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Receptor
PDB id Resolution Class Description Source Keywords
2PEH 2.11 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE UHM DOMAIN OF HUMAN SPF45 IN COMPLE SF3B155-ULM5 HOMO SAPIENS RRM UHM PROTEIN BINDING
Ref.: U2AF-HOMOLOGY MOTIF INTERACTIONS ARE REQUIRED FOR ALTERNATIVE SPLICING REGULATION BY SPF45. NAT.STRUCT.MOL.BIOL. V. 14 620 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS ARG LYS SER ARG TRP ASP GLU THR PRO C:333;
D:334;
Valid;
Valid;
none;
none;
Kd = 1.1 uM
986.054 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2PEH 2.11 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE UHM DOMAIN OF HUMAN SPF45 IN COMPLE SF3B155-ULM5 HOMO SAPIENS RRM UHM PROTEIN BINDING
Ref.: U2AF-HOMOLOGY MOTIF INTERACTIONS ARE REQUIRED FOR ALTERNATIVE SPLICING REGULATION BY SPF45. NAT.STRUCT.MOL.BIOL. V. 14 620 2007
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2PEH Kd = 1.1 uM LYS ARG LYS SER ARG TRP ASP GLU THR PRO n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar ligands found: 119
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 1 1
2 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.594937 0.824324
3 ARG GLU ARG SER PRO THR ARG 0.552239 0.857143
4 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.546512 0.90411
5 ALA ASN SER ARG TRP GLN THR SER ILE ILE 0.546012 0.810811
6 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.531646 0.763889
7 ILE SER PRO ARG THR LEU ASP ALA TRP 0.530726 0.932432
8 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.52809 0.90411
9 GLU LEU ARG SER ARG TYR TRP ALA ILE 0.52071 0.792208
10 GLU ALA ASP LYS TRP GLN SER 0.519481 0.771429
11 GLU GLN ASP LYS TRP ALA SER 0.516129 0.771429
12 GLU LEU ASP NRG TRP ALA SER 0.515337 0.7625
13 ALA ASN SER ARG TRP PRO THR SER ALY ILE 0.513812 0.933333
14 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.513699 0.819444
15 ALA LEU ASP LYS TRP ALA SER 0.509934 0.75
16 ALA THR ALY ALA ALA ARG ALY SER ALA PRO 0.506494 0.861111
17 ALA ASN SER ARG TRP PRO ALY SER ILE ILE 0.505495 0.945946
18 ALA SER ASN GLU ASN TRP GLU THR MET 0.503226 0.688312
19 ALA ASN SER ARG TRP ALY THR SER ILE ILE 0.502924 0.826667
20 ALA ASN SER ARG TRP PRO THR THR ARG LEU 0.50289 0.932432
21 ALA ASN SER ARG TRP PRO THR SER FAK ILE 0.502703 0.884615
22 GLU ASN ASP LYS TRP ALA SER 0.5 0.760563
23 ALA ASN SER ARG TRP PRO THR SER 2KK ILE 0.497355 0.873418
24 SER ARG TYR TRP ALA ILE ARG THR ARG 0.494118 0.789474
25 GLU LEU ASP ORN TRP ALA SER 0.49359 0.736111
26 SER PRO LEU ASP SER LEU TRP TRP ILE 0.490909 0.851351
27 GLU LEU ASP LYS TRP ALA SER 0.490446 0.75
28 ALA ASN SER ARG TRP PRO THR SER 2KP ILE 0.489583 0.873418
29 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.489474 0.864865
30 PRO SER ARG TRP 0.486486 0.842857
31 ARG GLN TRP GLY PRO ASP PRO ALA ALA VAL 0.481081 0.915493
32 ARG LEU TRP SER 0.47619 0.777778
33 ARG ARG ARG ARG SER TRP TYR 0.475862 0.814286
34 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.474359 0.694444
35 GLU LEU GLU LYS TRP ALA SER 0.471338 0.736111
36 ALA GLN ASP ILE TYR ARG ALA SER TYR 0.46988 0.710526
37 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.468354 0.808219
38 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.466667 0.7125
