Receptor
PDB id Resolution Class Description Source Keywords
1hkn 2 Å NON-ENZYME: BINDING A COMPLEX BETWEEN ACIDIC FIBROBLAST GROWTH FACTOR AND 5-AMIN NAPHTHALENESULFONATE HOMO SAPIENS GROWTH FACTOR MITOGEN ANGIOGENESIS HEPARIN-BINDING
Ref.: LEADS FOR DEVELOPMENT OF NEW NAPHTHALENESULFONATE DERIVATIVES WITH ENHANCED ANTIANGIOGENIC ACTIVITY: STRUCTURE OF ACIDIC FIBROBLAST GROWTH FACTOR IN COM 5-AMINO-2-NAPHTHALENESULFONATE J.BIOL.CHEM. V. 278 21774 2003
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
N2M C:4138;
D:5139;
 Valid;
Valid;
 none;
none;
 submit data
223.248 C10 H9 N O3 S c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3K1X 1.98 Å NON-ENZYME: BINDING ACIDIC FIBROBLAST GROWTH FACTOR (FGF-1) COMPLEXED WITH DOBES HOMO SAPIENS ACIDIC FIBROBLAST GROWTH FACTOR INHIBITORS ACETYLATION HO
Ref.: GENTISIC ACID, A COMPOUND ASSOCIATED WITH PLANT DEF A METABOLITE OF ASPIRIN, HEADS A NEW CLASS OF IN VI FIBROBLAST GROWTH FACTOR INHIBITORS. J.BIOL.CHEM. V. 285 11714 2010
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 3JUT - GTQ C7 H6 O4 c1cc(c(cc1....
2 1HKN - N2M C10 H9 N O3 S c1cc2cc(cc....
3 2UUS - GU4 YYJ n/a n/a
4 3K1X - DBX C6 H6 O5 S c1cc(c(cc1....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 3JUT - GTQ C7 H6 O4 c1cc(c(cc1....
2 1HKN - N2M C10 H9 N O3 S c1cc2cc(cc....
3 2UUS - GU4 YYJ n/a n/a
4 3K1X - DBX C6 H6 O5 S c1cc(c(cc1....
50% Homology Family (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 181 families.
1 3JUT - GTQ C7 H6 O4 c1cc(c(cc1....
2 1HKN - N2M C10 H9 N O3 S c1cc2cc(cc....
3 2UUS - GU4 YYJ n/a n/a
4 3K1X - DBX C6 H6 O5 S c1cc(c(cc1....
5 1BFC - SGN IDS SGN IDS SGN UAP n/a n/a
6 1BFB - SGN IDS SGN UAP n/a n/a
7 4OEE Kd = 1.73 uM IDY GNX n/a n/a
8 4OEG Kd = 9.01 uM IDY SUS n/a n/a
9 4OEF Kd = 17.5 uM IDY SGN n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: N2M; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 N2M 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: N2M; Similar ligands found: 642
No: Ligand Similarity coefficient
1 H2B 1.0000
2 SKF 0.9790
3 SG2 0.9596
4 IL5 0.9582
5 MAJ 0.9565
6 4R1 0.9526
7 EVF 0.9512
8 G6P 0.9502
9 BG6 0.9502
10 V1T 0.9491
11 GO8 0.9469
12 5GT 0.9456
13 0JD 0.9436
14 2O6 0.9432
15 9ZE 0.9424
16 PMP 0.9422
17 A5P 0.9394
18 EUE 0.9388
19 S0E 0.9388
20 IOS 0.9387
21 ARP 0.9383
22 EXD 0.9380
23 GNM 0.9375
24 15N 0.9364
25 PLP PMP 0.9349
