Receptor
PDB id Resolution Class Description Source Keywords
1ZOE 1.77 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF PROTEIN KINASE CK2 IN COMPLEX WITH TBB- DERIVATIVES INHIBITORS ZEA MAYS PROTEIN KINASE INHIBITOR COMPLEX TRANSFERASE
Ref.: INSPECTING THE STRUCTURE-ACTIVITY RELATIONSHIP OF PROTEIN KINASE CK2 INHIBITORS DERIVED FROM TETRABROMO-BENZIMIDAZOLE. CHEM.BIOL. V. 12 1211 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:601;
Invalid;
none;
submit data
35.453 Cl [Cl-]
DMS A:701;
Invalid;
none;
submit data
78.133 C2 H6 O S CS(=O...
K25 A:501;
Valid;
none;
Ki = 0.04 uM
476.788 C9 H7 Br4 N3 CN(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2PVN 2 Å EC: 2.7.11.1 STRUCTURE-BASED DESIGN OF PYRAZOLO[1,5-A][1,3,5]TRIAZINE DERIVATIVES AS POTENT INHIBITORS OF PROTEIN KINASE CK2 ZEA MAYS STRUCTURE-BASED DRUG DESIGN ENZYME-INHIBITOR COMPLEX CASEIN KINASE II PROTEIN KINASE CK2 TRANSFERASE
Ref.: STRUCTURE-BASED DESIGN, SYNTHESIS, AND STUDY OF PYRAZOLO[1,5-A][1,3,5]TRIAZINE DERIVATIVES AS POTENT INHIBITORS OF PROTEIN KINASE CK2. BIOORG.MED.CHEM.LETT. V. 17 4191 2007
Members (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
2 1M2P - HNA C14 H7 N O6 c1cc2c(c(c....
3 1LPU - BEN C7 H8 N2 [H]/N=C(c1....
4 2QC6 ic50 = 0.1 uM G12 C10 H6 Br2 O3 CC1=C(C(=O....
5 4ANM ic50 = 28 nM WUL C15 H14 Br N3 O3 c1cc2c(cc1....
6 1DAW - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
7 4RLK - E91 C21 H14 N2 O2 c1ccc2c(c1....
8 2OXD - K32 C7 H2 Br4 N2 O c12c(c(c(c....
9 2PVM Ki = 0.36 uM P29 C17 H15 N9 c1ccc(cc1)....
10 1J91 - TBS C6 H Br4 N3 c12c(c(c(c....
11 4DGO ic50 = 0.57 uM 0JW C10 H10 N2 O3 c1cc(c(cc1....
12 3FL5 - TXQ C14 H8 O6 c1cc(c(c2c....
13 3PWD ic50 = 0.22 uM CZ0 C14 H9 N O5 CC1=CC(=O)....
14 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
15 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
16 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
17 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
18 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
19 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
20 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
21 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
22 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
23 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
24 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
25 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
26 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
27 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
28 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
29 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
30 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
31 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
32 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
33 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
34 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
35 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
36 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
70% Homology Family (98)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
3 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
4 3MB6 ic50 = 100 nM 01I C16 H8 O6 c1cc2c(cc(....
5 5M4F - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
6 5CVH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
7 3BQC ic50 ~ 2 uM EMO C15 H10 O5 Cc1cc2c(c(....
8 5CU2 - 54G C8 H8 O3 Cc1ccc(c(c....
9 5MO5 - 4IH C17 H21 Cl N2 O2 S CS(=O)(=O)....
10 5M4I - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
11 5MP8 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
12 5MOV - HC4 C9 H8 O3 c1cc(ccc1C....
13 5MOH - YTX C9 H10 O4 COc1cc(ccc....
14 5CSH Kd = 270 uM 54E C13 H12 Cl N c1ccc(cc1)....
15 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
16 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
17 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
18 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
19 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
20 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
21 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
22 5H8E ic50 < 0.003 uM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
23 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
24 5MOE Kd = 500 uM OQC C11 H10 Cl N O c1cc(c(cc1....
25 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
26 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
27 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
28 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
29 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
30 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
31 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
32 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
33 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
34 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
35 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
36 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
37 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
38 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
39 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
40 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
41 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
42 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
43 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
44 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
45 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
46 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
47 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
48 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
49 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
50 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
51 3PE1 Ki = 0.38 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
52 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
53 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
54 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
55 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
56 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
57 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
58 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
59 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
60 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
61 1M2P - HNA C14 H7 N O6 c1cc2c(c(c....
62 1LPU - BEN C7 H8 N2 [H]/N=C(c1....
