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Receptor
PDB id Resolution Class Description Source Keywords
1Z2P 1.22 Å EC: 2.-.-.- INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE IN COMPLEX WITH MG2+ PCP/INS(1,3,4)P3 ENTAMOEBA HISTOLYTICA INOSITOL PHOSPHATE KINASE ATP-GRASP TRANSFERASE
Ref.: SPECIFICITY DETERMINANTS IN INOSITOL POLYPHOSPHATE SYNTHESIS: CRYSTAL STRUCTURE OF INOSITOL 1,3,4-TRIS 5/6-KINASE. MOL.CELL V. 18 201 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACP X:1476;
Valid;
none;
submit data
505.208 C11 H18 N5 O12 P3 c1nc(...
I3S X:500;
Valid;
none;
submit data
420.096 C6 H15 O15 P3 [C@H]...
MG X:1295;
X:1296;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1Z2P 1.22 Å EC: 2.-.-.- INOSITOL 1,3,4-TRISPHOSPHATE 5/6-KINASE IN COMPLEX WITH MG2+ PCP/INS(1,3,4)P3 ENTAMOEBA HISTOLYTICA INOSITOL PHOSPHATE KINASE ATP-GRASP TRANSFERASE
Ref.: SPECIFICITY DETERMINANTS IN INOSITOL POLYPHOSPHATE SYNTHESIS: CRYSTAL STRUCTURE OF INOSITOL 1,3,4-TRIS 5/6-KINASE. MOL.CELL V. 18 201 2005
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 1Z2P - I3S C6 H15 O15 P3 [C@H]1([C@....
2 1Z2O - I4P C6 H16 O18 P4 C1([C@H]([....
3 1Z2N - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 1Z2P - I3S C6 H15 O15 P3 [C@H]1([C@....
2 1Z2O - I4P C6 H16 O18 P4 C1([C@H]([....
3 1Z2N - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 1Z2P - I3S C6 H15 O15 P3 [C@H]1([C@....
2 1Z2O - I4P C6 H16 O18 P4 C1([C@H]([....
3 1Z2N - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ACP; Similar ligands found: 368
No: Ligand ECFP6 Tc MDL keys Tc
1 ACP 1 1
2 ACQ 0.866667 1
3 A2D 0.857143 0.945205
4 6YZ 0.833333 1
5 BA3 0.833333 0.945205
6 AP5 0.821918 0.945205
7 B4P 0.821918 0.945205
8 ADP 0.821918 0.972222
9 AT4 0.810811 0.933333
10 AN2 0.810811 0.958904
11 AP2 0.808219 0.986301
12 A12 0.808219 0.986301
13 M33 0.8 0.932432
14 HEJ 0.789474 0.972222
15 ATP 0.789474 0.972222
16 5FA 0.779221 0.972222
17 AR6 0.779221 0.945205
18 AQP 0.779221 0.972222
19 APR 0.779221 0.945205
20 AGS 0.769231 0.921053
21 SAP 0.769231 0.921053
22 AD9 0.769231 0.945946
23 AMP 0.763889 0.944444
24 A 0.763889 0.944444
25 APC 0.75641 0.986301
26 CA0 0.753247 0.92
27 ADX 0.753247 0.851852
28 ANP 0.75 0.945946
29 50T 0.74359 0.932432
30 PRX 0.734177 0.87013
31 ABM 0.733333 0.893333
32 ATF 0.731707 0.933333
33 SRA 0.706667 0.894737
34 A22 0.705882 0.958904
35 RBY 0.703704 0.959459
36 ADV 0.703704 0.959459
37 5AL 0.698795 0.906667
38 A3R 0.689655 0.909091
39 A1R 0.689655 0.909091
40 ADQ 0.689655 0.92
41 AU1 0.6875 0.945946
42 TAT 0.686747 0.933333
43 T99 0.686747 0.933333
44 SRP 0.682353 0.907895
45 9X8 0.674157 0.896104
46 OAD 0.674157 0.92
47 4TC 0.673469 0.922078
48 4AD 0.670455 0.921053
49 AMO 0.670455 0.933333
50 00A 0.662921 0.860759
51 ADP PO3 0.662651 0.917808
52 3OD 0.659341 0.92
53 BIS 0.659341 0.909091
54 25A 0.659091 0.945205
55 OOB 0.659091 0.906667
56 8QN 0.659091 0.906667
57 5SV 0.659091 0.82716
58 SON 0.654321 0.933333
59 25L 0.652174 0.958904
60 PAJ 0.651685 0.8625
61 DLL 0.644444 0.906667
62 AHX 0.644444 0.897436
63 TXA 0.641304 0.907895
64 3UK 0.637363 0.894737
65 ALF ADP 0.632184 0.848101
66 ADP ALF 0.632184 0.848101
67 PR8 0.630435 0.851852
68 WAQ 0.630435 0.884615
69 B5V 0.630435 0.883117
70 LAD 0.630435 0.8625
71 MAP 0.629214 0.921053
72 LMS 0.628205 0.807229
73 GAP 0.627907 0.87013
