Receptor
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:601;
A:602;
A:605;
A:607;
A:608;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
UAP SGN IDS SGN IDS A:801;
Valid;
none;
submit data
1385.05 n/a S(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HYV 1.42 Å NON-ENZYME: OTHER HUMAN ANNEXIN A2 WITH HEPARIN HEXASACCHARIDE BOUND HOMO SAPIENS CALCIUM-BINDING PROTEIN MEMBRANE-BINDING PROTEIN HELIX BUNHEPARIN HEXASACCHARIDE METAL BINDING PROTEIN
Ref.: CRYSTALLOGRAPHIC ANALYSIS OF CALCIUM-DEPENDENT HEPA BINDING TO ANNEXIN A2. J.BIOL.CHEM. V. 281 31689 2006
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 2HYU - UAP SGN IDS SGN n/a n/a
2 2HYV - UAP SGN IDS SGN IDS n/a n/a
3 1A8B - GPE C5 H14 N O6 P C(CO[P@](=....
4 1A8A - GSE C6 H14 N O8 P C([C@H](CO....
5 1G5N - UAP SGN IDS SGN n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: UAP SGN IDS SGN IDS; Similar ligands found: 17
No: Ligand ECFP6 Tc MDL keys Tc
1 UAP SGN IDS SGN IDS 1 1
2 UAP SGN IDS SGN 0.794643 0.969231
3 SGN IDS UAP SGN IDS SGN 0.794643 0.969231
4 SGN IDS UAP SGN 0.794643 0.969231
5 UAP SGN IDS SGN IDS SGN 0.794643 0.969231
6 SGN IDS SGN IDS 0.596639 0.938462
7 H1S 0.571429 0.953846
8 SGN IDS SGN IDS SGN 0.554688 0.939394
9 IDS SGN IDS SGN IDS 0.542636 0.924242
10 NGY BDP SGN IDS SGN BDP 0.539568 0.898551
11 IDS SGN IDS SGN IDS IDS 0.538462 0.939394
12 SGN IDS SGN IDS SGN IDS 0.526718 0.939394
13 IDS SGN IDS SGN IDS SUS IDS SGN 0.507463 0.953846
14 H3S 0.470085 0.939394
15 SGN IDY 0.46281 0.910448
16 SUS IDY 0.430894 0.880597
17 GNS BDP GNS IDS GNS BDP NPO 0.412162 0.815789
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HYV; Ligand: UAP SGN IDS SGN IDS; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2hyv.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
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