26 PZP 0.9349
27 PLP 0.9347
28 ZEC 0.9344
29 APS 0.9339
30 PLR 0.9335
31 IAC 0.9331
32 SLS 0.9331
33 0FK 0.9329
34 P9E 0.9328
35 GLP 0.9325
36 E1T 0.9317
37 R9Y 0.9316
38 GJP 0.9315
39 HA5 0.9315
40 D6G 0.9302
41 N91 0.9299
42 CTE 0.9296
43 PXP 0.9292
44 5TY 0.9290
45 N1E 0.9287
46 JP2 0.9287
47 QMS 0.9283
48 1QV 0.9281
49 KTW 0.9281
50 GO2 0.9277
51 3VX 0.9272
52 KLV 0.9267
53 61M 0.9264
54 DTR 0.9259
55 6ZW 0.9255
56 428 0.9250
57 4CM 0.9249
58 ICB 0.9244
59 SNO 0.9243
60 JG8 0.9239
61 P0P 0.9239
62 27B 0.9236
63 ZHA 0.9232
64 6QF 0.9232
65 BZJ 0.9231
66 4NZ 0.9230
67 LR5 0.9228
68 3D3 0.9225
69 ESX 0.9221
70 36E 0.9220
71 1F1 0.9214
72 K97 0.9213
73 68A 0.9213
74 2K8 0.9211
75 ZYR 0.9210
76 X04 0.9204
77 NAG 0.9201
78 PNP 0.9199
79 BZ2 0.9197
80 ESI 0.9196
81 ESP 0.9195
82 STT 0.9192
83 4RU 0.9191
84 THA 0.9189
85 UFO 0.9188
86 0W1 0.9180
87 8XL 0.9174
88 M6D 0.9173
89 TSR 0.9165
90 MUX 0.9164
91 4NP 0.9163
92 8ZE 0.9162
93 12T 0.9160
94 8NX 0.9159
95 BPY 0.9159
96 E7S 0.9157
97 AN3 0.9155
98 1VK 0.9152
99 ANC 0.9149
100 KYA 0.9148
101 HBO 0.9144
102 8W9 0.9142
103 6FZ 0.9141
104 MP5 0.9140
105 2JK 0.9138
106 0HN 0.9136
107 BZE 0.9134
108 LOT 0.9132
109 1HN 0.9131
110 JAW 0.9128
111 6KT 0.9125
112 JB8 0.9125
113 M6P 0.9125
114 TMG 0.9121
115 HRM 0.9119
116 PPY 0.9119
117 BQ2 0.9118
118 3A9 0.9118
119 XCG 0.9117
120 FF2 0.9116
121 CC5 0.9116
122 8HC 0.9114
123 DHC 0.9111
124 ZYQ 0.9109
125 JF1 0.9109
126 KMY 0.9104
127 X0U 0.9103
128 4BY 0.9101
129 MD6 0.9100
130 HBI 0.9098
131 JF2 0.9097
132 JDN 0.9091
133 549 0.9091
134 6NI 0.9086
135 1L5 0.9086
136 363 0.9086
137 M5H 0.9086
138 H4B 0.9086
139 BGP 0.9084
140 2ZM 0.9084
141 6NT 0.9079
142 BIO 0.9079
143 9R5 0.9076
144 6FB 0.9076
145 0HO 0.9076
146 344 0.9076
147 RNO 0.9075
148 HHS 0.9075
149 3R4 0.9074
150 N2I 0.9066
151 5NI 0.9062
152 4LW 0.9062
153 5WN 0.9062
154 F5C 0.9060
155 CH9 0.9060
156 AM4 0.9057
157 6L6 0.9056
158 TRP 0.9055
159 2FX 0.9054
160 3NY 0.9054
161 3ZB 0.9053
162 BGU 0.9050
163 BHQ 0.9049
164 2HC 0.9049
165 TU0 0.9042
166 ANF 0.9042
167 DPT 0.9035
168 AZM 0.9033
169 J6W 0.9033
170 UNJ 0.9032
171 DNA 0.9027
172 GDL 0.9027
173 EYV 0.9027
174 4AB 0.9026
175 B21 0.9026
176 AA 0.9026
177 MXD 0.9025
178 LIP 0.9024
179 KDV 0.9023
180 DNF 0.9022
181 KYN 0.9021
182 8NB 0.9021
183 4BL 0.9019
184 I2E 0.9019
185 FBF 0.9018
186 SYE 0.9018
187 7I2 0.9015
188 RP3 0.9014
189 F2W 0.9014
