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Receptor
PDB id Resolution Class Description Source Keywords
2HYQ 2 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH 6ALPHA-MA GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC, THERMODYNAMIC, AND MOLECULAR MODE STUDIES OF THE MODE OF BINDING OF OLIGOSACCHARIDES POTENT ANTIVIRAL PROTEIN GRIFFITHSIN. PROTEINS V. 67 661 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MAN MAN A:122;
A:124;
A:126;
B:122;
B:124;
B:126;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
Kd = 88.3 uM
342.297 n/a O(CC1...
SO4 A:201;
B:202;
B:203;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYQ 2 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF A COMPLEX OF GRIFFITHSIN WITH 6ALPHA-MA GRIFFITHSIA GRIFFITHSIN LECTINS DOMAIN SWAPPING MANNOSE BINDING HIVSUGAR BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC, THERMODYNAMIC, AND MOLECULAR MODE STUDIES OF THE MODE OF BINDING OF OLIGOSACCHARIDES POTENT ANTIVIRAL PROTEIN GRIFFITHSIN. PROTEINS V. 67 661 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2HYQ Kd = 88.3 uM MAN MAN n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 2HYQ Kd = 88.3 uM MAN MAN n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 2HYQ Kd = 88.3 uM MAN MAN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MAN MAN; Similar ligands found: 178
No: Ligand ECFP6 Tc MDL keys Tc
1 BGC GLA 1 1
2 GAL GLC 1 1
3 GLA BGC 1 1
4 BGC GLC 1 1
5 GLA GLC 1 1
6 LAK 1 1
7 GAL GAL 1 1
8 GLC BGC 1 1
9 MLB 1 1
10 MAN BMA 1 1
11 MAN MAN 1 1
12 BMA GLA 1 1
13 BMA MAN 1 1
14 GLC GLC 1 1
15 GLA BMA 1 1
16 BMA MAN MAN 0.953488 1
17 GLC GLC GLC GLC GLC BGC 0.953488 1
18 MAN MAN MAN 0.953488 1
19 GLC GLC GLC 0.953488 1
20 GLC GLC GLC GLC BGC 0.953488 1
21 AHR AHR 0.75 0.857143
22 FUB AHR 0.75 0.857143
23 MAN MAN MAN MAN 0.732143 1
24 MAN MAN BMA MAN 0.732143 1
25 AHR AHR AHR AHR AHR AHR 0.702128 0.857143
26 FUB AHR AHR 0.702128 0.857143
27 MAN BMA MAN 0.672727 1
28 MAN MMA 0.66 0.942857
29 GLC GLC GLC BGC 0.633333 1
30 M5S 0.606557 1
31 MAN BMA MAN MAN MAN 0.606557 1
32 MAN MAN MAN BMA MAN 0.575758 1
33 BMA BMA GLA BMA BMA 0.546875 1
34 MAN MMA MAN 0.540984 0.942857
35 MAN MAN MAN MAN MAN MAN MAN 0.535211 1
36 RAF 0.515625 0.891892
37 GIV 0.511628 0.848485
38 GLA 0.511628 0.848485
39 WOO 0.511628 0.848485
40 MAN 0.511628 0.848485
41 GAL 0.511628 0.848485
42 GLC 0.511628 0.848485
43 BGC 0.511628 0.848485
44 GXL 0.511628 0.848485
45 BMA 0.511628 0.848485
46 ALL 0.511628 0.848485
47 STW 0.507692 0.891892
48 MAN MAN MAN BMA MAN MAN MAN 0.5 0.942857
49 BMA MAN MAN MAN MAN 0.485294 1
50 NGB 0.485294 0.622642
51 4CQ 0.483871 0.970588
52 WZ2 0.477612 0.868421
53 LBT 0.472727 1
54 N9S 0.472727 1
55 CBI 0.472727 1
56 MAB 0.472727 1
57 LAT 0.472727 1
