Receptor
PDB id Resolution Class Description Source Keywords
2A19 2.5 Å EC: 2.7.1.- PKR KINASE DOMAIN- EIF2ALPHA- AMP-PNP COMPLEX. SACCHAROMYCES CEREVISIAE TRANSFERASE KINASE PROTEIN BIOSYNTHESIS PROTEIN SYNTHESISTRANSFERASE COMPLEX
Ref.: HIGHER-ORDER SUBSTRATE RECOGNITION OF EIF2ALPHA BY RNA-DEPENDENT PROTEIN KINASE PKR. CELL(CAMBRIDGE,MASS.) V. 122 887 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP B:1640;
C:2640;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MG B:1641;
B:1642;
C:2641;
C:2642;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
PO4 C:901;
Invalid;
none;
submit data
94.971 O4 P [O-]P...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2A19 2.5 Å EC: 2.7.1.- PKR KINASE DOMAIN- EIF2ALPHA- AMP-PNP COMPLEX. SACCHAROMYCES CEREVISIAE TRANSFERASE KINASE PROTEIN BIOSYNTHESIS PROTEIN SYNTHESISTRANSFERASE COMPLEX
Ref.: HIGHER-ORDER SUBSTRATE RECOGNITION OF EIF2ALPHA BY RNA-DEPENDENT PROTEIN KINASE PKR. CELL(CAMBRIDGE,MASS.) V. 122 887 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 2A19 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 2A19 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2A19 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 358
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 ADP 0.802632 0.972222
5 AP5 0.802632 0.945205
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 ATP 0.772152 0.972222
9 AN2 0.769231 0.986111
10 AQP 0.7625 0.972222
11 5FA 0.7625 0.972222
12 M33 0.759494 0.932432
13 MAP 0.752941 0.972973
14 ACP 0.75 0.945946
15 APR 0.740741 0.945205
16 AR6 0.740741 0.945205
17 ACQ 0.73494 0.945946
18 AD9 0.731707 0.945946
19 SAP 0.731707 0.921053
20 AGS 0.731707 0.921053
21 AMP 0.723684 0.944444
22 A 0.723684 0.944444
23 ATF 0.717647 0.933333
24 ADX 0.716049 0.851852
25 CA0 0.716049 0.92
26 50T 0.707317 0.932432
27 PRX 0.698795 0.87013
28 ABM 0.696203 0.893333
29 AMP MG 0.683544 0.868421
30 AP2 0.679012 0.933333
31 A12 0.679012 0.933333
32 APC 0.678571 0.933333
33 TAT 0.674419 0.933333
34 A22 0.674157 0.958904
35 SRA 0.670886 0.894737
36 SRP 0.670455 0.883117
37 5AL 0.666667 0.906667
38 ADQ 0.659341 0.92
39 A1R 0.659341 0.884615
40 ADP MG 0.654762 0.881579
41 3OD 0.648936 0.92
42 BIS 0.648936 0.909091
43 5SV 0.648352 0.82716
44 BEF ADP 0.647059 0.858974
45 ADP BEF 0.647059 0.858974
46 OAD 0.645161 0.92
47 25L 0.642105 0.958904
48 AMO 0.641304 0.907895
49 G5P 0.636364 0.897436
50 DLL 0.634409 0.906667
51 AHX 0.634409 0.897436
52 00A 0.634409 0.860759
53 ANP MG 0.633333 0.921053
54 ADV 0.632184 0.907895
55 ADP PO3 0.632184 0.917808
56 RBY 0.632184 0.907895
57 NB8 0.631579 0.897436
58 25A 0.630435 0.945205
59 8QN 0.630435 0.906667
60 OOB 0.630435 0.906667
61 G3A 0.626263 0.897436
62 ATP MG 0.625 0.881579
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 1ZZ 0.614583 0.819277
67 TXA 0.614583 0.907895
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 3UK 0.610526 0.894737
71 SON 0.604651 0.907895
72 ADP ALF 0.604396 0.848101
73 ALF ADP 0.604396 0.848101
74 WAQ 0.604167 0.860759
75 PR8 0.604167 0.829268
76 4UV 0.6 0.871795
77 GAP 0.6 0.87013
78 FYA 0.597938 0.881579
79 PTJ 0.597938 0.873418
80 ADP VO4 0.597826 0.906667
81 VO4 ADP 0.597826 0.906667
82 UP5 0.596154 0.896104
83 YAP 0.59596 0.871795
84 FA5 0.59596 0.883117
85 PAP 0.595506 0.958333
86 A4P 0.59434 0.823529
87 XAH 0.59 0.841463
88 4UU 0.588235 0.871795
89 AFH 0.588235 0.8625
90 9SN 0.585859 0.85
91 2A5 0.58427 0.894737
92 T5A 0.583333 0.821429
