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Receptor
PDB id Resolution Class Description Source Keywords
2Q7D 1.6 Å EC: 2.7.1.134 CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6- (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+ HOMO SAPIENS INOSITOL INOSITOL KINASE KINASE ITPK1 INOSITOL 1 3 4-5KINASE PHOSPHATE INOSITOL PHOSPHATE INOSITOLPHOSPHATE POLYPHOSPHATE TRANSFERASE
Ref.: INTEGRATION OF INOSITOL PHOSPHATE SIGNALING PATHWAY HUMAN ITPK1. J.BIOL.CHEM. V. 282 28117 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ANP A:917;
B:918;
Valid;
Valid;
none;
none;
submit data
506.196 C10 H17 N6 O12 P3 c1nc(...
MN A:901;
A:902;
B:903;
B:904;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
54.938 Mn [Mn+2...
SO4 A:907;
A:908;
A:911;
A:912;
A:914;
A:915;
A:916;
B:905;
B:906;
B:909;
B:910;
B:913;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Q7D 1.6 Å EC: 2.7.1.134 CRYSTAL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATE 5/6- (ITPK1) IN COMPLEX WITH AMPPNP AND MN2+ HOMO SAPIENS INOSITOL INOSITOL KINASE KINASE ITPK1 INOSITOL 1 3 4-5KINASE PHOSPHATE INOSITOL PHOSPHATE INOSITOLPHOSPHATE POLYPHOSPHATE TRANSFERASE
Ref.: INTEGRATION OF INOSITOL PHOSPHATE SIGNALING PATHWAY HUMAN ITPK1. J.BIOL.CHEM. V. 282 28117 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 2Q7D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 2QB5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ANP; Similar ligands found: 373
No: Ligand ECFP6 Tc MDL keys Tc
1 ANP 1 1
2 A2D 0.810811 0.945205
3 B4P 0.802632 0.945205
4 AP5 0.802632 0.945205
5 ADP 0.802632 0.972222
6 BA3 0.789474 0.945205
7 AU1 0.782051 1
8 HEJ 0.772152 0.972222
9 ATP 0.772152 0.972222
10 AT4 0.769231 0.933333
11 AN2 0.769231 0.986111
12 5FA 0.7625 0.972222
13 AQP 0.7625 0.972222
14 M33 0.759494 0.932432
15 MAP 0.752941 0.972973
16 ACP 0.75 0.945946
17 AR6 0.740741 0.945205
18 APR 0.740741 0.945205
19 ACQ 0.73494 0.945946
20 AD9 0.731707 0.945946
21 SAP 0.731707 0.921053
22 AGS 0.731707 0.921053
23 A 0.723684 0.944444
24 AMP 0.723684 0.944444
25 ATF 0.717647 0.933333
26 ADX 0.716049 0.851852
27 CA0 0.716049 0.92
28 6YZ 0.709302 0.945946
29 50T 0.707317 0.932432
30 PRX 0.698795 0.87013
31 ABM 0.696203 0.893333
32 AP2 0.679012 0.933333
33 A12 0.679012 0.933333
34 APC 0.678571 0.933333
35 T99 0.674419 0.933333
36 TAT 0.674419 0.933333
37 A22 0.674157 0.958904
38 SRA 0.670886 0.894737
39 SRP 0.670455 0.883117
40 5AL 0.666667 0.906667
41 A1R 0.659341 0.884615
42 ADQ 0.659341 0.92
43 A3R 0.659341 0.884615
44 3OD 0.648936 0.92
45 BIS 0.648936 0.909091
46 5SV 0.648352 0.82716
47 9X8 0.645161 0.896104
48 OAD 0.645161 0.92
49 25L 0.642105 0.958904
50 AMO 0.641304 0.907895
51 G5P 0.636364 0.897436
52 DLL 0.634409 0.906667
53 AHX 0.634409 0.897436
54 00A 0.634409 0.860759
55 ADV 0.632184 0.907895
56 RBY 0.632184 0.907895
57 ADP PO3 0.632184 0.917808