74 VO4 ADP 0.625 0.906667
75 ADP VO4 0.625 0.906667
76 PTJ 0.623656 0.873418
77 FYA 0.623656 0.906667
78 ME8 0.623656 0.841463
79 1ZZ 0.623656 0.819277
80 NB8 0.623656 0.897436
81 UP5 0.62 0.896104
82 G3A 0.618557 0.897436
83 G5P 0.612245 0.897436
84 AFH 0.612245 0.886076
85 9SN 0.610526 0.85
86 DQV 0.606061 0.932432
87 GTA 0.606061 0.864198
88 9ZD 0.604396 0.884615
89 9ZA 0.604396 0.884615
90 YAP 0.604167 0.896104
91 FA5 0.604167 0.907895
92 B5Y 0.604167 0.871795
93 B5M 0.604167 0.871795
94 TXD 0.60396 0.884615
95 XAH 0.597938 0.841463
96 ADN 0.597222 0.821918
97 RAB 0.597222 0.821918
98 XYA 0.597222 0.821918
99 GA7 0.59596 0.907895
100 48N 0.594059 0.897436
101 DAL AMP 0.593407 0.881579
102 2A5 0.593023 0.92
103 AOC 0.592593 0.8
104 4UV 0.591837 0.871795
105 NXX 0.588235 0.907895
106 6V0 0.588235 0.873418
107 NAX 0.588235 0.875
108 DND 0.588235 0.907895
109 NAI 0.588235 0.884615
110 ATR 0.586207 0.944444
111 PAP 0.586207 0.958333
112 ADP BMA 0.585106 0.894737
113 LAQ 0.584158 0.819277
114 5AS 0.583333 0.761364
115 OMR 0.582524 0.831325
116 TXE 0.582524 0.884615
117 5N5 0.581081 0.797297
118 4UU 0.58 0.871795
119 A A 0.578947 0.918919
120 7D3 0.578313 0.881579
121 AP0 0.576923 0.873418
122 A4D 0.573333 0.797297
123 5CD 0.573333 0.783784
124 JB6 0.572917 0.884615
125 4UW 0.572816 0.839506
126 A4P 0.571429 0.823529
127 CNA 0.570093 0.907895
128 ITT 0.569767 0.917808
129 7D4 0.569767 0.881579
130 A2R 0.565217 0.958904
131 M2T 0.564103 0.716049
132 YLP 0.563107 0.821429
133 139 0.560748 0.851852
134 ADJ 0.560748 0.831325
135 T5A 0.560748 0.843373
136 TAD 0.558824 0.910256
137 ATP A A A 0.555556 0.905405
138 A3P 0.552941 0.944444
139 TYM 0.552381 0.907895
140 IOT 0.551402 0.833333
141 EP4 0.551282 0.734177
142 MYR AMP 0.55102 0.797619
143 F2R 0.550459 0.865854
144 7D5 0.55 0.855263
145 A3D 0.54955 0.894737
146 80F 0.54955 0.843373
147 GCP 0.548387 0.922078
148 UPA 0.54717 0.884615
149 YLC 0.54717 0.841463
150 YLB 0.54717 0.821429
151 NAD 0.545455 0.906667
152 COD 0.545455 0.813953
153 G5A 0.544444 0.781609
154 HFD 0.544444 0.921053
155 DTA 0.544304 0.766234
156 3DH 0.54321 0.753247
157 DZD 0.540541 0.910256
158 AHZ 0.538462 0.797619
159 MTA 0.5375 0.753247
160 3AM 0.536585 0.90411
161 A2P 0.534884 0.930556
162 AR6 AR6 0.533981 0.893333
163 PPS 0.532609 0.851852
164 6AD 0.532609 0.886076
165 YLA 0.53211 0.821429
166 TYR AMP 0.529412 0.871795
167 AMP DBH 0.529412 0.87013
168 AYB 0.527273 0.811765
169 A5A 0.526882 0.788235
170 TSB 0.526316 0.8
171 6RE 0.52381 0.7625
172 S4M 0.523256 0.670455
173 SSA 0.521277 0.802326
174 NA7 0.520408 0.959459
175 7MD 0.519231 0.864198
176 ARG AMP 0.519231 0.831325
177 LPA AMP 0.518868 0.797619
178 BTX 0.517857 0.843373
179 NAE 0.517241 0.871795
180 54H 0.515789 0.770115
181 52H 0.515789 0.761364
182 VMS 0.515789 0.770115
183 BT5 0.513274 0.833333
184 NAQ 0.512821 0.85
185 ZAS 0.511905 0.746835
186 J7C 0.511628 0.772152
187 A3N 0.511628 0.766234
188 IMO 0.511628 0.90411
189 AV2 0.510638 0.893333
190 53H 0.510417 0.761364
191 8X1 0.510417 0.755556
192 5CA 0.510417 0.802326
193 ARU 0.510204 0.839506
194 AF3 ADP 3PG 0.509259 0.839506
195 M24 0.508621 0.829268
196 ZID 0.508475 0.894737
197 2AM 0.506024 0.917808
198 V3L 0.505376 0.945205
199 3AT 0.505376 0.972222
200 AVV 0.505155 0.897436
201 NSS 0.5 0.802326
202 EAD 0.5 0.851852
203 DSZ 0.5 0.802326
204 MAO 0.5 0.761905