93 NAI 0.580952 0.884615
94 ITT 0.579545 0.917808
95 ATR 0.577778 0.944444
96 OMR 0.575472 0.831325
97 5AS 0.574713 0.781609
98 YLP 0.571429 0.8
99 48N 0.571429 0.873418
100 AP0 0.570093 0.873418
101 4TC 0.570093 0.873418
102 7D3 0.569767 0.881579
103 ADJ 0.568807 0.831325
104 GNP 0.568421 0.922078
105 DAL AMP 0.568421 0.881579
106 NXX 0.566038 0.907895
107 TXD 0.566038 0.884615
108 NAX 0.566038 0.851852
109 4UW 0.566038 0.839506
110 6V0 0.566038 0.873418
111 DND 0.566038 0.907895
112 XYA 0.565789 0.821918
113 ADN 0.565789 0.821918
114 RAB 0.565789 0.821918
115 AOC 0.564706 0.8
116 7D4 0.561798 0.881579
117 ADP BMA 0.561224 0.894737
118 TXE 0.560748 0.884615
119 TYM 0.560748 0.883117
120 YLB 0.555556 0.8
121 YLC 0.555556 0.819277
122 139 0.554545 0.851852
123 5N5 0.551282 0.797297
124 JB6 0.55 0.860759
125 LAQ 0.54717 0.819277
126 MYR AMP 0.544554 0.797619
127 A4D 0.544304 0.797297
128 5CD 0.544304 0.783784
129 7MD 0.542857 0.864198
130 6AD 0.542553 0.886076
131 A2R 0.541667 0.958904
132 UPA 0.541284 0.884615
133 YLA 0.540541 0.8
134 A A 0.54 0.918919
135 COD 0.539823 0.793103
136 BTX 0.539823 0.821429
137 G5A 0.537634 0.781609
138 CNA 0.535714 0.907895
139 AYB 0.535714 0.790698
140 3DH 0.535714 0.753247
141 BT5 0.535088 0.811765
142 ATP A A A 0.533981 0.905405
143 IOT 0.531532 0.811765
144 MTA 0.53012 0.753247
145 3AM 0.529412 0.90411
146 A3P 0.52809 0.944444
147 NAD 0.526316 0.906667
148 PPS 0.526316 0.851852
149 EP4 0.52439 0.734177
150 7D5 0.52381 0.855263
151 AMP DBH 0.52381 0.87013
152 J7C 0.522727 0.75
153 A5A 0.520833 0.809524
154 EAD 0.520661 0.851852
155 TSB 0.520408 0.821429
156 AHZ 0.518519 0.797619
157 M2T 0.518072 0.716049
158 DTA 0.518072 0.766234
159 A3D 0.517241 0.894737
160 6RE 0.517241 0.740741
161 YLY 0.516949 0.790698
162 SSA 0.515464 0.802326
163 NA7 0.514852 0.933333
164 TYR AMP 0.514286 0.858974
165 AR6 AR6 0.514019 0.893333
166 7MC 0.513514 0.843373
167 A2P 0.511111 0.930556
168 52H 0.510204 0.781609
169 VMS 0.510204 0.790698
170 54H 0.510204 0.790698
171 TAD 0.509259 0.8625
172 NAQ 0.508333 0.85
173 A3N 0.505618 0.766234
174 AV2 0.505155 0.893333
175 5CA 0.50505 0.802326
176 53H 0.50505 0.781609
177 ARU 0.504951 0.839506
178 ARG AMP 0.504587 0.809524
179 ZID 0.504132 0.894737
180 P1H 0.504 0.831325
181 3AT 0.5 0.945205
182 NAE 0.5 0.871795
183 AVV 0.5 0.873418
184 P5A 0.495146 0.747253
185 DSZ 0.49505 0.802326
186 LSS 0.49505 0.764045
187 NSS 0.49505 0.802326
188 N0B 0.491803 0.8
189 AF3 ADP 3PG 0.491071 0.817073
190 LA8 ALF 3PG 0.491071 0.817073
191 ALF ADP 3PG 0.491071 0.817073
192 NVA LMS 0.490196 0.764045
193 DAT 0.489362 0.881579
194 IMO 0.488889 0.90411
195 ZAS 0.488636 0.792208
196 FDA 0.488372 0.813953
197 NAJ PZO 0.487395 0.85
198 4TA 0.487179 0.788235
199 LPA AMP 0.486486 0.797619
200 LEU LMS 0.485437 0.764045
201 DTP 0.484536 0.881579
202 V3L 0.484536 0.945205
203 GJV 0.483516 0.731707
204 S4M 0.483516 0.651685
205 DZD 0.483051 0.8625
206 2AM 0.482759 0.917808
207 5AD 0.481013 0.726027
208 KAA 0.480769 0.755556
209 GSU 0.480769 0.781609
210 NDE 0.480315 0.907895
211 M24 0.479339 0.851852
212 MAO 0.478261 0.761905
213 DSH 0.477778 0.707317
214 NEC 0.477778 0.727273
215 FAD 0.477273 0.831325
216 FAS 0.477273 0.831325
217 RGT 0.476636 0.933333
218 0WD 0.474576 0.897436
219 G A A A 0.474576 0.85
220 FNK 0.474074 0.786517
221 5X8 0.473684 0.74359
222 6FA 0.473282 0.821429
223 FB0 0.472868 0.786517
224 NDC 0.472868 0.85
225 YSA 0.472222 0.781609
226 7DD 0.468085 0.958333