58 CBK 0.472727 1
59 B2G 0.472727 1
60 BGC BMA 0.472727 1
61 GLC GAL 0.472727 1
62 GLA GLA 0.472727 1
63 BMA GAL 0.472727 1
64 GLA GAL 0.472727 1
65 MAL 0.472727 1
66 GAL BGC 0.472727 1
67 BGC GAL 0.472727 1
68 NAG MAN MAN 0.472222 0.733333
69 RGG 0.471698 0.882353
70 SUC GLA 0.471429 0.891892
71 DMJ MAN 0.466667 0.695652
72 NOJ BGC 0.466667 0.695652
73 WZ3 0.463768 0.916667
74 DEG 0.462963 0.769231
75 IFM MAN 0.459016 0.711111
76 EMZ 0.458333 0.783784
77 M6P 0.45098 0.674419
78 G6P 0.45098 0.674419
79 BG6 0.45098 0.674419
80 M6D 0.45098 0.674419
81 A6P 0.45098 0.674419
82 BGP 0.45098 0.674419
83 AHR AHR AHR 0.45 0.805556
84 EBG 0.446429 0.837838
85 M3M 0.446429 1
86 LB2 0.446429 1
87 NGR 0.446429 1
88 EBQ 0.446429 0.789474
89 MAN GLC 0.446429 1
90 MT7 0.440678 1
91 MAN BMA BMA BMA BMA BMA 0.440678 1
92 DXI 0.440678 1
93 GLC GAL GAL 0.440678 1
94 BGC BGC BGC BGC 0.440678 1
95 GLC BGC BGC BGC BGC BGC 0.440678 1
96 GLC BGC GLC 0.440678 1
97 CEX 0.440678 1
98 GLC BGC BGC BGC BGC 0.440678 1
99 BGC GLC GLC GLC GLC GLC GLC 0.440678 1
100 MLR 0.440678 1
101 BGC BGC BGC BGC BGC 0.440678 1
102 CE5 0.440678 1
103 MAN BMA BMA BMA BMA 0.440678 1
104 BMA BMA BMA BMA BMA 0.440678 1
105 MTT 0.440678 1
106 MAN MAN BMA BMA BMA BMA 0.440678 1
107 GLC GLC GLC GLC GLC 0.440678 1
108 BGC GLC GLC 0.440678 1
109 BMA MAN BMA 0.440678 1
110 BGC GLC GLC GLC 0.440678 1
111 GLA GAL GLC 0.440678 1
112 CT3 0.440678 1
113 BGC BGC BGC 0.440678 1
114 BGC BGC GLC 0.440678 1
115 BGC BGC BGC BGC BGC BGC BGC BGC BGC 0.440678 1
116 CTR 0.440678 1
117 CEY 0.440678 1
118 GLC BGC BGC 0.440678 1
119 GLA GAL BGC 0.440678 1
120 BMA BMA BMA BMA BMA BMA 0.440678 1
121 GLC GLC BGC 0.440678 1
122 CTT 0.440678 1
123 BGC BGC BGC BGC BGC BGC 0.440678 1
124 BGC BGC BGC GLC 0.440678 1
125 MAN BMA BMA 0.440678 1
126 B4G 0.440678 1
127 GAL GAL GAL 0.440678 1
128 BGC GLC GLC GLC GLC 0.440678 1
129 CE8 0.440678 1
130 BMA BMA BMA 0.440678 1
131 GLC BGC BGC BGC 0.440678 1
132 GLC GLC GLC GLC GLC GLC GLC GLC GLC 0.440678 1
133 CE6 0.440678 1
134 ACY 1GN GAL 1GN BGC ACY GAL BGC 0.439024 0.6875
135 1GN ACY GAL ACY 1GN BGC GAL BGC 0.439024 0.6875
136 JZR 0.438596 0.714286
137 BHG 0.438596 0.714286
138 GLC HEX 0.438596 0.714286
139 TRE 0.4375 1
140 BMA Z4Y NAG 0.435897 0.717391
141 B7G 0.431034 0.738095
142 KGM 0.431034 0.738095
143 2M4 0.428571 1
144 MBG 0.428571 0.857143
145 MMA 0.428571 0.857143
146 GYP 0.428571 0.857143
147 AMG 0.428571 0.857143
148 GAL GAL SO4 0.424242 0.66
149 BOG 0.423729 0.738095
150 BNG 0.423729 0.738095
151 HSJ 0.423729 0.738095
152 M1P 0.423077 0.697674
153 XGP 0.423077 0.697674
154 G1P 0.423077 0.697674
155 GL1 0.423077 0.697674
156 BGC BGC XYS BGC 0.418919 0.942857
157 GAL FUC 0.416667 0.941176
158 SER MAN 0.416667 0.72093
159 XYT 0.415385 0.767442
