Receptor
PDB id Resolution Class Description Source Keywords
2BB7 1.7 Å EC: 3.4.11.18 MN FORM OF E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH A QUINOLINYL SULFONAMIDE INHIBITOR ESCHERICHIA COLI TRIMETALLIC MN(II)-FORM HYDROLASE ENZYME-INHIBITOR COMPLEX METALLOENZYME
Ref.: METAL MEDIATED INHIBITION OF METHIONINE AMINOPEPTIDASE BY QUINOLINYL SULFONAMIDES BIOCHEM.BIOPHYS.RES.COMMUN. V. 339 506 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:301;
A:302;
A:303;
 Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
 submit data
54.938 Mn [Mn+2...
NA A:304;
 Part of Protein;
 none;
 submit data
22.99 Na [Na+]
QMS A:305;
 Valid;
 none;
 ic50 = 2.14 uM
222.264 C10 H10 N2 O2 S CS(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YVM 1.6 Å EC: 3.4.11.18 E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH THIABENDAZOLE ESCHERICHIA COLI HYDROLASE(ALPHA-AMINOACYLPEPTIDE) METAL COMPLEX THIABENDAZOLE METHIONINE AMINOPEPTIDASE INHIBITOR
Ref.: METAL IONS AS COFACTORS FOR THE BINDING OF INHIBITORS TO METHIONINE AMINOPEPTIDASE: A CRITICAL VIEW OF THE RELEVANCE OF IN VITRO METALLOENZYME ASSAYS. ANGEW.CHEM.INT.ED.ENGL. V. 44 3620 2005
Members (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
70% Homology Family (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
50% Homology Family (69)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
21 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
22 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
23 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
24 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
25 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
26 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
27 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
28 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
29 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
30 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
31 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
32 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
33 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
34 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
35 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
36 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
37 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
38 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
39 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
40 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
41 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
42 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
43 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
44 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
45 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
46 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
47 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
48 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
49 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
50 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
51 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
52 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
53 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
54 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
55 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
56 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
57 4IU6 - FZ1 C24 H23 N5 O COc1ccc(cc....
58 1QXZ ic50 = 19 uM M3C C8 H14 N2 O2 S2 CSCC[C@@H]....
59 1QXY ic50 = 16 uM M2C C10 H16 N2 O2 S CSCC[C@@H]....
60 1QXW ic50 = 7 uM M1C C10 H22 N2 O2 CCCC[C@@H]....
61 3IU9 ic50 = 0.24 uM T07 C9 H8 Cl2 N4 S c1cc(c(cc1....
62 3IU7 ic50 = 16 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
63 3PKE - Y10 C21 H31 N O5 CC(C)(C)/C....
64 3PKB ic50 = 0.62 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
65 3PKA ic50 = 0.54 uM Y02 C23 H37 N O6 Cc1cc(c(c(....
66 3PKC ic50 = 0.96 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
67 3IU8 ic50 = 0.58 uM T03 C9 H8 F N3 S c1cc(ccc1C....
68 3PKD ic50 = 0.76 uM Y10 C21 H31 N O5 CC(C)(C)/C....