227 OVE 0.466667 0.881579
228 NAD IBO 0.466102 0.848101
229 MHZ 0.463158 0.701149
230 A3G 0.461538 0.779221
231 6C6 0.459184 0.858974
232 U A G G 0.458333 0.860759
233 SFG 0.458333 0.730769
234 7D7 0.45679 0.723684
235 128 0.45614 0.8
236 SFD 0.455224 0.736842
237 DDS 0.454545 0.855263
238 GDP 0.454545 0.896104
239 6IA 0.454545 0.817073
240 NJP 0.453782 0.921053
241 ODP 0.453782 0.886076
242 7DT 0.453608 0.958333
243 A7D 0.452632 0.75641
244 Z5A 0.452381 0.802326
245 WSA 0.452174 0.790698
246 7C5 0.45045 0.797468
247 FAY 0.449275 0.841463
248 NDP 0.449153 0.897436
249 A5D 0.44898 0.766234
250 SA8 0.44898 0.690476
251 NAJ PYZ 0.448 0.851852
252 71V 0.446809 0.884615
253 GGZ 0.446602 0.804878
254 RFL 0.446043 0.802326
255 2SA 0.445545 0.907895
256 AMP NAD 0.444444 0.858974
257 GP3 0.444444 0.897436
258 SAI 0.444444 0.716049
259 SAH 0.444444 0.725
260 A A A 0.443396 0.881579
261 PO4 PO4 A A A A PO4 0.443396 0.878378
262 4YB 0.442478 0.764045
263 GTP 0.441176 0.896104
264 SMM 0.441176 0.670455
265 S7M 0.441176 0.674419
266 Y3J 0.440476 0.706667
267 SAM 0.44 0.674419
268 649 0.439655 0.747253
269 12D 0.438596 0.809524
270 A3S 0.4375 0.789474
271 NPW 0.436975 0.864198
272 GCP 0.436893 0.873418
273 AAT 0.435644 0.690476
274 EEM 0.435644 0.674419
275 GNH 0.435644 0.909091
276 DCA 0.435484 0.804598
277 ETB 0.435484 0.813953
278 N6P 0.433962 0.890411
279 TXP 0.433333 0.897436
280 NZQ 0.433333 0.886076
281 PGS 0.43299 0.860759
282 APU 0.432203 0.871795
283 PUA 0.432 0.8625
284 62F 0.431655 0.841463
285 F2N 0.431507 0.795455
286 DA 0.430108 0.855263
287 D5M 0.430108 0.855263
288 J7V 0.429688 0.813953
289 NIA 0.428571 0.848101
290 6K6 0.428571 0.905405
291 A3T 0.428571 0.8
292 0T1 0.428571 0.804598
293 COA 0.428571 0.804598
294 P5F 0.427586 0.804598
295 AAM 0.425532 0.944444
296 0UM 0.424528 0.682353
297 G1R 0.423077 0.884615
298 AMZ 0.422222 0.891892
299 C2R 0.422222 0.88
300 A U 0.420168 0.848101
301 IDP 0.42 0.894737
302 GSP 0.419048 0.851852
303 COS 0.418605 0.786517
304 CAO 0.418605 0.777778
305 AMX 0.418605 0.813953
306 30N 0.418605 0.736842
307 DG1 0.418605 0.897436
308 1DG 0.418605 0.897436
309 TM1 0.418182 0.797619
310 A6D 0.416667 0.746988
311 K15 0.416667 0.666667
312 V1N 0.415929 0.893333
313 SCO 0.415385 0.804598
314 CMX 0.415385 0.804598
315 GEK 0.415094 0.719512
316 NHD 0.414634 0.881579
317 XNP 0.414634 0.851852
318 AIR 0.413793 0.876712
319 COK 0.413534 0.786517
320 G2R 0.412844 0.8625
321 FCX 0.412214 0.777778
322 FAM 0.412214 0.786517
323 ACO 0.412214 0.777778
324 NAP 0.410853 0.92
325 CNV FAD 0.409722 0.775281
326 FA9 0.409396 0.843373
327 SXZ 0.409091 0.694118
328 HAX 0.409091 0.806818
329 PLP AAD 0.408 0.744444
330 TAP 0.407692 0.884615
331 2MC 0.407407 0.752688
332 62X 0.407407 0.651685
333 GKE 0.40708 0.8625
334 GDD 0.40708 0.8625
335 GDC 0.40708 0.8625
336 FYN 0.406015 0.804598
337 3KK 0.406015 0.786517
338 U G A 0.405797 0.819277
339 NA0 0.40458 0.907895
340 101 0.404255 0.855263
341 G 0.40404 0.883117
342 5GP 0.40404 0.883117
343 MGP 0.403846 0.8625
344 MCD 0.402985 0.786517
345 OXK 0.402985 0.786517
346 CA6 0.402985 0.714286
347 SOP 0.402985 0.786517
348 3AD 0.402299 0.783784
349 S8M 0.401869 0.78481
350 YE1 0.40146 0.795455
351 1VU 0.4 0.777778
352 2VA 0.4 0.779221
353 CMC 0.4 0.786517
354 7RP 0.4 0.902778
355 GMV 0.4 0.873418
356 6G0 0.4 0.8625
357 CO6 0.4 0.786517
358 NMX 0.4 0.782609
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2A19; Ligand: ANP; Similar sites found: 424
