Receptor
PDB id Resolution Class Description Source Keywords
1YWO 1.81 Å EC: 3.1.4.11 PHOSPHOLIPASE CGAMMA1 SH3 IN COMPLEX WITH A SLP-76 MOTIF RATTUS NORVEGICUS SH3 PHOSPHOLIPASE C-GAMMA1 SLP-76 SH2 DOMAIN-CONTAINING LPHOSPHOPROTEIN OF 76 KD HYDROLASE SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF THE T CELL ADAP PROTEIN SLP-76 BY THE SH3 DOMAIN OF PHOSPHOLIPASE C J.MOL.BIOL. V. 352 1 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLN PRO PRO VAL PRO PRO GLN ARG PRO MET P:1;
 Valid;
 none;
 Kd = 12.5 uM
1147.39 n/a S(CCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YWO 1.81 Å EC: 3.1.4.11 PHOSPHOLIPASE CGAMMA1 SH3 IN COMPLEX WITH A SLP-76 MOTIF RATTUS NORVEGICUS SH3 PHOSPHOLIPASE C-GAMMA1 SLP-76 SH2 DOMAIN-CONTAINING LPHOSPHOPROTEIN OF 76 KD HYDROLASE SIGNALING PROTEIN
Ref.: STRUCTURAL BASIS FOR RECOGNITION OF THE T CELL ADAP PROTEIN SLP-76 BY THE SH3 DOMAIN OF PHOSPHOLIPASE C J.MOL.BIOL. V. 352 1 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 40 families.
1 6A9C - LYS VAL ALA PRO PRO ILE PRO HIS ARG n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
9 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
10 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
11 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
12 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
13 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
14 4HXJ Kd ~ 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLN PRO PRO VAL PRO PRO GLN ARG PRO MET; Similar ligands found: 92
No: Ligand ECFP6 Tc MDL keys Tc
1 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 1 1
2 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.730769 1
3 GLN VAL PRO LEU ARG PRO MET THR TYR LYS 0.538922 0.878378
4 ASN PRO ARG ALA MET GLN ALA LEU LEU 0.534722 0.926471
5 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.533835 0.876923
6 ACE GLN GLU ARG GLU VAL PRO CYS 0.514493 0.893939
7 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.511278 0.863636
8 PRO ARG ARG PRO VAL ILE MET ARG ARG 0.510204 0.939394
9 VAL PRO LEU ARG PRO MET THR TYR 0.509677 0.864865
10 MET CYS PRO ARG MET THR ALA VAL MET 0.506579 0.9
11 PHE ASN ARG PRO VAL 0.5 0.814286
12 ARG PRO PRO LYS PRO ARG PRO ARG 0.5 0.815385
13 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.496732 0.882353
14 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.492308 0.863636
15 THR PRO ARG VAL THR GLY GLY GLY ALA MET 0.48366 0.901408
16 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.475309 0.810811
17 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.474453 0.818182
18 ALA MET ALA PRO ARG THR LEU LEU LEU 0.472973 0.873239
19 VAL MET ALA PRO ARG ALA LEU LEU LEU 0.472603 0.939394
20 ACE SER LEU ARG PRO ALA PRO LPD 0.468531 0.830986
21 GLY MET PRO ARG GLY ALA 0.467626 0.909091
22 LEU PRO PHE GLU ARG ALA THR VAL MET 0.464286 0.875
23 ALA ILE MET PRO ALA ARG PHE TYR PRO LYS 0.462857 0.851351
24 ASN ARG PRO ILE LEU SER LEU 0.458904 0.819444
25 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.458904 0.746479
26 SER PRO LYS ARG ILE ALA 0.457143 0.8
27 SER ARG ASP HIS SER ARG THR PRO MET 0.45509 0.864865
28 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.453237 0.802817
29 SER ALA GLU PRO VAL PRO LEU GLN LEU 0.44898 0.785714
30 ARG PRO LYS ARG ILE ALA 0.448276 0.878788
31 5JP PRO LYS ARG ILE ALA 0.444444 0.828571
32 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.444444 0.910448
33 ARG GLN ALA SEP ILE GLU LEU PRO SER MET 0.443182 0.831169
34 LEU PRO PHE ASP ARG THR THR ILE MET 0.443114 0.876712
