Receptor
PDB id Resolution Class Description Source Keywords
2EWB 1.85 Å EC: 3.4.11.1 THE CRYSTAL STRUCTURE OF BOVINE LENS LEUCINE AMINOPEPTIDASE WITH ZOFENOPRILAT BOS TAURUS AMINOPEPTIDASE METALLOPEPTIDASE HYDROLASE
Ref.: METAL ION SUBSTITUTION IN THE CATALYTIC SITE GREATL THE BINDING OF SULFHYDRYL-CONTAINING COMPOUNDS TO L AMINOPEPTIDASE. BIOCHEMISTRY V. 45 3226 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CO3 A:500;
Invalid;
none;
submit data
60.009 C O3 C(=O)...
MPD A:501;
A:502;
A:503;
A:504;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
118.174 C6 H14 O2 C[C@@...
NA A:490;
Part of Protein;
none;
submit data
22.99 Na [Na+]
ZED A:2000;
Valid;
none;
Ki = 0.8 uM
325.446 C15 H19 N O3 S2 C[C@H...
ZN A:488;
A:489;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1LAN 1.9 Å EC: 3.4.11.1 LEUCINE AMINOPEPTIDASE COMPLEX WITH L-LEUCINAL BOS TAURUS AMINOPEPTIDASE EXOPEPTIDASE METALLOPEPTIDASE HYDROLASE (AAMINOACYLPEPTIDE)
Ref.: TWO-METAL ION MECHANISM OF BOVINE LENS LEUCINE AMINOPEPTIDASE: ACTIVE SITE SOLVENT STRUCTURE AND B MODE OF L-LEUCINAL, A GEM-DIOLATE TRANSITION STATE BY X-RAY CRYSTALLOGRAPHY. BIOCHEMISTRY V. 34 14792 1995
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
70% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2J9A ic50 = 1.3 uM ALA MLE TYR TYR AHY n/a n/a
2 1LCP Ki = 0.23 uM PLU C5 H14 N O3 P CC(C)C[C@H....
3 2EWB Ki = 0.8 uM ZED C15 H19 N O3 S2 C[C@H](CS)....
4 1BLL - L2O VAL VAL ASP n/a n/a
5 1LAN Ki = 60 nM LEU C6 H13 N O2 CC(C)C[C@@....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ZED; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ZED 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: ZED; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: 18
This union binding pocket(no: 2) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5NTD BES 31.405
2 5NTD BES 31.405
3 5NTD BES 31.405
4 5NTD BES 31.405
5 5NTD BES 31.405
6 5NTD BES 31.405
7 5NTD BES 31.405
8 5NTD BES 31.405
9 5NTD BES 31.405
10 5NTD BES 31.405
11 5NTD BES 31.405
12 5NTD BES 31.405
13 5NTD BES 31.405
14 5NTD BES 31.405
15 5NTD BES 31.405
16 5NTD BES 31.405
17 5NTD BES 31.405
18 5NTD BES 31.405
Pocket No.: 3; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 1LAN; Ligand: LEU; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 1lan.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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