Receptor
PDB id Resolution Class Description Source Keywords
1Y60 1.9 Å EC: 4.-.-.- STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEH ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AMB OUND 5,10-METHYLENE TETRAHYDROMETHANOPTERIN METHYLOBACTERIUM EXTORQUENS PENTAMER; BETA-ALPHA-BETA LEFT HANDED CROSSOVER; TETRAHYDROMETHANOPTERIN-BINDING LYASE
Ref.: HOW AN ENZYME BINDS THE C1-CARRIER TETRAHYDROMETHAN STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBA EXTORQUENS AM1 J.BIOL.CHEM. V. 280 13712 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
H4M B:997;
B:998;
C:995;
D:994;
E:996;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
submit data
788.693 C31 H45 N6 O16 P C[C@H...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Y60 1.9 Å EC: 4.-.-.- STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEH ACTIVATING ENZYME (FAE) FROM METHYLOBACTERIUM EXTORQUENS AMB OUND 5,10-METHYLENE TETRAHYDROMETHANOPTERIN METHYLOBACTERIUM EXTORQUENS PENTAMER; BETA-ALPHA-BETA LEFT HANDED CROSSOVER; TETRAHYDROMETHANOPTERIN-BINDING LYASE
Ref.: HOW AN ENZYME BINDS THE C1-CARRIER TETRAHYDROMETHAN STRUCTURE OF THE TETRAHYDROMETHANOPTERIN DEPENDENT FORMALDEHYDE-ACTIVATING ENZYME (FAE) FROM METHYLOBA EXTORQUENS AM1 J.BIOL.CHEM. V. 280 13712 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 38 families.
1 1Y60 - H4M C31 H45 N6 O16 P C[C@H]1[C@....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 35 families.
1 1Y60 - H4M C31 H45 N6 O16 P C[C@H]1[C@....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 27 families.
1 1Y60 - H4M C31 H45 N6 O16 P C[C@H]1[C@....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: H4M; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 H4M 1 1
2 E4M 0.653595 0.94382
3 H4Z 0.645161 0.931818
4 N4M 0.559006 0.897727
5 F4M 0.554878 0.931818
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1Y60; Ligand: H4M; Similar sites found: 10
This union binding pocket(no: 1) in the query (biounit: 1y60.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4IYO NAK 0.01136 0.4119 1.77515
2 1JS8 MAN MAN BMA 0.01654 0.41881 3.5503
3 1MFD GLA MMA ABE 0.01264 0.40593 3.5503
4 4Y8D 49J 0.0313 0.40184 3.57143
5 4N7C AEF 0.01257 0.41947 4.14201
6 4LZB URA 0.03012 0.40356 5.32544
7 4ETZ C2E 0.02214 0.40553 5.91716
8 1PEA ACM 0.02043 0.4161 7.10059
9 1MFA GLA MMA ABE 0.002119 0.46659 9.16667
10 4AU8 Z3R 0.01381 0.41176 11.8343
Pocket No.: 2; Query (leader) PDB : 1Y60; Ligand: H4M; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1y60.bio1) has 24 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 1Y60; Ligand: H4M; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1y60.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1Y60; Ligand: H4M; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1y60.bio1) has 25 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1Y60; Ligand: H4M; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1y60.bio1) has 23 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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