69 1YJ3 - MET C5 H11 N O2 S CSCC[C@@H]....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: QMS; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 QMS 1 1
2 G8L 0.431373 0.769231
Similar Ligands (3D)
Ligand no: 1; Ligand: QMS; Similar ligands found: 918
No: Ligand Similarity coefficient
1 790 0.9938
2 M3Q 0.9925
3 6DP 0.9749
4 IOS 0.9707
5 NLA 0.9623
6 ZON 0.9609
7 I59 0.9598
8 KED 0.9541
9 67Y 0.9515
10 IAC 0.9515
11 MQB 0.9488
12 KYA 0.9451
13 8XQ 0.9433
14 NVU 0.9426
15 5OF 0.9426
16 SKF 0.9424
17 CSN 0.9419
18 FXH 0.9401
19 OA3 0.9399
20 M5H 0.9398
21 8GK 0.9391
22 TSR 0.9379
23 BK9 0.9378
24 T6Z 0.9372
25 2O6 0.9369
26 DTR 0.9364
27 IBM 0.9345
28 4KL 0.9343
29 MAJ 0.9322
30 54X 0.9320
31 PLP 0.9315
32 PXP 0.9315
33 TSS 0.9313
34 30G 0.9311
35 TRP 0.9309
36 AIN 0.9307
37 7I2 0.9301
38 EYY 0.9287
39 MP5 0.9284
40 N2M 0.9283
41 5GT 0.9281
42 2GQ 0.9280
43 9UL 0.9280
44 4OG 0.9273
45 CKA 0.9271
46 772 0.9258
47 C2Y 0.9255
48 57O 0.9254
49 LIP 0.9253
50 0FK 0.9252
51 HA5 0.9243
52 SYE 0.9242
53 SG2 0.9238
54 SRO 0.9236
55 5NS 0.9235
56 15N 0.9235
57 P9E 0.9234
58 61M 0.9233
59 LL1 0.9229
60 9BF 0.9224
61 DNC 0.9222
62 ZME 0.9222
63 5V7 0.9220
64 G1P 0.9220
65 ARP 0.9214
66 EUE 0.9213
67 JR2 0.9213
68 XFE 0.9211
69 MNP 0.9210
70 PEY 0.9206
71 EXD 0.9206
72 8HC 0.9204
73 KFH 0.9201
74 4ME 0.9194
75 EWG 0.9194
76 9AP 0.9194
77 92P 0.9193
78 LEL 0.9191
79 9ZE 0.9189
80 LDR 0.9187
81 YKG 0.9185
82 IPD 0.9181
83 0JD 0.9180
84 EV2 0.9178
85 2SX 0.9177
86 LP8 0.9177
87 GT1 0.9177
88 6VD 0.9175
89 5WN 0.9170
90 5WU 0.9169
91 YO5 0.9167
92 5F5 0.9167
93 1QP 0.9166
94 AMR 0.9165
95 22L 0.9163
96 JP2 0.9162
97 LZ2 0.9160
98 EYJ 0.9159
99 GTV 0.9158
100 P9T 0.9157
101 TU0 0.9157
102 C0W 0.9157
103 5JT 0.9153
104 I4D 0.9153
105 MHK 0.9153
106 L8J 0.9152
107 EXR 0.9152
108 E1T 0.9152
109 SLS 0.9152
110 9GP 0.9152
111 BG6 0.9151
112 OIA 0.9149
113 CX4 0.9149
114 G6P 0.9149
115 TWB 0.9148
116 7SX 0.9148
117 PMP 0.9148
118 APS 0.9147
119 VM1 0.9147
120 S0E 0.9146
121 2ZQ 0.9146
122 DNA 0.9145
123 2JK 0.9141
124 N1E 0.9141
125 7ZE 0.9140
126 9KH 0.9140
127 MUR 0.9139
128 28S 0.9139
129 6J9 0.9137
130 96R 0.9135
131 PRZ 0.9135
132 NPA 0.9134
133 MZM 0.9133
134 4R1 0.9130
135 ZIQ 0.9129
136 67X 0.9129
137 AKH 0.9124
138 DRG 0.9123
139 EYM 0.9123
140 7AP 0.9121
141 DNF 0.9121
142 TQU 0.9120
143 BB4 0.9120
144 5WY 0.9120
145 EYA 0.9118
