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Receptor
PDB id Resolution Class Description Source Keywords
1ZY5 2 Å EC: 2.7.1.37 CRYSTAL STRUCTURE OF EIF2ALPHA PROTEIN KINASE GCN2: R794G HYPERACTIVATING MUTANT COMPLEXED WITH AMPPNP. SACCHAROMYCES CEREVISIAE TRANSLATION REGULATOR PROTEIN KINASE SIGNAL TRANSDUCTION ACID STARVATION STARVATION STRESS RESPONSE EIF2ALPHA KINATRANSFERASE
Ref.: STRUCTURAL BASIS FOR AUTOINHIBITION AND MUTATIONAL ACTIVATION OF EUKARYOTIC INITIATION FACTOR 2{ALPHA} KINASE GCN2 J.BIOL.CHEM. V. 280 29289 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:303;
B:304;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MG A:305;
B:306;
Invalid;
Invalid;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1ZY5 2 Å EC: 2.7.1.37 CRYSTAL STRUCTURE OF EIF2ALPHA PROTEIN KINASE GCN2: R794G HYPERACTIVATING MUTANT COMPLEXED WITH AMPPNP. SACCHAROMYCES CEREVISIAE TRANSLATION REGULATOR PROTEIN KINASE SIGNAL TRANSDUCTION ACID STARVATION STARVATION STRESS RESPONSE EIF2ALPHA KINATRANSFERASE
Ref.: STRUCTURAL BASIS FOR AUTOINHIBITION AND MUTATIONAL ACTIVATION OF EUKARYOTIC INITIATION FACTOR 2{ALPHA} KINASE GCN2 J.BIOL.CHEM. V. 280 29289 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 16 families.
1 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 13 families.
1 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 4G31 ic50 = 0.4 nM 0WH C24 H20 F3 N5 O Cn1cc(c2c1....
2 4X7H - 3Z2 C32 H26 N6 O5 CN1C(=C(C(....
3 4X7J ic50 = 41 nM 3Z1 C25 H22 F3 N5 O2 Cc1ccc(c(c....
4 4X7K ic50 = 4 nM 3Z3 C33 H27 F N6 O2 Cc1ccc(c(c....
5 4X7L ic50 = 9 nM 3Z4 C32 H27 N5 O2 S Cc1ccc(c(c....
6 4X7N ic50 = 6 nM 3Z5 C34 H28 N4 O2 Cc1ccc(c(c....
7 1ZY5 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 373
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 AP5 0.802632 0.945205
5 ADP 0.802632 0.972222
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 HEJ 0.772152 0.972222
9 ATP 0.772152 0.972222
10 AT4 0.769231 0.933333
11 AN2 0.769231 0.986111
12 5FA 0.7625 0.972222
13 AQP 0.7625 0.972222
14 M33 0.759494 0.932432
15 MAP 0.752941 0.972973
16 ACP 0.75 0.945946
17 AR6 0.740741 0.945205
18 APR 0.740741 0.945205
19 ACQ 0.73494 0.945946
20 AD9 0.731707 0.945946
21 SAP 0.731707 0.921053
22 AGS 0.731707 0.921053
23 A 0.723684 0.944444
24 AMP 0.723684 0.944444
25 ATF 0.717647 0.933333
26 ADX 0.716049 0.851852
27 CA0 0.716049 0.92
28 6YZ 0.709302 0.945946
29 50T 0.707317 0.932432
30 PRX 0.698795 0.87013
31 ABM 0.696203 0.893333
32 AP2 0.679012 0.933333
33 A12 0.679012 0.933333
34 APC 0.678571 0.933333
35 T99 0.674419 0.933333
36 TAT 0.674419 0.933333
37 A22 0.674157 0.958904
38 SRA 0.670886 0.894737
39 SRP 0.670455 0.883117
40 5AL 0.666667 0.906667
41 A1R 0.659341 0.884615
42 ADQ 0.659341 0.92
43 A3R 0.659341 0.884615
44 3OD 0.648936 0.92
45 BIS 0.648936 0.909091
46 5SV 0.648352 0.82716
