SAH 13.9037
629 5LOG SAH 14.1631
630 4CNK FAD 14.4385
631 1PNO NAP 14.4444
632 2OOR TXP 14.9425
633 2O5L MNR 15.0327
634 4FZV SAM 15.0628
635 1L3I SAH 15.1042
636 3IHG FAD 15.2406
637 5W7R SAH 15.508
638 5W7R 9Z7 15.508
639 1IM8 SAI 15.5738
640 5U19 SAH 15.7754
641 5U19 827 15.7754
642 5E8J SAH 15.9091
643 4KIB SAH 16.2465
644 6ECU SAH 16.4557
645 3GDH SAH 16.5975
646 6ECW SAH 16.8254
647 1DJL NAP 16.9082
648 4PNE SAH 17.2185
649 6ECT SAM 17.4455
650 4M73 SAH 17.8042
651 4M73 M72 17.8042
652 4Y30 SAH 17.9487
653 4Y30 49L 17.9487
654 3Q87 SAM 18.4
655 4ONQ SFG 18.7675
656 2HNK SAH 18.8285
657 4KRI SAH 19.2513
658 5GM1 SAH 19.2513
659 3P9C SAH 19.7802
660 5YJF SAH 20.7746
661 5YJF 8WO 20.7746
662 5ICE 2H4 21.3068
663 5ICE SAH 21.3068
664 5E1M PRO PRO LYS ARG ILE ALA 21.5768
665 5E1M SAH 21.5768
666 1R18 SAH 22.0264
667 3TKY SAH 25.8152
668 1KYZ SAH 26.3014
669 1KYZ FER 26.3014
670 1JG3 ADN 27.234
671 4A6D SAM 28.3286
672 5FA8 SAM 30.4348
673 1FP2 SAH 30.6818
674 1FP2 HMO 30.6818
675 4E70 N7I 33.4225
676 3GWZ SAH 36.3144
677 3GXO SAH 36.3144
678 1FP1 SAH 36.3636
679 1ZGA SAH 40.3361
680 3LST SAH 43.1034
681 6C5B SAH 44.2815
Pocket No.: 3; Query (leader) PDB : 1XDS; Ligand: DRA; Similar sites found with APoc: 7
This union binding pocket(no: 3) in the query (biounit: 1xds.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 2ZCQ B65 0.682594
2 5EOB 5QQ 1.88088
3 3CV2 OXL 3.47594
4 1MAI I3P 4.58015
5 5ODQ 9SB 17.1429
6 5ICE 2H4 21.3068
7 4E70 N7I 33.4225
Pocket No.: 4; Query (leader) PDB : 1XDS; Ligand: SAM; Similar sites found with APoc: 28
This union binding pocket(no: 4) in the query (biounit: 1xds.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 1PVN MZP 2.13904
2 2XT3 ADP 2.32558
3 1JJV ATP 2.91262
4 1Q19 SSC 2.94118
5 5GUD 2IT 2.94118
6 5GUD NDP 2.94118
7 2YQS UD1 3.47594
8 1FK8 NAD 3.50195
9 3KIF GDL 3.77358
10 1HSK FAD 4.29448
11 3A4V NAD 4.4164
12 5K7U SAM 4.44444
13 4NBT NAD 4.58333
14 1EK6 UPG 4.5977
15 1EK6 NAI 4.5977
16 5IL1 SAM 4.71698
17 3NUG NAD 4.8583
18 3TW1 AHN 5.48523
19 5YRF GLC GLC 6.33803
20 2XYQ SAH 6.55738
21 2QE4 JJ3 6.85484
22 1JV1 UD1 7.21925
23 3M94 M7M 7.40741
24 5TCI MLI 7.6087
25 2OG2 MLI 7.75401
26 5K4W THR 9.96885
27 5K4W NAI 9.96885
28 4X7Y SAH 12.7737
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