Receptor
PDB id Resolution Class Description Source Keywords
2FOO 2.2 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 359-362 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU PRO GLY GLY SER ARG B:358;
 Valid;
 none;
 submit data
601.618 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FOJ 1.6 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 364-367 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLU PRO GLY GLY SER ARG; Similar ligands found: 41
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU PRO GLY GLY SER ARG 1 1
2 DPN PRO ARG 0.477876 0.83871
3 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.472222 0.909091
4 ARG SER ARG 0.463918 0.737705
5 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.458333 0.865672
6 GLU LYS PRO SER SER SER 0.456897 0.885246
7 THR PRO ARG VAL THR GLY GLY GLY ALA MET 0.453901 0.830986
8 THR LYS PRO ARG 0.45045 0.883333
9 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.444444 0.90625
10 SER PRO LYS ARG ILE ALA 0.444444 0.920635
11 DPN PRO DAR CYS NH2 0.442623 0.825397
12 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.43949 0.867647
13 ASN ARG PRO ILE LEU SER LEU 0.43609 0.880597
14 GLY ASP CYS PHE SER LYS PRO ARG 0.435374 0.9375
15 GLU ARG GLY SER GLY ARG 0.434783 0.786885
16 ARG VAL ALA SER PRO THR SER GLY VAL 0.426471 0.907692
17 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.42446 0.893939
18 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.421429 0.835821
19 ARG THR PHE SER PRO THR TYR GLY LEU 0.421053 0.808219
20 DPN PRO DAR DTH NH2 0.420635 0.875
21 ARG PRO PRO GLY PHE 0.418605 0.828125
22 ARG PRO PRO GLY PHE SER PRO PHE ARG 0.418605 0.828125
23 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.418301 0.909091
24 ACE GLN GLU ARG GLU VAL PRO CYS 0.416667 0.846154
25 MBN ABN RNG GLY VAL ARG 0.413793 0.714286
26 ARG PRO LYS ARG ILE ALA 0.413534 0.830769
27 LYS PRO VAL LEU ARG THR ALA 0.413043 0.892308
28 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.412587 0.785714
29 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.409722 0.867647
30 1IP CYS PHE SER LYS PRO ARG 0.409396 0.895522
31 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.409091 0.842857
32 THR PRO ARG ARG SER MLZ SER ALA 0.407692 0.84058
33 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.40625 0.819444
34 ILE GLY PRO GLY ARG ALA PHE TYR ALA 0.405229 0.763889
35 ARG GLU ARG SER PRO THR ARG 0.404959 0.967213
36 ARG VAL ALA SEP PRO THR SER GLY VAL 0.40411 0.830986
37 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.403846 0.855072
38 ARG SER LEU SEP ALA PRO GLY ASN 0.402878 0.805556
39 ARG ARG ARG GLU ARG SER PRO THR ARG 0.402878 0.952381
40 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.402685 0.867647
41 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.4 0.785714
Similar Ligands (3D)
Ligand no: 1; Ligand: GLU PRO GLY GLY SER ARG; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FOJ; Ligand: GLY ALA ARG ALA HIS SER SER; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2foj.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
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