47 9X8 0.645161 0.896104
48 OAD 0.645161 0.92
49 25L 0.642105 0.958904
50 AMO 0.641304 0.907895
51 G5P 0.636364 0.897436
52 DLL 0.634409 0.906667
53 AHX 0.634409 0.897436
54 00A 0.634409 0.860759
55 ADV 0.632184 0.907895
56 RBY 0.632184 0.907895
57 ADP PO3 0.632184 0.917808
58 NB8 0.631579 0.897436
59 25A 0.630435 0.945205
60 OOB 0.630435 0.906667
61 8QN 0.630435 0.906667
62 G3A 0.626263 0.897436
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 TXA 0.614583 0.907895
67 1ZZ 0.614583 0.819277
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 9ZD 0.612903 0.909091
71 9ZA 0.612903 0.909091
72 3UK 0.610526 0.894737
73 SON 0.604651 0.907895
74 ADP ALF 0.604396 0.848101
75 ALF ADP 0.604396 0.848101
76 PR8 0.604167 0.829268
77 B5V 0.604167 0.883117
78 WAQ 0.604167 0.860759
79 4UV 0.6 0.871795
80 GAP 0.6 0.87013
81 PTJ 0.597938 0.873418
82 FYA 0.597938 0.881579
83 VO4 ADP 0.597826 0.906667
84 ADP VO4 0.597826 0.906667
85 LMS 0.597561 0.829268
86 UP5 0.596154 0.896104
87 FA5 0.59596 0.883117
88 YAP 0.59596 0.871795
89 PAP 0.595506 0.958333
90 A4P 0.59434 0.823529
91 XAH 0.59 0.841463
92 4UU 0.588235 0.871795
93 AFH 0.588235 0.8625
94 9SN 0.585859 0.85
95 2A5 0.58427 0.894737
96 T5A 0.583333 0.821429
97 DQV 0.582524 0.932432
98 NAI 0.580952 0.884615
99 B5M 0.58 0.871795
100 B5Y 0.58 0.871795
101 ITT 0.579545 0.917808
102 ATR 0.577778 0.944444
103 OMR 0.575472 0.831325
104 5AS 0.574713 0.781609
105 YLP 0.571429 0.8
106 48N 0.571429 0.873418
107 AP0 0.570093 0.873418
108 4TC 0.570093 0.873418
109 7D3 0.569767 0.881579
110 ADJ 0.568807 0.831325
111 GNP 0.568421 0.922078
112 9GM 0.568421 0.922078
113 DAL AMP 0.568421 0.881579
114 6V0 0.566038 0.873418
115 TXD 0.566038 0.884615
116 DND 0.566038 0.907895
117 NAX 0.566038 0.851852
118 4UW 0.566038 0.839506
119 NXX 0.566038 0.907895
120 XYA 0.565789 0.821918
121 RAB 0.565789 0.821918
122 ADN 0.565789 0.821918
123 AOC 0.564706 0.8
124 7D4 0.561798 0.881579
125 ADP BMA 0.561224 0.894737
126 TXE 0.560748 0.884615
127 TYM 0.560748 0.883117
128 GA7 0.557692 0.883117
129 YLC 0.555556 0.819277
130 YLB 0.555556 0.8
131 139 0.554545 0.851852
132 5N5 0.551282 0.797297
133 JB6 0.55 0.860759
134 LAQ 0.54717 0.819277
135 F2R 0.544643 0.843373
136 MYR AMP 0.544554 0.797619
137 5CD 0.544304 0.783784
138 A4D 0.544304 0.797297
139 80F 0.54386 0.821429
140 7MD 0.542857 0.864198
141 6AD 0.542553 0.886076
142 A2R 0.541667 0.958904
143 UPA 0.541284 0.884615
144 YLA 0.540541 0.8
145 A A 0.54 0.918919
146 BTX 0.539823 0.821429
147 COD 0.539823 0.793103
148 HFD 0.537634 0.921053
149 G5A 0.537634 0.781609
150 3DH 0.535714 0.753247
151 AYB 0.535714 0.790698
152 CNA 0.535714 0.907895
153 BT5 0.535088 0.811765
154 ATP A A A 0.533981 0.905405
155 IOT 0.531532 0.811765
156 MTA 0.53012 0.753247
157 3AM 0.529412 0.90411
158 A3P 0.52809 0.944444
159 PPS 0.526316 0.851852
