Receptor
PDB id Resolution Class Description Source Keywords
2NXE 1.75 Å EC: 2.1.1.- T. THERMOPHILUS RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE (PRM COMPLEX WITH S-ADENOSYL-L-METHIONINE THERMUS THERMOPHILUS S-ADENOSYL-L-METHIONINE DEPENDENT METHYLTRANSFERASE POSTRANMODIFICATION TRANSFERASE
Ref.: RECOGNITION OF RIBOSOMAL PROTEIN L11 BY THE PROTEIN TRIMETHYLTRANSFERASE PRMA. EMBO J. V. 26 567 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM A:302;
B:303;
Valid;
Valid;
none;
none;
Kd = 5.5 uM
398.437 C15 H22 N6 O5 S C[S@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2NXE 1.75 Å EC: 2.1.1.- T. THERMOPHILUS RIBOSOMAL PROTEIN L11 METHYLTRANSFERASE (PRM COMPLEX WITH S-ADENOSYL-L-METHIONINE THERMUS THERMOPHILUS S-ADENOSYL-L-METHIONINE DEPENDENT METHYLTRANSFERASE POSTRANMODIFICATION TRANSFERASE
Ref.: RECOGNITION OF RIBOSOMAL PROTEIN L11 BY THE PROTEIN TRIMETHYLTRANSFERASE PRMA. EMBO J. V. 26 567 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 57 families.
1 2NXE Kd = 5.5 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 50 families.
1 2NXE Kd = 5.5 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 44 families.
1 2NXE Kd = 5.5 uM SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 192
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 XYA 0.565789 0.773333
9 ADN 0.565789 0.773333
10 RAB 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 AMP MG 0.511364 0.710843
25 5AL 0.510417 0.743902
26 VMS 0.510204 0.673913
27 54H 0.510204 0.673913
28 0UM 0.51 0.857143
29 A 0.505747 0.707317
30 AMP 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 DAL AMP 0.50505 0.765432
34 NVA LMS 0.504951 0.725275
35 K15 0.5 0.883117
36 6RE 0.5 0.78481
37 5AD 0.5 0.75
38 SSA 0.5 0.684783
39 SON 0.5 0.746988
40 SRP 0.5 0.746988
41 LSS 0.49505 0.706522
42 CA0 0.494624 0.714286
43 A12 0.494505 0.705882
44 AP2 0.494505 0.705882
45 ME8 0.490385 0.841463
46 5CA 0.49 0.684783
47 TSB 0.49 0.681319
48 53H 0.49 0.666667
49 ACP 0.489362 0.694118
50 5AS 0.48913 0.648936
51 ADP 0.48913 0.690476
52 A2D 0.488889 0.690476
53 J7C 0.488889 0.772152
54 ZAS 0.488636 0.769231
55 8QN 0.485149 0.743902
56 GAP 0.484536 0.73494
57 AN2 0.483871 0.682353
58 A3S 0.483871 0.813333
59 A7D 0.483871 0.851351
60 GJV 0.483516 0.775
61 SRA 0.483146 0.694118
62 LAD 0.480769 0.752941
63 KAA 0.480769 0.698925
64 GSU 0.480769 0.722222
65 AMO 0.480392 0.746988
66 DSZ 0.480392 0.703297
67 52H 0.48 0.666667
68 ADP MG 0.478723 0.702381
69 M33 0.478723 0.722892
70 MAO 0.478261 0.82716
71 BA3 0.478261 0.690476
72 AOC 0.477778 0.776316
73 DSH 0.477778 0.842105
74 NEC 0.477778 0.75
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 Y3J 0.47561 0.706667
78 G5A 0.474227 0.684783
79 A3T 0.473684 0.8
80 ADP BEF 0.473684 0.686047
81 BEF ADP 0.473684 0.686047
82 B4P 0.473118 0.690476
83 AP5 0.473118 0.690476
84 A3N 0.472527 0.766234
85 KB1 0.471698 0.833333
86 LEU LMS 0.471154 0.706522
87 APC 0.46875 0.705882
88 PRX 0.46875 0.73494
89 PAJ 0.466019 0.712644
90 4AD 0.466019 0.759036
91 RBY 0.463918 0.72619
92 ADP PO3 0.463918 0.728395
93 ADV 0.463918 0.72619
94 ADX 0.463158 0.666667
95 MHZ 0.463158 0.82716
96 AU1 0.463158 0.674419
97 YAP 0.462963 0.738095
98 TXA 0.462264 0.72619
99 NB8 0.462264 0.72093
100 A3G 0.461538 0.802632
101 VRT 0.459184 0.842105
102 ATP MG 0.459184 0.702381
103 YSA 0.458716 0.684783
104 XAH 0.458716 0.715909
105 50T 0.458333 0.682353
106 ATP 0.458333 0.690476
107 7D7 0.45679 0.723684
108 ANP MG 0.455446 0.678161
109 KH3 0.455357 0.871795
110 ACQ 0.454545 0.694118
111 AQP 0.453608 0.690476
112 5FA 0.453608 0.690476
113 AR6 0.453608 0.710843
114 APR 0.453608 0.710843
115 NSS 0.451923 0.703297
116 FA5 0.449541 0.746988