58 NB8 0.631579 0.897436
59 25A 0.630435 0.945205
60 OOB 0.630435 0.906667
61 8QN 0.630435 0.906667
62 G3A 0.626263 0.897436
63 4AD 0.623656 0.896104
64 PAJ 0.623656 0.8625
65 LAD 0.621053 0.839506
66 TXA 0.614583 0.907895
67 1ZZ 0.614583 0.819277
68 ME8 0.614583 0.819277
69 GTA 0.613861 0.864198
70 9ZD 0.612903 0.909091
71 9ZA 0.612903 0.909091
72 3UK 0.610526 0.894737
73 SON 0.604651 0.907895
74 ADP ALF 0.604396 0.848101
75 ALF ADP 0.604396 0.848101
76 PR8 0.604167 0.829268
77 B5V 0.604167 0.883117
78 WAQ 0.604167 0.860759
79 4UV 0.6 0.871795
80 GAP 0.6 0.87013
81 PTJ 0.597938 0.873418
82 FYA 0.597938 0.881579
83 VO4 ADP 0.597826 0.906667
84 ADP VO4 0.597826 0.906667
85 LMS 0.597561 0.829268
86 UP5 0.596154 0.896104
87 FA5 0.59596 0.883117
88 YAP 0.59596 0.871795
89 PAP 0.595506 0.958333
90 A4P 0.59434 0.823529
91 XAH 0.59 0.841463
92 4UU 0.588235 0.871795
93 AFH 0.588235 0.8625
94 9SN 0.585859 0.85
95 2A5 0.58427 0.894737
96 T5A 0.583333 0.821429
97 DQV 0.582524 0.932432
98 NAI 0.580952 0.884615
99 B5M 0.58 0.871795
100 B5Y 0.58 0.871795
101 ITT 0.579545 0.917808
102 ATR 0.577778 0.944444
103 OMR 0.575472 0.831325
104 5AS 0.574713 0.781609
105 YLP 0.571429 0.8
106 48N 0.571429 0.873418
107 AP0 0.570093 0.873418
108 4TC 0.570093 0.873418
109 7D3 0.569767 0.881579
110 ADJ 0.568807 0.831325
111 GNP 0.568421 0.922078
112 9GM 0.568421 0.922078
113 DAL AMP 0.568421 0.881579
114 6V0 0.566038 0.873418
115 TXD 0.566038 0.884615
116 DND 0.566038 0.907895
117 NAX 0.566038 0.851852
118 4UW 0.566038 0.839506
119 NXX 0.566038 0.907895
120 XYA 0.565789 0.821918
121 RAB 0.565789 0.821918
122 ADN 0.565789 0.821918
123 AOC 0.564706 0.8
124 7D4 0.561798 0.881579
125 ADP BMA 0.561224 0.894737
126 TXE 0.560748 0.884615
127 TYM 0.560748 0.883117
128 GA7 0.557692 0.883117
129 YLC 0.555556 0.819277
130 YLB 0.555556 0.8
131 139 0.554545 0.851852
132 5N5 0.551282 0.797297
133 JB6 0.55 0.860759
134 LAQ 0.54717 0.819277
135 F2R 0.544643 0.843373
136 MYR AMP 0.544554 0.797619
137 5CD 0.544304 0.783784
138 A4D 0.544304 0.797297
139 80F 0.54386 0.821429
140 7MD 0.542857 0.864198
141 6AD 0.542553 0.886076
142 A2R 0.541667 0.958904
143 UPA 0.541284 0.884615
144 YLA 0.540541 0.8
145 A A 0.54 0.918919
146 BTX 0.539823 0.821429
147 COD 0.539823 0.793103
148 HFD 0.537634 0.921053
149 G5A 0.537634 0.781609
150 3DH 0.535714 0.753247
151 AYB 0.535714 0.790698
152 CNA 0.535714 0.907895
153 BT5 0.535088 0.811765
154 ATP A A A 0.533981 0.905405
155 IOT 0.531532 0.811765
156 MTA 0.53012 0.753247
157 3AM 0.529412 0.90411
158 A3P 0.52809 0.944444
159 PPS 0.526316 0.851852
160 NAD 0.526316 0.906667
161 EP4 0.52439 0.734177
162 7D5 0.52381 0.855263
163 AMP DBH 0.52381 0.87013
164 J7C 0.522727 0.75
165 A5A 0.520833 0.809524
166 EAD 0.520661 0.851852
167 TSB 0.520408 0.821429
168 AHZ 0.518519 0.797619
169 DTA 0.518072 0.766234
170 M2T 0.518072 0.716049