146 NBG 0.9117
147 9F8 0.9117
148 MD6 0.9115
149 M5E 0.9114
150 2LY 0.9113
151 C9E 0.9109
152 MQG 0.9104
153 IOP 0.9103
154 ALN 0.9102
155 SBK 0.9100
156 KF5 0.9097
157 Q6T 0.9097
158 1A7 0.9096
159 M0Q 0.9095
160 8NX 0.9094
161 BNX 0.9092
162 B56 0.9091
163 EXL 0.9091
164 4I8 0.9090
165 3IL 0.9090
166 7VS 0.9089
167 M4E 0.9086
168 PLR 0.9083
169 JB8 0.9083
170 NPL 0.9082
171 EUH 0.9081
172 1X7 0.9080
173 JF2 0.9080
174 CTE 0.9079
175 AZM 0.9078
176 28N 0.9077
177 LAO 0.9077
178 1F1 0.9075
179 V1T 0.9074
180 BQ2 0.9074
181 0LH 0.9072
182 CFA 0.9069
183 PZP 0.9068
184 PLP PMP 0.9068
185 FWB 0.9066
186 IL5 0.9066
187 4Z9 0.9066
188 EVF 0.9065
189 TXW 0.9065
190 ETV 0.9064
191 ITW 0.9061
192 L21 0.9060
193 DK1 0.9060
194 LTN 0.9057
195 3Y7 0.9056
196 F95 0.9056
197 6XI 0.9056
198 PDC 0.9055
199 DHY 0.9055
200 6HP 0.9054
201 535 0.9053
202 ONR 0.9052
203 HLZ 0.9051
204 XEN 0.9051
205 AC2 0.9051
206 ST2 0.9048
207 GC2 0.9048
208 42C 0.9047
209 9FE 0.9047
210 1VQ 0.9045
211 HJB 0.9043
212 S3P 0.9041
213 GLP 0.9040
214 EYV 0.9040
215 7WR 0.9037
216 QQQ 0.9036
217 0F9 0.9036
218 ONZ 0.9036
219 P0P 0.9034
220 STT 0.9034
221 FLV 0.9033
222 AM1 0.9032
223 THA 0.9031
224 78U 0.9030
225 KGK 0.9029
226 JDN 0.9028
227 CR1 0.9027
228 3A9 0.9026
229 H5B 0.9026
230 1X8 0.9026
231 4TU 0.9025
232 GXG 0.9024
233 HNQ 0.9024
234 GRX 0.9022
235 2ZM 0.9021
236 R1P 0.9019
237 1QV 0.9018
238 F12 0.9018
239 ICO 0.9016
240 N8Y 0.9015
241 ZYR 0.9014
242 Z5P 0.9012
243 0HO 0.9011
244 BZJ 0.9010
245 3VX 0.9010
246 NAG 0.9010
247 7MX 0.9008
248 363 0.9007
249 YTX 0.9006
250 6NT 0.9005
251 JAW 0.9004
252 IQ5 0.9004
253 QPR 0.9002
254 7FF 0.9002
255 PD2 0.9002
256 CC5 0.8999
257 OTD 0.8997
258 0HN 0.8997
259 2VQ 0.8997
260 X04 0.8997
261 BY5 0.8997
262 96Z 0.8996
263 EV3 0.8995
264 HA7 0.8994
265 N91 0.8993
266 HA6 0.8992
267 OW7 0.8988
268 IBC 0.8985
269 N2I 0.8985
270 RVE 0.8982
271 M0W 0.8980
272 89J 0.8980
273 EY7 0.8979
274 I7A 0.8978
275 55D 0.8977
276 1SV 0.8976
277 KTW 0.8976
278 DHC 0.8976
279 BDP 0.8976
280 JYT 0.8975
281 KYN 0.8975
282 LZB 0.8974
283 505 0.8973
284 6NI 0.8973
285 HBO 0.8972
286 W8G 0.8972
287 3NY 0.8971
288 BA5 0.8971
289 RD4 0.8970
290 BIO 0.8969
291 M02 0.8969
292 I2E 0.8969
293 2K8 0.8968
294 UAN 0.8968
295 F52 0.8968
296 61O 0.8968
297 FUJ 0.8967
298 NCV 0.8967
299 428 0.8965
300 FWD 0.8965
301 8XL 0.8964
302 5NI 0.8963
303 68A 0.8962