117 AGS 0.44898 0.678161
118 SAP 0.44898 0.678161
119 A5D 0.44898 0.789474
120 AD9 0.44898 0.674419
121 PTJ 0.448598 0.72093
122 YLB 0.448276 0.758621
123 YLP 0.447368 0.738636
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 TYR AMP 0.445455 0.746988
128 MYR AMP 0.444444 0.776471
129 3AM 0.444444 0.674699
130 OAD 0.443396 0.73494
131 2VA 0.443299 0.779221
132 OOB 0.442308 0.722892
133 S8M 0.442308 0.831169
134 ADP VO4 0.441176 0.702381
135 VO4 ADP 0.441176 0.702381
136 ANP 0.44 0.674419
137 TAT 0.44 0.686047
138 WAQ 0.439252 0.75
139 ARG AMP 0.438596 0.727273
140 YLC 0.435897 0.755814
141 AAT 0.435644 0.797468
142 3OD 0.435185 0.73494
143 1ZZ 0.435185 0.755814
144 NVA 2AD 0.434343 0.815789
145 DLL 0.433962 0.722892
146 00A 0.433962 0.689655
147 7MD 0.433628 0.715909
148 ATF 0.431373 0.666667
149 SO8 0.43 0.792208
150 3UK 0.429907 0.714286
151 A6D 0.429907 0.72619
152 5SV 0.428571 0.741176
153 AMP DBH 0.428571 0.714286
154 WSA 0.42735 0.692308
155 TYM 0.42735 0.746988
156 9SN 0.427273 0.681818
157 AHZ 0.426087 0.755814
158 A A 0.425926 0.710843
159 3NZ 0.425926 0.807692
160 P5A 0.425926 0.691489
161 PR8 0.425926 0.744186
162 A1R 0.424528 0.709302
163 2A5 0.424242 0.674419
164 7MC 0.423729 0.719101
165 7D5 0.422222 0.658824
166 FYA 0.422018 0.722892
167 JB6 0.422018 0.709302
168 AYB 0.421488 0.75
169 PLP AAD 0.419355 0.764045
170 A22 0.419048 0.682353
171 MAP 0.419048 0.659091
172 2AM 0.417582 0.666667
173 TAD 0.417391 0.712644
174 A3P 0.416667 0.686747
175 ADP BMA 0.416667 0.714286
176 25A 0.415094 0.690476
177 YLA 0.413223 0.719101
178 ADQ 0.411215 0.694118
179 48N 0.410256 0.72093
180 0XU 0.41 0.824324
181 NAD IBO 0.406504 0.717647
182 7D3 0.40625 0.643678
183 PAP 0.405941 0.678571
184 OVE 0.404255 0.662791
185 4UV 0.403509 0.697674
186 ALF ADP 3PG 0.403361 0.712644
187 AF3 ADP 3PG 0.403361 0.712644
188 LA8 ALF 3PG 0.403361 0.712644
189 3AD 0.402299 0.783784
190 CMP 0.402062 0.691358
191 2BA 0.402062 0.682927
192 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2NXE; Ligand: SAM; Similar sites found: 596
This union binding pocket(no: 1) in the query (biounit: 2nxe.bio1) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5O4J 9KH 0.0004646 0.47472 1.1811
2 5O4J SAH 0.0004646 0.47472 1.1811
3 5O4J PJL 0.0004704 0.47311 1.1811
4 1V59 NAD 0.00005931 0.46423 1.5748
5 1V59 FAD 0.00172 0.46056 1.5748
6 5UAV NDP 0.007103 0.42257 1.5748
7 5UAV TFB 0.007103 0.42257 1.5748
8 4NTC FAD 0.01439 0.4132 1.5748
9 3Q3C NAD 0.009697 0.40244 1.5748
10 5MPT SAH 0.00005766 0.48966 1.9685
11 1SOW NAD 0.0009678 0.45745 1.9685
12 1FEC FAD 0.002568 0.45321 1.9685
13 3CGD COA 0.01127 0.44022 1.9685
14 3CGD FAD 0.01127 0.44022 1.9685
15 3CGD NAD 0.01127 0.44022 1.9685
16 3BGD SAH 0.001303 0.43927 1.9685
17 3BGD PM6 0.001836 0.43917 1.9685
18 2BRY FAD 0.002981 0.43645 1.9685
19 1XSE NDP 0.01213 0.41575 1.9685
20 1DSS NAD 0.007477 0.40895 1.9685
21 3CH6 NAP 0.03793 0.40598 1.9685
22 3CH6 311 0.03793 0.40598 1.9685
23 5UAO FAD 0.01925 0.40443 1.9685
24 3GEG NAD 0.002456 0.4335 2.02429
25 2VDV SAM 0.00002816 0.52105 2.03252
26 3C3Y SAH 0.001478 0.43124 2.1097
27 5N5D SAM 0.000055 0.49297 2.21239
28 5KVA SAM 0.00008947 0.48828 2.3622
29 1BZL FAD 0.004066 0.4697 2.3622
30 3L9W AMP 0.0005141 0.46852 2.3622
31 3L9W GSH 0.0005316 0.46486 2.3622
32 3GD4 FAD 0.003009 0.45807 2.3622
33 3GD4 NAD 0.004611 0.45807 2.3622
34 4GKV NAD 0.003187 0.43634 2.3622
35 1YKJ FAD 0.01351 0.42883 2.3622
36 1KYQ NAD 0.002457 0.41631 2.3622
37 2YYY NAP 0.008535 0.41057 2.3622
38 4L8V NAP 0.01034 0.40808 2.3622
39 4MP8 NAD 0.01902 0.4037 2.3622
40 3RIY NAD 0.01388 0.40228 2.3622
41 1UAY ADN 0.002547 0.40499 2.47934
42 2CUL FAD 0.008749 0.41729 2.58621