171 A3D 0.517241 0.894737
172 6RE 0.517241 0.740741
173 YLY 0.516949 0.790698
174 SSA 0.515464 0.802326
175 NA7 0.514852 0.933333
176 ARG AMP 0.514019 0.809524
177 AR6 AR6 0.514019 0.893333
178 7MC 0.513514 0.843373
179 A2P 0.511111 0.930556
180 52H 0.510204 0.781609
181 VMS 0.510204 0.790698
182 54H 0.510204 0.790698
183 TYR AMP 0.509434 0.848101
184 TAD 0.509259 0.8625
185 NAQ 0.508333 0.85
186 A3N 0.505618 0.766234
187 AV2 0.505155 0.893333
188 53H 0.50505 0.781609
189 5CA 0.50505 0.802326
190 8X1 0.50505 0.755556
191 ARU 0.504951 0.839506
192 ZID 0.504132 0.894737
193 P1H 0.504 0.831325
194 NAE 0.5 0.871795
195 3AT 0.5 0.945205
196 AVV 0.5 0.873418
197 P5A 0.495146 0.747253
198 NSS 0.49505 0.802326
199 LSS 0.49505 0.764045
200 DSZ 0.49505 0.802326
201 N0B 0.491803 0.8
202 AF3 ADP 3PG 0.491071 0.817073
203 NVA LMS 0.490196 0.755556
204 DAT 0.489362 0.881579
205 IMO 0.488889 0.90411
206 ZAS 0.488636 0.792208
207 FDA 0.488372 0.813953
208 NAJ PZO 0.487395 0.85
209 4TA 0.487179 0.788235
210 LPA AMP 0.486486 0.797619
211 LEU LMS 0.485437 0.755556
212 DTP 0.484536 0.881579
213 V3L 0.484536 0.945205
214 S4M 0.483516 0.651685
215 GJV 0.483516 0.731707
216 DZD 0.483051 0.8625
217 2AM 0.482759 0.917808
218 5AD 0.481013 0.726027
219 GSU 0.480769 0.781609
220 KAA 0.480769 0.755556
221 NDE 0.480315 0.907895
222 M24 0.479339 0.851852
223 MAO 0.478261 0.761905
224 NEC 0.477778 0.727273
225 DSH 0.477778 0.707317
226 FAS 0.477273 0.831325
227 FAD 0.477273 0.831325
228 RGT 0.476636 0.933333
229 9K8 0.47619 0.698925
230 G A A A 0.474576 0.85
231 0WD 0.474576 0.897436
232 FNK 0.474074 0.786517
233 5X8 0.473684 0.74359
234 6FA 0.473282 0.821429
235 NDC 0.472868 0.85
236 FB0 0.472868 0.786517
237 YSA 0.472222 0.781609
238 7DD 0.468085 0.958333
239 OVE 0.466667 0.881579
240 MHZ 0.463158 0.701149
241 8PZ 0.462963 0.802326
242 A G 0.462185 0.860759
243 AMP NAD 0.462185 0.881579
244 A3G 0.461538 0.779221
245 NAJ PYZ 0.459677 0.809524
246 6C6 0.459184 0.858974
247 SFG 0.458333 0.730769
248 U A G G 0.458333 0.860759
249 7D7 0.45679 0.723684
250 128 0.45614 0.8
251 SFD 0.455224 0.736842
252 6IA 0.454545 0.817073
253 DDS 0.454545 0.855263
254 GDP 0.454545 0.896104
255 ODP 0.453782 0.886076
256 NJP 0.453782 0.921053
257 7DT 0.453608 0.958333
258 A7D 0.452632 0.75641
259 Z5A 0.452381 0.802326
260 WSA 0.452174 0.790698
261 U A 0.45082 0.884615
262 7C5 0.45045 0.797468
263 FAY 0.449275 0.841463
264 NDP 0.449153 0.897436
265 SA8 0.44898 0.690476
266 A5D 0.44898 0.766234
267 71V 0.446809 0.884615
268 GGZ 0.446602 0.804878
269 RFL 0.446043 0.802326
270 2SA 0.445545 0.907895
271 SAI 0.444444 0.716049
272 GP3 0.444444 0.897436
273 SAH 0.444444 0.725
274 PO4 PO4 A A A A PO4 0.443396 0.878378
275 A A A 0.443396 0.881579
276 4YB 0.442478 0.764045
277 SMM 0.441176 0.670455
278 S7M 0.441176 0.674419
279 GTP 0.441176 0.896104
280 Y3J 0.440476 0.706667