190 X48 0.9013
191 5WT 0.9012
192 NPL 0.9011
193 ALE 0.9011
194 IOP 0.9009
195 9BF 0.9007
196 30G 0.9006
197 D9Z 0.9005
198 ZSP 0.9005
199 7AP 0.9004
200 GHM 0.9004
201 NDG 0.9003
202 JND 0.9001
203 6HP 0.9000
204 4MB 0.9000
205 9FE 0.8999
206 FQX 0.8996
207 3Y7 0.8994
208 0FR 0.8994
209 3J8 0.8992
210 92O 0.8990
211 4SX 0.8987
212 BP7 0.8986
213 657 0.8984
214 PH2 0.8984
215 S60 0.8984
216 TZP 0.8983
217 4I8 0.8980
218 Y3L 0.8980
219 PUE 0.8978
220 H5B 0.8978
221 4KL 0.8978
222 54X 0.8977
223 B4O 0.8976
224 4NS 0.8975
225 NLA 0.8974
226 QME 0.8970
227 ZIQ 0.8969
228 GNY 0.8964
229 6DP 0.8964
230 A6P 0.8962
231 4NB 0.8961
232 NPA 0.8961
233 M78 0.8959
234 QIV 0.8959
235 JTH 0.8959
236 A5Q 0.8958
237 LQ2 0.8958
238 LL1 0.8951
239 KF5 0.8950
240 YZM 0.8950
241 EV2 0.8947
242 FCD 0.8947
243 BNX 0.8945
244 6Q3 0.8944
245 HSX 0.8944
246 SRO 0.8944
247 9FL 0.8943
248 CHQ 0.8942
249 AY4 0.8942
250 2GQ 0.8941
251 PTS 0.8940
252 JTA 0.8938
253 0SY 0.8938
254 K4V 0.8936
255 IPD 0.8936
256 DK1 0.8936
257 L22 0.8936
258 9CA 0.8934
259 GZ2 0.8933
260 EN1 0.8933
261 2HU 0.8933
262 8WT 0.8933
263 3W8 0.8929
264 DBS 0.8928
265 GF4 0.8927
266 R20 0.8925
267 YTX 0.8925
268 5WS 0.8925
269 X0T 0.8924
270 XDE 0.8921
271 ABF 0.8920
272 ZRK 0.8919
273 0J4 0.8918
274 KWB 0.8918
275 CKA 0.8918
276 5RO 0.8917
277 ITE 0.8916
278 GNV 0.8915
279 ABI 0.8912
280 4WL 0.8912
281 1PS 0.8911
282 X11 0.8910
283 EGR 0.8910
284 MRW 0.8907
285 0XT 0.8907
286 1IT 0.8906
287 M3Q 0.8905
288 M3E 0.8904
289 PJW 0.8904
290 8WO 0.8903
291 92P 0.8899
292 CSN 0.8898
293 BIK 0.8892
294 CNI 0.8891
295 HHR 0.8891
296 4XF 0.8890
297 AH9 0.8889
298 VXX 0.8888
299 TWO 0.8886
300 ZME 0.8886
301 BVA 0.8886
302 P80 0.8886
303 3VQ 0.8886
304 C9E 0.8885
305 F4E 0.8881
306 A29 0.8878
307 I4D 0.8877
308 1A7 0.8876
309 AX3 0.8876
310 F02 0.8873
311 S7J 0.8873
312 5VL 0.8872
313 9UL 0.8870
314 DEZ 0.8867
315 DRG 0.8867
316 G14 0.8865
317 MPV 0.8865
318 A7H 0.8863
319 WS7 0.8863
320 DAH 0.8860
321 22L 0.8857
322 2CZ 0.8855
323 ET0 0.8853
324 TCA 0.8853
325 TXW 0.8852
326 FER 0.8851
327 PEY 0.8851
328 SJK 0.8849
329 1M2 0.8848
330 535 0.8847
331 QMR 0.8846
332 R2P 0.8846
333 N8Y 0.8846
334 7O4 0.8843
335 YE7 0.8842
336 78Y 0.8842
337 YO5 0.8841
338 PRL 0.8840
339 5RP 0.8840
340 2BG 0.8840
341 TZM 0.8839
342 TCR 0.8837
343 4NO 0.8836
344 2LT 0.8835
345 YE6 0.8834
346 DT7 0.8832
347 CXH 0.8831