304 8U3 0.8961
305 O2A 0.8961
306 OX2 0.8958
307 GJP 0.8955
308 TCR 0.8954
309 A6P 0.8953
310 X6P 0.8952
311 S7G 0.8951
312 1HN 0.8950
313 AY4 0.8950
314 VXX 0.8950
315 5F8 0.8949
316 M1H 0.8949
317 2KU 0.8948
318 JTH 0.8947
319 NQH 0.8946
320 AA 0.8945
321 O2Y 0.8945
322 657 0.8944
323 CH9 0.8943
324 JXK 0.8943
325 78P 0.8943
326 DX3 0.8942
327 HBI 0.8941
328 H2B 0.8941
329 5VL 0.8940
330 ABF 0.8939
331 PJW 0.8939
332 KMY 0.8938
333 CPW 0.8937
334 6KT 0.8936
335 B41 0.8936
336 3LJ 0.8934
337 H4B 0.8932
338 KP2 0.8932
339 2CZ 0.8932
340 27B 0.8931
341 NOK 0.8929
342 L07 0.8929
343 AX3 0.8929
344 TRF 0.8928
345 DXK 0.8928
346 KFN 0.8928
347 BOQ 0.8928
348 ANF 0.8928
349 5VJ 0.8927
350 U7E 0.8926
351 MS0 0.8926
352 7ZC 0.8925
353 BZM 0.8925
354 GO2 0.8925
355 M6Z 0.8924
356 091 0.8924
357 BCU 0.8922
358 5TY 0.8922
359 HLD 0.8922
360 F5C 0.8921
361 3J8 0.8921
362 5TZ 0.8920
363 HHS 0.8919
364 GNR 0.8919
365 BGC 0.8919
366 OSB 0.8918
367 M5N 0.8917
368 49O 0.8917
369 5FL 0.8915
370 AVA 0.8915
371 9R5 0.8915
372 II4 0.8914
373 NFM 0.8914
374 B61 0.8913
375 B4O 0.8912
376 JYW 0.8912
377 1SS 0.8912
378 OKM 0.8911
379 PVK 0.8910
380 PVQ 0.8910
381 60Q 0.8909
382 GCU 0.8908
383 HWH 0.8907
384 INE 0.8907
385 P7Y 0.8907
386 GV9 0.8907
387 CUT 0.8905
388 XQK 0.8905
389 3TC 0.8904
390 DTE 0.8900
391 ALX 0.8900
392 ZZ8 0.8900
393 4RU 0.8899
394 MB1 0.8899
395 36E 0.8898
396 8WZ 0.8898
397 HPT 0.8897
398 CCV 0.8896
399 344 0.8896
400 2HU 0.8896
401 M6D 0.8895
402 2J9 0.8895
403 M6P 0.8894
404 1L5 0.8893
405 I7B 0.8891
406 0GZ 0.8890
407 NIY 0.8889
408 0W1 0.8888
409 ABI 0.8888
410 5RN 0.8887
411 ZEC 0.8887
412 GDL 0.8886
413 9UG 0.8886
414 8G0 0.8885
415 J9Q 0.8884
416 CIP 0.8883
417 ROI 0.8882
418 8ZE 0.8882
419 DBJ 0.8881
420 KDV 0.8880
421 AJD 0.8879
422 512 0.8878
423 FT6 0.8877
424 5OO 0.8876
425 YE7 0.8875
426 5OB 0.8873
427 GCB 0.8873
428 0DN 0.8872
429 2UZ 0.8871
430 UFV 0.8871
431 ASE 0.8870
432 NID 0.8870
433 M4B 0.8870
434 THM 0.8868
435 CWD 0.8868
436 MYI 0.8868
437 GO8 0.8867
438 BPU 0.8866
439 3IB 0.8865
440 6ZW 0.8865
441 DA4 0.8863
442 KLK 0.8863
443 5PX 0.8862
444 JF1 0.8862
445 D80 0.8862
446 1FE 0.8862
447 Q5M 0.8861
448 96U 0.8859
449 N3W 0.8859
450 7ME 0.8859
451 M78 0.8859
452 ISJ 0.8859
453 F69 0.8858
454 9FL 0.8858
455 I6G 0.8856
456 PH2 0.8854
457 1AL 0.8854
458 ESI 0.8853
459 3VW 0.8851
460 226 0.8851
461 7CT 0.8851