205 LSS 0.5 0.764045
206 DSH 0.5 0.728395
207 P5A 0.5 0.747253
208 YLY 0.495726 0.811765
209 9K8 0.49505 0.698925
210 NVA LMS 0.494949 0.755556
211 DAT 0.494505 0.906667
212 5X8 0.494505 0.766234
213 AMP NAD 0.491228 0.881579
214 7MC 0.490909 0.843373
215 LEU LMS 0.49 0.755556
216 SMM 0.489583 0.689655
217 SAM 0.489362 0.694118
218 DTP 0.489362 0.906667
219 7DD 0.488889 0.958333
220 GJV 0.488636 0.753086
221 OVE 0.488372 0.881579
222 5AD 0.486842 0.726027
223 GSU 0.485149 0.781609
224 KAA 0.485149 0.755556
225 P1H 0.483871 0.831325
226 NDE 0.483871 0.907895
227 N0B 0.483333 0.821429
228 A3G 0.482759 0.802632
229 NAJ PZO 0.478632 0.82716
230 4TA 0.478261 0.809524
231 SFG 0.478261 0.753247
232 NDC 0.47619 0.85
233 YSA 0.47619 0.781609
234 FB0 0.47619 0.827586
235 7DT 0.473118 0.958333
236 A7D 0.472527 0.779221
237 NJP 0.469565 0.921053
238 FDA 0.46875 0.835294
239 SA8 0.468085 0.710843
240 A5D 0.468085 0.766234
241 MHZ 0.467391 0.701149
242 8PZ 0.466667 0.802326
243 71V 0.466667 0.884615
244 G A A A 0.465517 0.85
245 0WD 0.465517 0.897436
246 6FA 0.465116 0.843373
247 GGZ 0.464646 0.804878
248 SAI 0.463158 0.7375
249 SAH 0.463158 0.746835
250 6C6 0.463158 0.883117
251 NAJ PYZ 0.46281 0.788235
252 Y3J 0.4625 0.706667
253 7D7 0.461538 0.723684
254 TXP 0.46087 0.897436
255 PO4 PO4 A A A A PO4 0.460784 0.878378
256 S7M 0.459184 0.694118
257 6IA 0.458333 0.839506
258 DDS 0.458333 0.855263
259 FAS 0.458015 0.853659
260 FAD 0.458015 0.853659
261 SFD 0.458015 0.736842
262 ODP 0.456897 0.886076
263 A3S 0.456522 0.813333
264 U A 0.453782 0.884615
265 7C5 0.453704 0.797468
266 EEM 0.453608 0.694118
267 AAT 0.453608 0.710843
268 A G 0.452991 0.860759
269 RGT 0.45283 0.933333
270 NPW 0.452174 0.8875
271 NDP 0.452174 0.897436
272 FAY 0.451852 0.864198
273 PGS 0.451613 0.860759
274 D5M 0.449438 0.88
275 DA 0.449438 0.88
276 NEC 0.449438 0.727273
277 U A G G 0.449153 0.860759
278 2SA 0.44898 0.933333
279 NIA 0.448276 0.802469
280 NZQ 0.448276 0.910256
281 A U 0.447368 0.848101
282 A3T 0.446809 0.8
283 A A A 0.446602 0.906667
284 128 0.446429 0.758621
285 6K6 0.445545 0.905405
286 GEK 0.445545 0.740741
287 4YB 0.445455 0.764045
288 AAM 0.444444 0.944444
289 FNK 0.444444 0.806818
290 62F 0.444444 0.864198
291 Z5A 0.443548 0.761364
292 WSA 0.442478 0.790698
293 AMZ 0.44186 0.891892
294 C2R 0.44186 0.88
295 12D 0.441441 0.767442
296 XNP 0.440678 0.851852
297 RFL 0.437956 0.823529
298 62X 0.436893 0.670455
299 N6P 0.436893 0.890411
300 AIR 0.433735 0.876712
301 GP3 0.43299 0.897436
302 A6D 0.432692 0.705882
303 V1N 0.431193 0.893333
304 649 0.429825 0.747253
305 GP2 0.428571 0.910256
306 GDP 0.428571 0.896104
307 NA0 0.428571 0.907895
308 0UM 0.427184 0.702381
309 ETB 0.42623 0.835294
310 DCA 0.42623 0.825581
311 8Q2 0.426087 0.775281
312 9JJ 0.425532 0.841463
313 GNH 0.424242 0.884615
314 NAP 0.424 0.92
315 PUA 0.422764 0.8625
316 APU 0.422414 0.871795
317 101 0.422222 0.855263
318 3AD 0.421687 0.808219
319 FA9 0.42069 0.865854
320 TAP 0.420635 0.884615
321 TM1 0.420561 0.755814
322 P5F 0.41958 0.825581
323 0T1 0.419355 0.825581
324 COA 0.419355 0.825581
325 K15 0.419048 0.686047
326 7RP 0.417582 0.902778
327 S8M 0.417476 0.7625
328 NHD 0.416667 0.881579
329 GTP 0.415842 0.896104
330 FCX 0.414062 0.797753
331 F2N 0.413793 0.816092
332 AS 0.413043 0.835443
333 7RA 0.413043 0.931507
334 G1R 0.411765 0.884615