39 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.464286 0.777778
40 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.464286 0.777778
41 MET SER LEU PRO GLY ARG TRP LYS PRO LYS 0.463542 0.907895
42 PHE LEU TRP GLY PRO ARG ALA LEU VAL 0.461538 0.863014
43 PRO ALA TRP ASP GLU THR ASN LEU 0.461538 0.756757
44 ALA GLN TRP GLY PRO ASP PRO ALA ALA ALA 0.460227 0.842857
45 ALA LEU ASP LYS TRP ASP 0.46 0.708333
46 ASP ASP TRP ASN TRP GLU VAL GLU ASP 0.46 0.657534
47 GLU LEU ASP LYS TRP ALA ASN 0.459627 0.712329
48 ACE PRO TRP ALA THR CYS ASP SER NH2 0.458333 0.876712
49 GLU LEU ASP HOX TRP ALA SER 0.45679 0.68
50 GLU LEU ASP HIS TRP ALA SER 0.453988 0.726027
51 SER SER THR ARG GLY ILE SER GLN LEU TRP 0.451977 0.824324
52 PRO GLN PRO VAL ASP SER TRP VAL 0.450867 0.887324
53 ASN ASP TRP LEU LEU PRO SER TYR 0.446927 0.818182
54 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.446541 0.743243
55 PRO ARG PRO ILE LEU LEU PRO TRP ARG NH2 0.445714 0.835616
56 SER LEU SER ARG THR PRO ALA ASP GLY ARG 0.443787 0.887324
57 MET TRP ARG PRO TRP 0.443787 0.776316
58 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.44375 0.821918
59 GLU LEU ASP LYS TRP ALA GLY 0.44375 0.708333
60 PRO LYS LEU GLU PRO TRP LYS HIS PRO 0.441489 0.808219
61 ASP TRP GLU ILE VAL 0.437086 0.616438
62 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.434555 0.786667
63 ASP ALA GLU PHE ARG HIS ASP 0.434211 0.671429
64 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.431818 0.701299
65 GLU PRO GLN ALA PRO TRP MET GLU GLN 0.431034 0.773333
66 GLU PRO GLN ALA PRO TRP MET GLU 0.431034 0.773333
67 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.427136 0.881579
68 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.42515 0.756757
69 SER TRP PHE PRO 0.424837 0.830986
70 ALA LEU ASP LYS TRP GLN ASN 0.424837 0.694444
71 ILE ASP TRP PHE GLU GLY LYS GLU 0.424419 0.712329
72 ILE ASP TRP PHE ASP GLY LYS GLU 0.424419 0.712329
73 ARG PRO GLY ASN PHE LEU GLN SER ARG PRO 0.423913 0.90411
74 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.423077 0.797297
75 SER ARG ASP HIS SER ARG THR PRO MET 0.423077 0.857143
76 SER TRP PHE GLN THR ASP LEU 0.422619 0.702703
77 ACE ASN TRP GLU THR PHE 0.421384 0.684932
78 THR LEU PRO TRP ASP LEU TRP THR THR 0.421053 0.824324
79 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.420732 0.732394
80 ASP ALA GLU PHE ARG HIS ASP SER 0.420732 0.760563
81 ARG PHE PRO LEU THR PHE GLY TRP 0.420213 0.905405
82 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.417143 0.662162
83 GLY ARG PRO ARG THR THR SER PHE ALA GLU 0.416667 0.915493
84 VAL ASP SER LYS ASN THR SER SER TRP 0.416667 0.753425
85 ARG ARG ALA SEP ALA PRO LEU PRO 0.416667 0.782051
86 ALA LEU TRP GLY PRO ASP PRO ALA ALA ALA 0.41573 0.819444
87 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.415301 0.710526
88 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.415205 0.746667
89 LYS GLN TRP ASP ASN TYR GLU PTR ILE TRP 0.414894 0.626506
90 ALA ALA ARG KCR SER ALA PRO ALA 0.414201 0.873239
91 ARG PHE PRO LEU THR PHE GLY TRP CYS PHE 0.414141 0.906667
92 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.414013 0.814286
93 ARG TYR PRO LEU THR PHE GLY TRP CYS PHE 0.413793 0.87013
94 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.412429 0.636364