348 BHS 0.8830
349 XIY 0.8829
350 M1Z 0.8828
351 TSS 0.8827
352 PNZ 0.8826
353 PQT 0.8825
354 F1X 0.8825
355 5AD 0.8823
356 CK2 0.8823
357 GJK 0.8822
358 1QP 0.8822
359 NEU 0.8821
360 AC2 0.8821
361 K25 0.8820
362 3R6 0.8819
363 HNT 0.8818
364 DIN 0.8817
365 3L1 0.8816
366 6VD 0.8816
367 M4E 0.8816
368 NBG 0.8811
369 MPU 0.8810
370 ZZA 0.8810
371 ODK 0.8810
372 N3W 0.8809
373 AMR 0.8809
374 N7I 0.8808
375 5LA 0.8808
376 P7Y 0.8806
377 KW8 0.8805
378 F31 0.8802
379 8U3 0.8801
380 4JC 0.8800
381 CIY 0.8800
382 DDU 0.8800
383 15E 0.8799
384 G1P 0.8798
385 MUK 0.8798
386 DNQ 0.8795
387 L14 0.8794
388 3VW 0.8793
389 78P 0.8792
390 J38 0.8792
391 7ME 0.8790
392 5V7 0.8789
393 2FQ 0.8789
394 14W 0.8788
395 GI1 0.8788
396 FDR 0.8787
397 5OF 0.8785
398 5GV 0.8784
399 BY5 0.8783
400 RA7 0.8782
401 RP5 0.8781
402 XFE 0.8779
403 4TP 0.8779
404 XDK 0.8778
405 94W 0.8777
406 BPN 0.8776
407 5XC 0.8775
408 S7A 0.8774
409 C53 0.8773
410 D3G 0.8773
411 BA5 0.8773
412 PO6 0.8772
413 5NS 0.8771
414 M4S 0.8771
415 WV7 0.8769
416 K3Q 0.8768
417 HX4 0.8765
418 1ZC 0.8765
419 CLZ 0.8765
420 X0W 0.8765
421 3DT 0.8764
422 RSV 0.8763
423 3VS 0.8760
424 JBZ 0.8760
425 K7H 0.8759
426 MR1 0.8759
427 MTS 0.8757
428 3TC 0.8756
429 4V2 0.8756
430 537 0.8755
431 S0G 0.8754
432 4BZ 0.8753
433 7D7 0.8752
434 36M 0.8751
435 BZQ 0.8751
436 RYV 0.8749
437 NEO 0.8749
438 GA2 0.8748
439 LDP 0.8747
440 9KZ 0.8746
441 S0D 0.8746
442 EQA 0.8744
443 KJU 0.8743
444 LJ3 0.8742
445 5SJ 0.8740
446 B56 0.8739
447 6RQ 0.8737
448 3QV 0.8737
449 EZL 0.8736
450 5E5 0.8734
451 F6P 0.8734
452 14Z 0.8733
453 HC4 0.8733
454 A7W 0.8732
455 6J9 0.8731
456 MPP 0.8730
457 Q9T 0.8730
458 4MU 0.8729
459 0F3 0.8729
460 3N1 0.8728
461 0NX 0.8728
462 4FF 0.8728
463 6E8 0.8727
464 ANN 0.8726
465 SYV 0.8725
466 3D1 0.8724
467 K68 0.8724
468 3AE 0.8724
469 2JX 0.8722
470 LOG 0.8721
471 XIZ 0.8720
472 TJM 0.8718
473 ENO 0.8717
474 CDY 0.8717
475 Y0V 0.8716
476 B23 0.8715
477 IWT 0.8714
478 DEE 0.8714
479 CFA 0.8714
480 9NB 0.8713
481 LZ2 0.8713
482 C2Y 0.8711
483 9F8 0.8710
484 BPU 0.8710
485 VFG 0.8709
486 1KP 0.8708
487 WUB 0.8708
488 GI3 0.8707
489 E1K 0.8706
490 5OB 0.8706
491 27K 0.8703
492 CUT 0.8703
493 D2G 0.8702
494 7MX 0.8702
495 55D 0.8700
496 CL9 0.8699
497 0OK 0.8699
498 JCZ 0.8699
499 795 0.8698
500 NPX 0.8697
501 NPS 0.8697
502 LP8 0.8697
503 L3L 0.8696
504 JGB 0.8696
505 MMS 0.8696
506 4LV 0.8695