43 1G55 SAH 0.00003312 0.49148 2.75591
44 1MO9 KPC 0.001606 0.48395 2.75591
45 1MO9 FAD 0.002308 0.47545 2.75591
46 2YG3 FAD 0.0008609 0.4696 2.75591
47 5X62 SAH 0.0002707 0.46562 2.75591
48 4PLG NAI 0.001326 0.45747 2.75591
49 4USQ FAD 0.001239 0.45518 2.75591
50 5D4V SAH 0.000528 0.4546 2.75591
51 1YQZ FAD 0.004226 0.45161 2.75591
52 4EIP FAD 0.002812 0.44949 2.75591
53 3PFG TLO 0.002362 0.44909 2.75591
54 1D4D FAD 0.002783 0.44875 2.75591
55 5U8U FAD 0.006268 0.44657 2.75591
56 4EIP K2C 0.003732 0.44548 2.75591
57 5BUK FAD 0.003699 0.44385 2.75591
58 1DLJ NAI 0.004778 0.44291 2.75591
59 5E9W SAH 0.0001935 0.44157 2.75591
60 1ZK7 FAD 0.004356 0.44139 2.75591
61 3GF4 UPG 0.007072 0.43997 2.75591
62 1H82 FAD 0.0069 0.43978 2.75591
63 1H82 GZZ 0.008242 0.43876 2.75591
64 3GF4 FAD 0.007358 0.43697 2.75591
65 1I8T FAD 0.004108 0.43681 2.75591
66 2RGJ FAD 0.003185 0.43513 2.75591
67 2ZXI FAD 0.004797 0.43156 2.75591
68 2WA2 SAM 0.001074 0.43045 2.75591
69 5FTW SAH 0.0007078 0.42924 2.75591
70 1Q1R FAD 0.005408 0.42914 2.75591
71 1RYD NDP 0.006627 0.42504 2.75591
72 4G74 FAD 0.006769 0.42354 2.75591
73 3PFG SAM 0.02977 0.4226 2.75591
74 4G74 UQ5 0.01222 0.42171 2.75591
75 1DLJ UGA 0.02133 0.4116 2.75591
76 5XDT MB3 0.01046 0.41147 2.75591
77 1XKQ NDP 0.01151 0.40956 2.75591
78 4N49 SAM 0.006715 0.40459 2.75591
79 5XDT GDP 0.01094 0.403 2.75591
80 4NBU NAI 0.009389 0.41123 2.8
81 2EWM NAD 0.009741 0.41051 2.81124
82 3KLJ FAD 0.00113 0.45571 2.85714
83 2HK9 NAP 0.01263 0.4002 2.90909
84 2BZG SAH 0.0006764 0.44376 3.01724
85 2HQM FAD 0.001515 0.46021 3.13152
86 2DPM SAM 0.000003233 0.55127 3.14961
87 3S1S SAH 0.00004329 0.50421 3.14961
88 1OBB NAD 0.0004418 0.46174 3.14961
89 1V5F FAD 0.003038 0.46142 3.14961
90 2CDU FAD 0.001093 0.46016 3.14961
91 2YVF NAD 0.003065 0.45985 3.14961
92 2YVF FAD 0.002964 0.45985 3.14961
93 4BV6 FAD 0.001817 0.45547 3.14961
94 3EVF GTA 0.001671 0.45504 3.14961
95 3EVF SAH 0.00141 0.45504 3.14961
96 3LZW FAD 0.002035 0.44996 3.14961
97 3CTY FAD 0.002904 0.44883 3.14961
98 3LAD FAD 0.002763 0.44792 3.14961
99 3ICS FAD 0.002357 0.44699 3.14961
100 5J60 FAD 0.003022 0.44408 3.14961
101 3ICR FAD 0.003096 0.44039 3.14961
102 3ICT FAD 0.003628 0.43719 3.14961
103 5FJN BE2 0.007768 0.42944 3.14961
104 5FJN FAD 0.006814 0.42944 3.14961
105 3RC1 TLO 0.004807 0.42814 3.14961
106 3RC1 NAP 0.00587 0.42748 3.14961
107 2HJR APR 0.002789 0.42474 3.14961
108 1VJT NAD 0.002159 0.42413 3.14961
109 1H6C NDP 0.007264 0.42318 3.14961
110 2CDU ADP 0.002067 0.41803 3.14961
111 3ICS ADP 0.001043 0.41704 3.14961
112 3ICT ADP 0.00122 0.41507 3.14961
113 2XVE FAD 0.02655 0.41307 3.14961
114 2XVF FAD 0.01504 0.40846 3.14961
115 1U7T TDT 0.01885 0.40764 3.14961
116 1RLZ NAD 0.01288 0.40497 3.14961
117 1H6C SIN 0.0223 0.40237 3.14961
118 1E3W NAD 0.01429 0.4017 3.14961
119 3GWZ SAH 0.0008629 0.42966 3.25203
120 3GXO SAH 0.002838 0.40389 3.25203
121 1VM6 NAD 0.009019 0.40533 3.50877
122 3LST SAH 0.00004529 0.51158 3.54331
123 1KYZ SAH 0.00009344 0.48066 3.54331
124 1PN0 FAD 0.00152 0.46497 3.54331
125 1PN0 IPH 0.001588 0.46497 3.54331
126 1UP7 NAD 0.0004525 0.46306 3.54331
127 1Y8Q ATP 0.0006374 0.45472 3.54331
128 3UCL NAP 0.006546 0.44752 3.54331
129 3UCL CYH 0.005998 0.44752 3.54331
130 3UCL FAD 0.005998 0.44752 3.54331
131 1X87 NAD 0.0009975 0.44436 3.54331
132 4J36 1HR 0.003615 0.44338 3.54331
133 4J36 FAD 0.002533 0.43969 3.54331
134 1SAY PYR 0.003152 0.43656 3.54331
135 3UOY NAP 0.01488 0.42919 3.54331
136 3FG2 FAD 0.004339 0.42899 3.54331
137 1X7D ORN 0.005696 0.42809 3.54331
138 1X7D NAD 0.003566 0.42766 3.54331
139 1XHL NDP 0.004409 0.42744 3.54331
140 4K28 NAD 0.003459 0.42384 3.54331
141 2WET FAD 0.009311 0.42211 3.54331