160 BQZ 0.415094 0.909091
161 6SA 0.414894 0.733333
162 GAL BGC NAG GAL 0.413333 0.733333
163 GAL BGC BGC XYS 0.410959 0.942857
164 BGC BGC BGC GLC BGC BGC 0.409836 1
165 GLC BGC BGC BGC BGC BGC BGC 0.409836 1
166 GLA EGA 0.409836 0.942857
167 DGD 0.409639 0.733333
168 BMA NAG MAN MAN MAN MAN MAN MAN MAN 0.409091 0.733333
169 NAG NAG BMA MAN MAN 0.406977 0.6875
170 T6P 0.40678 0.767442
171 GLA GAL GAL 0.40625 1
172 IAB 0.404494 0.733333
173 MAN MAN BMA 0.403226 1
174 BMA BMA MAN 0.403226 1
175 GLC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
176 BGC BGC BGC XYS BGC XYS XYS 0.402597 0.942857
177 BGC BGC XYS BGC XYS BGC XYS 0.402597 0.942857
178 BMA MAN MAN MAN 0.4 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 316
This union binding pocket(no: 1) in the query (biounit: 2hyq.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1LES GLC FRU None
2 2BQP GLC None
3 1OFS SUC None
4 2GJ5 VD3 None
5 1WPY BTN None
6 5Z2L NDP None
7 2B4B COA None
8 2JAP NDP 1.63934
9 2JE7 XMM 2.45902
10 2WTX UDP 2.45902
11 2WTX VDO 2.45902
12 2ZC0 PMP 2.45902
13 3RFV NAI 2.45902
14 3OU2 SAH 3.27869
15 1O8B ABF 3.27869
16 3UOY FAD 3.27869
17 3UOY NAP 3.27869
18 2WSB NAD 3.27869
19 5MQ5 ASP 4.09836
20 6HOY AR6 4.09836
21 1VFS DCS 4.09836
22 4MO2 FDA 4.09836
23 5ZYN FAD 4.09836
24 3TKY SAH 4.09836
25 4MO2 FAD 4.09836
26 1SOW NAD 4.09836
27 1W5F G2P 4.09836
28 2RGJ FAD 4.09836
29 2I0K FAD 4.09836
30 1TB3 FMN 4.09836
31 5I3B HQE 4.09836
32 4X6I 3Y1 4.09836
33 2A8X FAD 4.09836
34 1YKJ PHB 4.09836
35 1YKJ FAD 4.09836
36 3V1Y NAD 4.09836
37 1XDS SAM 4.09836
38 1Z82 NDP 4.09836
39 3VPH NAD 4.19355
40 2JB2 FAD 4.91803
41 2JB2 PHE 4.91803
42 4K5S FAD 4.91803
43 4K5S PM0 4.91803
44 4O4F IHP 4.91803
45 4O4F ATP 4.91803
46 3KLJ FAD 4.91803
47 3ICS ADP 4.91803
48 4ZGS NAD 4.91803
49 4EMI NAD 4.91803
50 3NZK C90 4.91803
51 3CW9 01A 4.91803
52 3B20 NAD 4.91803
53 3P3G UKW 4.91803
54 3P3G 3P3 4.91803
55 1ZEM NAD 4.91803
56 1QO8 FAD 4.91803
57 5U8U FAD 4.91803
58 3LST SAH 4.91803
59 2BNE U5P 4.91803
60 3L4S NAD 4.91803
61 3L4S 3PG 4.91803
62 2PUL ACP 4.91803
63 4Z0G 5GP 4.91803
64 4J7U YTZ 4.91803
65 4J7U NAP 4.91803
66 4EIL NDP 4.91803
67 2ZXI FAD 5.7377
68 2AE2 NAP 5.7377
69 2AE2 PTO 5.7377
70 6F97 FAD 5.7377
71 2HQM FAD 5.7377
72 3STK PLM 5.7377
73 5TWB FAD 5.7377
74 4OOE NDP 5.7377
75 1ZGA SAH 5.7377
76 2PWY SAH 5.7377
77 3AB4 THR 5.7377
78 3QV1 NAD 5.7377
79 4O33 TZN 5.7377
80 4O33 3PG 5.7377
81 1RM4 NDP 5.7377
82 2YYY NAP 5.7377
83 4L77 CNL 5.7377
84 3KO8 NAD 5.7377
85 1XSE NDP 5.7377
86 4HKP TKW 5.7377
87 4U36 TNR 5.7377
88 2GMH FAD 5.7377
89 2GNM MAN 6.55738
90 5EYY MDM 6.55738
91 2PHF MAN MAN BMA MAN 6.55738
92 2GN3 MAN 6.55738
93 2PHF MAN MAN 6.55738
94 2GN3 MMA 6.55738
95 3ZYR NAG NAG BMA MAN MAN NAG NAG 6.55738
96 2GNB MAN 6.55738