160 NAD 0.526316 0.906667
161 EP4 0.52439 0.734177
162 7D5 0.52381 0.855263
163 AMP DBH 0.52381 0.87013
164 J7C 0.522727 0.75
165 A5A 0.520833 0.809524
166 EAD 0.520661 0.851852
167 TSB 0.520408 0.821429
168 AHZ 0.518519 0.797619
169 DTA 0.518072 0.766234
170 M2T 0.518072 0.716049
171 A3D 0.517241 0.894737
172 6RE 0.517241 0.740741
173 YLY 0.516949 0.790698
174 SSA 0.515464 0.802326
175 NA7 0.514852 0.933333
176 ARG AMP 0.514019 0.809524
177 AR6 AR6 0.514019 0.893333
178 7MC 0.513514 0.843373
179 A2P 0.511111 0.930556
180 52H 0.510204 0.781609
181 VMS 0.510204 0.790698
182 54H 0.510204 0.790698
183 TYR AMP 0.509434 0.848101
184 TAD 0.509259 0.8625
185 NAQ 0.508333 0.85
186 A3N 0.505618 0.766234
187 AV2 0.505155 0.893333
188 53H 0.50505 0.781609
189 5CA 0.50505 0.802326
190 8X1 0.50505 0.755556
191 ARU 0.504951 0.839506
192 ZID 0.504132 0.894737
193 P1H 0.504 0.831325
194 NAE 0.5 0.871795
195 3AT 0.5 0.945205
196 AVV 0.5 0.873418
197 P5A 0.495146 0.747253
198 NSS 0.49505 0.802326
199 LSS 0.49505 0.764045
200 DSZ 0.49505 0.802326
201 N0B 0.491803 0.8
202 AF3 ADP 3PG 0.491071 0.817073
203 NVA LMS 0.490196 0.755556
204 DAT 0.489362 0.881579
205 IMO 0.488889 0.90411
206 ZAS 0.488636 0.792208
207 FDA 0.488372 0.813953
208 NAJ PZO 0.487395 0.85
209 4TA 0.487179 0.788235
210 LPA AMP 0.486486 0.797619
211 LEU LMS 0.485437 0.755556
212 DTP 0.484536 0.881579
213 V3L 0.484536 0.945205
214 S4M 0.483516 0.651685
215 GJV 0.483516 0.731707
216 DZD 0.483051 0.8625
217 2AM 0.482759 0.917808
218 5AD 0.481013 0.726027
219 GSU 0.480769 0.781609
220 KAA 0.480769 0.755556
221 NDE 0.480315 0.907895
222 M24 0.479339 0.851852
223 MAO 0.478261 0.761905
224 NEC 0.477778 0.727273
225 DSH 0.477778 0.707317
226 FAS 0.477273 0.831325
227 FAD 0.477273 0.831325
228 RGT 0.476636 0.933333
229 9K8 0.47619 0.698925
230 G A A A 0.474576 0.85
231 0WD 0.474576 0.897436
232 FNK 0.474074 0.786517
233 5X8 0.473684 0.74359
234 6FA 0.473282 0.821429
235 NDC 0.472868 0.85
236 FB0 0.472868 0.786517
237 YSA 0.472222 0.781609
238 7DD 0.468085 0.958333
239 OVE 0.466667 0.881579
240 MHZ 0.463158 0.701149
241 8PZ 0.462963 0.802326
242 A G 0.462185 0.860759
243 AMP NAD 0.462185 0.881579
244 A3G 0.461538 0.779221
245 NAJ PYZ 0.459677 0.809524
246 6C6 0.459184 0.858974
247 SFG 0.458333 0.730769
248 U A G G 0.458333 0.860759
249 7D7 0.45679 0.723684
250 128 0.45614 0.8
251 SFD 0.455224 0.736842
252 6IA 0.454545 0.817073
253 DDS 0.454545 0.855263
254 GDP 0.454545 0.896104
255 ODP 0.453782 0.886076
256 NJP 0.453782 0.921053
257 7DT 0.453608 0.958333
258 A7D 0.452632 0.75641
259 Z5A 0.452381 0.802326
260 WSA 0.452174 0.790698
261 U A 0.45082 0.884615
262 7C5 0.45045 0.797468
263 FAY 0.449275 0.841463
264 NDP 0.449153 0.897436
265 SA8 0.44898 0.690476
266 A5D 0.44898 0.766234
267 71V 0.446809 0.884615
268 GGZ 0.446602 0.804878