335 SXZ 0.411215 0.714286
336 ACK 0.411111 0.837838
337 QQY 0.411111 0.794872
338 CAO 0.409449 0.797753
339 COS 0.409449 0.806818
340 DG1 0.409449 0.897436
341 30N 0.409449 0.755319
342 AMX 0.409449 0.835294
343 1DG 0.409449 0.897436
344 J7V 0.409449 0.813953
345 EO7 0.408602 0.770115
346 8BR 0.408602 0.883117
347 NVA 2AD 0.408163 0.7625
348 D3Y 0.407767 0.792208
349 GSP 0.407767 0.851852
350 9GM 0.407767 0.873418
351 GNP 0.407767 0.873418
352 G2P 0.407767 0.910256
353 CC5 0.407407 0.819444
354 KB1 0.407407 0.702381
355 N01 0.406504 0.881579
356 A C A C 0.406504 0.82716
357 SCO 0.40625 0.825581
358 CMX 0.40625 0.825581
359 HDV 0.405941 0.87013
360 CMP 0.404255 0.876712
361 2BA 0.404255 0.890411
362 ACO 0.403101 0.797753
363 FAM 0.403101 0.806818
364 2VA 0.402062 0.779221
365 3NZ 0.401869 0.78481
366 HAX 0.4 0.806818
367 QQX 0.4 0.78481
368 26A 0.4 0.74359
Ligand no: 2; Ligand: I3S; Similar ligands found: 16
No: Ligand ECFP6 Tc MDL keys Tc
1 I3P 1 1
2 I3S 1 1
3 4IP 0.724138 0.966667
4 2IP 0.692308 1
5 I0P 0.678571 0.966667
6 ITP 0.655172 1
7 I4P 0.653846 0.933333
8 IP2 0.642857 1
9 5IP 0.6 0.933333
10 IP5 0.6 0.933333
11 I5P 0.6 0.933333
12 5MY 0.6 0.933333
13 I4D 0.566667 0.966667
14 IBS 0.511111 0.789474
15 IHP 0.481481 0.933333
16 I6P 0.481481 0.933333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1Z2P; Ligand: ACP; Similar sites found with APoc: 359
This union binding pocket(no: 1) in the query (biounit: 1z2p.bio1) has 37 residues
No: Leader PDB Ligand Sequence Similarity
1 5KK4 44E None
2 3KN5 ANP 1.23457
3 1GT4 UNA 1.25786
4 4D4U FUC GAL 1.26984
5 4D52 GIV 1.26984
6 4D52 GXL 1.26984
7 4I94 ANP 1.33333
8 1NWW HPN 1.34228
9 5LPB ADP 1.35135
10 1U59 STU 1.39373
11 5EXK 5AD 1.54321
12 4FL3 ANP 1.54321
13 3HQ9 OXL 1.54321
14 4OTH DRN 1.54321
15 6DAW ARG 1.54321
16 6BFN DL1 1.54321
17 4CC6 L5Y 1.57233
18 2F57 23D 1.57729
19 4X7Q 3YR 1.60256
20 3SHR CMP 1.67224
21 3RGA ILD 1.76678
22 5OES ADP 1.85185
23 5I35 ANP 1.85185
24 3TXO 07U 1.85185
25 4BTK DTQ 1.85185
26 5YF9 NIO 1.85185
27 4U44 3D9 1.85185
28 4IDT T28 1.85185
29 5DMZ ADP 1.85185
30 4U98 ACP 1.85185
31 4LH7 1X8 1.85759
32 1GSA ADP 1.89873
33 4FG8 ATP 1.90476
34 3ORK AGS 1.92926
35 4NFN 2KC 1.94175
36 4USF 6UI 1.97368
37 5CEO 50D 2
38 3M2W L8I 2.00669
39 2QK4 ATP 2.16049
40 4WTV ATP 2.16049
41 6AC9 ANP 2.16049
42 3TPV ADE 2.16049
43 4XH0 ADP 2.16049
44 3DNT ATP 2.16049
45 5DXT 5H5 2.16049
46 4UAL 3FV 2.16049
47 6FYV 3NG 2.16049
48 5VZ0 ADP 2.16049
49 3ALN ANP 2.16049
50 4H9T HL4 2.16049
51 1Y79 LYS TRP 2.16049
52 3TII ANP 2.16049
53 5X8I SQZ 2.16049
54 6G33 5ID 2.16049
55 1GXU 2HP 2.1978
56 5ISY NAD 2.3166
57 3V4S ADP 2.32558
58 3V4S ATP 2.32558
59 4KS7 X4Z 2.39726
60 5AIG VPR 2.4
61 4YZN 4K5 2.43902
62 5VLQ ANP 2.46914
63 3KAL ADP 2.46914
64 2QF7 AGS 2.46914
65 1OKE BOG 2.46914
66 5EQY 5RA 2.46914
67 6FYL 3NG 2.46914
68 5FI4 5XV 2.47678
69 4NST ADP 2.61194
70 1OBD ATP 2.61438
71 3BU5 ATP 2.61438
72 1IR3 ANP 2.61438
73 4WW7 AMP 2.6738
74 1K3A ACP 2.67559
75 4FE2 ADP 2.7451
76 2AQX ATP 2.76817
77 4UWH JXM 2.77778
78 4AZW ATP 2.77778
79 3HZT J60 2.77778
80 4OCV ANP 2.77778
81 5EFQ ADP 2.77778
82 5ZTN CUR 2.77778
83 3PTG 932 2.77778
84 3IGO ANP 2.77778
85 3GC8 B45 2.77778
86 2PVN P63 2.77778
87 1V0O INR 2.77778
88 4PU5 ANP 2.77778
89 5LXM ADP 2.82686
90 5HVJ ANP 2.85714
91 1AUX AGS 2.89389
92 2WQN ADP 2.90323
93 4RDL FUC GAL NDG FUC 2.92208
94 4AUA 4AU 2.9316
95 3SLS ANP 2.96053
96 3SCH TB6 3.0303
97 1NYW DAU 3.04569
98 3DLS ADP 3.08642
99 4Y0X ADP 3.08642
100 2PZI AXX 3.08642
101 1Q8Y ADE 3.08642
102 5TDF ADP 3.08642
103 2YAB AMP 3.08642
104 2IO8 ADP 3.08642
105 5C03 AGS 3.08642
106 4Y8D 49J 3.08642
107 1PK8 ATP 3.08642
108 5OMY 9YE 3.08642
109 4OAV ACP 3.08642
110 1Q8Y ADP 3.08642
111 4DFU QUE 3.10559
112 3VZS NAP 3.11284
113 1Y9Q MED 3.125
114 2QX0 PH2 3.14465
115 4WOV 3SM 3.15457
116 5A6N U7E 3.18021
117 2VZ6 FEF 3.19489
118 4R78 AMP 3.23625
119 4CQE CQE 3.23741
120 3AQV TAK 3.26087
121 2VN9 GVD 3.32226
122 1PHK ATP 3.3557
123 3X01 AMP 3.39506
124 5Y86 HRM 3.39506
125 1EHI ADP 3.39506
126 6EZ6 C5Z 3.39506
127 5LPZ ADP 3.39506
128 6A1G 9OL 3.39506
129 2PVF ACP 3.39506
130 5LI1 ANP 3.39506
131 3ZGJ RMN 3.39506
132 4K33 ACP 3.39506
133 4M69 ANP 3.51438
134 3RI1 3RH 3.51438
135 1OFZ FUL 3.52564
136 1I7L ATP 3.55987
137 5AX9 4KT 3.57143
138 1S68 AMP 3.61446
139 3PLS ANP 3.69128
140 3VOT ADP 3.7037
141 5CKW ANP 3.7037
142 4DC2 ADE 3.7037
143 3UIM ANP 3.7037
144 4KBA 1QM 3.7037
145 5LI9 ACP 3.7037
146 5OKT 9XK 3.7037
147 5IM3 DTP 3.7037
148 4AU8 Z3R 3.71622
149 3UDZ ADP 3.85396
150 2V7O DRN 3.86905
151 5H4S RAM 3.87324
152 5GZ9 ANP 3.93443
153 4YMJ 4EJ 3.94737
154 4JLS 3ZE 3.94737
155 3SRV S19 3.97112
156 4JR7 GNP 4.01235
157 1O9U ADZ 4.01235
158 4NM5 ADP 4.01235
159 3ZRM ZRM 4.01235
160 2F2U M77 4.01235
161 3ETH ATP 4.01235
162 3F7Z 34O 4.01235
163 2B9J ADP 4.01235
164 2B9I ADP 4.01235
165 2B9F ADP 4.01235
166 2B9H ADP 4.01235
167 2JLD AG1 4.01235
168 1T36 ADP 4.01235
169 3HMO STU 4.01235
170 5JZJ AN2 4.0404
171 4MV1 ADP 4.05983
172 4TWL ASC 4.06504
173 3TDV GDP 4.24837
174 5OF1 SAL 4.28571
175 3C0G 3AM 4.32099
176 2VPQ ANP 4.32099
177 4H3P ANP 4.32099
178 2YW2 ATP 4.32099
179 3N29 NSD 4.32099
180 6CMJ F6J 4.36137
181 3WVR AMP 4.47427
182 5T7I LAT NAG GAL 4.51613
183 1ZY5 ANP 4.62046
184 4H3Q ANP 4.62963
185 3RE4 TO1 4.65116
186 3GGF GVD 4.65116
187 1KR3 113 4.74138
188 6F3G CJN 4.74576
189 5K2M ADP 4.7619
190 4IAW LIZ 4.78723
191 5COU ATP 4.93827
192 4CYI ATP 4.93827
193 2WU6 DKI 4.93827
194 1IA9 ANP 5
195 2CSN CKI 5.05051
196 2QLU ADE 5.09554
197 5L8L ADP 5.12821
198 5LVP ATP 5.14469
199 5USZ SKE 5.19031
200 5C1P ADP 5.22876
201 5C1P DAL DAL 5.22876
202 2HGS ADP 5.24691
203 5Y80 IRE 5.24691
204 1XJD STU 5.24691
205 6G34 5ID 5.24691
206 4FFG 0U8 5.24691
207 4OUC 5ID 5.24691
208 3W0O ADP 5.24691
209 3W0O HY0 5.24691
210 1TZD ADP 5.45455
211 3H9R TAK 5.50459
212 4UX9 ANP 5.55556
213 4BHN BH9 5.55556
214 1KJ8 ATP 5.55556
215 1KJ8 GAR 5.55556
216 4IZY 1J2 5.55556
217 4UXL 5P8 5.59006
218 4O4F ATP 5.64516
219 4O4F IHP 5.64516
220 1W2D ADP 5.66038
221 3LXN MI1 5.66038
222 1W2D 4IP 5.66038
223 2ZV2 609 5.7047
224 4RYV ZEA 5.80645
225 1C1L GAL BGC 5.83942
226 4E1Z 0MX 5.84192
227 4ZS4 ATP 5.86319
228 1UNH IXM 5.8642
229 2R5T ANP 5.8642
230 5AWM ANP 5.8642
231 4BHL ARG 5.8642
232 5T8O 76Z 5.8642
233 6BXI ANP 5.8642
234 4LRJ ANP 5.91716
235 4WNP 3RJ 5.92335
236 4IX4 ADP 6
237 2WEL K88 6
238 2BKK ADP 6.06061
239 4XCB AKG 6.13027
240 3V8S 0HD 6.17284
241 6GZD LCI 6.17284
242 1IOW ADP 6.20915
243 1IOW PHY 6.20915
244 5G1X ADP 6.34921
245 4YGF AZM 6.41026
246 2YRX AMP 6.43016
247 3WO0 ALA 6.48148
248 3WO0 ADP 6.48148
249 4NW6 2NS 6.50155
250 2Z7R STU 6.54206
251 5MJA 7O3 6.55738
252 4O1P ANP 6.79012