35 DPN PRO ARG 0.442748 0.776119
36 LEU PRO PHE GLU ARG ALA THR ILE MET 0.44186 0.863014
37 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.440252 0.869565
38 ARG ILE ILE PRO ARG HIS LEU GLN LEU 0.439024 0.884058
39 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.43871 0.924242
40 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.438596 0.844156
41 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.4375 0.768116
42 LYS PRO VAL LEU ARG THR ALA 0.437086 0.828571
43 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.434783 0.969231
44 SER HIS PRO ARG PRO ILE ARG VAL 0.433962 0.810811
45 VAL MET ALA PRO ARG THR LEU PHE LEU 0.433735 0.849315
46 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.432099 0.780822
47 SER ALA PRO ASP THR ARG PRO ALA 0.430464 0.819444
48 THR LYS PRO ARG 0.429688 0.815385
49 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.429577 0.892308
50 SER SER TYR ARG ARG PRO VAL GLY ILE 0.429448 0.789474
51 LEU PRO PRO GLU GLU ARG LEU ILE 0.426667 0.909091
52 MET TRP ARG PRO TRP 0.425 0.830986
53 ACE GLU VAL ASN PRO PRO VAL LPD 0.423611 0.768116
54 ASN ARG PRO VAL TYR ILE PRO ARG PRO PRO 0.42236 0.819444
55 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.422222 0.835616
56 ARG PRO LYS PRO LEU VAL ASP PRO 0.41958 0.892308
57 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.419355 0.830986
58 ALA LEU MET PRO GLY GLN PHE PHE VAL 0.41875 0.811594
59 GLN ALA SER TPO PRO ARG NIT 0.416667 0.666667
60 GLN MET PRO THR GLU ASP GLU TYR 0.416149 0.77027
61 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.416107 0.808824
62 THR PRO GLN ASP LEU ASN THR MET LEU 0.415584 0.802817
63 DPN PRO DAR ILE NH2 0.415493 0.794118
64 DPN PRO DAR DTH NH2 0.415493 0.736111
65 1IP CYS PHE SER LYS PRO ARG 0.414634 0.783784
66 DPN PRO DAR CYS NH2 0.414286 0.764706
67 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.414201 0.794521
68 ALA ASN SER ARG ALY PRO THR SER ILE ILE 0.413174 0.810811
69 GLU PRO GLY GLY SER ARG 0.412587 0.785714
70 ARG PRO MET THR PHE LYS GLY ALA LEU 0.410112 0.863014
71 ARG PRO MET THR TYR LYS GLY ALA LEU 0.407821 0.853333
72 ILE MET ASP GLN VAL PRO PHE SER VAL 0.407186 0.780822
73 PTR VAL PRO MET LEU 0.406667 0.75
74 ASN LEU VAL PRO MET VAL ALA ALA VAL 0.406667 0.808824
75 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.406061 0.786667
76 ALA PRO ASP THR ARG PRO ALA PRO 0.405405 0.830986
77 SER MET PRO GLU LEU SER PRO VAL LEU 0.405405 0.842857
78 PRO PRO LYS ARG ILE ALA 0.405229 0.878788
79 ASN LEU VAL PRO GLN VAL ALA THR VAL 0.405229 0.732394
80 TYR PRO LYS ARG ILE ALA 0.405063 0.805556
81 LYS ALA PRO ARG ALY GLN LEU ALA THR LYS 0.403614 0.84507
82 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.402685 0.722222
83 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.402597 0.805556
84 SER PRO ILE VAL PRO SER PHE ASP MET 0.402439 0.808219
85 ALA PHE ARG ILE PRO LEU THR ARG 0.402439 0.808219
86 ACE GLU VAL ALA PRO PRO VAL LPD 0.401408 0.80303
87 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.401361 0.848485
88 LYS THR PHE PRO PRO THR GLU PRO LYS 0.401235 0.736111
89 ASN LEU VAL PRO MET VAL ALA THR VAL 0.4 0.788732
90 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.4 0.808219
91 LEU ASP PRO ARG 0.4 0.878788
92 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.4 0.84058
Similar Ligands (3D)
Ligand no: 1; Ligand: GLN PRO PRO VAL PRO PRO GLN ARG PRO MET; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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