269 RFL 0.446043 0.802326
270 2SA 0.445545 0.907895
271 SAI 0.444444 0.716049
272 GP3 0.444444 0.897436
273 SAH 0.444444 0.725
274 PO4 PO4 A A A A PO4 0.443396 0.878378
275 A A A 0.443396 0.881579
276 4YB 0.442478 0.764045
277 SMM 0.441176 0.670455
278 S7M 0.441176 0.674419
279 GTP 0.441176 0.896104
280 Y3J 0.440476 0.706667
281 SAM 0.44 0.674419
282 649 0.439655 0.747253
283 12D 0.438596 0.809524
284 A3S 0.4375 0.789474
285 NPW 0.436975 0.864198
286 GCP 0.436893 0.873418
287 AAT 0.435644 0.690476
288 GNH 0.435644 0.909091
289 EEM 0.435644 0.674419
290 ETB 0.435484 0.813953
291 DCA 0.435484 0.804598
292 N6P 0.433962 0.890411
293 NZQ 0.433333 0.886076
294 TXP 0.433333 0.897436
295 PGS 0.43299 0.860759
296 APU 0.432203 0.871795
297 PUA 0.432 0.8625
298 62F 0.431655 0.841463
299 F2N 0.431507 0.795455
300 DA 0.430108 0.855263
301 D5M 0.430108 0.855263
302 J7V 0.429688 0.813953
303 NIA 0.428571 0.848101
304 COA 0.428571 0.804598
305 6K6 0.428571 0.905405
306 A3T 0.428571 0.8
307 0T1 0.428571 0.804598
308 P5F 0.427586 0.804598
309 AAM 0.425532 0.944444
310 0UM 0.424528 0.682353
311 8Q2 0.423729 0.775281
312 G1R 0.423077 0.884615
313 AMZ 0.422222 0.891892
314 C2R 0.422222 0.88
315 A U 0.420168 0.848101
316 IDP 0.42 0.894737
317 GSP 0.419048 0.851852
318 30N 0.418605 0.736842
319 CAO 0.418605 0.777778
320 DG1 0.418605 0.897436
321 1DG 0.418605 0.897436
322 COS 0.418605 0.786517
323 AMX 0.418605 0.813953
324 TM1 0.418182 0.797619
325 A6D 0.416667 0.746988
326 K15 0.416667 0.666667
327 V1N 0.415929 0.893333
328 CMX 0.415385 0.804598
329 SCO 0.415385 0.804598
330 GEK 0.415094 0.719512
331 XNP 0.414634 0.851852
332 NHD 0.414634 0.881579
333 9JJ 0.413793 0.841463
334 AIR 0.413793 0.876712
335 COK 0.413534 0.786517
336 G2R 0.412844 0.8625
337 ACO 0.412214 0.777778
338 FAM 0.412214 0.786517
339 FCX 0.412214 0.777778
340 NAP 0.410853 0.92
341 FA9 0.409396 0.843373
342 SXZ 0.409091 0.694118
343 HAX 0.409091 0.806818
344 TAP 0.407692 0.884615
345 2MC 0.407407 0.752688
346 62X 0.407407 0.651685
347 GKE 0.40708 0.8625
348 GDC 0.40708 0.8625
349 GDD 0.40708 0.8625
350 3KK 0.406015 0.786517
351 FYN 0.406015 0.804598
352 NVA 2AD 0.405941 0.740741
353 NA0 0.40458 0.907895
354 101 0.404255 0.855263
355 G 0.40404 0.883117
356 5GP 0.40404 0.883117
357 HDV 0.403846 0.87013
358 MGP 0.403846 0.8625
359 OXK 0.402985 0.786517
360 MCD 0.402985 0.786517
361 CA6 0.402985 0.714286
362 SOP 0.402985 0.786517
363 3AD 0.402299 0.783784
364 S8M 0.401869 0.78481
365 YE1 0.40146 0.795455
366 NMX 0.4 0.782609
367 7RP 0.4 0.902778
368 2VA 0.4 0.779221
369 1VU 0.4 0.777778
370 CO6 0.4 0.786517
371 CMC 0.4 0.786517
372 6G0 0.4 0.8625
373 GMV 0.4 0.873418
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1ZY5; Ligand: ANP; Similar sites found with APoc: 504
This union binding pocket(no: 1) in the query (biounit: 1zy5.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