63 2QC6 ic50 = 0.1 uM G12 C10 H6 Br2 O3 CC1=C(C(=O....
64 4ANM ic50 = 28 nM WUL C15 H14 Br N3 O3 c1cc2c(cc1....
65 1DAW - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
66 4RLK - E91 C21 H14 N2 O2 c1ccc2c(c1....
67 2OXD - K32 C7 H2 Br4 N2 O c12c(c(c(c....
68 2PVM Ki = 0.36 uM P29 C17 H15 N9 c1ccc(cc1)....
69 1J91 - TBS C6 H Br4 N3 c12c(c(c(c....
70 4DGO ic50 = 0.57 uM 0JW C10 H10 N2 O3 c1cc(c(cc1....
71 3FL5 - TXQ C14 H8 O6 c1cc(c(c2c....
72 3PWD ic50 = 0.22 uM CZ0 C14 H9 N O5 CC1=CC(=O)....
73 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
74 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
75 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
76 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
77 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
78 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
79 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
80 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
81 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
82 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
83 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
84 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
85 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
86 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
87 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
88 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
89 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
90 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
91 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
92 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
93 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
94 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
95 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
96 5M56 - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
97 5M4U - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
98 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
3 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
4 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
5 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
6 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
7 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: K25; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 K25 1 1
2 K37 0.444444 0.666667
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2PVN; Ligand: P63; Similar sites found: 249
This union binding pocket(no: 1) in the query (biounit: 2pvn.bio1) has 29 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5GZ9 ANP 0.00000001877 0.57051 1.31148
2 1W6P NDG GAL 0.005683 0.44753 1.49254
3 3ETH ATP 0.0003322 0.41737 1.70455
4 2Q7D ANP 0.001366 0.42371 2.02312
5 5KO1 6UY 0.000000193 0.6332 2.12014
6 4RDL FUC GAL NDG FUC 0.00469 0.45442 2.27273
7 2X3J ATP 0.005122 0.41578 2.27273
8 4CLI 5P8 0.00000007137 0.60817 2.44648
9 4ANW O92 0.00004833 0.47878 2.44898
10 2YLN CYS 0.01818 0.41427 2.4735
11 3VPC ADP 0.0003018 0.41734 2.48227
12 4CC6 L5Y 0.004586 0.44631 2.51572
13 4XMF HSM 0.0001837 0.52938 2.71739
14 5W2I ADP 0.0002085 0.43183 2.72374
15 5W2I I3P 0.0002085 0.43183 2.72374
