Receptor
PDB id Resolution Class Description Source Keywords
1tn6 1.8 Å EC: 2.5.1.58 PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A RAP2A PEPTIDE S AND A FPP ANALOG AT 1.8A RESOLUTION HOMO SAPIENS FTASE FARNESYLTRANSFERASE FARNESYL TRANSFERASE PRENYLTRANCAAX RAS LIPID MODIFICATION PRENYLATION SUBSTRATE SELECTRANSFERASE
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CAAX PRENYLTRANSFERASE COMPLEXED WITH SUBSTRATES DEFINES RULES OF PROTEIN SELECTIVITY J.MOL.BIOL. V. 343 417 2004
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACY A:3004;
B:3001;
 Invalid;
Invalid;
 none;
none;
 submit data
60.052 C2 H4 O2 CC(=O...
FII B:1;
 Valid;
 none;
 submit data
359.398 C17 H30 N O5 P CC(=C...
ZN B:1001;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
GLC FRU D:1;
 Invalid;
 none;
 submit data
340.281 n/a O=CC1...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1TN6 1.8 Å EC: 2.5.1.58 PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A RAP2A PEPTIDE S AND A FPP ANALOG AT 1.8A RESOLUTION HOMO SAPIENS FTASE FARNESYLTRANSFERASE FARNESYL TRANSFERASE PRENYLTRANCAAX RAS LIPID MODIFICATION PRENYLATION SUBSTRATE SELECTRANSFERASE
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CAAX PRENYLTRANSFERASE COMPLEXED WITH SUBSTRATES DEFINES RULES OF PROTEIN SELECTIVITY J.MOL.BIOL. V. 343 417 2004
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1TN6 - FII C17 H30 N O5 P CC(=CCC/C(....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1TN6 - FII C17 H30 N O5 P CC(=CCC/C(....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 1TN6 - FII C17 H30 N O5 P CC(=CCC/C(....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: FII; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FII 1 1
2 DSL 0.553571 0.603448
3 0K3 0.553571 0.603448
4 FJP 0.553571 0.614035
5 GRG 0.507937 0.666667
6 FPP 0.507937 0.666667
7 VTP 0.507937 0.655172
8 OTP 0.507937 0.655172
9 ZTP 0.507937 0.655172
10 FPQ 0.5 0.683333
11 GPP 0.444444 0.649123
12 C0X 0.444444 0.622951
13 FPS 0.41791 0.6
14 GGS 0.41791 0.6
15 FFF 0.402778 0.633333
Similar Ligands (3D)
Ligand no: 1; Ligand: FII; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1TN6; Ligand: FII; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1tn6.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
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