Receptor
PDB id Resolution Class Description Source Keywords
1YWO 1.81 Å EC: 3.1.4.11 PHOSPHOLIPASE CGAMMA1 SH3 IN COMPLEX WITH A SLP-76 MOTIF RATTUS NORVEGICUS SH3 PHOSPHOLIPASE C-GAMMA1 SLP-76 SH2 DOMAIN-CONTAINING LPHOSPHOPROTEIN OF 76 KD HYDROLASE SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF THE T CELL ADAP PROTEIN SLP-76 BY THE SH3 DOMAIN OF PHOSPHOLIPASE C J.MOL.BIOL. V. 352 1 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLN PRO PRO VAL PRO PRO GLN ARG PRO MET P:1;
Valid;
none;
Kd = 12.5 uM
1147.39 n/a S(CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YWO 1.81 Å EC: 3.1.4.11 PHOSPHOLIPASE CGAMMA1 SH3 IN COMPLEX WITH A SLP-76 MOTIF RATTUS NORVEGICUS SH3 PHOSPHOLIPASE C-GAMMA1 SLP-76 SH2 DOMAIN-CONTAINING LPHOSPHOPROTEIN OF 76 KD HYDROLASE SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF THE T CELL ADAP PROTEIN SLP-76 BY THE SH3 DOMAIN OF PHOSPHOLIPASE C J.MOL.BIOL. V. 352 1 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
50% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 4LNP Kd = 214 uM VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU n/a n/a
8 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
9 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
10 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
11 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
12 3THK - PRO PRO PRO VAL PRO PRO TYR SER ALA GLY n/a n/a
13 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
14 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
15 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
16 4HXJ Kd = 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLN PRO PRO VAL PRO PRO GLN ARG PRO MET; Similar ligands found: 77
No: Ligand ECFP6 Tc MDL keys Tc
1 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 1 1
2 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.723077 1
3 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.542683 0.878378
4 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.542253 0.940298
5 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.537879 0.876923
6 ARG PRO PRO LYS PRO ARG PRO ARG 0.526316 0.815385
7 PHE ASN ARG PRO VAL 0.50365 0.814286
8 VAL PRO LEU ARG PRO MET THR TYR 0.503226 0.864865
9 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.49375 0.810811
10 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.493243 0.939394
11 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.485075 0.863636
12 ACE GLN GLU ARG GLU VAL PRO CYS 0.479167 0.893939
13 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.464789 0.863636
14 THR LYS PRO ARG 0.463415 0.815385
15 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.462428 0.851351
16 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.459854 0.818182
17 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.458904 0.939394
18 LEU PRO PHE GLU ARG ALA THR VAL MET 0.458333 0.875
19 ALA MET ALA PRO ARG THR LEU LEU LEU 0.456376 0.873239
20 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.455782 0.71831
21 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.452055 0.785714
22 SER ARG ASP HIS SER ARG THR PRO MET 0.445783 0.864865
23 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.44375 0.969231
24 ARG PRO LYS ARG ILE ALA 0.440559 0.878788
25 ASN ARG PRO ILE LEU SER LEU 0.439189 0.819444
26 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.43787 0.844156
27 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.436709 0.869565
28 GLN MET PRO THR GLU ASP GLU TYR 0.436709 0.77027
29 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.43662 0.788732
30 MET TRP ARG PRO TRP 0.435897 0.830986
31 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.435065 0.910448
32 LEU PRO PHE GLU ARG ALA THR ILE MET 0.433526 0.863014
33 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.433121 0.819444
34 DPN PRO ARG 0.430769 0.776119
35 VAL MET ALA PRO ARG THR LEU PHE LEU 0.430303 0.849315
36 LYS PRO VAL LEU ARG THR ALA 0.42953 0.828571
37 LEU PRO PHE ASP ARG THR THR ILE MET 0.428571 0.876712
38 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.428571 0.780822
39 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.426966 0.831169
40 SER SER TYR ARG ARG PRO VAL GLY ILE 0.426829 0.789474
41 ARG PRO LYS PRO LEU VAL ASP PRO 0.425532 0.892308
42 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.423313 0.802817
43 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.422535 0.892308
44 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.421687 0.794521
45 ARG PRO PRO GLY PHE THR PRO PHE ARG 0.421488 0.815385
46 CYS THR PRO SER ARG 0.421429 0.788732
47 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.42069 0.768116
48 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.420455 0.835616
49 DPN PRO DAR CYS NH2 0.42029 0.776119
50 GLU ARG THR ILE PRO ILE THR ARG GLU 0.42 0.830986
51 SER HIS PRO ARG PRO ILE ARG VAL 0.41875 0.810811
52 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.418301 0.830986
53 SER MET PRO GLU LEU SER PRO VAL LEU 0.418301 0.828571
54 SER PRO LYS ARG ILE ALA 0.417808 0.814286
55 SER ALA PRO ASP THR ARG PRO ALA 0.417219 0.819444
56 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.416667 0.884058
57 LYS THR PHE PRO PRO THR GLU PRO LYS 0.416149 0.708333
58 GLU VAL ALA PRO PRO GLU TYR HIS ARG LYS 0.415301 0.8
59 PTR VAL PRO MET LEU 0.413333 0.736842
60 MET GLN SER TPO PRO LEU 0.411765 0.74026
61 DPN PRO DAR DTH NH2 0.411348 0.746479
62 DPN PRO DAR ILE NH2 0.411348 0.794118
63 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.411043 0.84507
64 ARG PRO MET THR TYR LYS GLY ALA LEU 0.409091 0.853333
65 GLN ALA SER TPO PRO ARG NIT 0.408284 0.666667
66 ARG ARG ARG GLU ARG SER PRO THR ARG 0.407895 0.802817
67 THR PRO GLN ASP LEU ASN THR MET LEU 0.407643 0.802817
68 ILE MET ASP GLN VAL PRO PHE SER VAL 0.407186 0.780822
69 ARG PRO MET THR PHE LYS GLY ALA LEU 0.405714 0.863014
70 GLU PRO GLY GLY SER ARG 0.405594 0.785714
71 ALA PRO ASP THR ARG PRO ALA PRO 0.405405 0.830986
72 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.405229 0.805556
73 ALA PRO ASP THR ARG PRO 0.40411 0.830986
74 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.403974 0.820895
75 LEU PRO PRO GLU GLU ARG LEU ILE 0.403974 0.909091
76 TYR PRO LYS ARG ILE ALA 0.401274 0.805556
77 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.4 0.786667
Similar Binding Sites (Proteins are less than 50% similar to leader)
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