253 2FB3 5AD 6.79012
254 2FB3 MET 6.79012
255 2VQD AP2 6.79012
256 5HES 032 6.84039
257 4Y9T PA1 6.93642
258 2X2M X2M 7.00637
259 6CQF F97 7.07071
260 2IF8 ADP 7.09877
261 3IDB ANP 7.09877
262 2QCS ANP 7.09877
263 3FHI ANP 7.09877
264 4WB7 ATP 7.09877
265 4WB6 ATP 7.09877
266 5UN9 NHT 7.09877
267 5DBX ANP 7.09877
268 4OUJ LBT 7.16612
269 4L3L 5FI 7.23684
270 5WO4 B7V 7.28477
271 3K5I AIR 7.40741
272 3ORQ ADP 7.40741
273 3K5I ADP 7.40741
274 3TY5 ATP 7.40741
275 3TY5 ADP 7.40741
276 1SLT NDG GAL 7.46269
277 5ZCT ANP 7.51634
278 5U6C 7YS 7.61905
279 1Y7P RIP 7.62332
280 4F9C 0SX 7.63889
281 2WT9 NIO 7.65957
282 6C7Y ADP 7.69231
283 4GNC ASO 7.69231
284 4PZ6 GMP 7.71605
285 5JU6 BGC 7.71605
286 5ODT ADP 7.77385
287 6F9G PUT 7.78816
288 4XYM A12 7.82609
289 4XZ3 ACP 7.82609
290 2VWA PTY 7.92079
291 1SDW IYT 7.96178
292 1E4E ADP 8.02469
293 5MW8 ATP 8.02469
294 4BFM ANP 8.02469
295 1GZW GAL BGC 8.20895
296 5DZT AMP 8.33333
297 1M0W ANP 8.33333
298 4CS9 AMP 8.46561
299 2A19 ANP 8.57143
300 2PUL ACP 8.64198
301 5WNL STU 8.64198
302 3LQV ADE 8.69565
303 2BPM 529 8.73786
304 4CFU 2WC 8.91089
305 6GUE FB8 8.9404
306 2V58 LZJ 8.95062
307 3MVH WFE 8.95062
308 1W6M GAL 8.95522
309 4BCM T7Z 8.9701
310 4BCQ TJF 8.9701
311 4BCN T9N 9
312 4OFG PCG 9.02778
313 5LMK 6ZK 9.09091
314 3AKK ADP 9.25926
315 2JDR L20 9.25926
316 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 9.25926
317 5EO8 TFU 9.32476
318 3NV3 GAL NAG MAN 9.42029
319 5HQ0 LZ9 9.52381
320 6GU6 1QK 9.52381
321 4C2W ANP 9.61539
322 3I8T LBT 9.7561
323 4GLW 0XT 9.83607
324 5YK1 ANP 10.1852
325 4NZN 2OU 10.4938
326 4NZN ANP 10.4938
327 2GQR ADP 10.5485
328 1BYG STU 10.7914
329 4G17 0VN 10.8025
330 5C4L 4XR 10.8025
331 4ZGP ADP 10.9215
332 2GQS ADP 10.9705
333 2PYW ADP 11.1111
334 2R7K ACP 11.1111
335 2R7K AMZ 11.1111
336 6D61 4AA 11.2821
337 3PN1 IVH 11.3208
338 3PVW QRX 11.4198
339 4Q5H ANP 11.4943
340 2HY0 306 11.8012
341 4Y85 499 12.3457
342 3O0G 3O0 12.7517
343 3DAK ANP 12.7586
344 5M06 ADP 13.7681
345 3VPD ANP 14.2349
346 2ZX2 RAM 14.359
347 4XQM MAN 14.8936
348 5GP0 GPP 16.7785
349 5XQW 8EU 17.0507
350 3DGY 2GP 18.5567
351 3VPC ADP 18.7943
352 3VPB ADP 18.7943
353 5C8W PCG 23.0769
354 5LXT ACP 24.4755
355 5UPK ANP 27.0833
356 2VFK AMP 27.8049
357 4OH4 ANP 33.3333
358 3CY2 MB9 35.7143
359 2Q7D ANP 45.0617
Pocket No.: 2; Query (leader) PDB : 1Z2P; Ligand: I3S; Similar sites found with APoc: 359
This union binding pocket(no: 2) in the query (biounit: 1z2p.bio1) has 37 residues
No: Leader PDB Ligand Sequence Similarity
1 5KK4 44E None
2 3KN5 ANP 1.23457
3 1GT4 UNA 1.25786
4 4D4U FUC GAL 1.26984
5 4D52 GIV 1.26984
6 4D52 GXL 1.26984
7 4I94 ANP 1.33333
8 1NWW HPN 1.34228
9 5LPB ADP 1.35135
10 1U59 STU 1.39373
11 5EXK 5AD 1.54321
12 4FL3 ANP 1.54321
13 3HQ9 OXL 1.54321
14 4OTH DRN 1.54321
15 6DAW ARG 1.54321
16 6BFN DL1 1.54321
17 4CC6 L5Y 1.57233
18 2F57 23D 1.57729
19 4X7Q 3YR 1.60256
20 3SHR CMP 1.67224
21 3RGA ILD 1.76678
22 5OES ADP 1.85185
23 5I35 ANP 1.85185
24 3TXO 07U 1.85185
25 4BTK DTQ 1.85185
26 5YF9 NIO 1.85185
27 4U44 3D9 1.85185
28 4IDT T28 1.85185
29 5DMZ ADP 1.85185
30 4U98 ACP 1.85185
31 4LH7 1X8 1.85759
32 1GSA ADP 1.89873
33 4FG8 ATP 1.90476
34 3ORK AGS 1.92926
35 4NFN 2KC 1.94175
36 4USF 6UI 1.97368
37 5CEO 50D 2
38 3M2W L8I 2.00669
39 2QK4 ATP 2.16049
40 4WTV ATP 2.16049
41 6AC9 ANP 2.16049
42 3TPV ADE 2.16049