97 3ZYR ASN NAG NAG BMA MAN MAN NAG NAG 6.55738
98 2GMM MAN MAN 6.55738
99 1UKG MMA 6.55738
100 2PHU MAN MAN 6.55738
101 1Q8Q MAN MMA 6.55738
102 2GND MAN 6.55738
103 1LOF MAN BMA NAG NAG MAN NAG GAL GAL 6.55738
104 1Q8V MAN MAN 6.55738
105 1Q8O MAN MMA 6.55738
106 2PHT MAN MAN MAN 6.55738
107 1Q8V MAN MAN MAN 6.55738
108 2PHX MAN MAN MAN MAN 6.55738
109 2GND MAN MMA 6.55738
110 2PHW MAN MAN 6.55738
111 1Q8P MAN MMA 6.55738
112 2PHR MAN MAN 6.55738
113 2PHR MAN MAN BMA MAN 6.55738
114 2GMP NAG MAN 6.55738
115 6F7L FAD 6.55738
116 1Q8S MAN MMA 6.55738
117 2PHX MAN MAN 6.55738
118 3NKS FAD 6.55738
119 2PHT MAN MAN MAN BMA MAN 6.55738
120 1LOB MMA 6.55738
121 2PHU MAN MAN MAN BMA MAN 6.55738
122 2PHW MAN MAN MAN BMA MAN MAN MAN 6.55738
123 6GAR FAD 6.55738
124 2CUL FAD 6.55738
125 2AUY NAG MAN MMA 6.55738
126 5A1S FLC 6.55738
127 2AR6 NAG MAN 6.55738
128 2CUN 3PG 6.55738
129 2R4J 13P 6.55738
130 2R4J FAD 6.55738
131 5K4G ASP 6.55738
132 5LD5 NAD 6.55738
133 1L3I SAH 6.55738
134 3X0V FAD 6.55738
135 5NDF LU2 6.55738
136 5NDF UDP 6.55738
137 1FP1 SAH 6.55738
138 1OFD AKG 6.55738
139 1V59 FAD 6.55738
140 4O0L NDP 6.55738
141 1OFD FMN 6.55738
142 2AR6 NAG MAN MAN MAN NAG 6.55738
143 5NUE NAD 6.55738
144 6CI9 NAP 7.37705
145 1BXG NAD 7.37705
146 5I60 67W 7.37705
147 2C5A GDC 7.37705
148 2C5A NAD 7.37705
149 5J60 FAD 7.37705
150 2B4R AES 7.37705
151 2D7I NGA 7.37705
152 4RPL 3UC 7.37705
153 4RPL FAD 7.37705
154 1N5D NDP 7.37705
155 2B4R NAD 7.37705
156 5JY6 NAD 7.37705
157 3AI8 HNQ 7.37705
158 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 7.37705
159 2JDR L20 7.37705
160 2VD9 IN5 7.37705
161 2VD9 EPC 7.37705
162 3LAD FAD 7.37705
163 5U3B 7TD 7.37705
164 1ZFJ IMP 7.37705
165 1F8G NAD 7.37705
166 5IVE 6E8 7.37705
167 4M00 SUC 8.19672
168 1AE1 NAP 8.19672
169 1RYI GOA 8.19672
170 1RYI FAD 8.19672
171 4MDH NAD 8.19672
172 5MDH NAD 8.19672
173 2ABJ CBC 8.19672
174 3UZO GLU 8.19672
175 5MST FUM 8.19672
176 4E70 N7I 8.19672
177 5DEX 5E0 8.19672
178 4MRT COA 8.19672
179 2P53 NNG 8.19672
180 6C4M NAP 8.19672
181 4AP3 NAP 9.01639
182 4AP3 FAD 9.01639
183 5T2U NAP 9.01639
184 4PLG OXM 9.01639
185 4PLG NAI 9.01639
186 2F5Z FAD 9.01639
187 5J5Z FAD 9.01639
188 5KOX FAD 9.01639
189 5KOX RFP 9.01639
190 5GM9 CBK 9.01639
191 2IVN ANP 9.01639
192 1LDN NAD 9.01639
193 3E1T FAD 9.01639
194 2PI8 NAG NAG NAG NAG NAG NAG 9.01639
195 2A92 NAI 9.01639
196 1KAO GDP 9.58084
197 5F52 ASP 9.83607
198 2UYT LRH 9.83607
199 2UYT ADP 9.83607
200 5JWC FAD 9.83607
201 5AB7 MLC 9.83607
202 1LYX PGA 9.83607
203 3AB1 FAD 9.83607
204 3UCL NAP 9.83607
205 3UCL CYH 9.83607
206 3UCL FAD 9.83607
207 1XI9 PLP 9.83607
208 6N35 MAN MAN 9.83607
209 4YSX FAD 9.83607
210 4CQM NAP 9.83607
211 1FFU FAD 9.83607
212 2WLT ASP 9.83607
213 5THQ NDP 9.83607