95 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.412429 0.888889
96 ARG TYR PRO LEU THR PHE GLY TRP 0.412371 0.881579
97 ALA GLN PHE SER ALA SER ALA SER ARG 0.411765 0.742857
98 ASP SER TRP LYS ASP GLY CYS TYR 0.411429 0.72
99 ARG TYR PRO LEU THR LEU GLY TRP CYS PHE 0.408867 0.883117
100 LEU PRO PHE GLU ARG ALA THR VAL MET 0.408602 0.818182
101 ASP GLU ASP LYS TRP ASP ASP PHE 0.407643 0.690141
102 ABA SER LEU TRP ASN GLY PRO HIS LEU 0.407609 0.864865
103 PHE PRO ARG PRO TRP LEU HIS GLY LEU 0.407216 0.864865
104 ACE GLU TRP TRP TRP 0.407143 0.619718
105 GLN THR ALA ARG MYK SER THR GLY GLY TRP 0.406417 0.851351
106 PLM GLN THR ALA ARG LYS SER THR GLY GLY TRP 0.406417 0.851351
107 ALA ARG THR GLU LEU TYR ARG SER LEU 0.406061 0.72
108 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 0.404494 0.733333
109 LEU PRO PHE GLU ARG ALA THR ILE MET 0.404255 0.807692
110 THR SER THR THR SER VAL ALA SER SER TRP 0.403846 0.694444
111 MET ASP TRP ASN MET HIS ALA ALA 0.403509 0.671053
112 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.403141 0.75641
113 ARG ILE PRO SER TYR ARG TYR ARG TYR 0.402367 0.855263
114 PHE SER ASP PRO TRP GLY GLY 0.402299 0.859155
115 GLY SER ASP PRO TRP LYS 0.401198 0.871429
116 GLY GLU GLU TRP GLY PRO TRP VAL NH2 0.401198 0.791667
117 ALA ASN SER ARG ALA PRO THR SER ILE ILE 0.401163 0.851351
118 MET HIS PRO ALA GLN THR SER GLN TRP 0.401042 0.831169
119 ALA ARG SER HIS SEP TYR PRO ALA 0.4 0.825
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2PEH; Ligand: LYS ARG LYS SER ARG TRP ASP GLU THR PRO; Similar sites found with APoc: 224
This union binding pocket(no: 1) in the query (biounit: 2peh.bio3) has 16 residues
No: Leader PDB Ligand Sequence Similarity
1 4RJD TFP None
2 6C8X BVR None
3 5LGA 6VH None
4 5DRB 5FJ None
5 4KBS PX2 None
6 3VRV YSD None
7 3OKI OKI None
8 3E3U NVC None
9 2P3B 3TL None
10 3EKK GS2 None
11 2AZC 3TL None
12 5CHR 4NC None
13 2P3C 3TL None
14 3TGE TGE None
15 3V49 PK0 None
16 4OIV XX9 None
17 1XCL SAH None
18 1ZUI SKM None
19 4CQK PIO None
20 5KK4 44E None
21 2VYT MLZ None
22 2VWA PTY None
23 5DJU FMN None
24 3AKI AH8 None
25 2AX9 BHM None
26 2V0U FMN None
27 2FKW RG1 None
28 4LSJ LSJ None
29 6GL8 F3Q None
30 2QZT PLM None
31 1S17 GNR None
32 4WGF HX2 None
33 3MBG FAD None
34 3EEL 53T None
35 2PR5 FMN None
36 1M2Z DEX None
37 4NJS G08 None
38 1LQY BB2 None
39 2D5Z L35 1.90476
40 3O01 DXC 2.85714
41 4ZGM 32M 2.85714
42 5TO8 7FM 2.85714
43 2Q1H AS4 2.85714
44 5IH9 6BF 2.85714
45 5FVJ ACO 2.85714
46 1ZPT FAD 2.85714
47 3ZQE DXC 2.85714
48 5EYK 5U5 2.85714
49 5OMY 9YE 2.85714
50 1G8S MET 2.85714
51 4ONA UW1 3.80952
52 4BNU 9KQ 3.80952
53 1SBR VIB 3.80952
54 5IF4 6AK 3.80952
55 5IM3 DTP 3.80952
56 1GHE ACO 3.80952
57 2UW1 GVM 3.80952
58 2ZCQ B65 3.80952
59 6BR8 PGV 3.80952
60 1QRP HH0 3.80952
61 5MTE BB2 3.80952
62 2FXU ATP 3.80952
63 1XX4 BAM 4.7619
64 1T27 PCW 4.7619
65 5UGW GSH 4.7619
66 2E3N 6CM 4.7619
67 1ZED PNP 4.7619
68 4NKW PLO 4.7619
69 1U3D FAD 4.7619
70 1OW4 2AN 4.7619
71 4RLT FSE 4.7619
72 2Q0D ATP 4.7619
73 4P6X HCY 4.7619
74 2XXP DSL 4.7619
75 4ZW3 4S9 4.7619
76 2A3I C0R 5.71429
77 5OCA 9QZ 5.71429
78 5CSD ACD 5.71429
79 5L7G 6QE 5.71429
80 1NP7 FAD 5.71429
81 5MWY YNU 5.71429
82 2YJD YJD 5.71429
83 5B4B LP5 5.71429
84 2I0G I0G 5.71429
85 2AMV BIN 5.71429