This union binding pocket(no: 1) in the query (biounit: 2a19.bio1) has 16 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3WVR AMP 0.0002277 0.4836 2.28571
2 2HGS ADP 0.000608 0.47673 2.8169
3 5I35 ANP 0.000001125 0.59601 2.85714
4 1GSA ADP 0.0001906 0.50138 2.85714
5 5AHW CMP 0.01412 0.40077 3.40136
6 3VPD ANP 0.0006869 0.47217 3.42857
7 3DNT ATP 0.001974 0.45345 3.42857
8 4O4F IHP 0.003094 0.44708 3.42857
9 4O4F ATP 0.002873 0.44708 3.42857
10 3TPV ADE 0.002017 0.44545 3.42857
11 2CFM AMP 0.005002 0.41528 3.42857
12 4LH7 1X8 0.0008059 0.40789 3.42857
13 4OCJ NDG 0.0001194 0.53309 3.52113
14 4AZT LY2 0.001491 0.43982 3.52113
15 1OGX EQU 0.01187 0.40229 3.81679
16 2WFG ZZB 0.01373 0.4052 3.83142
17 4OCV ANP 0.00006461 0.51746 3.87324
18 5EQY 5RA 0.00003982 0.568 4
19 3VPC ADP 0.001012 0.46397 4
20 5TT5 NAD 0.001955 0.45535 4
21 2QK4 ATP 0.001659 0.43295 4
22 3K5I AIR 0.01077 0.42675 4
23 3K5I ADP 0.006083 0.42419 4
24 4NJH SAM 0.02035 0.41265 4
25 4NJH 2K8 0.02035 0.41265 4
26 4FMU 0UM 0.01937 0.40295 4
27 3E85 BSU 0.04129 0.40392 4.43038
28 5MW8 ATP 0.000003401 0.58696 4.57143
29 1IA9 ANP 0.00003217 0.53205 4.57143
30 3TM0 B31 0.0001652 0.52018 4.57143
31 3TM0 ANP 0.0001541 0.52018 4.57143
32 4OUC 5ID 0.00009303 0.50199 4.57143
33 2VPQ ANP 0.001294 0.46067 4.57143
34 2AQX ATP 0.003396 0.43835 4.57143
35 4AUT FAD 0.04549 0.40169 4.57143
36 4ZS4 ATP 0.00000595 0.56736 4.57746
37 2IO8 ADP 0.002947 0.44487 4.57746
38 3PDT ADP 0.00001242 0.54334 4.72727
39 3MJY IJZ 0.03078 0.40457 4.92958
40 3MJY FMN 0.03078 0.40457 4.92958
41 1ZTH ADP 0.0000007122 0.59462 5.14286
42 1ZP9 ATP 0.000001089 0.59332 5.14286
43 3W0O ADP 0.00001337 0.57031 5.14286
44 3W0O HY0 0.00001337 0.57031 5.14286
45 3RE4 TO1 0.00001061 0.53995 5.14286
46 4R78 AMP 0.0001146 0.48656 5.14286
47 2YW2 ATP 0.001631 0.45193 5.14286
48 3Q8G PEE 0.0217 0.42931 5.14286
49 2R3A SAM 0.006435 0.41916 5.14286
50 4OMJ 2TX 0.02199 0.41208 5.14286
51 2C6Q NDP 0.03712 0.40986 5.14286
52 5IGI GMP 0.0006504 0.49396 5.28169
53 5IGI ZIT 0.0006882 0.49396 5.28169
54 4LRJ ANP 0.00000142 0.59119 5.32544
55 2PYW ADP 0.00000247 0.58854 5.6338
56 3ZGJ RMN 0.004824 0.40516 5.6338
57 1I7L ATP 0.0003269 0.49187 5.71429
58 1E4E ADP 0.007498 0.41792 5.71429
59 3H78 BE2 0.02028 0.41032 5.71429
60 1LC8 33P 0.0262 0.40213 5.71429
61 2P4Y C03 0.03288 0.41739 5.77617
62 3KAL ADP 0.0009905 0.48067 5.98592
63 1M0W ANP 0.0009676 0.45388 5.98592
64 2IF8 ADP 0.0005209 0.44981 5.98592
65 3TII ANP 0.002283 0.43119 5.98592
66 2V58 LZJ 0.001651 0.48097 6.28571
67 1IOW ADP 0.00163 0.47099 6.28571
68 1IOW PHY 0.00163 0.47099 6.28571
69 2GQS ADP 0.001219 0.45154 6.28571
70 3I0O ADP 0.0009199 0.4496 6.28571
71 3V4S ATP 0.002269 0.44689 6.28571
72 2GQR ADP 0.001968 0.44163 6.28571
73 3V4S ADP 0.01891 0.41766 6.28571
74 3AKK ADP 0.0001593 0.49858 6.85714
75 4U98 ACP 0.0003453 0.47763 6.85714
76 4UWH JXM 0.0006782 0.46118 6.85714
77 1AUX AGS 0.0002083 0.49058 7.04225
78 1PK8 ATP 0.0004386 0.48743 7.04225
79 3WO0 ALA 0.001025 0.48506 7.04225
80 3ETH ATP 0.00115 0.46127 7.04225
81 5C1P DAL DAL 0.006363 0.42998 7.04225
82 5C1P ADP 0.003109 0.42748 7.04225
83 5VZ0 ADP 0.0003016 0.48042 7.42857
84 2R7K AMZ 0.001585 0.46465 7.42857
85 2ZYI STE 0.00537 0.43363 7.42857
86 4CC6 L5Y 0.003102 0.41929 7.42857
87 4NZN 2OU 0.001595 0.48072 7.74648
88 4NZN ANP 0.001595 0.48072 7.74648
89 3UDZ ADP 0.000001731 0.59319 8
90 3ORQ ADP 0.003637 0.43504 8
91 4ZGP ADP 0.003829 0.42785 8
