Receptor
PDB id Resolution Class Description Source Keywords
2HYU 1.86 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN TETRASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN TETRASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:501;
A:502;
A:505;
A:507;
A:508;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
SGN IDS SGN UAP B:1;
Valid;
none;
submit data
1146.88 n/a S(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2HYU - SGN IDS SGN UAP n/a n/a
2 2HYV - IDS SGN IDS SGN UAP n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6TWU Kd ~ 1 mM SER SER ARG THR ARG ARG GLU GLU GLN LEU n/a n/a
2 6TWX Kd ~ 2.5 mM SER SER ARG THR ARG ARG GLU TPO GLN LEU n/a n/a
3 2HYU - SGN IDS SGN UAP n/a n/a
4 2HYV - IDS SGN IDS SGN UAP n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6TWU Kd ~ 1 mM SER SER ARG THR ARG ARG GLU GLU GLN LEU n/a n/a
2 6TWX Kd ~ 2.5 mM SER SER ARG THR ARG ARG GLU TPO GLN LEU n/a n/a
3 2HYU - SGN IDS SGN UAP n/a n/a
4 2HYV - IDS SGN IDS SGN UAP n/a n/a
5 1A8B - GPE C5 H14 N O6 P C(CO[P@](=....
6 1A8A - GSE C6 H14 N O8 P C([C@H](CO....
7 1G5N - SGN IDS SGN UAP n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: SGN IDS SGN UAP; Similar ligands found: 18
No: Ligand ECFP6 Tc MDL keys Tc
1 SGN IDS SGN UAP 1 1
2 SGN IDS SGN IDS SGN UAP 1 1
3 IDS SGN IDS SGN UAP 0.794643 0.969231
4 SGN IDS SGN IDS 0.757282 0.96875
5 SGN IDS SGN IDS SGN 0.681416 0.939394
6 IDS SGN IDS SGN IDS 0.583333 0.953846
7 GNS UAP 0.582524 0.969231
8 IDS SGN IDS SGN IDS SGN 0.578512 0.939394
9 IDS SGN IDS SGN IDS SUS IDS SGN 0.556452 0.953846
10 ZDO IDS SUS BDP SGN 0.534884 0.925373
11 SGN IDU 0.5 0.938462
12 IDY SGN 0.5 0.910448
13 SGN UAP 0.482456 0.925373
14 IDY SUS 0.464912 0.880597
15 GNS IDR GNS IDR GNS IDR GNS IDR 0.441667 0.953846
16 BDP NPO GNS IDS GNS BDP GNS 0.438849 0.815789
17 IDY GNX 0.408696 0.867647
18 8EX GCD 0.408333 0.880597
Similar Ligands (3D)
Ligand no: 1; Ligand: SGN IDS SGN UAP; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYV; Ligand: IDS SGN IDS SGN UAP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2hyv.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
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