214 1U6R ADP 9.83607
215 5YRV 5AD 9.83607
216 2YVJ FAD 10.0917
217 1B8U OAA 10.3343
218 1B8U NAD 10.3343
219 1MVQ MMA 10.6557
220 1QX4 FAD 10.6557
221 4DQ2 BTX 10.6557
222 4XQC NAD 10.6557
223 3CIF NAD 10.6557
224 6CEP NAD 10.6557
225 1D4D FAD 10.6557
226 1QZZ SAM 10.6557
227 2ZUX RAM 10.6557
228 6FA4 GNP 10.9827
229 2FLI DX5 11.4754
230 2IVD FAD 11.4754
231 3P9C SAH 11.4754
232 4Z0H NAD 11.4754
233 2Z6J FMN 11.4754
234 5BSR COA 11.4754
235 5BSR AMP 11.4754
236 1GET FAD 11.4754
237 1GET NAP 11.4754
238 1NAA 6FA 11.4754
239 2Q4W FAD 11.4754
240 2RAB NAD 12.2951
241 2RAB FAD 12.2951
242 5WGR FAD 12.2951
243 5FOI MY8 12.2951
244 2HIM ASP 12.2951
245 2HIM ASN 12.2951
246 5UR0 NAD 12.2951
247 5XWV NDP 12.2951
248 5XWV 8H6 12.2951
249 4XH4 ANP 12.2951
250 2Q1W NAD 12.2951
251 5X8G S0N 12.2951
252 5X68 FAD 13.1148
253 1BW9 NAD 13.1148
254 1EQ2 NAP 13.1148
255 1C1X NAD 13.1148
256 1KYZ SAH 13.1148
257 4D7E FAD 13.1148
258 1EZ4 NAD 13.1148
259 3RNM FAD 13.7931
260 4C3Y FAD 13.9344
261 4C3Y ANB 13.9344
262 5ERG SAM 13.9344
263 5WPJ NDP 13.9344
264 1LTH NAD 13.9344
265 6FDF SAH 13.9344
266 5DNC ASN 13.9344
267 1DQX BMP 13.9344
268 1F5N GNP 13.9344
269 1GUA GNP 13.9344
270 1I9G SAM 13.9344
271 4PLT OXM 13.9344
272 4R8L ASP 13.9344
273 1U7T TDT 13.9344
274 3MB5 SAM 14.7541
275 1TZJ A3B 14.7541
276 3HDY FAD 15.5738
277 5NMX FAD 15.5738
278 5TS5 FAD 15.5738
279 5NMX NAP 15.5738
280 1FL2 FAD 17.2131
281 3AXK NDP 18.0328
282 1IYE PGU 18.0328
283 2JK0 ASP 18.0328
284 3SSO SAH 18.0328
285 2X6T NAP 18.8525
286 4BV6 FAD 18.8525
287 5V6F MAN BMA MAN 19.6721
288 2WET FAD 19.6721
289 3PT9 SAH 19.6721
290 1C0I FAD 19.6721
291 1C0I BE2 19.6721
292 2FMD MAN MAN 20.4918
293 1ELI PYC 21.3115
294 6GAS FAD 21.3115
295 1XXR MAN 23.7705
296 1VBO MAN 24.5902
297 1VBO MAN MAN MAN 24.5902
298 1JOT GAL A2G 24.5902
299 6CGD GNP 24.5902
300 6CGD AKN 24.5902
301 1KPG SAH 26.2295
302 1U1I NAD 29.5082
303 1C3M MAN MAN 34.4262
304 1WS4 AMG 37.7049
305 1WS4 GYP 37.7049
306 1WS5 MMA 37.7049
307 1UGY GLA BGC 37.7049
308 1UGY GLA GLC 37.7049
309 1UGW GAL 37.7049
310 1KUJ MMA 37.7049
311 1M26 GAL A2G 37.7049
312 1JAC AMG 37.7049
313 1UGX GAL MGC 37.7049
314 1TOQ AMG 40.1639
315 6FLZ MMA 45.082
316 2BMZ XLM 48.3607
Pocket No.: 2; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 68
This union binding pocket(no: 2) in the query (biounit: 2hyq.bio1) has 7 residues
No: Leader PDB Ligand Sequence Similarity
1 3BGD SAH None
2 2HMT NAI None
3 2HNK SAH 0.83682
4 2CVQ NDP 1.63934
5 4YMH SAH 1.63934
6 3VZ3 SSN 1.63934
7 1U8Z GDP 2.45902
8 4JWF SAH 3.27869
9 4QT2 RAP 3.27869
10 6GKV SAH 4.09836
11 2OBF SAH 4.09836
12 2OBF F83 4.09836
13 2PYW ADP 4.09836
14 3AY6 NAI 4.91803
15 4GN8 ASO 4.91803
16 5YJF 8WO 4.91803
17 5YJF SAH 4.91803
18 1SB8 NAD 4.91803
19 1SB8 UD2 4.91803