16 4AXD ANP 0.000007934 0.51774 2.84091
17 4U98 ACP 0.0009359 0.46104 3.125
18 5NCY 8TK 0.0003483 0.43561 3.125
19 2VQD AP2 0.0001928 0.42442 3.125
20 5FQK 6NT 0.02423 0.41363 3.125
21 3VPD ANP 0.0005338 0.40814 3.20285
22 5T7I LAT NAG GAL 0.03619 0.40472 3.22581
23 4D4U FUC GAL NAG 0.02747 0.41149 3.49206
24 2IO8 ADP 0.00007887 0.44873 3.69318
25 4XBT 3ZQ 0.008306 0.41313 3.87097
26 4XBT FLC 0.01371 0.40313 3.87097
27 5IQD RIO 0.00001107 0.51196 3.93443
28 5IQD GNP 0.00001013 0.51196 3.93443
29 3X01 AMP 0.0001578 0.53151 3.97727
30 1GSA ADP 0.00002156 0.46508 4.11392
31 1PK8 ATP 0.0001182 0.4463 4.26136
32 4X5S AZM 0.03687 0.40462 4.31034
33 3I0O ADP 0.0001224 0.40044 4.42478
34 1I7L ATP 0.0002028 0.43426 4.53074
35 2PUL ACP 0.000004361 0.46035 4.54545
36 4YVN EBS 0.02928 0.40976 4.54545
37 5FI4 5XV 0.001491 0.40345 4.54545
38 5L9B AKG 0.03116 0.40334 4.7619
39 5BTX CMP 0.0374 0.4085 4.79452
40 1AUX AGS 0.00003294 0.43747 4.82315
41 5I35 ANP 0.000001741 0.58859 4.82955
42 2YW2 ATP 0.001423 0.44021 4.82955
43 3WO0 ALA 0.005521 0.40419 5.11364
44 4OAV ACP 0.0000005063 0.48583 5.68182
45 3UDZ ADP 0.000003185 0.47604 5.68182
46 3KAL ADP 0.00206 0.41637 5.68182
47 5FS0 5JC 0.02653 0.40698 5.6872
48 3TM0 B31 0.0003667 0.44583 5.70342
49 3TM0 ANP 0.0003365 0.44583 5.70342
50 4O1P ANP 0.000000732 0.49037 5.96591
51 5MRH Q9Z 0.002969 0.45602 5.96591
52 2V58 LZJ 0.001057 0.43963 5.96591
53 5IGI ZIT 0.005236 0.40511 5.98007
54 5IGI GMP 0.005436 0.40334 5.98007
55 4OCJ NDG 0.00002393 0.49859 6.25
56 4OCV ANP 0.00001488 0.45818 6.25
57 1TQP ATP 0.000009931 0.48266 6.38298
58 3ZJX BOG 0.00687 0.44317 6.53409
59 5TDF ADP 0.000217 0.42217 6.53409
60 4PU5 ANP 0.0001473 0.43657 6.81818
61 4GYI ADP 0.00001689 0.43434 6.81818
62 3RET SAL 0.01094 0.41468 6.93069
63 2VPQ ANP 0.0003158 0.42384 7.10227
64 1Y7P RIP 0.005343 0.46524 7.17489
65 5MW8 ATP 0.000001084 0.513 7.38636
66 2PYW ADP 0.000006659 0.47307 7.38636
67 4WW7 AMP 0.0000003266 0.52063 7.48663
68 4ZS4 ATP 0.000002516 0.56737 7.67045
69 3PDT ADP 0.00001492 0.43845 7.67045
70 5VZ0 ADP 0.0001757 0.40815 7.67045
71 5LXT ACP 0.0008632 0.44207 7.69231
72 5LPZ ADP 0.00000001485 0.67598 7.83133
73 4XYM A12 0.0003546 0.40893 8.26087
74 5LPB ADP 0.00000006712 0.48605 8.78378
75 3DNT ATP 0.0002023 0.43674 9.375
76 5TT6 ATP 0.008512 0.403 9.39086
77 5H4I 7HQ 0.03401 0.40498 9.43396
78 3W0O ADP 0.000223 0.44967 9.45559
79 3W0O HY0 0.000223 0.44269 9.45559
80 5CKW ANP 0.00000284 0.44533 10.5114
81 1ZP9 ATP 0.000001451 0.46659 10.8527
82 1ZTH ADP 0.000001357 0.4528 10.8527
83 5C03 AGS 0.0000003473 0.61339 11.4035
84 4Q5H ANP 0.000000104 0.63732 11.4943
85 4WVW SLT 0.02938 0.40238 11.8056
86 4YRD 3IT 0.03919 0.4051 11.9318
87 3HAV ATP 0.0007073 0.42229 12.2159
88 4WOV 3SM 0.000005277 0.58067 12.3028
89 1IA9 ANP 0.00001776 0.45772 12.5
90 3TDV GDP 0.0000005386 0.49456 12.7451
91 3VHE 42Q 0.000002113 0.52802 13.3523
92 4AZW ATP 0.00001392 0.46099 13.6364
93 4IX4 ADP 0.00001254 0.46137 13.7143
94 5USZ SKE 0.000000008199 0.62538 13.8408
95 3VPB ADP 0.0001976 0.43938 14.2857
96 3UIM ANP 0.000000006626 0.55497 14.4172
97 4K33 ACP 0.00000003704 0.53796 14.7692
98 2X2M X2M 0.0000001001 0.53818 14.9682
