Receptor
PDB id Resolution Class Description Source Keywords
2FOO 2.2 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 359-362 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU PRO GLY GLY SER ARG B:358;
Valid;
none;
submit data
601.618 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2FOJ 1.6 Å EC: 3.1.2.15 THE CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HAUSP/USP7 WITH P53 PEPTIDE 364-367 HOMO SAPIENS MATH DOMAIN HYDROLASE
Ref.: MOLECULAR RECOGNITION OF P53 AND MDM2 BY USP7/HAUSP NAT.STRUCT.MOL.BIOL. V. 13 285 2006
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2FOP - GLU LYS PRO SER SER SER n/a n/a
2 4KG9 - ARG VAL SER PRO SER THR SER TYR THR PRO n/a n/a
3 2FOO - GLU PRO GLY GLY SER ARG n/a n/a
4 2FOJ - GLY ALA ARG ALA HIS SER SER n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLU PRO GLY GLY SER ARG; Similar ligands found: 43
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU PRO GLY GLY SER ARG 1 1
2 CYS THR PRO SER ARG 0.530435 0.90625
3 THR LYS PRO ARG 0.509615 0.883333
4 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.489051 0.9375
5 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.478873 0.909091
6 DPN PRO ARG 0.468468 0.83871
7 GLU LYS PRO SER SER SER 0.447368 0.868852
8 GLY LEU LEU GLY SER PRO VAL ARG ALA 0.443609 0.90625
9 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.439189 0.909091
10 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.4375 0.865672
11 GLY GLU ARG THR ILE PRO ILE THR ARG GLU 0.437037 0.893939
12 ARG PRO GLY ASN PHE PHE GLN SER ARG PRO 0.436242 0.855072
13 ARG SER ARG 0.43299 0.737705
14 ARG PRO GLY ASN PHE LEU GLN SER SER PRO 0.432258 0.855072
15 ASP VAL GLN THR GLY ARG ARG PRO TYR GLU 0.430464 0.842857
16 ARG VAL ALA SER PRO THR SER GLY VAL 0.42963 0.907692
17 GLU ARG THR ILE PRO ILE THR ARG GLU 0.428571 0.893939
18 ASN ARG PRO ILE LEU SER LEU 0.428571 0.880597
19 SER PRO LYS ARG ILE ALA 0.426357 0.90625
20 ARG ARG ARG GLU ARG SER PRO THR ARG 0.425373 0.952381
21 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.42446 0.835821
22 ASN TYR THR PRO GLY PRO GLY THR ARG PHE 0.423077 0.819444
23 GLU ARG GLY SER GLY ARG 0.421053 0.786885
24 MBN ABN RNG GLY VAL ARG 0.421053 0.714286
25 DPN PRO DAR DTH NH2 0.419355 0.859375
26 ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 0.419355 0.855072
27 ARG PRO LYS ARG ILE ALA 0.418605 0.830769
28 DPN PRO DAR CYS NH2 0.418033 0.809524
29 LYS PRO VAL LEU ARG THR ALA 0.41791 0.892308
30 ARG PRO GLY ASN PHE LEU GLN SER ARG LEU 0.416667 0.855072
31 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.414966 0.757143
32 ARG PRO PRO GLY PHE SER PRO PHE ARG 0.413534 0.815385
33 ASN TYR THR PRO GLY PRO GLY ILE ARG PHE 0.4125 0.783784
34 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.412121 0.8
35 ALA ASN SER ARG VAL PRO THR SER ILE ILE 0.411765 0.865672
36 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.411392 0.842857
37 ALA GLY SER VAL GLU GLN TPO PRO LYS LYS 0.409396 0.763889
38 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.408163 0.867647
39 DPN PRO DAR ILE NH2 0.408 0.772727
40 PHE ASN ARG PRO VAL 0.407692 0.848485
41 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.405594 0.785714
42 ARG PRO GLN VAL PRO LEU ARG PRO MET 0.405594 0.785714
43 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.4 0.794521
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2FOJ; Ligand: GLY ALA ARG ALA HIS SER SER; Similar sites found: 7
This union binding pocket(no: 1) in the query (biounit: 2foj.bio1) has 14 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4UZI IMD 0.02074 0.40754 1.93548
2 5FPE 3TR 0.0003755 0.4076 3.22581
3 2PKA BEN 0.009607 0.40959 4.60526
4 2W68 SIA GAL BGC 0.01858 0.40181 5.80645
5 2IRY DGT 0.01637 0.40812 7.74194
6 2B6N ALA PRO THR 0.02636 0.40093 7.74194
7 3IVV ASP GLU VAL THR SER THR THR SER SER SER 0.00002244 0.53338 20
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