20 1Z6Z NAP 4.91803
21 5VN0 NAI 4.91803
22 5ICE 2H4 5.7377
23 5ICE SAH 5.7377
24 5YJI SAH 5.7377
25 5YJI 8WO 5.7377
26 3F3E LEU 5.7377
27 6B3V ANP 5.7377
28 5MPT SAH 5.7377
29 4EI7 GDP 5.7377
30 1QPG MAP 5.7377
31 1RPN NDP 6.26866
32 5NUF NAD 6.55738
33 3LU1 NAD 7.37705
34 2GOU FMN 7.37705
35 1E3W NAD 7.37705
36 1T3Q FAD 7.37705
37 3C3Y SAH 8.19672
38 2VPQ ANP 8.19672
39 3PPM JG1 9.01639
40 2A14 SAH 9.01639
41 1JQD HSM 9.83607
42 4A6D SAM 9.83607
43 2AOT SAH 9.83607
44 1JQD SAH 9.83607
45 3PFD FDA 9.83607
46 5WP5 SAH 10.6557
47 4TXI FAD 11.4754
48 1PFK ADP 11.4754
49 3DUW SAH 12.2951
50 1MO9 FAD 12.2951
51 1MO9 KPC 12.2951
52 5LOG SAH 12.2951
53 1KYZ FER 13.1148
54 5ZW3 SAH 13.9344
55 3HDY GDU 15.5738
56 3HDY FDA 15.5738
57 5L3S GNP 15.5738
58 1FP2 SAH 16.3934
59 1FP2 HMO 16.3934
60 1RP7 TZD 17.2131
61 5FPE 3TR 19.6721
62 2A2C NG1 19.6721
63 2A2C ADP 19.6721
64 1PJS NAD 21.3115
65 1CCW TAR 23.7705
66 5IN4 6CK 24.5902
67 5IN4 NAP 24.5902
68 5IN4 GDP 24.5902
Pocket No.: 3; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 123
This union binding pocket(no: 3) in the query (biounit: 2hyq.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
1 1VL0 NAI None
2 1AX2 NDG GAL 1.63934
3 3P8N L4T 1.63934
4 3KEE 30B 1.63934
5 4M7V RAR 2.45902
6 4M7V NAP 2.45902
7 3RFV 15L 2.45902
8 1IIM TTP 2.45902
9 3H2B SAH 2.45902
10 2O4C NAD 2.45902
11 4MIG G3F 3.27869
12 1ZK7 FAD 3.27869
13 4JWH SAH 3.27869
14 3ITJ FAD 4.09836
15 16PK BIS 4.09836
16 5TTJ FAD 4.09836
17 2HSA FMN 4.09836
18 2DKH FAD 4.09836
19 3SJU NDP 4.09836
20 3GBR PRP 4.09836
21 1SBZ FMN 4.91803
22 5VN0 FAD 4.91803
23 4ZCC FAD 4.91803
24 5EEH P9P 4.91803
25 5EEH SAH 4.91803
26 4RSL FAD 4.91803
27 2XVF FAD 4.91803
28 5E1M SAH 4.91803
29 5E1M PRO PRO LYS ARG ILE ALA 4.91803
30 1A5Z NAD 4.91803
31 2D2I NAP 4.91803
32 2Q3R FMN 4.91803
33 3B1J NAD 4.91803
34 4UCI ADN 4.91803
35 4D04 FAD 5.7377
36 4D04 NAP 5.7377
37 4JB1 NAP 5.7377
38 4JB1 FAD 5.7377
39 3CGB FAD 5.7377
40 4MO4 ACP 5.7377
41 2XVE FAD 5.7377
42 5GSN NAP 5.7377
43 5GSN FAD 5.7377
44 3ZNN 4WL 5.7377
45 3ZNN FAD 5.7377
46 2D3N GLC GLC GLC 5.7377
47 1T9D FAD 5.7377
48 5FAW CHT 6.55738
49 6ECW SAH 6.55738
50 6FP4 FAD 6.55738
51 2D3S TNR 6.55738
52 4F7E 0SH 6.55738
53 3T7S SAM 6.55738
54 1GUZ NAD 6.55738
55 2HJR APR 6.55738
56 1O6Z NAD 6.55738
57 5T52 NGA 7.37705
58 5T52 A2G 7.37705
59 5OVL NAP 7.37705
60 6GNC FAD 7.37705
61 1BXG HCI 7.37705
62 2R5C C6P 7.37705
63 4KQ6 DLZ 7.37705
64 5OVK NDP 7.37705
65 1B63 ANP 8.19672
66 3HNC TTP 8.19672
67 5BRT FAD 8.19672
68 4EXS X8Z 8.19672
69 1F76 FMN 8.19672
70 4XYB NDP 8.19672
71 2VYN NAD 8.19672
72 1BZL FAD 8.19672
73 1Q9I FAD 9.01639
74 1Q9I TEO 9.01639
75 4RHE FMN 9.01639
76 1YKF NAP 9.01639
77 1WMA NDP 9.01639
78 1WMA AB3 9.01639
79 2XYQ SAH 9.01639