99 4CYI ATP 0.000003033 0.47776 15.0568
100 5C4L 4XR 0.000008092 0.50731 15.2648
101 5C4L SIS 0.00004427 0.47859 15.2648
102 2QLU ADE 0.000001256 0.6462 15.6051
103 3GQI ACP 0.00000003659 0.52886 15.6442
104 4O4F ATP 0.001157 0.42983 15.7258
105 4O4F IHP 0.001189 0.42612 15.7258
106 5UR1 YY9 0.00000168 0.55091 16.3987
107 5HZX 2GE 0.02341 0.4059 16.4773
108 5K2M ADP 0.0005794 0.41847 16.9811
109 4Y85 499 0.00000349 0.4596 17.1687
110 5VC5 96M 0.00000004068 0.58611 18.4659
111 3RI1 3RH 0.000001663 0.52185 19.4888
112 4F4P 0SB 0.0000002022 0.60764 19.6023
113 3SRV S19 0.00000000114 0.56263 19.6023
114 5JKG 6LF 0.00001019 0.51339 19.6141
115 2A19 ANP 0.0000004507 0.64207 19.7183
116 4L9I 8PR 0.00000426 0.57043 20.4545
117 3LQV ADE 0.02079 0.41034 20.5128
118 4XH0 ADP 0.00001941 0.57996 22.1591
119 2CSN CKI 0.00000001119 0.60058 23.2323
120 4BTK DTQ 0.000000933 0.49267 23.4421
121 4E93 GUI 0.00000006204 0.59182 23.8636
122 5T8O 76Z 0.00000008389 0.62579 24.4318
123 4WNK 453 0.00000002252 0.6044 24.4318
124 4IDT T28 0.00000002016 0.52787 24.4318
125 4KBA 1QM 0.0000322 0.48447 24.4318
126 3KMW ATP 0.00007881 0.42037 24.7232
127 1VJY 460 0.0000000004159 0.67681 25.2841
128 4Y93 746 0.000000566 0.56438 25.2841
129 5JGA 6KC 0.00000009211 0.55291 25.2841
130 4YZC STU 0.00000001661 0.62274 25.679
131 5JFS 6K0 0.000003353 0.5358 25.8523
132 5FBN 5WF 0.000002872 0.53033 25.8523
133 3SXS PP2 0.000002649 0.484 25.8523
134 4BHN BH9 0.00000005124 0.63518 26.0479
135 3PP0 03Q 0.0000007095 0.53303 26.1364
136 4ASE AV9 0.00001296 0.49066 26.1364
137 4AG8 AXI 0.000002625 0.48172 26.1364
138 5CEO 50D 0.000006394 0.45851 26.1364
139 3C1X CKK 0.0001163 0.42997 26.1364
140 1U59 STU 0.000000005343 0.55669 26.4205
141 5HX8 66P 0.000000007615 0.63341 26.7045
142 3H9R TAK 0.00000007416 0.47185 26.7045
143 4BKJ STI 0.0005771 0.42106 26.7045
144 4GJ3 0XP 0.0000000135 0.6154 26.9886
145 3LXK MI1 0.00000001318 0.60456 26.9886
146 4R78 AMP 0.000004354 0.60136 27.2727
147 5U6C 7YS 0.0000002119 0.6011 27.2727
148 5HCY 60D 0.0000001501 0.59504 27.2727
149 2HK5 1BM 0.0000001266 0.52859 27.2727
150 4EWH T77 0.00000007718 0.58721 27.8409
151 5NKB 8ZT 0.00000007899 0.50162 27.8409
152 5UOX 8GY 0.00000001808 0.64708 28.125
153 3G5D 1N1 0.0000002251 0.60197 28.125
154 3PVW QRX 0.0000002753 0.54867 28.125
155 2H8H H8H 0.00000001676 0.53344 28.125
156 1Y57 MPZ 0.0000003438 0.52693 28.125
157 5UKL SIX 0.000001942 0.52271 28.125
158 1U5R ATP 0.00000001242 0.53391 28.1609
159 3GNI ATP 0.000000006408 0.56686 28.4091
160 5TA6 79D 0.0000003813 0.56001 28.4091
161 3KRL KRL 0.00000137 0.49971 28.4091
162 4YMJ 4EJ 0.00000006427 0.71452 28.6932
163 4FL3 ANP 0.00000001074 0.57162 28.6932
164 4WB7 ATP 0.000000005563 0.56751 28.6932
165 4U0I 0LI 0.000009247 0.50506 28.6932
166 5HES 032 0.000001071 0.50158 28.6932
167 2F57 23D 0.0000009853 0.47301 29.0221
168 4QMN DB8 0.00000002314 0.55053 29.2614
169 3VRY B43 0.000006017 0.49323 29.2614
170 1BYG STU 0.000000005095 0.53495 29.4964
171 4WB6 ATP 0.0000000002484 0.66077 29.5455
172 2F2U M77 0.0000002155 0.65811 29.5455
173 4E1Z 0MX 0.000000007885 0.65468 29.5455
174 1K3A ACP 0.000003478 0.44906 29.7659
175 2QCS ANP 0.0000000001928 0.66477 30.1136