92 1KJ8 GAR 0.01408 0.42639 8
93 1KJ8 ATP 0.01343 0.42639 8
94 2QF7 AGS 0.01782 0.41056 8
95 4GLW 0XT 0.005266 0.41012 8
96 1TDF FAD 0.04583 0.40811 8
97 4PU5 ANP 0.00399 0.4367 8.09859
98 5W2I ADP 0.000207 0.50162 8.56031
99 5W2I I3P 0.000207 0.50162 8.56031
100 3X01 AMP 0.0000387 0.48115 8.57143
101 5TT6 ATP 0.003225 0.43944 8.57143
102 5UWA 8ND 0.01871 0.41333 8.57143
103 3AJH BL3 0.006811 0.41994 9.14286
104 3MB5 SAM 0.01547 0.40933 9.41177
105 5K2M ADP 0.000238 0.49865 9.43396
106 3TDV GDP 0.00001971 0.53962 9.50704
107 5COU ATP 0.006417 0.41716 9.71429
108 5DMZ ADP 0.0000004787 0.61696 9.85915
109 4F9C 0SX 0.0000008743 0.60122 10.2857
110 4ANW O92 0.00007154 0.53705 10.2857
111 5C4L 4XR 0.0001932 0.51366 10.2857
112 5C4L SIS 0.000484 0.49355 10.2857
113 4YNM SAM 0.01318 0.40418 10.2857
114 4B7X NAP 0.03686 0.40159 10.2857
115 4FE2 ADP 0.003945 0.42262 10.8571
116 4AXD ANP 0.00000457 0.60598 10.9155
117 2FXD DR7 0.007894 0.43103 11.1111
118 2BKK ADP 0.00003026 0.52198 11.2426
119 5DXT 5H5 0.01061 0.41063 11.2676
120 2PUL ACP 0.0000005551 0.61061 11.4286
121 4AZW ATP 0.000008669 0.56213 11.4286
122 5NCY 8TK 0.0003473 0.49925 11.4286
123 3VOT ADP 0.0002235 0.47825 11.4286
124 1OX5 1PR 0.002725 0.45285 11.6197
125 4WW7 AMP 0.0000002251 0.64187 11.8774
126 5MY8 RXZ 0.0000002837 0.64499 11.9718
127 5DZT AMP 0.0002291 0.45458 12
128 1W2D 4IP 0.002074 0.45879 12.4528
129 1W2D ADP 0.0006213 0.45755 12.4528
130 3VPB ADP 0.00006311 0.52903 12.5
131 1OBD ATP 0.002589 0.43122 13.0282
132 4XYM A12 0.0004914 0.47501 13.1429
133 2VQD AP2 0.0005727 0.47396 13.1429
134 2EQA AMP 0.01041 0.41938 13.1429
135 1CKM GTP 0.01013 0.41343 13.1429
136 1TQP ATP 0.000005901 0.57761 13.7143
137 5IH1 GDP 0.005058 0.46 13.7143
138 5IH1 6BQ 0.005058 0.46 13.7143
139 4Z4P SAH 0.007331 0.41439 13.8554
140 2R85 AMP 0.01228 0.42262 14.2857
141 1S68 AMP 0.002873 0.41554 14.4578
142 4Q5H ANP 0.000007528 0.55965 14.4737
143 5IQD RIO 0.00001294 0.58272 14.8571
144 5IQD GNP 0.00001208 0.58272 14.8571
145 1EHI ADP 0.01634 0.40153 14.8571
146 3PN1 IVH 0.000261 0.45932 15.1408
147 5FI4 5XV 0.00293 0.445 15.4286
148 4LA7 A1O 0.02054 0.40469 15.4286
149 4JD3 COA 0.04898 0.40342 15.4286
150 5ML3 DL3 0.03142 0.40826 15.4362
151 5W4W 9WG 0.0000006729 0.63759 15.8451
152 4IJP 1EH 0.0000007983 0.6123 15.8451
153 4KBA 1QM 0.00002896 0.54973 15.8451
154 3Q60 ATP 0.00002308 0.53356 15.8451
155 4MV1 ADP 0.002996 0.45494 16
156 5TDF ADP 0.00138 0.45545 16.5714
157 4J7Q B7N 0.0286 0.40836 17.1429
158 5LXT ACP 0.0005603 0.47846 17.4825
159 4JR7 GNP 0.00000007683 0.65501 17.6056
160 4CYI ATP 0.00001094 0.55723 17.9577
161 1QG6 TCL 0.0323 0.41391 18.2857
162 1QG6 NAD 0.0323 0.41391 18.2857
163 4G17 0VN 0.000003308 0.57051 18.3099
164 3HAV ATP 0.00009567 0.46963 19.0141
165 4BKJ STI 0.0008228 0.47393 19.3662
166 2PVN P63 0.0000004507 0.64207 19.7183
167 3A7R LAQ 0.01967 0.41783 20
168 4OAV ACP 0.000000009931 0.69378 22.5352
169 4O1P ANP 0.0000000159 0.68778 25.1429
170 1T36 ADP 0.02418 0.40388 25.1429
171 2Q7D ANP 0.001391 0.46433 25.7143
172 5EOB 5QQ 0.000001188 0.65592 26.0563
173 3C1X CKK 0.000004999 0.5763 26.0563
174 3VHE 42Q 0.000005062 0.59149 26.7606
175 4I94 ANP 0.0000001497 0.63769 27.4648
176 3M2W L8I 0.0000002262 0.62183 27.8169
177 3RI1 3RH 0.00000002236 0.70221 28.169
178 5UR1 YY9 0.0000001703 0.68631 28.8732
179 3GQI ACP 0.00000001847 0.68465 28.8732
180 2WU6 DKI 0.0000001245 0.65727 29.2254
181 5CKW ANP 0.0000004624 0.60336 29.5775