462 FE DB1 0.8849
463 OUB 0.8848
464 3MG 0.8848
465 8G6 0.8846
466 VNL 0.8846
467 UFO 0.8845
468 8DA 0.8845
469 MXD 0.8844
470 BPY 0.8843
471 EVO 0.8843
472 JTA 0.8842
473 DDU 0.8841
474 3SU 0.8841
475 774 0.8839
476 DEW 0.8838
477 EOL 0.8837
478 5XC 0.8837
479 SYR 0.8837
480 KIB 0.8836
481 GNV 0.8836
482 X8D 0.8834
483 LTT 0.8833
484 CGW 0.8833
485 8WT 0.8832
486 CE2 0.8832
487 GDE 0.8831
488 JY2 0.8831
489 25O 0.8831
490 2HC 0.8830
491 BZ3 0.8830
492 GCO 0.8829
493 5NE 0.8829
494 GL1 0.8829
495 VK3 0.8827
496 EQA 0.8827
497 HHR 0.8826
498 BZQ 0.8825
499 QIF 0.8824
500 7M6 0.8824
501 HSX 0.8823
502 F40 0.8822
503 F1X 0.8822
504 6BL 0.8821
505 AKD 0.8820
506 QUS 0.8819
507 L7T 0.8818
508 S7B 0.8817
509 3D1 0.8817
510 3D8 0.8817
511 NBV 0.8816
512 878 0.8816
513 FNA 0.8816
514 GPM 0.8815
515 URC 0.8814
516 JXW 0.8814
517 S0G 0.8814
518 D87 0.8814
519 1IT 0.8813
520 NDG 0.8813
521 MDR 0.8812
522 M2K 0.8812
523 GI3 0.8811
524 2D3 0.8811
525 6R8 0.8811
526 DG2 0.8810
527 EVA 0.8809
528 3RI 0.8809
529 GL6 0.8809
530 S24 0.8809
531 9CA 0.8809
532 SYA 0.8808
533 FF2 0.8808
534 1VK 0.8808
535 3HP 0.8808
536 49N 0.8807
537 U1K 0.8807
538 HQD 0.8805
539 7L4 0.8803
540 3R6 0.8803
541 IPT 0.8802
542 97T 0.8802
543 1U7 0.8802
544 B2Y 0.8801
545 EGR 0.8801
546 B86 0.8799
547 QZ8 0.8798
548 R20 0.8798
549 15L 0.8798
550 TR7 0.8797
551 3B4 0.8797
552 2LB 0.8796
553 TMC 0.8796
554 12T 0.8795
555 5P3 0.8795
556 GNM 0.8794
557 4AV 0.8794
558 FBG 0.8793
559 NGT 0.8792
560 CKU 0.8792
561 5RO 0.8791
562 D07 0.8790
563 5AD 0.8790
564 IWD 0.8790
565 JRB 0.8789
566 GZ2 0.8789
567 8WO 0.8788
568 R9Y 0.8788
569 JV4 0.8787
570 F6P 0.8786
571 K3Q 0.8785
572 XI7 0.8785
573 64C 0.8784
574 M1E 0.8784
575 CUH 0.8784
576 7B3 0.8783
577 5BT 0.8783
578 X0T 0.8782
579 4XV 0.8781
580 9X5 0.8780
581 MR1 0.8779
582 2KA 0.8779
583 F9Y 0.8779
584 I3A 0.8779
585 MIL 0.8778
586 BIK 0.8777
587 C4E 0.8776
588 MJ2 0.8776
589 N2Z 0.8775
590 TNX 0.8775
591 8W9 0.8775
592 S7A 0.8775
593 FTV 0.8774
594 LLT 0.8773
595 CWJ 0.8772
596 36M 0.8771
597 5WT 0.8771
598 0FR 0.8771
599 A5H 0.8770
600 N7I 0.8770
601 H7S 0.8770
602 0J4 0.8770
603 GTR 0.8770
604 TVP 0.8769
605 4MU 0.8768
606 JXT 0.8767
607 4BY 0.8767
608 BPS 0.8766
609 4BL 0.8766
610 5E5 0.8764
611 XJE 0.8764
612 QR2 0.8763
613 TWO 0.8763
614 2UD 0.8762
615 XQG 0.8761
616 MPK 0.8760
617 3EB 0.8759
618 6QF 0.8758