80 1VDC FAD 9.01639
81 1U8X NAD 9.01639
82 3Q9T FAY 9.83607
83 4ZAL 4LR 9.83607
84 4ZAL FNR 9.83607
85 3GMB FAD 9.83607
86 3QJ4 FAD 9.83607
87 5T8U LPA 9.83607
88 2FR1 NDP 9.83607
89 5J7X FAD 10.6557
90 3GF4 UPG 10.6557
91 3GF4 FAD 10.6557
92 4KRG SAH 10.6557
93 6CEP OXM 10.6557
94 5OE4 3UK 10.6557
95 1NAA ABL 11.4754
96 3I53 SAH 11.4754
97 4DSG UDP 11.4754
98 4DSG FAD 11.4754
99 1KEV NDP 12.2951
100 3GFB NAD 12.2951
101 1YEJ PNF 12.2951
102 3CB2 GDP 13.1148
103 2B9W FAD 13.1148
104 3ZLB ANP 13.9344
105 1U7T NAD 13.9344
106 4PLT NAI 13.9344
107 2Q7V FAD 14.7541
108 2Q2V NAD 16.3934
109 1KGQ SCO 17.2131
110 1KGQ NPI 17.2131
111 3O26 NDP 17.2131
112 6ER9 NAP 18.0328
113 6ER9 FAD 18.0328
114 6ALW BMJ 18.0328
115 2BR6 HSL 18.0328
116 1FNZ A2G 19.6721
117 4YRY FAD 19.6721
118 5AYV KPL 21.3115
119 3D36 ADP 23.913
120 1RM0 NAI 27.0492
121 1RM0 D6P 27.0492
122 4UP3 FAD 27.0492
123 1S16 ANP 27.0492
Pocket No.: 4; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 79
This union binding pocket(no: 4) in the query (biounit: 2hyq.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1N2X SAM None
2 2DXU BT5 None
3 2YBQ SAH 3.27869
4 5X9D 80F 3.27869
5 1PZG A3D 3.27869
6 5BVA FAD 3.27869
7 3RG9 NDP 3.27869
8 6HOY TSN 4.09836
9 5BUK FAD 4.09836
10 4TW7 37K 4.09836
11 3VPH OXM 4.19355
12 4KGD FAD 4.91803
13 4KGD TDP 4.91803
14 2ZPA ACO 4.91803
15 4FL3 ANP 4.91803
16 4EMI FAD 4.91803
17 4GKY MAN 4.91803
18 1H6C NDP 4.91803
19 1H6C SIN 4.91803
20 2B1N LYS ALA SER VAL GLY 4.91803
21 1VPE ANP 5.7377
22 3C6K MTA 5.7377
23 3C6K SPD 5.7377
24 6C2Z P1T 5.7377
25 1QSM ACO 5.7377
26 2VAP GDP 5.7377
27 3K5I AIR 5.95534
28 3QFA FAD 6.55738
29 5YLT SFG 6.55738
30 5L4S NAP 6.55738
31 5L4S 6KX 6.55738
32 1B8O IMH 6.55738
33 2BHZ MAL 6.55738
34 1YQS BSA 6.55738
35 1V59 NAD 6.55738
36 3RDO BTN 6.55738
37 5NNA BZM 6.55738
38 2E5V FAD 6.55738
39 2OFD NGA 7.04225
40 4D9C PMP 7.37705
41 4UX9 ANP 7.37705
42 1RRM APR 7.37705
43 2QFY AKG 7.37705
44 6A3J SOE 7.37705
45 6A3J NAI 7.37705
46 1LVW TYD 7.37705
47 1O2D NAP 7.37705
48 3G5S FAD 7.37705
49 5Z20 NAI 8.19672
50 2YY7 NAD 8.19672
51 2WPU KYT 8.19672
52 4M52 FAD 8.19672
53 4M52 M52 8.19672
54 4POO SAM 9.01639
55 3KJS NAP 9.01639
56 2Q6B HR2 9.83607
57 1T26 GBD 9.83607
58 1T26 NAI 9.83607
59 4K81 GTP 9.83607
60 1VRP ADP 10.6557
61 3OEN GLU 10.6557
62 3B6R ADP 10.6557
63 1J2J GTP 10.6557
64 1O3Y GTP 10.6557
65 1G55 SAH 10.6557
66 3QMN COA 13.1148
67 4BG4 ADP 13.9344
68 3JQ8 NAP 13.9344
69 3NRZ FAD 13.9344
70 1M15 ADP 14.7541
71 1M15 ARG 14.7541
72 5GLN XYS 14.7541
73 4EKV BTN 14.7541
74 1GQG DCD 15.5738
75 3JQ3 ADP 17.2131
76 3ZEI AWH 19.6721
77 2NPX NAD 24.5902
78 2NPX FAD 24.5902
79 5Z75 NAD 37.7049
Pocket No.: 5; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 62