1 5C1P ADP 0.990099
2 5C1P DAL DAL 0.990099
3 1YXM ADE 1.32013
4 3SHR CMP 1.33779
5 3OCP CMP 1.43885
6 1EHI ADP 1.65016
7 3BP1 GUN 1.72414
8 4WOP CTP 1.77778
9 1TZD ADP 1.81818
10 4B1L FRU 1.81818
11 1W2D ADP 1.88679
12 1W2D 4IP 1.88679
13 4DDY DN6 1.90114
14 1F5F DHT 1.95122
15 1I7L ATP 1.9802
16 5W75 SUC 1.9802
17 2R7K ACP 1.9802
18 2R7K AMZ 1.9802
19 5IVE 6E8 1.9802
20 1SDW IYT 1.9802
21 5TG5 JW8 2.04082
22 5L3R GCP 2.04778
23 3VPC ADP 2.12766
24 4CS4 AXZ 2.18978
25 1KDK DHT 2.25989
26 4LH7 1X8 2.31023
27 3AKK ADP 2.31023
28 3WVR AMP 2.31023
29 1M0W ANP 2.31023
30 2XZ9 PYR 2.31023
31 1GPM AMP 2.31023
32 1GSA ADP 2.31023
33 4MOB ADP 2.31023
34 2G30 ALA ALA PHE 2.32558
35 5D9G GLU ASN LEU TYR PHE GLN 2.43902
36 4NFE BEN 2.53165
37 3T4L ZEA 2.59259
38 4XYM A12 2.6087
39 5C4L 4XR 2.64026
40 2PYW ADP 2.64026
41 5C4L SIS 2.64026
42 5YJS SAL 2.64026
43 4R78 AMP 2.64026
44 4RDL FUC GAL NDG FUC 2.64026
45 2CFM AMP 2.64026
46 4DFU QUE 2.64026
47 3DNT ATP 2.64026
48 5IM3 DTP 2.64026
49 3V4S ADP 2.64026
50 3V4S ATP 2.64026
51 2YGO PCF 2.65957
52 4XTX 590 2.96296
53 4OUC 5ID 2.9703
54 6FL8 TIY 2.9703
55 6FL8 ADP 2.9703
56 6G34 5ID 2.9703
57 4OCJ NDG 2.9703
58 3UDZ ADP 2.9703
59 2Q7D ANP 2.9703
60 5GZ9 ANP 2.9703
61 4ZS4 ATP 2.9703
62 5KJW 53C 2.9703
63 4YRI 4JH 2.9703
64 4OCV ANP 2.9703
65 1ZB6 GST 2.9703
66 5TDF ADP 2.9703
67 2DXU BT5 2.97872
68 1WPY BTN 2.97872
69 1GT4 UNA 3.14465
70 2YGN PCF 3.20513
71 4O4F IHP 3.22581
72 4O4F ATP 3.22581
73 3PDT ADP 3.27273
74 2QK4 ATP 3.30033
75 3I0O ADP 3.30033
76 4PZ6 GMP 3.30033
77 3KAL ADP 3.30033
78 3A16 PXO 3.30033
79 4WOE ADP 3.30033
80 5AE9 OKO 3.30033
81 3CBC DBS 3.53535
82 3VPB ADP 3.57143
83 2CBT TH2 3.57143
84 2PUL ACP 3.63036
85 2V58 LZJ 3.63036
86 6F3M NAD 3.63036
87 5GUD NDP 3.63036
88 3M3E GAL A2G NPO 3.72671
89 2ART LPA AMP 3.81679
90 4XZ3 ACP 3.91304
91 4CC6 L5Y 3.9604
92 1T36 ADP 3.9604
93 6C1S EFV 3.9604
94 2VQD AP2 3.9604
95 3A06 NDP 3.9604
96 4U98 ACP 3.9604
97 2FB3 MET 3.9604
98 3Q8G PEE 3.9604
99 1LSH PLD 3.9604
100 2QF7 AGS 3.9604
101 5M67 ADE 3.9604
102 5M67 NAD 3.9604
103 5M67 3D1 3.9604
104 1ZTH ADP 4.26357
105 3RE4 TO1 4.26357
106 1ZP9 ATP 4.26357
107 4WW7 AMP 4.27807
108 5MW8 ATP 4.29043
109 2IO8 ADP 4.29043
110 4NZN 2OU 4.29043
111 4NZN ANP 4.29043
112 1V8B NAD 4.29043
113 1P6O HPY 4.34783
114 1Y7P RIP 4.4843
115 1M26 GAL A2G 4.51128
116 2XG5 EC5 4.58716
117 2XG5 EC2 4.58716
118 3VOT ADP 4.62046
119 1Z2P I3S 4.62046
120 1Z2P ACP 4.62046
121 2HGS ADP 4.62046
122 4GLW 0XT 4.62046
123 2VL1 GLY GLY 4.62046
124 1IOW PHY 4.62046
125 1IOW ADP 4.62046
126 4B2Z P5S 4.62046
127 3KVY URA 4.62046
128 5LXT ACP 4.6875
129 4NJH 2K8 4.78261
130 4NJH SAM 4.78261
131 3ZJX BOG 4.84429
132 3TDV GDP 4.9505
133 3W0O ADP 4.9505
134 3W0O HY0 4.9505
135 2VPQ ANP 4.9505
136 3SAO DBH 5
137 6CC0 EWM 5.06329
