Receptor
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILL RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALINGCELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES CELLS J.MOL.BIOL. V. 369 665 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
VAL PRO PRO PRO VAL PRO PRO PRO PRO SER B:45;
 Valid;
 none;
 Kd = 288 uM
968.187 n/a O=C(C...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2O9V 1.63 Å NON-ENZYME: BINDING THE SECOND SH3 DOMAIN FROM PONSIN IN COMPLEX WITH THE PAXILL RICH REGION HOMO SAPIENS SH3 DOMAIN PONSIN PAXILLIN PROLINE-RICH-REGION SIGNALINGCELL ADHESION COMPLEX
Ref.: PAXILLIN AND PONSIN INTERACT IN NASCENT COSTAMERES CELLS J.MOL.BIOL. V. 369 665 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
2 4LNP Kd = 214 uM VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar ligands found: 24
No: Ligand ECFP6 Tc MDL keys Tc
1 VAL PRO PRO PRO VAL PRO PRO PRO PRO SER 1 1
2 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.59375 0.793651
3 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.526316 0.890909
4 THR GLY VAL ALA LEU THR PRO PRO SER 0.504274 0.916667
5 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.478261 0.892857
6 PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO 0.46087 0.83871
7 SER PRO SER PRO SER PRO SER PRO SER PRO 0.456522 0.928571
8 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.455357 0.836066
9 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.454545 0.765625
10 01B PRO PRO ALA NH2 0.44898 0.819672
11 VAL PRO LEU 0.447059 0.824561
12 ACE GLU VAL ALA PRO PRO VAL LPD 0.436364 0.87931
13 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.424779 0.78125
14 SER VAL PRO ILE 0.421053 0.866667
15 THR PRO PRO SER PRO PHE 0.420561 0.883333
16 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.419048 0.892857
17 ACE GLU VAL ASN PRO PRO VAL PRO NH2 0.418803 0.836066
18 MET PRO PRO PRO PRO SEP PRO CYS THR 0.418182 0.796875
19 ACE GLU VAL ASN PRO PRO VAL LPD 0.413793 0.836066
20 ALA VAL PRO ILE ALA GLN LYS 0.412371 0.807018
21 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.412281 0.815385
22 ACY 2L5 PRO PRO PRO PRO 2TL 0.405405 0.78125
23 MET PRO PRO PRO PRO TPO PRO ARG SER 0.4 0.78125
24 ALA VAL PRO ALA 0.4 0.821429
Similar Ligands (3D)
Ligand no: 1; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2O9V; Ligand: VAL PRO PRO PRO VAL PRO PRO PRO PRO SER; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2o9v.bio1) has 2 residues
No: Leader PDB Ligand Sequence Similarity
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