This union binding pocket(no: 5) in the query (biounit: 2hyq.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 5ZBL AMP None
2 5C5H 4YB 1.63934
3 1HYH NAD 2.45902
4 3CBG SAH 3.27869
5 3LL5 IP8 3.27869
6 4YKG FAD 4.09836
7 2DT9 THR 4.09836
8 3GDN HBX 4.91803
9 3GDN FAD 4.91803
10 1VKO NAD 4.91803
11 5Z21 NAI 4.91803
12 1OAA OAA 5.7377
13 2O3Z AI7 5.7377
14 3TO7 COA 5.7377
15 2QWO ADP 5.7377
16 2BUP ATP 5.7377
17 2BUP ADP 5.7377
18 1WPQ NAD 6.55738
19 6F3M NAD 6.55738
20 1E6W NAD 7.37705
21 4IXW IXW 7.37705
22 3GYQ SAM 7.37705
23 2Q8Z NUP 7.37705
24 1RVV INI 7.37705
25 3CQD ATP 8.19672
26 3QWI NAP 8.19672
27 3QWI CUE 8.19672
28 4XZ3 ACP 8.19672
29 2QZZ NAP 8.19672
30 2QZZ EMF 8.19672
31 2OEM 1AE 8.19672
32 1TDF NAP 9.01639
33 5ZBK AMP 9.83607
34 1LSS NAD 9.83607
35 1ZK4 AC0 10.6557
36 5EXW 7DT 10.6557
37 3CIF G3H 10.6557
38 5NUL FMN 10.8696
39 5GZ6 7C3 11.4754
40 5GZ6 NDP 11.4754
41 3QVP FAD 11.4754
42 6DIO NAD 11.4754
43 4L8V NAP 11.4754
44 1OYB FMN 11.4754
45 1OYB HBA 11.4754
46 4IPE ANP 11.4754
47 3OND NAD 13.1148
48 3OND ADN 13.1148
49 1E6E FAD 13.1148
50 2CDU ADP 13.1148
51 1ZC3 GNP 13.9344
52 4CM9 NAP 13.9344
53 3WGT FAD 14.7541
54 3WGT QSC 14.7541
55 2RCU BUJ 14.7541
56 2NXE SAM 14.7541
57 4MOP 2H5 15.5738
58 4IQY AR6 15.5738
59 5OC1 FAD 17.2131
60 1TMO 2MD 17.2131
61 4YRY NAD 19.6721
62 6G3R ADP 19.6721
Pocket No.: 6; Query (leader) PDB : 2HYQ; Ligand: MAN MAN; Similar sites found with APoc: 61
This union binding pocket(no: 6) in the query (biounit: 2hyq.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
1 1Q0H NDP None
2 1Q0H FOM None
3 3O61 GDD None
4 3CH6 NAP 1.63934
5 3CH6 311 1.63934
6 4I2D APC 1.63934
7 1TPY SAH 2.45902
8 3GD4 FAD 2.45902
9 3GD4 NAD 2.45902
10 3MPI FAD 3.27869
11 3LL5 ADP 3.27869
12 3LL5 IPE 3.27869
13 1XKQ NDP 4.09836
14 3K56 IS3 4.91803
15 1VL8 NAP 4.91803
16 3EYA FAD 4.91803
17 3RS8 APR 4.91803
18 4HA9 NDP 5.7377
19 2R14 TXD 5.7377
20 2R14 FMN 5.7377
21 2VVL FAD 5.7377
22 1TUU ADP 5.7377
23 5ZBC FAD 5.7377
24 6EL3 NAP 5.7377
25 2YVF NAD 6.55738
26 2YVF FAD 6.55738
27 1GPE FAD 6.55738
28 1M0S CIT 6.55738
29 1UPF URF 6.55738
30 4D42 NAP 7.37705
31 4D42 W0I 7.37705
32 1JG3 ADN 7.37705
33 3KAL HGS 8.19672
34 5MSD BEZ 8.19672
35 1CF2 NAP 8.19672
36 2JBH 5GP 9.01639
37 1DZK PRZ 9.01639
38 1MJH ATP 9.01639
39 3LXD FAD 9.83607
40 2YVJ NAI 10.0917
41 3HRD FAD 10.6557
42 5FFF 5XC 11.4754
43 3LZW FAD 12.2951
44 2UZ1 TPP 12.2951
45 1REO FAD 12.2951
46 3NRR D16 13.1148
47 1LVL FAD 13.1148
48 3NRR NAP 13.1148
49 2GAG NAD 13.1148
50 5K0A FAD 13.1148
51 4OM8 NAD 13.1148
52 4ONQ SFG 13.1148
53 1N62 FAD 14.7541
54 4ZOH FAD 17.2131
55 1H74 ILE 17.2131
56 5HSA FAS 23.7705
57 1KPH SAH 27.0492
58 4KP7 NAP 28.6885
59 4KP7 1UQ 28.6885
60 3WQQ IB3 28.6885
61 3WQQ NDP 28.6885
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