142 4JJF FE9 0.004673 0.42097 3.54331
143 4JJF N2I 0.005389 0.42091 3.54331
144 3QWI NAP 0.0104 0.41042 3.54331
145 3QWI CUE 0.01647 0.41042 3.54331
146 1KYZ FER 0.009459 0.40722 3.54331
147 3HAD NAD 0.02723 0.40572 3.54331
148 1LLU NAD 0.01899 0.40064 3.54331
149 3ICC NAP 0.01736 0.40022 3.54331
150 3PT9 SAH 0.00002587 0.5046 3.55097
151 3SQP FAD 0.03098 0.44037 3.55649
152 2ZFU SAH 0.0004166 0.45709 3.72093
153 3WLE NAD 0.0003013 0.48601 3.93701
154 3A27 SAM 0.0002105 0.46552 3.93701
155 2NVK FAD 0.001905 0.45451 3.93701
156 2B9W FAD 0.003618 0.45268 3.93701
157 5JCM NAD 0.005652 0.44879 3.93701
158 5JCM ISD 0.005652 0.44879 3.93701
159 5JCM FAD 0.005483 0.44879 3.93701
160 2Q7V FAD 0.002789 0.44673 3.93701
161 2X3N FAD 0.002281 0.44654 3.93701
162 5JGL SAM 0.0004293 0.44598 3.93701
163 4M52 FAD 0.003439 0.44344 3.93701
164 2R4J FAD 0.007718 0.43446 3.93701
165 2R4J 13P 0.007718 0.43446 3.93701
166 2A8X FAD 0.006505 0.43132 3.93701
167 4RQU NAD 0.003364 0.4288 3.93701
168 1ZEM NAD 0.002931 0.42857 3.93701
169 1BC5 SAH 0.002657 0.42566 3.93701
170 1SZD APR 0.008373 0.41817 3.93701
171 1BXG NAD 0.005998 0.41469 3.93701
172 1CF2 NAP 0.008204 0.4086 3.93701
173 1F8F NAD 0.007998 0.40765 3.93701
174 5HCF BGC 0.02986 0.40001 3.93701
175 4POO SAM 0.00001004 0.5343 4
176 3BXO SAM 0.0002548 0.44398 4.1841
177 3G2O SAM 0.000002846 0.54573 4.33071
178 3RNM FAD 0.0009958 0.46982 4.33071
179 1ZMD FAD 0.001129 0.46724 4.33071
180 5G3U FDA 0.0009329 0.46572 4.33071
181 3S5W FAD 0.0006029 0.46538 4.33071
182 1ZMD NAI 0.000422 0.4644 4.33071
183 2WPF FAD 0.006105 0.46019 4.33071
184 3HDY GDU 0.003186 0.45972 4.33071
185 3HDY FDA 0.003084 0.45972 4.33071
186 1XHC FAD 0.001247 0.45751 4.33071
187 3HDY FAD 0.003806 0.45523 4.33071
188 2WPF WPF 0.009438 0.45182 4.33071
189 3LKZ SFG 0.0005079 0.45128 4.33071
190 2RAB FAD 0.004423 0.44017 4.33071
191 2RAB NAD 0.008695 0.44017 4.33071
192 2AG8 NAP 0.001076 0.43918 4.33071
193 3A25 SAM 0.0009013 0.43841 4.33071
194 5G3U ITW 0.005807 0.43456 4.33071
195 4JNA FAD 0.007553 0.42733 4.33071
196 2GN4 NDP 0.03362 0.42404 4.33071
197 1DMR PGD 0.02178 0.42093 4.33071
198 4C3Y FAD 0.01017 0.4203 4.33071
199 4C3Y ANB 0.0138 0.41837 4.33071
200 2Q0L FAD 0.0124 0.41624 4.33071
201 1EZ4 NAD 0.006839 0.41214 4.33071
202 1J0X NAD 0.01729 0.41118 4.33071
203 4EDF UPG 0.02237 0.40909 4.33071
204 1IY8 NAD 0.01214 0.40615 4.33071
205 4HXY NDP 0.01259 0.40543 4.33071
206 4XYM COA 0.002992 0.4453 4.34783
207 4XZ3 COA 0.0005855 0.42202 4.34783
208 1J5P NAD 0.01338 0.40043 4.34783
209 5E8J SAH 0.0001775 0.48436 4.54545
210 1JNR FAD 0.02742 0.41917 4.66667
211 3TKA SAM 0.00007811 0.48867 4.72441
212 1R37 NAD 0.0008211 0.46337 4.72441
213 4REP FAD 0.001856 0.45292 4.72441
214 1YBH FAD 0.002324 0.44837 4.72441
215 4GUT FAD 0.004567 0.4413 4.72441
216 4JK3 NAD 0.001541 0.44104 4.72441
217 4HSU FAD 0.004333 0.44059 4.72441
218 4GUS FAD 0.004586 0.43942 4.72441
219 1NVM NAD 0.002425 0.43796 4.72441
220 1RYI FAD 0.004416 0.43735 4.72441
221 4FWE FAD 0.004851 0.43735 4.72441
222 2GVC FAD 0.003174 0.4352 4.72441
223 2GV8 FAD 0.003391 0.43511 4.72441
224 4IV9 FAD 0.005067 0.43356 4.72441
225 1VQW FAD 0.003649 0.43243 4.72441
226 2E5V FAD 0.007243 0.42911 4.72441
227 2F1K NAP 0.003174 0.42704 4.72441
228 1NAA ABL 0.01295 0.42432 4.72441
229 1NAA 6FA 0.00914 0.42432 4.72441
230 1A5Z NAD 0.0027 0.42362 4.72441
231 1G8K MGD 0.03633 0.41034 4.72441
232 3G5S FAD 0.01483 0.40874 4.72441
233 4MIG G3F 0.02419 0.40821 4.72441
234 3ZNN FAD 0.03487 0.40532 4.72441
235 3ZNN 4WL 0.03487 0.40532 4.72441
236 1ZH8 NAP 0.01115 0.404 4.72441
237 1YB5 NAP 0.0169 0.40298 4.72441
238 2DT5 NAD 0.0005745 0.46334 4.73934
239 3NUG NAD 0.01526 0.40161 4.8583