281 SAM 0.44 0.674419
282 649 0.439655 0.747253
283 12D 0.438596 0.809524
284 A3S 0.4375 0.789474
285 NPW 0.436975 0.864198
286 GCP 0.436893 0.873418
287 AAT 0.435644 0.690476
288 GNH 0.435644 0.909091
289 EEM 0.435644 0.674419
290 ETB 0.435484 0.813953
291 DCA 0.435484 0.804598
292 N6P 0.433962 0.890411
293 NZQ 0.433333 0.886076
294 TXP 0.433333 0.897436
295 PGS 0.43299 0.860759
296 APU 0.432203 0.871795
297 PUA 0.432 0.8625
298 62F 0.431655 0.841463
299 F2N 0.431507 0.795455
300 DA 0.430108 0.855263
301 D5M 0.430108 0.855263
302 J7V 0.429688 0.813953
303 NIA 0.428571 0.848101
304 COA 0.428571 0.804598
305 6K6 0.428571 0.905405
306 A3T 0.428571 0.8
307 0T1 0.428571 0.804598
308 P5F 0.427586 0.804598
309 AAM 0.425532 0.944444
310 0UM 0.424528 0.682353
311 8Q2 0.423729 0.775281
312 G1R 0.423077 0.884615
313 AMZ 0.422222 0.891892
314 C2R 0.422222 0.88
315 A U 0.420168 0.848101
316 IDP 0.42 0.894737
317 GSP 0.419048 0.851852
318 30N 0.418605 0.736842
319 CAO 0.418605 0.777778
320 DG1 0.418605 0.897436
321 1DG 0.418605 0.897436
322 COS 0.418605 0.786517
323 AMX 0.418605 0.813953
324 TM1 0.418182 0.797619
325 A6D 0.416667 0.746988
326 K15 0.416667 0.666667
327 V1N 0.415929 0.893333
328 CMX 0.415385 0.804598
329 SCO 0.415385 0.804598
330 GEK 0.415094 0.719512
331 XNP 0.414634 0.851852
332 NHD 0.414634 0.881579
333 9JJ 0.413793 0.841463
334 AIR 0.413793 0.876712
335 COK 0.413534 0.786517
336 G2R 0.412844 0.8625
337 ACO 0.412214 0.777778
338 FAM 0.412214 0.786517
339 FCX 0.412214 0.777778
340 NAP 0.410853 0.92
341 FA9 0.409396 0.843373
342 SXZ 0.409091 0.694118
343 HAX 0.409091 0.806818
344 TAP 0.407692 0.884615
345 2MC 0.407407 0.752688
346 62X 0.407407 0.651685
347 GKE 0.40708 0.8625
348 GDC 0.40708 0.8625
349 GDD 0.40708 0.8625
350 3KK 0.406015 0.786517
351 FYN 0.406015 0.804598
352 NVA 2AD 0.405941 0.740741
353 NA0 0.40458 0.907895
354 101 0.404255 0.855263
355 G 0.40404 0.883117
356 5GP 0.40404 0.883117
357 HDV 0.403846 0.87013
358 MGP 0.403846 0.8625
359 OXK 0.402985 0.786517
360 MCD 0.402985 0.786517
361 CA6 0.402985 0.714286
362 SOP 0.402985 0.786517
363 3AD 0.402299 0.783784
364 S8M 0.401869 0.78481
365 YE1 0.40146 0.795455
366 NMX 0.4 0.782609
367 7RP 0.4 0.902778
368 2VA 0.4 0.779221
369 1VU 0.4 0.777778
370 CO6 0.4 0.786517
371 CMC 0.4 0.786517
372 6G0 0.4 0.8625
373 GMV 0.4 0.873418
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: 467
This union binding pocket(no: 1) in the query (biounit: 2q7d.bio3) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 3ZW2 NAG GAL FUC None
2 3ZW0 FUC None
3 3CBG 4FE 1.2931
4 3V4S ATP 1.44509
5 3V4S ADP 1.44509
6 3HZT J60 1.44509
7 2CFM AMP 1.44509
8 3DLS ADP 1.49254
9 2VZ6 FEF 1.59744
10 3IT7 TLA 1.64835
11 2VN9 GVD 1.66113
12 5XVG 8FX 1.70648
13 5DRB 5FJ 1.71821
14 3WVR AMP 1.7341
15 3TXO 07U 1.7341
16 2PYW ADP 1.7341
17 1OKE BOG 1.7341
18 3MVH WFE 1.75439
19 4CSD MFU 1.83824
