Receptor
PDB id Resolution Class Description Source Keywords
2J5V 2.5 Å EC: 2.7.2.11 GLUTAMATE 5-KINASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTAMYL-5-PHOSPHATE AND PYROGLUTAMIC ACID ESCHERICHIA COLI PROLINE BIOSYNTHESIS GAMMA GLUTAMYL KINASE AMINO-ACID BIOSYNTHESIS GLUTAMATE KINASE KINASE TRANSFERASE FEEDBACK REGULATION GLUTAMATE 5-KINASE PUA DOMAIN AMINO ACID KINASE GLUTAMATE GLUTAMYL PHOSPHATE GAMMA GLUTAMYL PHOSPHATE PROLINE
Ref.: A NOVEL TWO-DOMAIN ARCHITECTURE WITHIN THE AMINO ACID KINASE ENZYME FAMILY REVEALED BY THE CRYSTAL STRUCTURE OF ESCHERICHIA COLI GLUTAMATE 5-KINASE. J.MOL.BIOL. V. 367 1431 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:1368;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
PCA A:1369;
B:1368;
Valid;
Valid;
none;
none;
submit data
129.114 C5 H7 N O3 C1CC(...
RGP A:1370;
B:1369;
Valid;
Valid;
none;
none;
submit data
227.109 C5 H10 N O7 P C(CC(...
SO4 A:1371;
B:1370;
Invalid;
Invalid;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2J5V 2.5 Å EC: 2.7.2.11 GLUTAMATE 5-KINASE FROM ESCHERICHIA COLI COMPLEXED WITH GLUTAMYL-5-PHOSPHATE AND PYROGLUTAMIC ACID ESCHERICHIA COLI PROLINE BIOSYNTHESIS GAMMA GLUTAMYL KINASE AMINO-ACID BIOSYNTHESIS GLUTAMATE KINASE KINASE TRANSFERASE FEEDBACK REGULATION GLUTAMATE 5-KINASE PUA DOMAIN AMINO ACID KINASE GLUTAMATE GLUTAMYL PHOSPHATE GAMMA GLUTAMYL PHOSPHATE PROLINE
Ref.: A NOVEL TWO-DOMAIN ARCHITECTURE WITHIN THE AMINO ACID KINASE ENZYME FAMILY REVEALED BY THE CRYSTAL STRUCTURE OF ESCHERICHIA COLI GLUTAMATE 5-KINASE. J.MOL.BIOL. V. 367 1431 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2J5V - PCA C5 H7 N O3 C1CC(=O)N[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2J5V - PCA C5 H7 N O3 C1CC(=O)N[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2J5V - PCA C5 H7 N O3 C1CC(=O)N[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PCA; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 PCA 1 1
Ligand no: 2; Ligand: RGP; Similar ligands found: 8
No: Ligand ECFP6 Tc MDL keys Tc
1 RGP 1 1
2 X2W 0.489362 0.857143
3 DGL 0.459459 0.648649
4 GLU 0.459459 0.648649
5 GGL 0.459459 0.648649
6 SEP 0.45 0.871795
7 2JJ 0.404762 0.897436
8 5OY 0.404762 0.897436
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2J5V; Ligand: PCA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2j5v.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2J5V; Ligand: PCA; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2j5v.bio1) has 9 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2J5V; Ligand: RGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2j5v.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2J5V; Ligand: RGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2j5v.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
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