176 4I6H 1C8 0.000001055 0.59133 30.1136
177 4DC2 ADE 0.00000002314 0.44091 30.1136
178 3LXN MI1 0.000000004366 0.57597 30.1887
179 2GU8 796 0.0000000006647 0.70794 30.6818
180 3FHI ANP 0.0000000003951 0.65356 30.6818
181 3IDB ANP 0.000000001487 0.60596 30.6818
182 1OPK P16 0.00001018 0.48601 30.6818
183 3BU5 ATP 0.00000008522 0.52285 30.719
184 4RFM 3P6 0.000006891 0.42448 30.8271
185 3NW7 LGV 0.000005014 0.53579 30.9446
186 3EKK GS2 0.00000006363 0.53021 30.9446
187 2OFV 242 0.000001686 0.54121 31.0469
188 5LI1 ANP 0.0000000001671 0.62966 31.25
189 4CSV STI 0.00002197 0.50934 31.2727
190 4XLI 1N1 0.0000006039 0.61006 31.3433
191 4AT3 LTI 0.000008154 0.49649 31.4381
192 2ZV2 609 0.00000003642 0.69674 31.5341
193 3PLS ANP 0.0000000454 0.52283 31.8792
194 4TWP AXI 0.000002001 0.44612 32.1033
195 3KRR DQX 0.000000001343 0.70509 32.3864
196 1ZY5 ANP 0.00000245 0.46532 33.2386
197 2PVF ACP 0.00000002948 0.52372 33.5227
198 4P5Z Q7M 0.0000007029 0.49003 33.5227
199 5MJA 7O3 0.0000005393 0.47592 33.5227
200 4YLL 4E3 0.00000001775 0.57536 34.9432
201 2Y6O 1N1 0.0000001353 0.53366 34.9432
202 3SLS ANP 0.00000001898 0.56479 35.2273
203 2XVD AS6 0.0000003534 0.5559 35.2273
204 3BZ3 YAM 0.00000007725 0.45175 35.8696
205 3E8N ATP 0.00000006952 0.61025 36.3636
206 3E8N VRA 0.00000006952 0.4892 36.3636
207 5TO8 7FM 0.0000006826 0.56197 36.5248
208 5N87 N66 0.000000008953 0.63133 36.9318
209 5EOB 5QQ 0.000001157 0.57098 36.9906
210 4D2S DYK 0.00000001168 0.51155 37.2159
211 3ALN ANP 0.0000000416 0.54696 37.5
212 3HZT J60 0.0000002986 0.46501 37.7841
213 5H2U 1N1 0.000001245 0.58804 37.8277
214 5DA3 58V 0.00000004724 0.69109 38.1132
215 3SXF BK5 0.000003393 0.52747 40.0568
216 2WEL K88 0.0000003968 0.43261 40.0612
217 3IGO ANP 0.0000001535 0.60713 40.3409
218 5MY8 RXZ 0.0000002592 0.54372 41.4773
219 4UX9 ANP 0.0000000003711 0.72907 41.7614
220 4IZY 1J2 0.000000002682 0.58124 42.0455
221 3TTI KBI 0.00000006592 0.58989 42.6136
222 2B9H ADP 0.00000001009 0.55796 42.6136
223 3HMO STU 0.000000001925 0.55516 42.6136
224 2B9I ADP 0.000000008421 0.55167 42.6136
225 2B9F ADP 0.00000001671 0.54318 42.6136
226 2B9J ADP 0.00000001307 0.53631 42.6136
227 3E7O 35F 0.00001691 0.47079 42.6136
228 3PTG 932 0.0000002444 0.46144 42.6136
229 4WHZ 3NL 0.0000004548 0.4567 42.6136
230 5LXC 7AA 0.0000000002826 0.57015 42.8977
231 2WU6 DKI 0.000000004916 0.59231 43.4659
232 4CRL C1I 0.0000003085 0.52679 43.75
233 4H3Q ANP 0.000000003073 0.59902 44.8864
234 3F7Z 34O 0.00000005939 0.5243 44.8864
235 4H3P ANP 0.00000001718 0.54278 45.4545
236 5BYZ 4WE 0.00001648 0.49529 45.4545
237 5BVE 4VG 0.000000001403 0.70157 45.7386
238 4LOO SB4 0.0003389 0.4062 45.7386
239 5X8I SQZ 0.00000000007948 0.77982 46.3068
240 3GC8 B45 0.000002459 0.49029 46.3068
241 4NST ADP 0.00000003525 0.53047 46.5909
242 5EFQ ADP 0.00000001712 0.53993 46.875
243 3ZRM ZRM 0.00000006844 0.5243 47.1591
244 4QTB 38Z 0.00000005795 0.58615 47.4432
245 2JLD AG1 0.0000000006592 0.67147 47.7273
246 4NM5 ADP 0.0000003705 0.58414 47.7273
247 1CM8 ANP 0.00000002495 0.52791 48.2955
248 5AWM ANP 0.00000006218 0.68512 48.5795
249 1OUK 084 0.000007005 0.5709 49.1477
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