138 5OES ADP 5.28053
139 5DZT AMP 5.28053
140 3WO0 ADP 5.28053
141 3WO0 ALA 5.28053
142 3E2M E2M 5.40541
143 1AUX AGS 5.61056
144 4PU5 ANP 5.61056
145 2QX0 PH2 5.66038
146 2BKK ADP 5.68182
147 3HAV ATP 5.68562
148 3TM0 B31 5.70342
149 3TM0 ANP 5.70342
150 4GYI ADP 5.94059
151 5MRH Q9Z 5.94059
152 3X01 AMP 5.94059
153 5A0U CHT 5.94059
154 2ET1 GLV 5.97015
155 3PAK MAN 6.08108
156 2UYN 2KT 6.20155
157 2AQX ATP 6.22837
158 3ORQ ADP 6.27063
159 3VPD ANP 6.40569
160 1S68 AMP 6.4257
161 3TII ANP 6.60066
162 5ZCT ANP 6.60066
163 1OBD ATP 6.60066
164 5DQ8 FLF 6.66667
165 5HWV MBN 6.92308
166 5EQY 5RA 6.93069
167 4UWH JXM 6.93069
168 2YW2 ATP 7.26073
169 3K5I ADP 7.26073
170 3K5I AIR 7.26073
171 2Z48 NGA 7.26073
172 6G9I CXX 7.26073
173 4MVK ACE VAL PHE PHE ALA GLU ASP NH2 7.44681
174 4NG2 OHN 7.6087
175 5VLQ ANP 7.92079
176 5VZ0 ADP 7.92079
177 5Y72 DST 7.92079
178 5G48 1FL 7.92079
179 1WW5 SGA BGC 8.125
180 6D6L FY4 8.23529
181 4WVO 3UZ 8.28729
182 5DYO FLU 8.49057
183 6CGD GNP 8.58086
184 6CGD AKN 8.58086
185 4AZW ATP 8.58086
186 5LRT ADP 8.58086
187 1E4E ADP 8.58086
188 5OLK DTP 8.58086
189 4FE2 AIR 8.58086
190 1G51 AMO 8.91089
191 4IX4 ADP 9.24092
192 4ZGP ADP 9.24092
193 2GQS C2R 9.2827
194 2GQS ADP 9.2827
195 5ML3 DL3 9.39597
196 2VDF OCT 9.48617
197 2IF8 ADP 9.57096
198 3UG4 AHR 9.57096
199 1KJ8 ATP 9.57096
200 1KJ8 GAR 9.57096
201 2GQR ADP 9.70464
202 2AG4 LP3 9.7561
203 2AG4 OLA 9.7561
204 5M06 ADP 9.78261
205 2YRX AMP 9.90099
206 5G5G MCN 10.0437
207 4LRJ ANP 10.0592
208 6AC9 ANP 10.231
209 3ETH ATP 10.4225
210 1PK8 ATP 10.4265
211 5I35 ANP 10.5611
212 3PN1 IVH 10.8911
213 4O1P ANP 11.5512
214 4CYI ATP 11.5512
215 5YK1 ANP 11.5512
216 4XMF HSM 11.9565
217 3CF6 SP1 12.5749
218 2BMB PMM 12.8713
219 4OAV ACP 13.2013
220 4RF7 ARG 13.5314
221 1FFU FAD 14.1914
222 2E5A LAQ 14.5215
223 3Q60 ATP 15.5116
224 1VBH PEP 15.5116
225 1TQP ATP 15.6028
226 1B7Y FYA 16.2857
227 6GZD LCI 16.5016
228 5OKT 9XK 16.5016
229 5W4W 9WG 16.5016
230 4G17 0VN 16.5016
231 4KBA 1QM 16.5016
232 4XH0 ADP 16.8317
233 5CKW ANP 17.1617
234 4MV1 ADP 17.1617
235 4Q5H ANP 17.3077
236 1Q8Y ADE 17.4917
237 4WOV 3SM 17.4917
238 1Q8Y ADP 17.4917
239 5C03 AGS 17.8218
240 2CSN CKI 18.1818
241 3VHE 42Q 18.4818
242 5K2M ADP 20.7547
243 5U6C 7YS 22.1122
244 3PP0 03Q 23.1023
245 4P5Z Q7M 23.1023
246 2Y6O 1N1 23.3677
247 6GWR FEW 23.7624
248 4YMJ 4EJ 24.4224
249 4Y0X ADP 24.7525
250 2PZI AXX 24.7525
251 5JFS 6K0 25.7426
252 4AT3 LTI 25.7525
253 4XIZ LPP 27.1429
254 5N87 N66 27.3927
255 4JR7 GNP 27.7228
256 3HMO STU 27.7228
257 5TO8 7FM 28.3688
258 4F9C 0SX 28.7129
259 4FL3 ANP 29.3729
260 1OPK P16 29.3729
261 3M2W L8I 29.4314
262 2XVD AS6 29.4702
263 3KMW ATP 29.8893
264 4I94 ANP 30.3333
265 5NKB 8ZT 30.6931
266 5EH0 5NW 31.0078
267 4Y93 746 31.0231
268 5MJA 7O3 31.0231
269 5DMZ ADP 31.0231
270 2WU6 DKI 31.3531
271 3GNI ATP 31.6832