43 4XH0 ADP 2.16049
44 3DNT ATP 2.16049
45 5DXT 5H5 2.16049
46 4UAL 3FV 2.16049
47 6FYV 3NG 2.16049
48 5VZ0 ADP 2.16049
49 3ALN ANP 2.16049
50 4H9T HL4 2.16049
51 1Y79 LYS TRP 2.16049
52 3TII ANP 2.16049
53 5X8I SQZ 2.16049
54 6G33 5ID 2.16049
55 1GXU 2HP 2.1978
56 5ISY NAD 2.3166
57 3V4S ADP 2.32558
58 3V4S ATP 2.32558
59 4KS7 X4Z 2.39726
60 5AIG VPR 2.4
61 4YZN 4K5 2.43902
62 5VLQ ANP 2.46914
63 3KAL ADP 2.46914
64 2QF7 AGS 2.46914
65 1OKE BOG 2.46914
66 5EQY 5RA 2.46914
67 6FYL 3NG 2.46914
68 5FI4 5XV 2.47678
69 4NST ADP 2.61194
70 1OBD ATP 2.61438
71 3BU5 ATP 2.61438
72 1IR3 ANP 2.61438
73 4WW7 AMP 2.6738
74 1K3A ACP 2.67559
75 4FE2 ADP 2.7451
76 2AQX ATP 2.76817
77 4UWH JXM 2.77778
78 4AZW ATP 2.77778
79 3HZT J60 2.77778
80 4OCV ANP 2.77778
81 5EFQ ADP 2.77778
82 5ZTN CUR 2.77778
83 3PTG 932 2.77778
84 3IGO ANP 2.77778
85 3GC8 B45 2.77778
86 2PVN P63 2.77778
87 1V0O INR 2.77778
88 4PU5 ANP 2.77778
89 5LXM ADP 2.82686
90 5HVJ ANP 2.85714
91 1AUX AGS 2.89389
92 2WQN ADP 2.90323
93 4RDL FUC GAL NDG FUC 2.92208
94 4AUA 4AU 2.9316
95 3SLS ANP 2.96053
96 3SCH TB6 3.0303
97 1NYW DAU 3.04569
98 3DLS ADP 3.08642
99 4Y0X ADP 3.08642
100 2PZI AXX 3.08642
101 1Q8Y ADE 3.08642
102 5TDF ADP 3.08642
103 2YAB AMP 3.08642
104 2IO8 ADP 3.08642
105 5C03 AGS 3.08642
106 4Y8D 49J 3.08642
107 1PK8 ATP 3.08642
108 5OMY 9YE 3.08642
109 4OAV ACP 3.08642
110 1Q8Y ADP 3.08642
111 4DFU QUE 3.10559
112 3VZS NAP 3.11284
113 1Y9Q MED 3.125
114 2QX0 PH2 3.14465
115 4WOV 3SM 3.15457
116 5A6N U7E 3.18021
117 2VZ6 FEF 3.19489
118 4R78 AMP 3.23625
119 4CQE CQE 3.23741
120 3AQV TAK 3.26087
121 2VN9 GVD 3.32226
122 1PHK ATP 3.3557
123 3X01 AMP 3.39506
124 5Y86 HRM 3.39506
125 1EHI ADP 3.39506
126 6EZ6 C5Z 3.39506
127 5LPZ ADP 3.39506
128 6A1G 9OL 3.39506
129 2PVF ACP 3.39506
130 5LI1 ANP 3.39506
131 3ZGJ RMN 3.39506
132 4K33 ACP 3.39506
133 4M69 ANP 3.51438
134 3RI1 3RH 3.51438
135 1OFZ FUL 3.52564
136 1I7L ATP 3.55987
137 5AX9 4KT 3.57143
138 1S68 AMP 3.61446
139 3PLS ANP 3.69128
140 3VOT ADP 3.7037
141 5CKW ANP 3.7037
142 4DC2 ADE 3.7037
143 3UIM ANP 3.7037
144 4KBA 1QM 3.7037
145 5LI9 ACP 3.7037
146 5OKT 9XK 3.7037
147 5IM3 DTP 3.7037
148 4AU8 Z3R 3.71622
149 3UDZ ADP 3.85396
150 2V7O DRN 3.86905
151 5H4S RAM 3.87324
152 5GZ9 ANP 3.93443
153 4YMJ 4EJ 3.94737
154 4JLS 3ZE 3.94737
155 3SRV S19 3.97112
156 4JR7 GNP 4.01235
157 1O9U ADZ 4.01235
158 4NM5 ADP 4.01235
159 3ZRM ZRM 4.01235
160 2F2U M77 4.01235
161 3ETH ATP 4.01235
162 3F7Z 34O 4.01235
163 2B9J ADP 4.01235
164 2B9I ADP 4.01235
165 2B9F ADP 4.01235
166 2B9H ADP 4.01235
167 2JLD AG1 4.01235
168 1T36 ADP 4.01235
169 3HMO STU 4.01235
170 5JZJ AN2 4.0404
171 4MV1 ADP 4.05983
172 4TWL ASC 4.06504
173 3TDV GDP 4.24837
174 5OF1 SAL 4.28571
175 3C0G 3AM 4.32099
176 2VPQ ANP 4.32099
177 4H3P ANP 4.32099
178 2YW2 ATP 4.32099
179 3N29 NSD 4.32099
180 6CMJ F6J 4.36137
181 3WVR AMP 4.47427
182 5T7I LAT NAG GAL 4.51613
183 1ZY5 ANP 4.62046
184 4H3Q ANP 4.62963
185 3RE4 TO1 4.65116
186 3GGF GVD 4.65116
187 1KR3 113 4.74138
188 6F3G CJN 4.74576
189 5K2M ADP 4.7619
190 4IAW LIZ 4.78723
191 5COU ATP 4.93827
192 4CYI ATP 4.93827
193 2WU6 DKI 4.93827
194 1IA9 ANP 5
195 2CSN CKI 5.05051
196 2QLU ADE 5.09554
197 5L8L ADP 5.12821
198 5LVP ATP 5.14469
199 5USZ SKE 5.19031
200 5C1P ADP 5.22876
201 5C1P DAL DAL 5.22876
202 2HGS ADP 5.24691
203 5Y80 IRE 5.24691
204 1XJD STU 5.24691
