Receptor
PDB id Resolution Class Description Source Keywords
2FIB 2.01 Å NON-ENZYME: OTHER RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) COMPLEXED TO THE PEPTIDE GLY- P RO-ARG-PRO AT PH 6.0 HOMO SAPIENS FIBRINOGEN BLOOD COAGULATION FIBRIN POLYMERIZATION COMPLEX (BLOOD COAGULATION/PEPTIDE)
Ref.: THE PRIMARY FIBRIN POLYMERIZATION POCKET: THREE-DIMENSIONAL STRUCTURE OF A 30-KDA C-TERMINAL GAMMA CHAIN FRAGMENT COMPLEXED WITH THE PEPTIDE GLY-PRO-ARG-PRO. PROC.NATL.ACAD.SCI.USA V. 94 7176 1997
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:412;
 Part of Protein;
 none;
 submit data
40.078 Ca [Ca+2...
GLY PRO ARG PRO B:2;
 Valid;
 none;
 submit data
411.507 n/a O=C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FIB 2.01 Å NON-ENZYME: OTHER RECOMBINANT HUMAN GAMMA-FIBRINOGEN CARBOXYL TERMINAL FRAGMENT (RESIDUES 143-411) COMPLEXED TO THE PEPTIDE GLY- P RO-ARG-PRO AT PH 6.0 HOMO SAPIENS FIBRINOGEN BLOOD COAGULATION FIBRIN POLYMERIZATION COMPLEX (BLOOD COAGULATION/PEPTIDE)
Ref.: THE PRIMARY FIBRIN POLYMERIZATION POCKET: THREE-DIMENSIONAL STRUCTURE OF A 30-KDA C-TERMINAL GAMMA CHAIN FRAGMENT COMPLEXED WITH THE PEPTIDE GLY-PRO-ARG-PRO. PROC.NATL.ACAD.SCI.USA V. 94 7176 1997
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2FIB - GLY PRO ARG PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 2FIB - GLY PRO ARG PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 2FIB - GLY PRO ARG PRO n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLY PRO ARG PRO; Similar ligands found: 31
No: Ligand ECFP6 Tc MDL keys Tc
1 GLY PRO ARG PRO 1 1
2 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.622449 0.946429
3 GLY ARG LEU LEU PRO 0.53125 0.864407
4 GLY HIS ARG PRO NH2 0.524752 0.913793
5 ALA PRO ASP THR ARG PRO ALA PRO 0.5 0.830769
6 ASP LEU THR ARG PRO 0.481132 0.787879
7 ARG GLU ARG SER PRO THR ARG 0.475248 0.83871
8 THR LYS PRO ARG 0.473684 0.910714
9 SER ARG SEP SER PRO 0.471154 0.761194
10 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.46789 0.898305
11 ARG ARG ALA SEP ALA PRO LEU PRO 0.467213 0.757143
12 ARG PRO PRO LYS PRO ARG PRO ARG 0.463636 0.981481
13 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.462963 0.931035
14 DMG PRO ARG ARG ARG SER ARG LYS PRO 0.462264 0.791045
15 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.455357 0.913793
16 GLY MET PRO ARG GLY ALA 0.45045 0.825397
17 ARG PRO LYS PRO LEU VAL ASP PRO 0.441441 0.898305
18 PRO GLN ILE ILE ASN ARG PRO GLN ASN 0.436975 0.854839
19 PRO ALA ILE ILE ASN ARG PRO GLN ASN 0.435897 0.854839
20 DPN PRO ARG 0.431373 0.862069
21 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.414815 0.818182
22 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.413534 0.857143
23 GLY PRO SER SER GLY GLY 0.412371 0.741935
24 DPN PRO DAR ILE NH2 0.410714 0.819672
25 DPN PRO DAR CYS NH2 0.409091 0.847458
26 THR PRO ARG ARG SER MLZ SER ALA 0.408696 0.753623
27 GLY PHE ARG PRO 0.40566 0.864407
28 LEU ASP PRO ARG 0.40367 0.822581
29 PRO PRO LYS LYS LYS ARG LYS VAL 0.4 0.896552
30 SER PRO LYS ARG ILE ALA 0.4 0.796875
31 GLY HIS ARG PRO 0.4 0.883333
Similar Ligands (3D)
Ligand no: 1; Ligand: GLY PRO ARG PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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