272 5OMY 9YE 31.7136
273 5Y86 HRM 32.0132
274 4EUU BX7 32.0132
275 3FHR P4O 32.0132
276 5T8O 76Z 32.0132
277 4IJP 1EH 32.0132
278 4NFN 2KC 32.3432
279 3SRV S19 32.491
280 4M69 ANP 32.5879
281 4BTK DTQ 32.6733
282 5ZTN CUR 32.6733
283 4F4P 0SB 32.967
284 6BFN DL1 33.0033
285 2PVN P63 33.2386
286 2QLU ADE 33.3333
287 5KO1 6UY 33.5689
288 4TWP AXI 33.5793
289 5JKG 6LF 33.6634
290 3KRL KRL 33.6634
291 3LXN MI1 33.9934
292 5QIN J2V 33.9934
293 3VRY B43 33.9934
294 4GJ3 0XP 34.106
295 5HES 032 34.3234
296 3H9R TAK 34.3234
297 1VJY 460 34.3234
298 5EKO N17 34.3234
299 6GU6 1QK 34.4371
300 5HQ0 LZ9 34.4371
301 3E8N VRA 34.6535
302 3E8N ATP 34.6535
303 6FYV 3NG 34.6535
304 5HCY 60D 34.6535
305 1U5R ATP 34.6535
306 5EFQ ADP 34.6535
307 4CLI 5P8 34.9835
308 6FYL 3NG 34.9835
309 4E1Z 0MX 35.0515
310 5FBN 5WF 35.0554
311 1U59 STU 35.1916
312 6GIN IR2 35.2159
313 1BYG STU 35.2518
314 5UR1 YY9 35.3135
315 4CRL C1I 35.3135
316 3E7O 35F 35.3135
317 5UIU 8CG 35.6037
318 4EWH T77 35.6364
319 3PTG 932 35.6436
320 3LXK MI1 35.6436
321 4CFU 2WC 35.6436
322 3TTI KBI 35.6436
323 4WHZ 3NL 35.6436
324 4IDT T28 35.6436
325 5YF9 NIO 35.6932
326 6GUE FB8 35.7616
327 4AU8 Z3R 35.8108
328 4BCM T7Z 35.8804
329 4BCQ TJF 35.8804
330 2BPM 529 35.9736
331 4OH4 ANP 35.9736
332 3GQI ACP 35.9736
333 4UAL 3FV 35.9736
334 4BCN T9N 36
335 3PE2 E1B 36.2018
336 1UNH IXM 36.3014
337 3O0G 3O0 36.3014
338 5LPZ ADP 36.3036
339 3ORK AGS 36.3036
340 4ASE AV9 36.3036
341 4AG8 AXI 36.3036
342 5LMK 6ZK 36.3636
343 2XMY CDK 36.5772
344 3UIM ANP 36.6337
345 4K33 ACP 36.6337
346 4E93 GUI 36.6337
347 5LPB ADP 36.8243
348 4RFM 3P6 36.8421
349 3TXO 07U 36.9637
350 2H8H H8H 36.9637
351 2B9I ADP 36.9637
352 4CSV STI 37.0909
353 2HY0 306 37.2937
354 2PVF ACP 37.2937
355 5EOB 5QQ 37.2937
356 3RI1 3RH 37.2937
357 3TKI S25 37.2937
358 1Y57 MPZ 37.6238
359 3C1X CKK 37.6238
360 5WO4 B7V 37.7483
361 5WNL STU 37.9538
362 5LI9 ACP 37.9538
363 4U0I 0LI 37.9538
364 5LI1 ANP 37.9538
365 3GC8 B45 37.9538
366 4USF 6UI 37.9538
367 2HK5 1BM 38.1481
368 1V0O INR 38.1944
369 4DC2 ADE 38.2838
370 4UXL 5P8 38.2838
371 4X7Q 3YR 38.2838
372 4U44 3D9 38.2838
373 5AX9 4KT 38.2838
374 3PLS ANP 38.5906
375 3ZRM ZRM 38.6139
376 3F7Z 34O 38.6139
377 4NM5 ADP 38.6139
378 5X8I SQZ 38.6139
379 2JLD AG1 38.6139
380 6G33 5ID 38.6139
381 1OUK 084 38.9439
382 4AUA 4AU 38.9439
383 4LOO SB4 38.9439
384 4QTB 38Z 38.9439
385 6F3G CJN 38.9831
386 3G5D 1N1 39.1608
387 3GC0 AMP 39.2739
388 3NW7 LGV 39.2739
389 1IR3 ANP 39.2739
390 1CM8 ANP 39.2739
391 4WNP 3RJ 39.3728
392 5USZ SKE 39.4464
393 1K3A ACP 39.4649
394 5BVE 4VG 39.604
395 3BU5 ATP 39.604
396 6ES0 BW8 39.604
397 4YZN 4K5 39.7213
398 6C7Y ADP 39.8601
399 1JPA ANP 39.934
400 4H3P ANP 39.934
401 5AWM ANP 39.934
402 4H3Q ANP 39.934
403 3EKK GS2 39.934
404 4XV1 904 40.0685
405 2X2M X2M 40.264
406 4WNK 453 40.264
407 5CEO 50D 40.3333