205 6G34 5ID 5.24691
206 4FFG 0U8 5.24691
207 4OUC 5ID 5.24691
208 3W0O ADP 5.24691
209 3W0O HY0 5.24691
210 1TZD ADP 5.45455
211 3H9R TAK 5.50459
212 4UX9 ANP 5.55556
213 4BHN BH9 5.55556
214 1KJ8 ATP 5.55556
215 1KJ8 GAR 5.55556
216 4IZY 1J2 5.55556
217 4UXL 5P8 5.59006
218 4O4F ATP 5.64516
219 4O4F IHP 5.64516
220 1W2D ADP 5.66038
221 3LXN MI1 5.66038
222 1W2D 4IP 5.66038
223 2ZV2 609 5.7047
224 4RYV ZEA 5.80645
225 1C1L GAL BGC 5.83942
226 4E1Z 0MX 5.84192
227 4ZS4 ATP 5.86319
228 1UNH IXM 5.8642
229 2R5T ANP 5.8642
230 5AWM ANP 5.8642
231 4BHL ARG 5.8642
232 5T8O 76Z 5.8642
233 6BXI ANP 5.8642
234 4LRJ ANP 5.91716
235 4WNP 3RJ 5.92335
236 4IX4 ADP 6
237 2WEL K88 6
238 2BKK ADP 6.06061
239 4XCB AKG 6.13027
240 3V8S 0HD 6.17284
241 6GZD LCI 6.17284
242 1IOW ADP 6.20915
243 1IOW PHY 6.20915
244 5G1X ADP 6.34921
245 4YGF AZM 6.41026
246 2YRX AMP 6.43016
247 3WO0 ALA 6.48148
248 3WO0 ADP 6.48148
249 4NW6 2NS 6.50155
250 2Z7R STU 6.54206
251 5MJA 7O3 6.55738
252 4O1P ANP 6.79012
253 2FB3 5AD 6.79012
254 2FB3 MET 6.79012
255 2VQD AP2 6.79012
256 5HES 032 6.84039
257 4Y9T PA1 6.93642
258 2X2M X2M 7.00637
259 6CQF F97 7.07071
260 2IF8 ADP 7.09877
261 3IDB ANP 7.09877
262 2QCS ANP 7.09877
263 3FHI ANP 7.09877
264 4WB7 ATP 7.09877
265 4WB6 ATP 7.09877
266 5UN9 NHT 7.09877
267 5DBX ANP 7.09877
268 4OUJ LBT 7.16612
269 4L3L 5FI 7.23684
270 5WO4 B7V 7.28477
271 3K5I AIR 7.40741
272 3ORQ ADP 7.40741
273 3K5I ADP 7.40741
274 3TY5 ATP 7.40741
275 3TY5 ADP 7.40741
276 1SLT NDG GAL 7.46269
277 5ZCT ANP 7.51634
278 5U6C 7YS 7.61905
279 1Y7P RIP 7.62332
280 4F9C 0SX 7.63889
281 2WT9 NIO 7.65957
282 6C7Y ADP 7.69231
283 4GNC ASO 7.69231
284 4PZ6 GMP 7.71605
285 5JU6 BGC 7.71605
286 5ODT ADP 7.77385
287 6F9G PUT 7.78816
288 4XYM A12 7.82609
289 4XZ3 ACP 7.82609
290 2VWA PTY 7.92079
291 1SDW IYT 7.96178
292 1E4E ADP 8.02469
293 5MW8 ATP 8.02469
294 4BFM ANP 8.02469
295 1GZW GAL BGC 8.20895
296 5DZT AMP 8.33333
297 1M0W ANP 8.33333
298 4CS9 AMP 8.46561
299 2A19 ANP 8.57143
300 2PUL ACP 8.64198
301 5WNL STU 8.64198
302 3LQV ADE 8.69565
303 2BPM 529 8.73786
304 4CFU 2WC 8.91089
305 6GUE FB8 8.9404
306 2V58 LZJ 8.95062
307 3MVH WFE 8.95062
308 1W6M GAL 8.95522
309 4BCM T7Z 8.9701
310 4BCQ TJF 8.9701
311 4BCN T9N 9
312 4OFG PCG 9.02778
313 5LMK 6ZK 9.09091
314 3AKK ADP 9.25926
315 2JDR L20 9.25926
316 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 9.25926
317 5EO8 TFU 9.32476
318 3NV3 GAL NAG MAN 9.42029
319 5HQ0 LZ9 9.52381
320 6GU6 1QK 9.52381
321 4C2W ANP 9.61539
322 3I8T LBT 9.7561
323 4GLW 0XT 9.83607
324 5YK1 ANP 10.1852
325 4NZN 2OU 10.4938
326 4NZN ANP 10.4938
327 2GQR ADP 10.5485
328 1BYG STU 10.7914
329 4G17 0VN 10.8025
330 5C4L 4XR 10.8025
331 4ZGP ADP 10.9215
332 2GQS ADP 10.9705
333 2PYW ADP 11.1111
334 2R7K ACP 11.1111
335 2R7K AMZ 11.1111
336 6D61 4AA 11.2821
337 3PN1 IVH 11.3208
338 3PVW QRX 11.4198
339 4Q5H ANP 11.4943
340 2HY0 306 11.8012
341 4Y85 499 12.3457
342 3O0G 3O0 12.7517
343 3DAK ANP 12.7586
344 5M06 ADP 13.7681
345 3VPD ANP 14.2349
346 2ZX2 RAM 14.359
347 4XQM MAN 14.8936
348 5GP0 GPP 16.7785
349 5XQW 8EU 17.0507
350 3DGY 2GP 18.5567
351 3VPC ADP 18.7943
352 3VPB ADP 18.7943
353 5C8W PCG 23.0769
354 5LXT ACP 24.4755
355 5UPK ANP 27.0833
356 2VFK AMP 27.8049
357 4OH4 ANP 33.3333
358 3CY2 MB9 35.7143
359 2Q7D ANP 45.0617
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