Receptor
PDB id Resolution Class Description Source Keywords
2I5S 1.9 Å EC: 3.1.27.- CRYSTAL STRUCTURE OF ONCONASE WITH BOUND NUCLEIC ACID RANA PIPIENS ONCONASE P-30 PROTEIN RIBONUCLEASE ANTI-TUMOR STRUCTURALGENOMICS PSI-2 PROTEIN STRUCTURE INITIATIVE CENTER FOR ESTRUCTURAL GENOMICS CESG HYDROLASE-DNA COMPLEX
Ref.: STRUCTURAL BASIS FOR CATALYSIS BY ONCONASE. J.MOL.BIOL. V. 375 165 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DA DU DG DA A:2;
 Valid;
 none;
 submit data
n/a n/a
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2GMK 1.65 Å EC: 3.1.27.- CRYSTAL STRUCTURE OF ONCONASE DOUBLE MUTANT WITH SPONTANEOUS ASSEMBLED (AMP) 4 STACK RANA PIPIENS ONCONASE P-30 PROTEIN RIBONUCLEASE ANTI-TUMOR PROTEIN STINITIATIVE PSI CENTER FOR EUKARYOTIC STRUCTURAL GENOMICSHYDROLASE
Ref.: STRUCTURAL BASIS FOR CATALYSIS BY ONCONASE. J.MOL.BIOL. V. 375 165 2008
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 7 families.
1 2I5S - DA DU DG DA n/a n/a
2 2GMK Ki = 590 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2I5S - DA DU DG DA n/a n/a
2 2GMK Ki = 590 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1OJ8 - DA DC DG DA n/a n/a
2 1OJ1 - CG2 C19 H25 N8 O12 P c1nc2c(n1[....
3 2I5S - DA DU DG DA n/a n/a
4 2GMK Ki = 590 uM AMP C10 H14 N5 O7 P c1nc(c2c(n....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: DA DU DG DA; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Ligands (3D)
Ligand no: 1; Ligand: DA DU DG DA; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2GMK; Ligand: AMP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2gmk.bio1) has 1 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2GMK; Ligand: AMP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2gmk.bio1) has 3 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2GMK; Ligand: AMP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2gmk.bio1) has 1 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2GMK; Ligand: AMP; Similar sites found with APoc: 3
This union binding pocket(no: 4) in the query (biounit: 2gmk.bio1) has 5 residues
No: Leader PDB Ligand Sequence Similarity
1 3DJV C3P 32.6923
2 3DJV C3P 32.6923
3 1U1B PAX 40.3846
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