Receptor
PDB id Resolution Class Description Source Keywords
2HL3 2.03 Å NON-ENZYME: MOBILE CRYSTAL STRUCTURE OF THE A49M MUTANT CAP-GLY DOMAIN OF HUMAN 1 (P150-GLUED) IN COMPLEX WITH HUMAN EB1 C-TERMINAL HEXAPEP HOMO SAPIENS MICROTUBULE BINDING DYNACTINCYTOSKELETON ASSOCIATED PROTEIP150GLUED EB1 +TIP PROTEIN COMPLEX STRUCTURE EEY/F-COO- MOTIF CLIP-170 ALPHA-TUBULIN STRUCTURAL PROTEIN
Ref.: KEY INTERACTION MODES OF DYNAMIC +TIP NETWORKS. MOL.CELL V. 23 663 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLU GLU GLN GLU GLU TYR C:266;
Valid;
none;
Kd = 0.17 uM
437.405 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HL3 2.03 Å NON-ENZYME: MOBILE CRYSTAL STRUCTURE OF THE A49M MUTANT CAP-GLY DOMAIN OF HUMAN 1 (P150-GLUED) IN COMPLEX WITH HUMAN EB1 C-TERMINAL HEXAPEP HOMO SAPIENS MICROTUBULE BINDING DYNACTINCYTOSKELETON ASSOCIATED PROTEIP150GLUED EB1 +TIP PROTEIN COMPLEX STRUCTURE EEY/F-COO- MOTIF CLIP-170 ALPHA-TUBULIN STRUCTURAL PROTEIN
Ref.: KEY INTERACTION MODES OF DYNAMIC +TIP NETWORKS. MOL.CELL V. 23 663 2006
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 61 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 39 families.
1 2HL3 Kd = 0.17 uM GLU GLU GLN GLU GLU TYR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLU GLU GLN GLU GLU TYR; Similar ligands found: 66
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU GLU GLN GLU GLU TYR 1 1
2 THR ASN GLU PHE TYR PHE 0.662338 0.863636
3 SER GLN ASN TYR 0.613333 0.791667
4 TYR GLN PHE 0.608108 0.904762
5 LYS LYS ALA THR GLN ALA SEP GLN GLU TYR 0.578313 0.722222
6 THR ASN GLU TYR TYR VAL 0.575 0.808511
7 GLU ASN GLN LYS GLU TYR PHE PHE 0.566667 0.8125
8 VAL TYR 0.5625 0.761905
9 TYR GLU TRP 0.552941 0.808511
10 SEP GLN GLU TYR NH2 0.542169 0.735849
11 ALA THR ALA ALA ALA THR GLU ALA TYR 0.528736 0.844444
12 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.52439 0.844444
13 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.519231 0.795918
14 ASP ALA ASP GLU TYR LEU 0.516854 0.844444
15 LYS TYR LYS 0.513514 0.883721
16 SEP GLN GLU PTR 0.511628 0.716981
17 THR ASN GLU TYR LYS VAL 0.511111 0.8125
18 GLU LEU LYS TPO GLU ARG TYR 0.509434 0.6
19 GLY TYR 0.5 0.785714
20 ASP PHE GLU ASP TYR GLU PHE ASP 0.488889 0.906977
21 GLU GLN TYR LYS PHE TYR SER VAL 0.484848 0.722222
22 ALA GLU THR PHE 0.481481 0.795455
23 ASP GLU LEU GLU ILE LYS ALA TYR 0.480769 0.795918
24 LYS GLU LYS 0.478261 0.72093
25 SER GLU LEU GLU ILE LYS ARG TYR 0.476636 0.65
26 GLU ASN LEU TYR PHE GLN 0.473684 0.795918
27 ACE ILE TYR GLU SER LEU 0.472527 0.76
28 THR ASN GLU PHE ALA PHE 0.471264 0.733333
29 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.46729 0.722222
30 CYS THR GLU LEU LYS LEU SER ASP TYR 0.462963 0.735849
31 GLU VAL TYR GLU SER 0.460674 0.826087
32 GLU LEU ASP LYS TYR ALA SER 0.46 0.764706
33 THR TYR LYS PHE PHE GLU GLN 0.458333 0.78
34 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.458333 0.78
35 SER SER ARG LYS GLU TYR TYR ALA 0.452632 0.709091
36 ASP PHE 0.449275 0.725
37 THR ASN GLU PHE TYR ALA 0.447917 0.77551
38 SER GLN TYR TYR TYR ASN SER LEU 0.446809 0.703704
39 SER GLU ASP GLU PHE TYR ASP ALA LEU SER 0.440367 0.764706
40 GLU LEU ARG ARG LYS MET MET TYR MET 0.438095 0.65
41 SER ASP TYR GLN ARG LEU 0.43299 0.722222
42 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.432 0.672414
43 GLU GLU PRO THR VAL ILE LYS LYS TYR 0.42623 0.629032
44 GLU LEU ASP 1OL VAL GLU PHE 0.425926 0.8
45 TYR GLN SER LYS LEU 0.425532 0.75
46 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.423423 0.614035
47 ARG ARG ILE TYR ASP LEU ILE GLU LEU 0.421053 0.684211
48 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.42 0.75
49 MET ASN TYR ASP ILE 0.419753 0.818182
50 GLU SER ASP PRO ILE VAL ALA GLN TYR 0.419355 0.6
51 ASP LEU TYR CYS TYR GLU GLN LEU ASN 0.419048 0.735849
52 ASP PHE GLU GLU ILE 0.41573 0.772727
53 ALA LYS GLU LYS SER ASP 0.414634 0.653061
54 GLU VAL ASN 1OL ALA GLU PHE 0.414414 0.75
55 GLY TYR GLN ASP TYR GLU PRO GLU ALA 0.40566 0.709091
56 THR GLU ASP ASN ASP ASP ASP LEU TYR GLY 0.405063 0.765957
57 LEU ASP GLU PTR VAL ALA THR ARG 0.404255 0.711538
58 LEU ALA ILE TYR SER 0.404255 0.75
59 LEU GLU LYS ALA ARG GLY SER THR TYR 0.403226 0.639344
60 PPN GLU ALA NLE SER 0.402299 0.618182
61 GLN SER TYR TPO VAL 0.402062 0.655172
62 ALA LEU ASP LEU PHE 0.4 0.704545
63 GLU THR PHE TYR VAL ASP GLY 0.4 0.730769
64 PHE LEU GLU LYS 0.4 0.73913
65 SER HIS PHE ASN GLU TYR GLU 0.4 0.684211
66 ASP ALA ASP GLU FTY LEU NH2 0.4 0.6
Similar Binding Sites (Proteins are less than 50% similar to leader)
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