408 3C0G 3AM 40.5941
409 2OO8 RAJ 40.5941
410 4YZC STU 40.5941
411 4L9I 8PR 40.9241
412 4PNI KQQ 40.9241
413 3CY2 MB9 40.9241
414 3BZ3 YAM 40.942
415 5Y80 IRE 41.2541
416 4L3L 5FI 41.2541
417 4Y8D 49J 41.2541
418 4N70 2HX 41.5842
419 6GQM F8H 41.5842
420 2WEL K88 41.9142
421 4CQE CQE 42.0863
422 3SXS PP2 42.1642
423 2VN9 GVD 42.1927
424 5HVJ ANP 42.2442
425 2VZ6 FEF 42.2442
426 2V7O DRN 42.5743
427 5UPK ANP 42.5743
428 3PVW QRX 42.5743
429 5UKL SIX 42.5743
430 4Y85 499 42.5743
431 5TA6 79D 42.9043
432 4OTH DRN 42.9043
433 4I6H 1C8 42.9043
434 6BXI ANP 42.9043
435 3FC2 IBI 42.9043
436 3KN5 ANP 43.2343
437 1XJD STU 43.2343
438 4UX9 ANP 43.5644
439 5VCV 1N1 43.5644
440 5DRB 5FJ 43.6426
441 2OFV 242 43.6823
442 5IH9 6BF 43.8944
443 3MVH WFE 43.8944
444 3DLS ADP 43.8944
445 6CMJ F6J 43.8944
446 6A1G 9OL 43.8944
447 5XVG 8FX 44.0273
448 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 44.2244
449 2JDR L20 44.2244
450 2Z7R STU 44.2244
451 4NST AF3 44.2244
452 4BFM ANP 44.2244
453 4NST ADP 44.2244
454 6C0T EE4 44.2244
455 3ALN ANP 44.2244
456 3V8S 0HD 44.5545
457 4WB6 ATP 44.5545
458 4FG8 ATP 44.5545
459 5DEY 59T 44.7811
460 2GU8 796 44.8845
461 2WQN ADP 44.8845
462 3IDB ANP 44.8845
463 2QCS ANP 44.8845
464 4WB7 ATP 44.8845
465 3FHI ANP 44.8845
466 1RE8 BD2 44.8845
467 2YAK OSV 44.9123
468 6E2O S0L 45.0847
469 4NW6 2NS 45.2145
470 2YAB AMP 45.2145
471 5DBX ANP 45.2145
472 4QMN DB8 45.2145
473 5H2U 1N1 45.3184
474 5VC5 96M 45.3287
475 2J7T 274 45.3642
476 3SLS ANP 45.5446
477 2R5T ANP 45.5446
478 5A6N U7E 45.583
479 2ZV2 609 45.6376
480 1PHK ATP 45.6376
481 5JZJ AN2 45.7912
482 6CZ3 FLJ 45.8333
483 2XK9 XK9 45.8746
484 4BHN BH9 45.8746
485 5LVP ATP 46.2046
486 3GGF GVD 46.2046
487 4KS7 X4Z 46.2329
488 4C2V YJA 46.3158
489 3AQV TAK 46.3768
490 3IGO ANP 46.5347
491 3RWP ABQ 46.8647
492 5DH3 5BS 46.8647
493 3DAK ANP 46.8966
494 2RIO ADP 47.1947
495 4C2W ANP 47.3118
496 5L8L ADP 47.3684
497 5G1X ADP 47.3684
498 5LXM ADP 47.7032
499 4ONA UW1 47.8548
500 5ODT ADP 48.0565
501 6CQF F97 48.1481
502 5EYK 5U5 48.1884
503 2WEI VGG 49.1289
504 5EW9 5VC 49.4465
Pocket No.: 2; Query (leader) PDB : 1ZY5; Ligand: ANP; Similar sites found with APoc: 25
This union binding pocket(no: 2) in the query (biounit: 1zy5.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 5CGE 51F 2.16606
2 2WKQ GTP 2.31023
3 6EOM ALA LYS 2.31023
4 5Z46 8XL 2.31023
5 4XT8 TMQ 2.32558
6 5KD6 6C7 2.64026
7 1UNQ 4IP 3.2
8 2CDC XYP 3.30033
9 2CDC XYS 3.30033
10 2CDC NAP 3.30033
11 4K38 SAM 3.30033
12 5TT6 ATP 3.63036
13 1MH1 GNP 3.76344
14 2H29 DND 4.2328
15 3OV6 MK0 4.62046
16 4XJ7 ADE 4.86891
17 6BE3 NAG 5.06912
18 4KYS VIB 7.59076
19 1TX4 ALF GDP 7.9096
20 2BRY FAD 8.65191
21 1NF3 GNP 11.7188
22 3LQV ADE 15.3846
23 1E96 GTP 19.7044
24 5FLJ QUE 27.4194
25 5UPK GNP 42.5743
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