182 3OFM 4B0 0.000004951 0.5589 29.7143
183 4XH0 ADP 0.00000001376 0.62171 30.2817
184 5M06 ADP 0.000004204 0.56559 30.7971
185 3PE2 E1B 0.000001809 0.63721 31.1573
186 4GYI ADP 0.00002329 0.52732 31.4286
187 5C03 AGS 0.0000003347 0.6244 32.3944
188 4WOV 3SM 0.000002852 0.57014 32.3944
189 4FL3 ANP 0.00000001583 0.69801 32.7465
190 2XVD AS6 0.0000002673 0.65343 32.7465
191 5U6C 7YS 0.000000008627 0.71085 33.0986
192 5JZJ AN2 0.00000009156 0.64786 33.0986
193 5UKL SIX 0.0000006638 0.63144 33.0986
194 3VRY B43 0.000002909 0.59505 33.0986
195 4BTK DTQ 0.000001469 0.59364 33.0986
196 4NFN 2KC 0.000005358 0.56374 33.0986
197 4BHN BH9 0.00000007511 0.66203 33.4507
198 3PVW QRX 0.0000001568 0.66024 33.4507
199 1Q8Y ADP 0.0000005883 0.61873 33.4507
200 5X8I SQZ 0.0000007024 0.60898 33.4507
201 5T8O 76Z 0.000001325 0.60165 33.4507
202 4IX4 ADP 0.000001551 0.59833 33.4507
203 1Q8Y ADE 0.0000003332 0.59803 33.4507
204 3FHR P4O 0.000003287 0.57978 33.4507
205 3PLS ANP 0.0000000004077 0.75978 33.8028
206 4CRL C1I 0.0000001459 0.67525 33.8028
207 1K3A ACP 0.0000001331 0.63265 33.8028
208 3NW7 LGV 0.000002708 0.62803 33.8028
209 1JPA ANP 0.0000002439 0.4626 33.8028
210 3KMW ATP 0.00004489 0.5198 33.9483
211 4H3P ANP 0.000000001455 0.73751 34.1549
212 5LI1 ANP 0.00000003692 0.6801 34.1549
213 4H3Q ANP 0.00000007125 0.66913 34.1549
214 4K33 ACP 0.00000005154 0.66671 34.1549
215 5LI9 ACP 0.0000003145 0.62887 34.1549
216 2Y6O 1N1 0.0000009115 0.61229 34.1549
217 4EWH T77 0.00000009494 0.67353 34.1818
218 5BVE 4VG 0.00000006375 0.73128 34.507
219 1PHK ATP 0.00000006496 0.66187 34.507
220 5JFS 6K0 0.0000004524 0.66102 34.507
221 4P5Z Q7M 0.0000009077 0.64209 34.507
222 4AT3 LTI 0.000001134 0.62413 34.507
223 2HK5 1BM 0.0000006367 0.61706 34.8148
224 5DEY 59T 0.0000002666 0.68919 34.8592
225 4UAL 3FV 0.00000004434 0.66644 34.8592
226 5HES 032 0.000004399 0.579 34.8592
227 3KN5 ANP 0.000002239 0.57508 34.8592
228 4L9I 8PR 0.00001772 0.53901 34.8592
229 5MJA 7O3 0.00002906 0.52588 34.8592
230 2QLU ADE 0.0000528 0.43074 34.8592
231 1BYG STU 0.0000002662 0.62226 34.8921
232 5UOX 8GY 0.0000001271 0.65397 35.0554
233 1OUK 084 0.0000003019 0.72466 35.2113
234 4WNK 453 0.00000003558 0.69964 35.2113
235 5NKB 8ZT 0.0000005448 0.65846 35.2113
236 4IDT T28 0.00000006004 0.65658 35.2113
237 5LXC 7AA 0.0000003836 0.61475 35.2113
238 4LOO SB4 0.00001761 0.54197 35.2113
239 3QCQ 3Q0 0.0000008977 0.68815 35.5634
240 5LVP ATP 0.0000001309 0.63298 35.5634
241 4EUU BX7 0.0000005764 0.63218 35.5634
242 2B9I ADP 0.0000002611 0.62957 35.5634
243 2B9F ADP 0.0000003851 0.62148 35.5634
244 2B9J ADP 0.0000003969 0.61754 35.5634
245 2B9H ADP 0.0000005626 0.6167 35.5634
246 4AUA 4AU 0.000002075 0.58335 35.5634
247 3HZT J60 0.000002292 0.57095 35.5634
248 3SRV S19 0.00000003271 0.66914 35.7401
249 5DA3 58V 0.000001936 0.57438 35.8491
250 5DRB 5FJ 0.0000002651 0.68093 35.9155
251 1U59 STU 0.00000005934 0.66038 35.9155
252 3V8S 0HD 0.0000001179 0.64263 35.9155
253 3ALN ANP 0.0000002881 0.63374 35.9155
254 5HVJ ANP 0.00000009296 0.56938 35.9155
255 5AWM ANP 0.000004047 0.55945 35.9155
256 5EKO N17 0.00009001 0.51733 35.9155
257 3H9R TAK 0.00002412 0.51279 35.9155
258 1O9U ADZ 0.0000001758 0.48918 35.9155
259 4F4P 0SB 0.000001192 0.6605 36.2637
260 1RE8 BD2 0.0000001119 0.70058 36.2676
261 3E8N ATP 0.0000003855 0.67093 36.2676
262 3IDB ANP 0.0000002062 0.64654 36.2676
263 4WB6 ATP 0.0000003942 0.64037 36.2676
264 2QCS ANP 0.0000004633 0.63689 36.2676