86 5J6A P46 5.71429
87 3WDM ADN 5.71429
88 1Z44 NPO 5.71429
89 4DXJ 0M9 5.71429
90 2PX6 DH9 5.71429
91 4GCZ FMN 5.71429
92 5HCV 60R 5.71429
93 3L1N PLM 5.71429
94 4EHQ GBL 5.71429
95 5LJ0 6XX 5.71429
96 3C6K MTA 5.71429
97 3C6K SPD 5.71429
98 5B0W 22B 6.66667
99 2Y69 CHD 6.66667
100 5Z84 CHD 6.66667
101 4J6C STR 6.66667
102 4UDB CV7 6.66667
103 3H0A D30 6.66667
104 5W97 CHD 6.66667
105 5ZCO CHD 6.66667
106 4MGB XDH 6.66667
107 3FUR Z12 6.66667
108 5C03 AGS 6.66667
109 1TD2 PXL 6.66667
110 2HFP NSI 6.66667
111 5TBM 79A 6.66667
112 2OEM 1AE 6.66667
113 5ZCO PGV 6.66667
114 3LN0 52B 6.66667
115 4XU6 TDA 6.66667
116 4XRZ SI6 6.66667
117 2P1C GG3 6.66667
118 6CAY ERG 6.66667
119 5LX9 OLB 7.61905
120 5HGR 45D 7.61905
121 5EW9 5VC 7.61905
122 1P1M MET 7.61905
123 2D5X L35 7.61905
124 5TDF ADE 7.61905
125 4GBD MCF 7.61905
126 2EVL GAL SPH EIC 7.61905
127 3QWI CUE 7.61905
128 5UR1 YY9 7.61905
129 1K3A ACP 7.61905
130 3TW1 AHN 7.61905
131 5OLK DTP 7.61905
132 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 8
133 5C0C ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 8
134 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 8
135 5WL1 CUY 8.08081
136 5WL1 D3D 8.08081
137 5C9J DAO 8.08081
138 5M36 9SZ 8.57143
139 1EYQ NAR 8.57143
140 4RQL SNE 8.57143
141 4LOO SB4 8.57143
142 5M37 9SZ 8.57143
143 5LXT 7AK 8.57143
144 5W7B MYR 8.57143
145 5FBN 5WF 8.57143
146 3V66 D3A 8.57143
147 3QFJ LEU LEU PHE GLY PHE PRO VAL TYR VAL 8.57143
148 1XON PIL 8.57143
149 1UOU CMU 8.57143
150 5A8E XTK 8.57143
151 3D78 NBB 8.57143
152 2GBB CIT 8.57143
153 3R1V AZB 8.57143
154 4RC8 STE 9.52381
155 1J78 OLA 9.52381
156 4RHP PEF 9.52381
157 5BVE 4VG 9.52381
158 4O4K 2PK 9.52381
159 5T67 JHZ 9.52381
160 2VPY PCI 9.52381
161 5T67 SAH 9.52381
162 3GWT 066 9.52381
163 2HQM FAD 9.52381
164 3ZJX BOG 9.52381
165 4COL DTP 9.52381
166 4I6G FAD 10.4762
167 1XVB BHL 10.4762
168 4MRP GSH 10.4762
169 5K7K 6RJ 11.4286
170 2C78 PUL 11.4286
171 1WD4 AHR 11.4286
172 4AG8 AXI 11.4286
173 5MZI FYK 11.4286
174 3WCA FPS 11.4286
175 1EWF PC1 11.4286
176 3E8T UQ8 12.381
177 5CX6 CDP 12.381
178 2OBD PCW 12.381
179 2FDW D3G 12.381
180 3X1M COA 12.381
181 2OBD 2OB 12.381
182 3KXC PLM 12.381
183 3KO0 TFP 12.8713
184 6BJ3 ILE PRO LEU THR GLU GLU ALA GLU LEU 13.3333
185 5U98 1KX 13.3333
186 3TL1 JRO 13.3333
187 3PVT 3HC 13.3333
188 5U98 VAL THR THR ASP ILE GLN VAL LYS VAL 13.3333
189 2WOR 2AN 14
190 4PYW ACE THR THR ALA ILE NH2 14.2857
191 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 14.2857
192 5K53 STE 14.2857
193 5C1M OLC 14.2857
194 4WVO 3UZ 14.2857
195 2VBA P4T 14.2857
196 6BYM HC3 15.2381
197 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 15.2381
198 5G57 6M5 15.2381
199 1T3Q FAD 15.2381
200 1G27 BB1 15.2381
201 4GU5 FAD 16.1905
202 6ESN BWE 16.1905
203 5NTW 98N 16.1905
204 3N7S 3N7 16.6667
205 2HPL ASP ASP LEU TYR GLY 17
206 5ZM0 FAD 18.0952
207 3B9Z CO2 20
208 2HI4 BHF 20
209 1ZPD CIT 20.9524
210 3GN8 DEX 21.9048
211 5UFS 1TA 22.8571
212 4E2J MOF 22.8571
213 4DR9 BB2 22.8571
214 1SR7 MOF 22.8571
215 2I80 G1L 22.8571
216 2QQC AG2 23.8095
217 1N13 AG2 23.8095
218 6ADI 9UO 23.8095
219 1EZV SMA 24.7619
220 4G31 0WH 25.7143
221 5TA6 79D 25.7143
222 3Q8G PEE 33.3333
223 5K52 OCD 33.3333
224 3MDV CL6 37.1429
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