240 3WV8 ATP 0.0006046 0.44801 5.04587
241 2EJU SAH 0.00000007621 0.6132 5.11811
242 5BW4 SAM 0.00002099 0.50158 5.11811
243 4DSG UDP 0.0007845 0.48808 5.11811
244 4DSG FAD 0.001026 0.48389 5.11811
245 4TM3 FAD 0.005531 0.45115 5.11811
246 4J4H NAI 0.003032 0.44978 5.11811
247 4J4H 1J1 0.003032 0.44978 5.11811
248 2JB2 PHE 0.003715 0.43988 5.11811
249 2JB2 FAD 0.003531 0.43988 5.11811
250 1PS9 FAD 0.00392 0.43979 5.11811
251 1GR0 NAD 0.003149 0.43658 5.11811
252 4HA6 FAD 0.007097 0.42953 5.11811
253 1SC6 NAD 0.004102 0.42887 5.11811
254 1NJR XYL 0.003546 0.42635 5.11811
255 1FL2 FAD 0.008071 0.4231 5.11811
256 1H2B NAJ 0.005944 0.42273 5.11811
257 1PS9 NAP 0.004692 0.41945 5.11811
258 2CVZ NDP 0.004869 0.41874 5.11811
259 3U4C NDP 0.007328 0.41356 5.11811
260 1WP4 NDP 0.009443 0.40725 5.11811
261 3WMX NAD 0.01333 0.40181 5.11811
262 3OJO NAD 0.001281 0.43959 5.33643
263 1E6E FAD 0.002038 0.44765 5.46875
264 1Q0S SAH 0.000004724 0.54875 5.51181
265 1ELI PYC 0.0001795 0.49899 5.51181
266 2VHW NAI 0.0002524 0.48956 5.51181
267 2IVD FAD 0.001154 0.45907 5.51181
268 4CNK FAD 0.001464 0.45661 5.51181
269 1VKO NAD 0.001757 0.44565 5.51181
270 3OA2 NAD 0.002719 0.43297 5.51181
271 2IXB A2G 0.005593 0.42952 5.51181
272 2IXB NAD 0.003721 0.42952 5.51181
273 2NPX NAD 0.01402 0.42543 5.51181
274 2NPX FAD 0.006499 0.42543 5.51181
275 4YNU FAD 0.009356 0.42473 5.51181
276 2V3V MGD 0.0213 0.42364 5.51181
277 4YNU LGC 0.01819 0.41419 5.51181
278 2PX8 SAH 0.003553 0.41282 5.51181
279 1LSS NAD 0.0001692 0.47409 5.71429
280 2BD0 NAP 0.01151 0.4084 5.7377
281 3C6K SPD 0.005641 0.4272 5.77428
282 3C6K MTA 0.005641 0.4272 5.77428
283 3MB5 SAM 0.000002577 0.55802 5.90551
284 4NTD FAD 0.002007 0.45024 5.90551
285 1MV8 NAD 0.001548 0.44095 5.90551
286 3NYC FAD 0.009905 0.42846 5.90551
287 4WCX MET 0.02121 0.41486 5.90551
288 4W6Z 8ID 0.01464 0.40799 5.90551
289 1MUU NAD 0.008437 0.40662 5.90551
290 1N4W FAD 0.00292 0.44776 5.95238
291 1KOL NAD 0.003898 0.43463 6.03015
292 2VT3 ATP 0.0002636 0.44022 6.04651
293 2GAG NAD 0.0006965 0.47042 6.06061
294 2GAG FAD 0.007928 0.42902 6.06061
295 2GAG FOA 0.007928 0.42902 6.06061
296 1DL5 SAH 0.00001071 0.53723 6.29921
297 3QOX SAH 0.00001125 0.52992 6.29921
298 3VYW SAM 0.0002938 0.46368 6.29921
299 4USR FAD 0.001549 0.44946 6.29921
300 1U1I NAD 0.002887 0.43831 6.29921
301 3K7M FAD 0.008915 0.43219 6.29921
302 3ABI NAD 0.00588 0.4192 6.29921
303 9LDB NAD 0.006583 0.41825 6.29921
304 9LDT NAD 0.006743 0.41778 6.29921
305 3QVP FAD 0.0132 0.41674 6.29921
306 3NKS FAD 0.01082 0.41512 6.29921
307 1P3D UMA 0.007087 0.41145 6.29921
308 1P31 EPU 0.004615 0.40794 6.29921
309 1EU1 MGD 0.01631 0.40682 6.29921
310 3WGT FAD 0.02926 0.40345 6.29921
311 4FC7 NAP 0.028 0.40035 6.29921
312 4FC7 COA 0.028 0.40035 6.29921
313 4RL4 PPV 0.02044 0.40684 6.60377
314 5MW4 5JU 0.000006991 0.56737 6.69291
315 4BLW AMP 0.00000977 0.55163 6.69291
316 4BLW SAH 0.00001019 0.5382 6.69291
317 3P9C SAH 0.001345 0.45094 6.69291
318 5MBX FAD 0.005023 0.44501 6.69291
319 5MBX SP5 0.005023 0.44501 6.69291
320 4D04 NAP 0.006832 0.44343 6.69291
321 4AP3 NAP 0.008171 0.43828 6.69291
322 3AYI FAD 0.007027 0.43643 6.69291
323 3AYI HCI 0.007287 0.43643 6.69291
324 1DJN ADP 0.001894 0.43213 6.69291
325 3T31 FAD 0.009638 0.43128 6.69291
326 3T31 DCQ 0.01041 0.43107 6.69291
327 4ITU NAI 0.005074 0.42588 6.69291
328 4ITU 1HS 0.008108 0.42588 6.69291
329 5EOW FAD 0.009001 0.41561 6.69291
330 3H9E NAD 0.009075 0.40664 6.69291
331 2AE2 NAP 0.01906 0.40651 6.69291
332 3HVJ 705 0.000002027 0.58792 6.78733
333 1XCL SAH 0.0008314 0.46045 6.80851
334 4EA7 JB2 0.001154 0.46365 6.81818
335 5XL4 SIA 0.01626 0.40574 6.81818
336 3DXY SAM 0.000002765 0.51542 6.88073
337 1NW5 SAM 0.00009102 0.48352 7.08661
338 4EMI NAD 0.001741 0.47115 7.08661
339 5KOK SAH 0.0001885 0.46007 7.08661
340 3LXD FAD 0.001292 0.45559 7.08661
341 4EMI FAD 0.002058 0.44973 7.08661
342 4RPL 3UC 0.006447 0.44723 7.08661
343 4RPL FAD 0.007191 0.44298 7.08661
344 1D1T NAD 0.002027 0.44282 7.08661
345 3GDN HBX 0.01127 0.42575 7.08661
346 3GDN FAD 0.008156 0.42575 7.08661
347 1XDS SAM 0.0009326 0.42359 7.08661
348 3EYA FAD 0.006805 0.42233 7.08661
349 1QZZ SAM 0.00143 0.41595 7.08661
350 1LDN NAD 0.0116 0.40704 7.08661
351 4E5N NAD 0.01332 0.40432 7.08661
352 1LTH NAD 0.01074 0.40046 7.08661
353 1EDO NAP 0.007591 0.41667 7.37705
354 3H2B SAH 0.000003616 0.54402 7.38916
355 4EMJ FAD 0.002077 0.45064 7.47664
356 4LWP SAH 0.000003516 0.54179 7.48031
357 4KRG SAH 0.00007089 0.47928 7.48031
358 1OMO NAD 0.001165 0.44316 7.48031
359 2G5C NAD 0.002382 0.43695 7.48031
360 4YAG NAI 0.007959 0.42625 7.48031
361 1J49 NAD 0.004305 0.42397 7.48031
362 2DTX BMA 0.01377 0.41222 7.48031
363 3H8V ATP 0.002631 0.41843 7.53425
364 1P1C SAH 0.0001983 0.47518 7.53769
365 2GN3 MMA 0.009702 0.41441 7.53968
366 2GN3 MAN 0.01561 0.40214 7.53968
367 5THZ SAH 0.00004745 0.50246 7.65432
368 5ULP KB1 0.00002683 0.46423 7.83582
369 5CUQ NSC 0.0003336 0.47851 7.87402
370 5JJR SAH 0.0002101 0.46556 7.87402
371 3EVG SAH 0.0002338 0.46357 7.87402
372 2P41 SAH 0.0002617 0.46146 7.87402
373 1RSG FAD 0.001857 0.45605 7.87402
374 1YY5 FAD 0.002659 0.45064 7.87402
375 1RM0 D6P 0.003604 0.44794 7.87402
376 1RM0 NAI 0.003314 0.44703 7.87402
377 5EZ7 FAD 0.003478 0.44019 7.87402
378 1O97 AMP 0.009949 0.43133 7.87402
379 2OBF F83 0.006228 0.43128 7.87402
380 1O94 ADP 0.002336 0.4298 7.87402
381 3O03 NAP 0.01082 0.40323 7.87402
382 1NM5 NAD 0.02619 0.40872 7.88177
383 1NM5 NAP 0.02532 0.40872 7.88177
384 2ZIF SAM 0.00002837 0.50538 8.26772
385 1GET NAP 0.00559 0.45092 8.26772
386 1GET FAD 0.005274 0.45092 8.26772
387 4D7E FAD 0.001735 0.45089 8.26772
388 4JDR FAD 0.004276 0.43801 8.26772
389 3OND ADN 0.006535 0.43473 8.26772
390 3OND NAD 0.006535 0.43473 8.26772
391 3NTA FAD 0.005552 0.42967 8.26772
392 3WE0 FAD 0.008785 0.42514 8.26772
393 3CGB FAD 0.008011 0.42121 8.26772
394 1KNR FAD 0.009857 0.42 8.26772
395 1DXY NAD 0.008657 0.40756 8.26772
396 5JE8 NAD 0.0007828 0.40635 8.26772
397 3NT6 FAD 0.02127 0.4024 8.26772
398 1S7G NAD 0.006323 0.41905 8.3004
399 1S7G APR 0.01404 0.40559 8.3004
400 1ZGA SAH 0.00009574 0.46339 8.40336
401 4NEC SAH 0.0002199 0.47469 8.66142
402 2Z3Y F2N 0.001555 0.46068 8.66142
403 1QO8 FAD 0.001533 0.45997 8.66142
404 4BJZ P3A 0.008148 0.44398 8.66142
405 3NTD FAD 0.005206 0.43097 8.66142
406 3GMB FAD 0.007471 0.41933 8.66142
407 1X14 NAD 0.002098 0.41803 8.66142
408 1PL6 NAD 0.004869 0.41067 8.66142
409 1PL6 572 0.01095 0.4094 8.66142
410 1PNO NAP 0.01469 0.40116 8.88889
411 4DCM SAM 0.000000249 0.57123 9.05512
412 2YX1 SFG 0.000001211 0.53575 9.05512
413 1G60 SAM 0.00001317 0.51978 9.05512
414 2DKH FAD 0.001867 0.44575 9.05512
415 2DKH 3HB 0.002644 0.44575 9.05512
416 2QA1 FAD 0.003523 0.43552 9.05512
417 2QQF A1R 0.003364 0.42438 9.05512
418 2OD9 A1R NCA 0.005487 0.42056 9.05512
419 4EUE NAI 0.01275 0.40636 9.05512
420 3CIF G3H 0.01453 0.40491 9.05512
421 3CIF NAD 0.01213 0.40366 9.05512
422 3MQ2 SAH 0.0006915 0.43754 9.17431
423 3JWH SAH 0.00002028 0.48177 9.21659
424 1I9G SAM 0.00000627 0.53626 9.44882
425 2AOT SAH 0.00008968 0.46905 9.44882
426 3IHG FAD 0.0008869 0.45486 9.44882
427 1LVL NAD 0.0006327 0.44921 9.44882
428 2Y6Q I7T 0.003626 0.44607 9.44882
429 2Y6Q FAD 0.00172 0.44607 9.44882
430 1CDO NAD 0.001405 0.44282 9.44882
431 1LVL FAD 0.005234 0.43579 9.44882
432 5EB4 FAD 0.006908 0.42725 9.44882