265 4Y93 746 0.0000005103 0.6324 36.2676
266 3FHI ANP 0.0000005986 0.63137 36.2676
267 4OH4 ANP 0.000000244 0.63097 36.2676
268 3TTI KBI 0.000001854 0.60922 36.2676
269 4WHZ 3NL 0.00002883 0.57656 36.2676
270 5LPB ADP 0.00000176 0.57631 36.2676
271 3PTG 932 0.00000106 0.57558 36.2676
272 3E8N VRA 0.004587 0.48626 36.2676
273 5H2U 1N1 0.0000184 0.54106 36.3296
274 2JLD AG1 0.000000001041 0.78425 36.6197
275 3F7Z 34O 0.0000000004624 0.76136 36.6197
276 4BFM ANP 0.000000002178 0.73651 36.6197
277 5LPZ ADP 0.000000004979 0.71192 36.6197
278 4QTB 38Z 0.0000000431 0.69308 36.6197
279 2GU8 796 0.0000004373 0.68028 36.6197
280 4L3L 5FI 0.0000002094 0.66097 36.6197
281 3ZRM ZRM 0.0000001272 0.64452 36.6197
282 4WB7 ATP 0.0000007858 0.64181 36.6197
283 2F2U M77 0.0000002812 0.61342 36.6197
284 3E7O 35F 0.000009933 0.58043 36.6197
285 4NM5 ADP 0.00004456 0.56884 36.6197
286 2JDR L20 0.0000001428 0.70752 36.9718
287 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.0000001428 0.70752 36.9718
288 4IZY 1J2 0.0000002481 0.63689 36.9718
289 3SXF BK5 0.000001516 0.62545 36.9718
290 4DC2 ADE 0.0000001645 0.55374 36.9718
291 5BYZ 4WE 0.000002007 0.61366 37.3239
292 5HQ0 LZ9 0.000001151 0.60461 37.3239
293 1V0O INR 0.0000002974 0.63004 37.6761
294 4E1Z 0MX 0.000001218 0.60878 38.0282
295 2BPM 529 0.000000004722 0.77602 38.3803
296 5IH9 6BF 0.0000001631 0.67672 38.3803
297 4CFU 2WC 0.0000000257 0.67027 38.3803
298 5EFQ ADP 0.00000004114 0.668 38.3803
299 4BCN T9N 0.00000005191 0.65185 38.3803
300 3O0G 3O0 0.0000001266 0.64117 38.3803
301 4YLL 4E3 0.0000003504 0.63527 38.3803
302 1UNH IXM 0.0000001981 0.62454 38.3803
303 4BCQ TJF 0.0000004349 0.6046 38.3803
304 2XMY CDK 0.00001676 0.60364 38.3803
305 2ZV2 609 0.000007272 0.54759 38.3803
306 4BCM T7Z 0.000007835 0.52507 38.3803
307 5LMK 6ZK 0.00003211 0.52383 38.3803
308 4AU8 Z3R 0.00005876 0.50529 38.3803
309 5UIU 8CG 0.000004762 0.59283 38.3901
310 4GJ3 0XP 0.00000002042 0.71411 38.7324
311 3LXN MI1 0.000000007339 0.71096 38.7324
312 3GC0 AMP 0.000001342 0.58552 38.7324
313 4USF 6UI 0.00004232 0.53553 39.0845
314 2PVF ACP 0.000000006513 0.7025 39.4366
315 4NST ADP 0.0000001002 0.64949 39.4366
316 1VJY 460 0.0000006898 0.63905 39.4366
317 3EKK GS2 0.000000008182 0.74524 39.7887
318 3BU5 ATP 0.000000002209 0.72883 39.7887
319 5HX8 66P 0.00000001135 0.71682 39.7887
320 4YMJ 4EJ 0.0000004091 0.56381 39.7887
321 1CM8 ANP 0.00001773 0.53901 39.7887
322 3G5D 1N1 0.0000001311 0.70822 40.1408
323 4YZN 4K5 0.0000000009096 0.76182 40.493
324 1Y57 MPZ 0.00000001042 0.70999 40.493
325 4N70 2HX 0.0000002823 0.68241 40.493
326 3CY2 MB9 0.00000006866 0.66992 40.493
327 4CLI 5P8 0.00000002261 0.73365 40.8451
328 2F57 23D 0.00000003285 0.66522 40.8451
329 4FF8 14S 0.001292 0.44273 40.8451
330 5KO1 6UY 0.0000002386 0.62806 40.9894
331 4E93 GUI 0.00000006794 0.68998 41.1972
332 3KRR DQX 0.000001159 0.66549 41.1972
333 4C2V YJA 0.00000525 0.5907 41.1972
334 3BZ3 YAM 0.000004159 0.62805 41.3043
335 2H8H H8H 0.00000002954 0.67489 41.5493
336 4Y0X ADP 0.00000009179 0.64412 41.5493
337 2PZI AXX 0.000004468 0.56099 41.5493
338 2VZ6 FEF 0.000005643 0.55623 41.5493
339 4KS7 X4Z 0.00000002702 0.68973 41.9014
340 3GNI ATP 0.00000008626 0.65912 41.9014
341 3GC8 B45 0.0000003962 0.62991 41.9014
342 2XK9 XK9 0.000001446 0.62828 41.9014
343 3C0G 3AM 0.0000006026 0.60185 41.9014
344 4C2W ANP 0.000000352 0.60888 41.9355
345 2Z7R STU 0.000000001485 0.74806 42.2535
346 2R5T ANP 0.0000003888 0.63031 42.2535
