Receptor
PDB id Resolution Class Description Source Keywords
2JGB 1.7 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP HOMO SAPIENS PHOSPHORYLATION INITIATION FACTOR 4EHP EIF4E RNA-BINDINGACETYLATION CAP-BINDING EUKARYOTIC INITIATION FACTOR PROSYNTHESIS INHIBITOR TRANSLATION PROTEIN BIOSYNTHESIS TRAREGULATION
Ref.: STRUCTURES OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, H ITS M7GTP-BOUND AND UNLIGANDED FORMS. J. MOL. BIOL. V. 368 691 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MGT B:1000;
Valid;
none;
Ka = 410000 M^-1
539.223 C11 H20 N5 O14 P3 CN1CN...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2JGB 1.7 Å NON-ENZYME: TRANSCRIPT_TRANSLATE STRUCTURE OF HUMAN EIF4E HOMOLOGOUS PROTEIN 4EHP WITH M7GTP HOMO SAPIENS PHOSPHORYLATION INITIATION FACTOR 4EHP EIF4E RNA-BINDINGACETYLATION CAP-BINDING EUKARYOTIC INITIATION FACTOR PROSYNTHESIS INHIBITOR TRANSLATION PROTEIN BIOSYNTHESIS TRAREGULATION
Ref.: STRUCTURES OF THE HUMAN EIF4E HOMOLOGOUS PROTEIN, H ITS M7GTP-BOUND AND UNLIGANDED FORMS. J. MOL. BIOL. V. 368 691 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 2JGB Ka = 410000 M^-1 MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 2JGB Ka = 410000 M^-1 MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1WKW - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 3HXG Kd = 0.27 uM GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
3 1EJ4 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
4 2V8W Kd = 0.146 uM MGO C12 H20 N4 O14 P3 C[n+]1cn(c....
5 2V8Y Kd = 1.96 uM MGV C17 H20 F N5 O8 P c1cc(ccc1C....
6 2V8X Kd = 6.95 uM MGQ C17 H21 N5 O8 P c1ccc(cc1)....
7 3M94 - M7M C13 H23 N5 O11 P2 CN1CN(C2=C....
8 2JGB Ka = 410000 M^-1 MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MGT; Similar ligands found: 16
No: Ligand ECFP6 Tc MDL keys Tc
1 MGT 1 1
2 M7G 0.910256 1
3 8GT 0.557895 0.914634
4 TPG 0.55 0.920455
5 G8D 0.505155 0.914634
6 M7M 0.49505 0.963855
7 CTP 0.453608 0.829268
8 HF4 0.453608 0.829268
9 UTP 0.447917 0.780488
10 6G0 0.438095 0.837209
11 8DG 0.433962 0.872093
12 01G 0.433628 0.791209
13 H6Y 0.428571 0.77907
14 MGP 0.428571 0.837209
15 8GM 0.414141 0.902439
16 GTP 0.411215 0.823529
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2JGB; Ligand: MGT; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2jgb.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback