Receptor
PDB id Resolution Class Description Source Keywords
2FHJ 2 Å EC: 2.3.1.101 CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH I TS COENZYMES METHANOPYRUS KANDLERI TETRAHYDROMETHANOPTERIN; METHANOFURAN; C1 METABOLISM; FORMYLTRANSFERASE; COMPLEX
Ref.: THE STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES J.MOL.BIOL. V. 357 870 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
H4Z A:905;
C:904;
Valid;
Valid;
none;
none;
submit data
804.693 C31 H45 N6 O17 P CC1[C...
K A:312;
A:313;
A:315;
A:316;
B:317;
B:319;
B:322;
B:504;
B:505;
C:303;
C:306;
C:309;
C:506;
D:500;
D:501;
D:502;
D:503;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
39.098 K [K+]
MFN A:900;
A:902;
C:901;
D:903;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
776.741 C35 H44 N4 O16 c1cc(...
PE3 C:3792;
Invalid;
none;
submit data
634.751 C28 H58 O15 C(COC...
PE4 A:922;
D:920;
D:921;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
354.436 C16 H34 O8 CCOCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FHJ 2 Å EC: 2.3.1.101 CRYSTAL STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH I TS COENZYMES METHANOPYRUS KANDLERI TETRAHYDROMETHANOPTERIN; METHANOFURAN; C1 METABOLISM; FORMYLTRANSFERASE; COMPLEX
Ref.: THE STRUCTURE OF FORMYLMETHANOFURAN: TETRAHYDROMETHANOPTERIN FORMYLTRANSFERASE IN COMPLEX WITH ITS COENZYMES J.MOL.BIOL. V. 357 870 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2FHJ - MFN C35 H44 N4 O16 c1cc(ccc1C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2FHJ - MFN C35 H44 N4 O16 c1cc(ccc1C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2FHJ - MFN C35 H44 N4 O16 c1cc(ccc1C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: H4Z; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 H4Z 1 1
2 F4M 0.77931 1
3 N4M 0.660131 0.963415
4 H4M 0.645161 0.931818
5 E4M 0.610063 0.964706
Ligand no: 2; Ligand: MFN; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 MFN 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: H4Z; Similar ligands found: 0
No: Ligand Similarity coefficient
Ligand no: 2; Ligand: MFN; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FHJ; Ligand: H4Z; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2fhj.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2FHJ; Ligand: MFN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2fhj.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2FHJ; Ligand: MFN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2fhj.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2FHJ; Ligand: H4Z; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2fhj.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 2FHJ; Ligand: MFN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2fhj.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2FHJ; Ligand: MFN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2fhj.bio1) has 22 residues
No: Leader PDB Ligand Sequence Similarity
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