507 LNR 0.8694
508 VC3 0.8694
509 FZM 0.8693
510 2WU 0.8693
511 AJY 0.8692
512 2D2 0.8692
513 OCZ 0.8691
514 7ZL 0.8689
515 F9Y 0.8689
516 P81 0.8687
517 AMH 0.8686
518 CR1 0.8685
519 7MW 0.8683
520 DXP 0.8683
521 S3C 0.8681
522 LVD 0.8680
523 XRS 0.8680
524 ST3 0.8679
525 E4P 0.8679
526 EKZ 0.8675
527 XI7 0.8672
528 OSB 0.8671
529 EMZ 0.8670
530 0FN 0.8670
531 4FE 0.8669
532 3XH 0.8668
533 T1N 0.8668
534 259 0.8666
535 CWJ 0.8664
536 1X4 0.8663
537 2J1 0.8663
538 CUH 0.8661
539 56D 0.8660
540 CCV 0.8657
541 FWD 0.8656
542 6J5 0.8656
543 W23 0.8656
544 LUM 0.8654
545 HA6 0.8652
546 5GU 0.8652
547 MUR 0.8652
548 ZRL 0.8651
549 RVE 0.8650
550 PBA 0.8650
551 KP2 0.8650
552 4JQ 0.8646
553 AJV 0.8646
554 M6Z 0.8642
555 2KU 0.8641
556 S98 0.8640
557 7EH 0.8640
558 1X8 0.8639
559 5B2 0.8638
560 774 0.8637
561 0J5 0.8637
562 BZ3 0.8637
563 APZ 0.8637
564 4CN 0.8635
565 DXK 0.8634
566 TR4 0.8631
567 JF8 0.8629
568 505 0.8629
569 K37 0.8628
570 7VP 0.8628
571 44V 0.8627
572 4NM 0.8626
573 M3F 0.8623
574 KT7 0.8622
575 5OO 0.8621
576 I7C 0.8620
577 D1G 0.8620
578 TYR 0.8620
579 THM 0.8620
580 PHE 0.8620
581 QQQ 0.8618
582 H70 0.8618
583 KUF 0.8617
584 GNG 0.8616
585 GVY 0.8616
586 GXD 0.8613
587 92G 0.8613
588 4YO 0.8612
589 3Z8 0.8611
590 N4E 0.8610
591 DT9 0.8608
592 OA3 0.8607
593 0TU 0.8607
594 ALR 0.8606
595 AAN 0.8606
596 209 0.8606
597 5F5 0.8605
598 ZYV 0.8602
599 O2Y 0.8602
600 YZ9 0.8601
601 4TU 0.8600
602 I7A 0.8599
603 MZM 0.8598
604 3D8 0.8596
605 I7B 0.8593
606 5WK 0.8591
607 HCI 0.8590
608 7FU 0.8590
609 E3D 0.8590
610 MFZ 0.8590
611 GNJ 0.8584
612 MS0 0.8580
613 IBP 0.8579
614 KBZ 0.8575
615 6HO 0.8574
616 MQN 0.8574
617 0DN 0.8572
618 NRA 0.8572
619 PQ0 0.8572
620 2LW 0.8568
621 8IG 0.8567
622 PFF 0.8565
623 8TX 0.8564
624 KLK 0.8559
625 03V 0.8559
626 GC2 0.8557
627 39O 0.8556
628 L99 0.8552
629 6X9 0.8552
630 HJ7 0.8551
631 0FO 0.8549
632 AES 0.8547
633 S8A 0.8547
634 IS2 0.8542
635 AH6 0.8537
636 TOH 0.8530
637 F4K 0.8529
638 CWD 0.8523
639 L15 0.8521
640 BWD 0.8520
641 H42 0.8518
642 PIQ 0.8515
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3K1X; Ligand: DBX; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 3k1x.bio2) has 7 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 3K1X; Ligand: DBX; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 3k1x.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback