Receptor
PDB id Resolution Class Description Source Keywords
2HL3 2.03 Å NON-ENZYME: MOBILE CRYSTAL STRUCTURE OF THE A49M MUTANT CAP-GLY DOMAIN OF HUMAN 1 (P150-GLUED) IN COMPLEX WITH HUMAN EB1 C-TERMINAL HEXAPEP HOMO SAPIENS MICROTUBULE BINDING DYNACTINCYTOSKELETON ASSOCIATED PROTEIP150GLUED EB1 +TIP PROTEIN COMPLEX STRUCTURE EEY/F-COO- MOTIF CLIP-170 ALPHA-TUBULIN STRUCTURAL PROTEIN
Ref.: KEY INTERACTION MODES OF DYNAMIC +TIP NETWORKS. MOL.CELL V. 23 663 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU GLU GLN GLU GLU TYR C:266;
 Valid;
 none;
 Kd = 0.17 uM
436.397 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HL3 2.03 Å NON-ENZYME: MOBILE CRYSTAL STRUCTURE OF THE A49M MUTANT CAP-GLY DOMAIN OF HUMAN 1 (P150-GLUED) IN COMPLEX WITH HUMAN EB1 C-TERMINAL HEXAPEP HOMO SAPIENS MICROTUBULE BINDING DYNACTINCYTOSKELETON ASSOCIATED PROTEIP150GLUED EB1 +TIP PROTEIN COMPLEX STRUCTURE EEY/F-COO- MOTIF CLIP-170 ALPHA-TUBULIN STRUCTURAL PROTEIN
Ref.: KEY INTERACTION MODES OF DYNAMIC +TIP NETWORKS. MOL.CELL V. 23 663 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 68 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 59 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 40 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLU GLU GLN GLU GLU TYR; Similar ligands found: 41
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU GLU GLN GLU GLU TYR 1 1
2 THR ASN GLU PHE TYR PHE 0.662338 0.866667
3 GLY GLU GLU GLU GLY GLU CYS TYR 0.65 0.869565
4 THR ASN GLU TYR TYR VAL 0.575 0.8125
5 LYS LYS ALA THR GLN ALA SEP GLN GLU TYR 0.571429 0.740741
6 GLU ASN GLN LYS GLU TYR PHE PHE 0.554348 0.8
7 TYR GLU TRP 0.54023 0.8125
8 VAL TYR 0.537313 0.790698
9 TYR GLN PHE 0.518987 0.928571
10 SER GLN ASN TYR 0.518519 0.8125
11 THR ASN GLU TYR LYS VAL 0.494624 0.8
12 ASP ASP ASP ASP TYR 0.493333 0.880952
13 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.48913 0.847826
14 ALA THR ALA ALA ALA THR GLU ALA TYR 0.488889 0.847826
15 SER SER ARG THR ARG ARG GLU GLU GLN LEU 0.486111 0.727273
16 GLY TYR 0.484848 0.795455
17 THR ASN GLU PHE ALA PHE 0.471264 0.73913
18 SEP GLN GLU TYR NH2 0.460674 0.754717
19 ACE ILE TYR GLU SER LEU 0.457447 0.745098
20 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.45045 0.769231
21 ALA GLU THR PHE 0.440476 0.8
22 ASP ALA ASP GLU TYR LEU 0.4375 0.847826
23 ASP ARG VAL TYR 0.436782 0.847826
24 SEP GLN GLU PTR 0.434783 0.735849
25 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.43 0.770833
26 THR ASN GLU PHE TYR ALA 0.428571 0.795918
27 SER ASP TYR GLN ARG LEU 0.424242 0.740741
28 SER SER ARG LYS GLU TYR TYR ALA 0.421569 0.727273
29 GLU VAL TYR GLU SER 0.419355 0.829787
30 ASP PHE GLU ASP TYR GLU PHE ASP 0.416667 0.851064
31 ASP PHE 0.416667 0.756098
32 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.415929 0.740741
33 ASP ALA ASP GLU GLU ASP PHE 0.411111 0.818182
34 ASP GLU LEU GLU ILE LYS ALA TYR 0.410714 0.784314
35 GLU GLU ASN ASP PRO ASP TYR 0.41 0.689655
36 MET ASN TYR ASP ILE 0.409639 0.822222
37 ASP GLU 0.409091 0.731707
38 SER GLU LEU GLU ILE LYS ARG TYR 0.405172 0.666667
39 ACE 1PA GLU GLU ILE 0.402299 0.755556
40 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.401869 0.714286
41 CYS THR GLU LEU LYS LEU SER ASP TYR 0.4 0.740741
Similar Ligands (3D)
Ligand no: 1; Ligand: GLU GLU GLN GLU GLU TYR; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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