433 1HYH NAD 0.006456 0.41864 9.44882
434 4FN4 NAD 0.009456 0.40985 9.44882
435 1JQD SAH 0.0001886 0.4082 9.44882
436 2O4C NAD 0.01586 0.40085 9.44882
437 5N53 8NB 0.007752 0.42962 9.74359
438 1QAN SAH 0.000005707 0.54049 9.83607
439 1T26 NAI 0.001394 0.46191 9.84252
440 1GTE FAD 0.006164 0.44428 9.84252
441 4X9M FAD 0.004156 0.4376 9.84252
442 1EFV FAD 0.008648 0.435 9.84252
443 1EFV AMP 0.01148 0.42901 9.84252
444 2V3A FAD 0.006489 0.42651 9.84252
445 4TQG NDP 0.004061 0.42511 9.84252
446 2V3B FAD 0.007175 0.42343 9.84252
447 3V1Y NAD 0.01193 0.40132 9.84252
448 2YY7 NAD 0.01347 0.40409 9.9359
449 3P2E SAH 0.00006854 0.49114 10.2222
450 3AB1 FAD 0.004431 0.43629 10.2362
451 5M67 NAD 0.006361 0.43612 10.2362
452 5M67 ADE 0.007161 0.43365 10.2362
453 5M67 3D1 0.008057 0.4312 10.2362
454 3AXB PRO 0.006677 0.42986 10.2362
455 1V8B NAD 0.005171 0.42895 10.2362
456 3AXB FAD 0.005559 0.42858 10.2362
457 5XVQ SAH 0.001265 0.40654 10.2362
458 3U31 NAD 0.002296 0.40337 10.2362
459 1M2K APR 0.0033 0.42775 10.4418
460 4XUC SAM 0.00000387 0.57007 10.5505
461 4XUC 43G 0.00000387 0.57007 10.5505
462 2XVM SAH 0.00004715 0.47323 10.5528
463 5MGZ SAH 0.0000388 0.48679 10.5932
464 5GM1 SAH 0.000008009 0.48837 10.6299
465 2FZW NAD 0.002504 0.45091 10.6299
466 2V6O FAD 0.009116 0.44269 10.6299
467 5GWX SAM 0.00006958 0.43411 10.6299
468 5GWX SAR 0.00006958 0.43411 10.6299
469 3GGO ENO 0.01227 0.41646 10.6299
470 3GGO NAI 0.01227 0.41646 10.6299
471 1ZBQ NAD 0.01593 0.40307 10.6299
472 2PXX SAH 0.0002485 0.46468 10.6977
473 4II2 ATP 0.0007534 0.44591 10.8434
474 5DX0 SFG 0.000001146 0.57824 11.0236
475 5DWQ SFG 0.000001062 0.57736 11.0236
476 5DX1 SFG 0.00000729 0.5426 11.0236
477 5DX8 SFG 0.000005733 0.49426 11.0236
478 5DXA SFG 0.00000779 0.48901 11.0236
479 3QFA FAD 0.00403 0.4402 11.0236
480 4RDH AMP 0.002161 0.43017 11.0236
481 4D79 ATP 0.002957 0.41625 11.0236
482 4RDI ATP 0.003834 0.4114 11.0236
483 1WDK NAD 0.005766 0.41085 11.0236
484 5TVF CGQ 0.01657 0.40533 11.0236
485 2D5A COA 0.002703 0.42533 11.1111
486 1TPY SAH 0.000008659 0.53259 11.4173
487 1SQF SAM 0.00001451 0.51537 11.4173
488 2O07 MTA 0.0002479 0.47811 11.4173
489 2O07 SPD 0.0002923 0.47811 11.4173
490 3VPH OXM 0.0005941 0.47112 11.4173
491 2PT9 S4M 0.001346 0.44205 11.4173
492 2PT9 2MH 0.002612 0.44031 11.4173
493 3VPH NAD 0.002684 0.43854 11.4173
494 3LCV SAM 0.002907 0.42395 11.4173
495 1Z3C SA8 0.0001904 0.48652 11.811
496 3TKY SAH 0.0003486 0.45833 11.811
497 3OZ2 FAD 0.00187 0.45384 11.811
498 1U3U BNF 0.003394 0.44371 11.811
499 1UXG NAD 0.00298 0.44225 11.811
500 2A14 SAH 0.001093 0.44079 11.811
501 3UBM COA 0.0101 0.40012 11.811
502 3E1T FAD 0.001632 0.4597 11.9141
503 5HJM MTA 0.0001692 0.46236 11.9318
504 3I7V ATP 0.01811 0.41118 11.9403
505 4YSX FAD 0.002339 0.44929 12.1795
506 4AZW SAM 0.00001308 0.51991 12.2047
507 4AZT SAM 0.00001577 0.51383 12.2047
508 3VSE SAH 0.00004063 0.46665 12.2047
509 3GCZ SAM 0.0003268 0.45732 12.2047
510 1COY FAD 0.00293 0.44573 12.2047
511 2I7C AAT 0.002185 0.44262 12.2047
512 1U2Z SAH 0.00002516 0.51456 12.5984
513 2C7G FAD 0.006935 0.43895 12.5984
514 2C7G ODP 0.006697 0.43895 12.5984
515 2RGH FAD 0.01664 0.4093 12.5984
516 2IVF MGD 0.02107 0.40259 12.6168
517 3Q9N COA 0.0005927 0.45954 12.766
518 1R18 SAH 0.000001026 0.57305 12.7753
519 2PWY SAH 0.00000224 0.5607 12.7907
520 4PNE SAH 0.000008063 0.53627 12.9921
521 4KGD FAD 0.003786 0.45994 12.9921
522 4KGD TDP 0.004007 0.45809 12.9921
523 2RGO FAD 0.001842 0.45085 12.9921
524 4K5S FAD 0.003458 0.4335 12.9921
525 4K5S PM0 0.007214 0.4335 12.9921
526 3T7S SAM 0.000002931 0.54518 13.3858
527 5DNK SAH 0.00001473 0.47478 13.3858
528 2VVL FAD 0.002302 0.45065 13.3858