20 4JR7 GNP 1.87166
21 3X01 AMP 2.02312
22 5TDF ADP 2.02312
23 4U98 ACP 2.02312
24 4XH0 ADP 2.02312
25 3TY5 ATP 2.02312
26 5AWM ANP 2.02312
27 3B99 U51 2.02312
28 3KLL MAL 2.02312
29 3TY5 ADP 2.02312
30 5I35 ANP 2.02312
31 2PVN P63 2.02312
32 4YZC STU 2.02312
33 3RFA SAM 2.02312
34 2WU6 DKI 2.02312
35 1W3T 3GR 2.04082
36 3E8N ATP 2.05279
37 3E8N VRA 2.05279
38 5YF9 NIO 2.0649
39 5A6N U7E 2.12014
40 6CGZ HL6 2.12766
41 3KN5 ANP 2.15385
42 1JA9 PYQ 2.18978
43 3LXN MI1 2.20126
44 5QIN J2V 2.21519
45 5HVJ ANP 2.22222
46 4D4U FUC GAL 2.22222
47 4D52 GXL 2.22222
48 4D52 GIV 2.22222
49 4D4U FUC 2.22222
50 4D4U FUC GAL NAG 2.22222
51 2X2M X2M 2.2293
52 5WKR NAR 2.24215
53 1AUX AGS 2.2508
54 1I7L ATP 2.26537
55 4RDL FUC GAL NDG FUC 2.27273
56 4ZS4 ATP 2.28013
57 3FXU TSU 2.29508
58 2XOC ADP 2.29885
59 2IO8 ADP 2.31214
60 2R7K AMZ 2.31214
61 2R7K ACP 2.31214
62 5CKW ANP 2.31214
63 4IP7 FLC 2.31214
64 4GJ3 0XP 2.31788
65 3HQ9 OXL 2.31884
66 5C03 AGS 2.33918
67 2JDR L20 2.33918
68 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 2.33918
69 6FL8 TIY 2.34043
70 6FL8 ADP 2.34043
71 4OJ8 AKG 2.38908
72 5AIG VPR 2.4
73 5L4R CPT 2.41546
74 1UPR 4IP 2.43902
75 4BAE RWX 2.43902
76 3G5D 1N1 2.44755
77 4NW6 2NS 2.47678
78 1TQP ATP 2.48227
79 2Z7R STU 2.49221
80 4WOV 3SM 2.52366
81 2PEL LBT 2.54237
82 1JPA ANP 2.5641
83 5VCV 1N1 2.57235
84 2WQN ADP 2.58065
85 5VLQ ANP 2.60116
86 4DFU QUE 2.60116
87 3K5I ADP 2.60116
88 2PUL ACP 2.60116
89 3K5I AIR 2.60116
90 4OCJ NDG 2.60116
91 4OCV ANP 2.60116
92 2REG CHT 2.60116
93 4CYI ATP 2.60116
94 2RIO ADP 2.60116
95 2B9F ADP 2.60116
96 2B9I ADP 2.60116
97 5HES 032 2.60586
98 4BTK DTQ 2.67062
99 3PLS ANP 2.68456
100 4BFM ANP 2.69461
101 3GC0 AMP 2.73556
102 4CLI 5P8 2.75229
103 2IF8 ADP 2.75482
104 3UIM ANP 2.76074
105 1U59 STU 2.78746
106 2HY0 306 2.79503
107 6CMJ F6J 2.80374
108 1Q8Y ADE 2.89017
109 3ETH ATP 2.89017
110 2VQD AP2 2.89017
111 5DXT 5H5 2.89017
112 4Y85 499 2.89017
113 6GZD LCI 2.89017
114 4AZW ATP 2.89017
115 4K37 SAM 2.89017
116 2ZJ1 ARJ 2.89017
117 2ZJ1 NAD 2.89017
118 4K39 SAM 2.89017
119 4K38 SAM 2.89017
120 2BO4 FLC 2.89017
121 1Q8Y ADP 2.89017
122 4NFN 2KC 2.91262
123 3BU5 ATP 2.94118
124 2IUW AKG 2.94118
125 2V2V V12 2.95203
126 1ZY5 ANP 2.9703
127 5WO4 B7V 2.98013
128 2PVF ACP 2.99401
129 3SCH TB6 3.0303
130 4AU8 Z3R 3.04054
131 3GQI ACP 3.06748
132 6C7Y ADP 3.14685
133 4FG8 ATP 3.1746
134 5YK1 ANP 3.17919
135 6AC9 ANP 3.17919
136 3V8S 0HD 3.17919
137 4CQB MLI 3.17919
138 3W0O HY0 3.17919
139 3W0O ADP 3.17919
140 5OMY 9YE 3.17919
141 5C4L 4XR 3.17919
142 6A1G 9OL 3.17919
143 3SZB I1E 3.17919
144 2Q09 DI6 3.17919
145 5C4L SIS 3.17919
146 3RI1 3RH 3.19489
147 5COU ATP 3.23529
148 4R78 AMP 3.23625
149 3PE2 E1B 3.2641
150 3TDV GDP 3.26797
151 5MJA 7O3 3.27869
152 5IH9 6BF 3.28358
153 3CQL NDG 3.29218
154 3CQL NAG 3.29218
155 4KBA 1QM 3.32326
156 5W4W 9WG 3.32326