619 5B2 0.8758
620 F31 0.8757
621 TOM 0.8756
622 K68 0.8756
623 DHK 0.8755
624 ESX 0.8755
625 YZM 0.8755
626 A1Y 0.8755
627 6ME 0.8754
628 2FD 0.8753
629 D1Y 0.8752
630 4XS 0.8752
631 0GY 0.8752
632 94W 0.8751
633 ALE 0.8751
634 DJN 0.8750
635 CHQ 0.8749
636 A5P 0.8748
637 52C 0.8748
638 GNG 0.8747
639 GAL 0.8747
640 BWD 0.8746
641 5MD 0.8746
642 NGW 0.8744
643 GLC 0.8743
644 3L1 0.8742
645 ZYV 0.8741
646 0OL 0.8740
647 K3Y 0.8740
648 0GA 0.8739
649 XG1 0.8739
650 JYK 0.8738
651 ANC 0.8737
652 PTS 0.8736
653 FDR 0.8736
654 TB8 0.8736
655 K97 0.8735
656 HQJ 0.8734
657 GI1 0.8733
658 RM1 0.8733
659 S3B 0.8733
660 THU 0.8732
661 MCY 0.8731
662 P4L 0.8731
663 42A 0.8730
664 NGO 0.8730
665 MIG 0.8729
666 IQZ 0.8728
667 6FZ 0.8728
668 78Y 0.8727
669 QUB 0.8727
670 LZM 0.8727
671 FUZ 0.8725
672 GFP 0.8725
673 3Z8 0.8725
674 2F6 0.8724
675 E7R 0.8722
676 4FH 0.8721
677 4SX 0.8721
678 HJH 0.8720
679 7M5 0.8719
680 ENG 0.8719
681 TT4 0.8719
682 JXZ 0.8717
683 L22 0.8717
684 MFZ 0.8717
685 2FY 0.8717
686 NWD 0.8716
687 582 0.8716
688 LDP 0.8715
689 4HC 0.8715
690 8Y7 0.8715
691 F34 0.8715
692 AUV 0.8715
693 7HQ 0.8714
694 PRO GLY 0.8714
695 0XT 0.8714
696 CRB 0.8713
697 LYL 0.8713
698 8S0 0.8712
699 692 0.8712
700 3MB 0.8712
701 8MO 0.8711
702 KG1 0.8711
703 OVM 0.8711
704 4NS 0.8711
705 KWQ 0.8710
706 LNR 0.8710
707 C09 0.8710
708 S3C 0.8709
709 ZSP 0.8708
710 CK2 0.8708
711 463 0.8708
712 GSY 0.8707
713 5NN 0.8706
714 XQI 0.8706
715 3R4 0.8705
716 6HO 0.8705
717 4VS 0.8705
718 H33 0.8704
719 3DT 0.8703
720 CLU 0.8703
721 DBS 0.8703
722 ICB 0.8702
723 BGP 0.8702
724 0OY 0.8701
725 1Z8 0.8701
726 ET0 0.8701
727 5LD 0.8698
728 3ZB 0.8698
729 B52 0.8698
730 4A5 0.8698
731 JG8 0.8697
732 7ZL 0.8697
733 CIT 0.8697
734 39U 0.8696
735 R8Y 0.8696
736 BZ2 0.8696
737 OW4 0.8696
738 DUR 0.8696
739 YOF 0.8695
740 CG8 0.8695
741 Q24 0.8694
742 RP5 0.8694
743 HWD 0.8694
744 KBG 0.8693
745 X0W 0.8693
746 KJ5 0.8692
747 G3F 0.8691
748 PQK 0.8691
749 2BG 0.8691
750 49P 0.8691
751 J9W 0.8690
752 N0Z 0.8690
753 OVP 0.8690
754 FA6 0.8689
755 982 0.8689
756 LFQ 0.8689
757 H7Y 0.8687
758 AQO 0.8686
759 L5V 0.8685
760 MEW 0.8684
761 9LI 0.8680
762 F06 0.8679
763 J6W 0.8679
764 GNJ 0.8678
765 TNF 0.8677
766 ID2 0.8676
767 CLZ 0.8675
768 TOH 0.8674
769 DCZ 0.8674
770 ODO 0.8672
771 GA2 0.8671
772 TZM 0.8671
773 6PB 0.8670
774 209 0.8670
775 7NI 0.8670
776 AEH 0.8670