529 2VVM FAD 0.00221 0.45044 13.3858
530 1G0N NDP 0.01321 0.41209 13.3858
531 1G0N PHH 0.01715 0.40959 13.3858
532 5XVK SAH 0.001076 0.40923 13.3858
533 4GQB 0XU 0.000009882 0.5346 13.6364
534 4KIB SAH 0.000005241 0.5261 13.7795
535 5THY SAH 0.00005024 0.47568 13.7795
536 1RP0 AHZ 0.00192 0.4439 13.7795
537 5ITV NAI 0.003192 0.43254 14.1732
538 2DFV NAD 0.01211 0.40239 14.1732
539 1PZG A3D 0.007882 0.42154 14.1994
540 4DMG SAM 0.00008327 0.50561 14.5669
541 2A92 NAI 0.0006187 0.4663 14.5669
542 1FP1 SAH 0.0001594 0.45996 14.5669
543 2HMT NAI 0.001037 0.4418 14.5833
544 3OU2 SAH 0.0001275 0.43037 14.6789
545 2RH4 EMO 0.01273 0.41922 14.8014
546 3FPF MTA 0.000004318 0.57571 14.9606
547 1L1E SAH 0.000014 0.5211 14.9606
548 3FPF TNA 0.000004318 0.41647 14.9606
549 5FA5 MTA 0.000222 0.4745 15
550 1KPG SAH 0.000007081 0.49846 15.3543
551 2YVJ NAI 0.002122 0.42245 15.5963
552 2YVJ FAD 0.02092 0.40176 15.5963
553 1XTP SAI 0.00001885 0.5105 15.748
554 1F3L SAH 0.0000009267 0.57498 16.1417
555 1KPH SAH 0.000006894 0.53691 16.1417
556 3ELW SAM 0.00104 0.46684 16.1417
557 3ELW GP3 0.001095 0.46684 16.1417
558 1REO FAD 0.003432 0.44045 16.1417
559 3AD8 NAD 0.0007544 0.46506 16.1616
560 3AD8 FAD 0.02004 0.42216 16.1616
561 3FZG SAM 0.0000173 0.52422 16.5
562 4OPC PGT 0.004018 0.47358 16.5354
563 4OPC FDA 0.003665 0.47249 16.5354
564 5LOG SAH 0.0003449 0.45854 17.5966
565 4A6D SAM 0.001521 0.4307 17.7165
566 4OBW SAM 0.0003135 0.4581 18.1102
567 4PQG NAG 0.01491 0.40761 18.1102
568 5XLX SAH 0.003841 0.41137 18.5039
569 4KRI SAH 0.000006769 0.53481 18.8976
570 3NJ4 NAD 0.02007 0.4403 18.8976
571 3NJ4 AFX 0.04867 0.41992 18.8976
572 1JG3 ADN 0.000002765 0.54627 20.0787
573 5F8F SFG 0.00125 0.44083 20.0787
574 5E72 SAM 0.0000003231 0.59497 20.4724
575 4YMH SAH 0.00007583 0.46833 21.25
576 5JE0 SAH 0.00001569 0.53724 21.8623
577 5JE0 AZ8 0.00001569 0.53724 21.8623
578 2F5Z FAD 0.001409 0.46271 21.875
579 4J56 FAD 0.005132 0.43711 21.9298
580 3Q87 SAM 0.00000000874 0.66648 22.3529
581 4PIO AVI 0.0000402 0.52192 22.8346
582 4PIO SAH 0.00004342 0.52192 22.8346
583 2HNK SAH 0.0001514 0.47619 23.431
584 1UWK URO 0.005435 0.43682 23.622
585 1UWK NAD 0.005435 0.43682 23.622
586 4R6W PC 0.00003761 0.54583 24.0157
587 4R6W SAH 0.00001127 0.54547 24.0157
588 1VE3 SAM 0.00006035 0.48881 24.6696
589 2IV2 MGD 0.01772 0.40412 24.8032
590 1I1N SAH 0.0000002548 0.6119 25.2212
591 5T67 JHZ 0.0003576 0.49292 25.9843
592 5T67 SAH 0.000287 0.49192 25.9843
593 1L3I SAH 0.00001056 0.5375 27.0833
594 5FA8 SAM 0.0000006283 0.53226 29.1925
595 5E1M PRO PRO LYS ARG ILE ALA 0.0001034 0.50464 29.8755
596 5E1M SAH 0.0001034 0.50464 29.8755
Pocket No.: 2; Query (leader) PDB : 2NXE; Ligand: SAM; Similar sites found: 22
This union binding pocket(no: 2) in the query (biounit: 2nxe.bio2) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2B4R AES 0.01525 0.40042 1.9685
2 2PZM UDP 0.02066 0.4075 2.3622
3 2PZM NAD 0.02066 0.4075 2.3622
4 2Q1S NAI 0.02418 0.40423 2.3622
5 4UP4 NDG 0.004604 0.44476 2.75591
6 5FUI APY 0.0001171 0.54016 3.0303
7 3LZW NAP 0.004107 0.45149 3.14961
8 4KWI NAP 0.023 0.40266 3.93701
9 4KWI 1TJ 0.02402 0.40266 3.93701
10 1E1M NAP 0.004844 0.44501 4.33071
11 1E1M FAD 0.004844 0.44501 4.33071
12 2GV8 NDP 0.003262 0.42339 4.72441
13 2AQJ TRP 0.006323 0.44235 5.11811
14 2AQJ FAD 0.006536 0.44235 5.11811
15 5KVS 6XR 0.01408 0.40554 5.51181
16 5KVS NAP 0.01045 0.40101 5.51181
17 2QRK AMP 0.02359 0.40028 5.90551
18 3WGT QSC 0.03304 0.40164 6.29921
19 1JQD HSM 0.0007149 0.40077 9.44882
20 1COY AND 0.01093 0.43004 12.2047
21 5JCA FAD 0.003645 0.44225 13.3858
22 5JCA NDP 0.007318 0.4413 13.3858
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