347 3TXO 07U 0.0000009444 0.59625 42.2535
348 1OPK P16 0.00008314 0.53212 42.2535
349 4JDI ANP 0.00000001094 0.70256 42.6056
350 2X4Z X4Z 0.0000001238 0.68088 42.6056
351 3DLS ADP 0.0000005707 0.60659 42.6056
352 5EYK 5U5 0.000000221 0.65524 42.7536
353 5USZ SKE 0.0000003684 0.64418 42.9066
354 4CSV STI 0.00009953 0.5152 42.9091
355 4OTH DRN 0.000000001643 0.74592 42.9577
356 2YAK OSV 0.000000007536 0.73349 42.9577
357 5N87 N66 0.0000001285 0.68202 42.9577
358 5DH3 5BS 0.0000001208 0.65203 42.9577
359 3LXK MI1 0.0000009329 0.62408 42.9577
360 5JKG 6LF 0.000002532 0.61917 42.9577
361 4NW6 2NS 0.00000003801 0.70274 43.3099
362 4UX9 ANP 0.0000001094 0.65413 43.3099
363 4X7Q 3YR 0.000000458 0.61787 43.3099
364 3PP0 03Q 0.00001411 0.56328 43.3099
365 3SXS PP2 0.000004356 0.57661 43.6567
366 4QMN DB8 0.000000007709 0.74447 43.662
367 5VCV 1N1 0.000000008502 0.71734 43.662
368 4M69 ANP 0.0000002091 0.64049 43.662
369 4Y85 499 0.000007275 0.55742 43.662
370 5TO8 7FM 0.000000664 0.65075 43.9716
371 4RFM 3P6 0.000005387 0.61494 43.985
372 4XV1 904 0.00000001362 0.72755 44.0141
373 5G1X ADP 0.00000004613 0.66203 44.0141
374 5L8L ADP 0.00000004158 0.65212 44.0141
375 3HMO STU 0.0000001162 0.64294 44.0141
376 4FG8 ATP 0.0000004417 0.62476 44.0141
377 3KRL KRL 0.0000006518 0.61938 44.0141
378 5DBX ANP 0.000004435 0.56114 44.0141
379 4XLI 1N1 0.00000475 0.56623 44.0299
380 5LXM ADP 0.00000005068 0.66009 44.1696
381 4YZC STU 0.00000001334 0.73436 44.3662
382 5HCY 60D 0.00000003381 0.72454 44.3662
383 2V7O DRN 0.00000001144 0.66401 44.3662
384 2VN9 GVD 0.00000009874 0.62075 44.3662
385 2J7T 274 0.000006804 0.58504 44.3662
386 2WEL K88 0.0000008757 0.54918 44.3662
387 3TKI S25 0.000000006433 0.77519 44.7183
388 3DAK ANP 0.00000000715 0.69654 44.7183
389 3GGF GVD 0.0000000225 0.673 44.7183
390 2RIO ADP 0.000000207 0.631 44.7183
391 2HY0 306 0.000001478 0.58355 44.7183
392 4Y8D 49J 0.000004401 0.57081 44.7183
393 4CQE CQE 0.0000003622 0.63181 44.964
394 4TWP AXI 0.0000001883 0.6872 45.0185
395 5FBN 5WF 0.000001171 0.63117 45.0185
396 3ORK AGS 0.0000001418 0.65987 45.0704
397 3SLS ANP 0.000000167 0.64818 45.0704
398 4ASE AV9 0.000001668 0.61151 45.0704
399 4AG8 AXI 0.0000103 0.5847 45.0704
400 4D2S DYK 0.0000141 0.53755 45.0704
401 2OFV 242 0.000006345 0.59545 45.1264
402 5A6N U7E 0.00000001283 0.6958 45.2297
403 3MVH WFE 0.000000004347 0.74549 45.4225
404 2X2M X2M 0.0000002731 0.63778 45.4225
405 4U0I 0LI 0.000163 0.51737 45.4225
406 3AQV TAK 0.0001371 0.49928 45.6522
407 5CEO 50D 0.000005223 0.56725 45.7746
408 4WNP 3RJ 0.000000003231 0.70847 45.993
409 1U5R ATP 0.00000001737 0.68223 46.1268
410 2WQN ADP 0.00000265 0.57164 46.1268
411 2OO8 RAJ 0.002342 0.44621 46.4789
412 5EW9 5VC 0.000002237 0.67547 46.4945
413 3E5A VX6 0.00000003216 0.52084 46.6418
414 5TA6 79D 0.00000001316 0.71629 46.831
415 3UIM ANP 0.0000001903 0.63614 46.831
416 3FC2 IBI 0.0001809 0.54923 46.831
417 2YAB AMP 0.00000006567 0.66164 47.1831
418 4U44 3D9 0.0000005933 0.61249 47.1831
419 5VC5 96M 0.000000002348 0.75359 47.8873
420 5JGA 6KC 0.0000001524 0.67222 47.8873
421 5AX9 4KT 0.0000002856 0.6277 48.2394
422 3IGO ANP 0.0000006553 0.51074 48.2394
423 4I6H 1C8 0.000002368 0.5837 48.5915
424 2WEI VGG 0.00001988 0.53367 48.5915
Pocket No.: 2; Query (leader) PDB : 2A19; Ligand: ANP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2a19.bio1) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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