157 5GP0 GPP 3.3557
158 2GQS ADP 3.37553
159 2GQR ADP 3.37553
160 4UXL 5P8 3.41615
161 3BP1 GUN 3.44828
162 2AQX ATP 3.46021
163 2V58 LZJ 3.46821
164 1CM8 ANP 3.46821
165 4DC2 ADE 3.46821
166 1CKN GTP 3.46821
167 1CKM GTP 3.46821
168 3VOT ADP 3.46821
169 3VSV XYS 3.46821
170 5X8I SQZ 3.46821
171 5LI9 ACP 3.46821
172 5MY8 RXZ 3.46821
173 5LI1 ANP 3.46821
174 1V0O INR 3.47222
175 4WNP 3RJ 3.48432
176 5OKT 9XK 3.50318
177 1RV1 IMZ 3.52941
178 5KO1 6UY 3.53357
179 1OJ4 CDM 3.53357
180 1ZZ7 S0H 3.53535
181 1PK8 ATP 3.5545
182 3HPY MCT 3.55987
183 4AUA 4AU 3.58306
184 1A8U BEZ 3.61011
185 3SLS ANP 3.61842
186 4G17 0VN 3.63636
187 3M2W L8I 3.67893
188 4PZ6 GMP 3.75723
189 4H3P ANP 3.75723
190 5ZTN CUR 3.75723
191 6C1S EFV 3.75723
192 5BVE 4VG 3.75723
193 4H3Q ANP 3.75723
194 2R5T ANP 3.75723
195 5DO8 BGC 3.75723
196 3PN1 IVH 3.77358
197 2QX0 PH2 3.77358
198 5BVB DOG 3.78788
199 4NFE BEN 3.79747
200 4XCB AKG 3.83142
201 1OFZ FUL 3.84615
202 1OFZ FUC 3.84615
203 5EO8 TFU 3.85852
204 5LVP ATP 3.85852
205 3RWP ABQ 3.85852
206 2I56 RNS 3.88128
207 6APF CIT 3.91459
208 4USF 6UI 3.94737
209 4L3L 5FI 3.94737
210 3AQV TAK 3.98551
211 1OGZ EQU 4
212 1PHK ATP 4.02685
213 6EZ6 C5Z 4.04624
214 3KAL ADP 4.04624
215 5Y86 HRM 4.04624
216 4F9C 0SX 4.04624
217 5AE9 OKO 4.04624
218 5EQY 5RA 4.04624
219 3TII ANP 4.04624
220 5VZ0 ADP 4.04624
221 4IX4 ADP 4.04624
222 4WB6 ATP 4.04624
223 4Y0X ADP 4.04624
224 1RE8 BD2 4.04624
225 2QCS ANP 4.04624
226 5T8O 76Z 4.04624
227 4IDT T28 4.04624
228 5CZY SAM 4.04624
229 5W75 SUC 4.04624
230 1XJD STU 4.05797
231 2GU8 796 4.1543
232 4GLW 0XT 4.2623
233 3RE4 TO1 4.26357
234 1ZTH ADP 4.26357
235 1ZP9 ATP 4.26357
236 1IA9 ANP 4.28571
237 4XZ3 ACP 4.31034
238 4XYM A12 4.31034
239 2Z77 NCA 4.31655
240 6GIN IR2 4.31894
241 4I94 ANP 4.33333
242 4GYI ADP 4.33526
243 1EHI ADP 4.33526
244 2VPQ ANP 4.33526
245 1KJ8 ATP 4.33526
246 1KJ8 GAR 4.33526
247 4UX9 ANP 4.33526
248 5IM3 DTP 4.33526
249 3O2K QRP 4.33526
250 4IZY 1J2 4.33526
251 3PTG 932 4.33526
252 6F3N ADN 4.33526
253 5M06 ADP 4.34783
254 3PDT ADP 4.36364
255 4EWH T77 4.36364
256 1O68 KIV 4.36364
257 3I0O ADP 4.42478
258 1GSA ADP 4.43038
259 6FYV 3NG 4.45104
260 1N5S ADL 4.46429
261 4BHN BH9 4.49102
262 5H2U 1N1 4.49438
263 6GR0 F8W 4.5977
264 4JGP PYR 4.60829
265 3VPC ADP 4.60993
266 3VPB ADP 4.60993
267 3DNT ATP 4.62428
268 4FL3 ANP 4.62428
269 5FI4 5XV 4.64396
270 3HAV ATP 4.68227
271 2PZI AXX 4.69897
272 1TZD ADP 4.72727
273 4TWP AXI 4.79705
274 5EXK 5AD 4.83384
275 4YZN 4K5 4.87805
276 1OBD ATP 4.90196
277 1W2D ADP 4.90566
278 1W2D 4IP 4.90566
279 2YAK OSV 4.91228
280 4UWH JXM 4.91329
281 4HY1 19X 4.91329
282 1KTG AMP 5.07246
283 4ZGP ADP 5.11945
284 4N70 2HX 5.18293
285 3FHI ANP 5.19481
286 2YW2 ATP 5.20231
287 3WO0 ALA 5.20231
288 3WO0 ADP 5.20231
289 2YAB AMP 5.20231
290 3TPV ADE 5.20231
291 3NJ4 AFX 5.20231
292 5EFQ ADP 5.22388
293 4NST ADP 5.22388
294 5OF1 SAL 5.2381
295 4O4F IHP 5.24194
296 4O4F ATP 5.24194
297 4YMJ 4EJ 5.26316
298 4CC6 L5Y 5.34591
299 6CZI 38E 5.35714
300 5LXB 7A9 5.3719
301 1BYG STU 5.39568
302 3CY2 MB9 5.41401
303 5X20 AOT 5.44872
304 1LSH PLD 5.49133
305 5DMZ ADP 5.49133
306 5OLK DTP 5.49133
307 4O1P ANP 5.49133
308 6F7X MFU 5.55556
309 6CGD GNP 5.57377
310 6CGD AKN 5.57377
311 5U6C 7YS 5.71429
312 5HCY 60D 5.74018
313 5EFC GTP 5.74713
314 6F3G CJN 5.76271
315 3SRV S19 5.77617
316 4MV1 ADP 5.78035
317 3ALN ANP 5.8104
318 5AX9 4KT 5.84416
319 2BKK ADP 5.91716
320 4LRJ ANP 5.91716
321 5IH1 GDP 5.96026
322 5IH1 6BQ 5.96026
323 5Y80 IRE 6.08108
324 4IJ6 SEP 6.16114
325 4KS7 X4Z 6.16438
326 5C8W PCG 6.29371
327 5DZT AMP 6.35838
328 4LH7 1X8 6.35838
329 2QF7 AGS 6.35838
330 2H8H H8H 6.35838
331 1Y57 MPZ 6.35838
332 2ZV2 609 6.37584
333 4M69 ANP 6.38978
334 3N8K D1X 6.39535
335 2CSN CKI 6.39731
336 2WCV FUC 6.42857
337 1XDN ATP 6.4982
338 4E1Z 0MX 6.52921
339 1VJY 460 6.60066
340 4U44 3D9 6.6474
341 5YW5 ADE 6.70391
342 1VBO MAN MAN MAN 6.71141
343 1UNH IXM 6.73077
344 5CXI 5TW 6.89655
345 5LPZ ADP 6.92771
346 3F7Z 34O 6.93642
347 4UAL 3FV 6.93642
348 2JLD AG1 6.93642
349 6BXI ANP 6.93642
350 1H2T GDP 7MG 6.93642
351 1KAE HSO 6.93642
352 4NZN 2OU 6.9697
353 4NZN ANP 6.9697
354 3K0T BGC 6.99301
355 5WNL STU 7.01754
356 6CQF F97 7.07071
357 1FAO 4IP 7.14286
358 4Y8D 49J 7.14286
359 6FOF LAT 7.14286
360 2IDO TMP 7.22892
361 3GNI ATP 7.33138
362 5AVF TAU 7.393
363 2IXC TRH 7.42574
364 3IDB ANP 7.45342
365 2BMB PMM 7.51445
366 5MW8 ATP 7.51445
367 3HNC TTP 7.51445
368 5C1P ADP 7.51634
369 5C1P DAL DAL 7.51634
370 1E4E ADP 7.58017
371 5HQ0 LZ9 7.61589
372 6GU6 1QK 7.61589
373 5LPB ADP 7.77027
374 5LXT ACP 7.80347
375 6FYL 3NG 7.80347
376 6G34 5ID 7.80347
377 1JBU BEN 7.93651
378 3C0G 3AM 7.97721
379 2V7O DRN 8.03571
380 6D61 4AA 8.20513
381 1Y9Q MED 8.33333
382 2HGS ADP 8.3815
383 1M0W ANP 8.3815
384 5W0N UPU 8.3815
385 3CQ5 PMP 8.3815
386 2BPM 529 8.41424
387 4OTH DRN 8.5044
388 3LXK MI1 8.56269
389 4CFU 2WC 8.58086
390 6GUE FB8 8.60927
391 4BCM T7Z 8.63787
392 4BCQ TJF 8.63787
393 4BCN T9N 8.66667
394 1T36 ADP 8.67052
395 1K3A ACP 8.69565
396 2XMY CDK 8.72483
397 5ZCT ANP 8.82353
398 2FB3 MET 8.82353
399 2FB3 5AD 8.82353
400 5WBF LAC 8.88889
401 4H9T HL4 9.09091
402 1NX4 AKG 9.15751
403 1KJ1 MAN 9.17431
404 3AKK ADP 9.23077
405 1U5R ATP 9.24856
406 3KMW ATP 9.30233
407 5NBW 8SK 9.34579
408 4PU5 ANP 9.53757
409 5LDQ NAP 9.60452
410 1S68 AMP 9.63855
411 6CS9 PIO 9.7561
412 4WB7 ATP 9.82659
413 3DAK ANP 10
414 6E8I PTR 10.0592
415 2YRX AMP 10.4046
416 4WTV ATP 10.4046
417 4XV1 904 10.6164
418 2WEL K88 10.6667
419 2D6M LBT 10.6918
420 4X7Q 3YR 10.6936
421 4CQE CQE 11.1511
422 1HBK MYR 11.236
423 5OES ADP 11.2717
424 2F2U M77 11.2717
425 3UDZ ADP 11.2717
426 5G3R NAG 11.2717
427 3DGY 2GP 11.3402
428 2QK4 ATP 12.1387
429 6BFN DL1 12.2807
430 3GGF GVD 12.2924