777 537 0.8669
778 NLQ 0.8669
779 DC5 0.8666
780 PRF 0.8665
781 7M2 0.8665
782 CXH 0.8665
783 MMS 0.8663
784 K82 0.8661
785 K25 0.8661
786 KJU 0.8661
787 DQU 0.8659
788 PFL 0.8659
789 ZZZ 0.8659
790 FLC 0.8659
791 LDC 0.8658
792 PE0 0.8658
793 PQ0 0.8656
794 JY4 0.8655
795 AZY 0.8654
796 RB2 0.8654
797 WUB 0.8653
798 JND 0.8653
799 H35 0.8652
800 KBB 0.8652
801 ADA 0.8652
802 3GX 0.8651
803 KLV 0.8651
804 4NP 0.8651
805 E4P 0.8651
806 BQ5 0.8650
807 TTY 0.8650
808 BHQ 0.8650
809 K48 0.8648
810 CBF 0.8648
811 FER 0.8648
812 IQQ 0.8645
813 JHY 0.8645
814 3AK 0.8645
815 1XA 0.8645
816 QSH 0.8644
817 ZYQ 0.8644
818 MOK 0.8644
819 AJ2 0.8642
820 PUE 0.8641
821 W22 0.8641
822 44V 0.8640
823 M5K 0.8640
824 ICT 0.8640
825 BZE 0.8639
826 AMQ 0.8639
827 LWS 0.8637
828 DPT 0.8636
829 EV0 0.8635
830 B21 0.8633
831 MEX 0.8633
832 TMG 0.8631
833 AHU 0.8631
834 GOX 0.8631
835 8HG 0.8628
836 E1K 0.8628
837 977 0.8627
838 5GU 0.8627
839 V55 0.8627
840 AS3 0.8627
841 2V0 0.8626
842 QBM 0.8623
843 EMZ 0.8623
844 86L 0.8620
845 QX4 0.8620
846 GJK 0.8619
847 APZ 0.8618
848 B62 0.8618
849 VYM 0.8617
850 5RP 0.8616
851 SHA 0.8615
852 5GV 0.8614
853 DI6 0.8614
854 7D7 0.8612
855 5WS 0.8608
856 FGZ 0.8608
857 M1Q 0.8606
858 TLM 0.8606
859 IV2 0.8604
860 LI6 0.8601
861 4NZ 0.8601
862 OAI 0.8600
863 NGA 0.8600
864 8NB 0.8598
865 ESP 0.8598
866 CIY 0.8598
867 14W 0.8597
868 PW1 0.8595
869 BGU 0.8595
870 EKZ 0.8593
871 AOJ 0.8592
872 HH6 0.8592
873 44W 0.8592
874 UNJ 0.8591
875 X11 0.8590
876 MAG 0.8587
877 4TP 0.8587
878 OQC 0.8586
879 ADN 0.8586
880 QBK 0.8586
881 X09 0.8585
882 9E3 0.8584
883 P80 0.8584
884 8RK 0.8583
885 GRF 0.8582
886 DEE 0.8582
887 JCZ 0.8580
888 A73 0.8579
889 94E 0.8578
890 YIE 0.8576
891 92O 0.8576
892 SNG 0.8576
893 2FX 0.8574
894 RSV 0.8574
895 SCT 0.8569
896 1WC 0.8568
897 2LW 0.8568
898 AVO 0.8566
899 X48 0.8560
900 SKM 0.8559
901 X0V 0.8557
902 3XR 0.8556
903 2MN 0.8555
904 PIQ 0.8547
905 AJ1 0.8545
906 AN3 0.8539
907 OCZ 0.8536
908 6FB 0.8534
909 KDG 0.8531
910 E7S 0.8529
911 GXD 0.8525
912 RNO 0.8523
913 XCG 0.8519
914 Q0K 0.8512
915 SNO 0.8512
916 MUA 0.8509
917 0FO 0.8504
918 CHB 0.8502
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1YVM; Ligand: TMG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1yvm.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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