431 6HL7 CP 12.3563
432 5UPK ANP 12.5
433 3O0G 3O0 12.7517
434 3VPD ANP 12.8114
435 3LQV ADE 12.8205
436 4PTN PYR 13.1195
437 4JH6 FCN 13.7681
438 4OFG PCG 13.8889
439 3N1S 5GP 14.2857
440 4Q5H ANP 14.4737
441 6E2B PT7 14.4737
442 5KK4 44E 14.5833
443 3PVW QRX 14.8649
444 4C2W ANP 15.3846
445 5E4R 40E 15.896
446 4WW7 AMP 16.5775
447 5CEO 50D 17
448 3DWB RDF 17.052
449 5USZ SKE 17.301
450 5ODT ADP 17.3913
451 4RYV ZEA 17.4194
452 5XQW 8EU 17.9724
453 1LRH NLA 20.8589
454 3ORQ ADP 21.3873
455 6MJ7 ARG 21.8182
456 3ZRM ZRM 21.875
457 1IOW PHY 23.2026
458 1IOW ADP 23.2026
459 5K2M ADP 24.5283
460 4NM5 ADP 25
461 2GGH NLQ 25.4335
462 2A19 ANP 25.7143
463 5N18 8HZ 28.4404
464 4OH4 ANP 28.5714
465 1O9U ADZ 33.3333
466 1Z2P ACP 45.0617
467 1Z2P I3S 45.0617
Pocket No.: 2; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: 62
This union binding pocket(no: 2) in the query (biounit: 2q7d.bio3) has 25 residues
No: Leader PDB Ligand Sequence Similarity
1 3OND ADN 2.02312
2 3OND NAD 2.02312
3 4Y93 746 2.02312
4 1SQL GUN 2.05479
5 3FC2 IBI 2.08955
6 4E93 GUI 2.31214
7 6C0T EE4 2.31214
8 5IGI ZIT 2.32558
9 5IGI GMP 2.32558
10 5TO8 7FM 2.48227
11 3A16 PXO 2.60116
12 1E8G FCR 2.60116
13 4P5Z Q7M 2.60116
14 3TM0 B31 2.6616
15 3TM0 ANP 2.6616
16 3TKI S25 2.78638
17 4IGQ OGA 2.89017
18 5JU6 BGC 2.89017
19 3BRN SRO 3.18471
20 5UR1 YY9 3.21543
21 5DEY 59T 3.367
22 1RPN GDP 3.58209
23 4G7A AZM 3.62903
24 4GNC ASO 3.67893
25 4Y9T PA1 3.75723
26 4AMW 5DI 3.75723
27 5YSQ INS 3.84615
28 1J71 THR ILE THR SER 3.89222
29 4K55 H6P 4.03226
30 6B9T 2HE 4.04624
31 2HJR CIT 4.33526
32 6F3M ADN 4.33526
33 5OD2 GLC 4.33526
34 4UHL VFV 4.62428
35 4QMN DB8 5.48387
36 2OVD DAO 5.49451
37 5Z49 RUB 5.85774
38 4F4P 0SB 5.86081
39 3GN8 DEX 6.0241
40 1MJT ITU 6.06936
41 5K21 6QF 7.0922
42 5V6F MAN BMA MAN 7.24638
43 2F7A BEZ 7.32759
44 5JP0 BGC 7.51445
45 2PA7 TYD 7.80142
46 1V8B ADN 7.80347
47 4P86 5GP 7.80347
48 4NJH SAM 7.82609
49 4NJH 2K8 7.82609
50 1JLX GAL A2G MBN 8.25082
51 5VGS 9A4 8.28025
52 3NW7 LGV 8.46906
53 3MPB FRU 9.7561
54 4R3U 5AD 10.1266
55 1OGX EQU 11.4504
56 2WT9 NIO 12.3404
57 1DTL BEP 12.4224
58 3PAK MAN 12.8378
59 1XVB BHL 13.5294
60 1RGE 2GP 13.5417
61 3NX2 FER 13.6905
62 5OO5 UUA 17.7419
Pocket No.: 3; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2q7d.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: 4
This union binding pocket(no: 4) in the query (biounit: 2q7d.bio4) has 27 residues
No: Leader PDB Ligand Sequence Similarity
1 3QP4 HL0 1.64835
2 6CI9 F3V 6.6474
3 3X27 TRP 8.09249
4 5E58 CPZ 8.09249
Pocket No.: 5; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2q7d.bio4) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2Q7D; Ligand: ANP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2q7d.bio2) has 27 residues
No: Leader PDB Ligand Sequence Similarity
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