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Receptor
PDB id Resolution Class Description Source Keywords
2QZT 1.7 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF STEROL CARRIER PROTEIN 2 LIKE 2 (SCP2-L AEDES AEGYPTI AEDES AEGYPTI STEROL CARRIER MOSQUITO FATTY ACID PALMITIC ACID CHOLESTLIPID TRANSPORT
Ref.: THREE-DIMENSIONAL STRUCTURE/FUNCTION ANALYSIS OF SC REVEALS DIFFERENCES AMONG SCP-2 FAMILY MEMBERS. J.LIPID RES. V. 49 644 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PLM A:300;
A:302;
B:301;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
256.424 C16 H32 O2 CCCCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2QZT 1.7 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF STEROL CARRIER PROTEIN 2 LIKE 2 (SCP2-L AEDES AEGYPTI AEDES AEGYPTI STEROL CARRIER MOSQUITO FATTY ACID PALMITIC ACID CHOLESTLIPID TRANSPORT
Ref.: THREE-DIMENSIONAL STRUCTURE/FUNCTION ANALYSIS OF SC REVEALS DIFFERENCES AMONG SCP-2 FAMILY MEMBERS. J.LIPID RES. V. 49 644 2008
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 3BDQ - PLM C16 H32 O2 CCCCCCCCCC....
2 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 3BDQ - PLM C16 H32 O2 CCCCCCCCCC....
2 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 1PZ4 - PLM C16 H32 O2 CCCCCCCCCC....
2 3BKS - PLM C16 H32 O2 CCCCCCCCCC....
3 3BKR - PLM C16 H32 O2 CCCCCCCCCC....
4 2QZT - PLM C16 H32 O2 CCCCCCCCCC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PLM; Similar ligands found: 62
No: Ligand ECFP6 Tc MDL keys Tc
1 MYR 1 1
2 EW8 1 1
3 TDA 1 1
4 F15 1 1
5 PLM 1 1
6 STE 1 1
7 X90 1 1
8 DAO 1 1
9 KNA 1 1
10 DCR 1 1
11 F23 1 1
12 11A 1 1
13 DKA 1 1
14 OCA 0.956522 1
15 SHV 0.833333 0.952381
16 KTC 0.793103 0.875
17 AZ1 0.73913 0.64
18 6NA 0.72 0.904762
19 ELA 0.71875 0.954545
20 OLA 0.71875 0.954545
21 NER 0.71875 0.954545
22 VCA 0.666667 0.954545
23 PAM 0.666667 0.954545
24 PML 0.625 0.6
25 3LA 0.606061 0.8
26 LEA 0.6 0.809524
27 MYZ 0.588235 0.909091
28 12H 0.586207 0.615385
29 ODD 0.567568 0.913043
30 BRC 0.566667 0.666667
31 14V 0.555556 0.740741
32 M12 0.545455 0.869565
33 14U 0.542857 0.703704
34 EIC 0.538462 0.913043
35 EOD 0.538462 0.7
36 D0G 0.5 0.954545
37 BMJ 0.5 0.954545
38 BNV 0.5 0.954545
39 BUA 0.48 0.666667
40 RCL 0.468085 0.84
41 FTT 0.459459 0.807692
42 HXD 0.459459 0.807692
43 56S 0.459459 0.653846
44 ODT 0.452381 0.782609
45 3X1 0.444444 0.818182
46 LNL 0.44186 0.826087
47 9J6 0.441176 0.666667
48 OOA 0.441176 0.76
49 CUY 0.435897 0.68
50 6UL 0.435897 0.68
51 CNS 0.435897 0.68
52 5UF 0.432432 0.807692
53 243 0.428571 0.807692
54 1QW 0.418605 0.606061
55 GYM 0.418605 0.606061
56 O8N 0.413793 0.75
57 1DO 0.413793 0.75
58 PL3 0.413793 0.75
59 OC9 0.413793 0.75
60 DE1 0.413793 0.75
61 F09 0.413793 0.75
62 T25 0.403846 0.677419
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found with APoc: 244
This union binding pocket(no: 1) in the query (biounit: 2qzt.bio1) has 28 residues
No: Leader PDB Ligand Sequence Similarity
1 4V1F BQ1 None
2 1UO5 PIH None
3 1UO4 PIH None
4 1ZZ7 S0H None
5 3KP6 SAL None
6 5AZC PGT None
7 3SCH TB6 None
8 1I06 TZL None
9 4JE7 BB2 None
10 1RL4 BL5 None
11 1RV1 IMZ None
12 2AGC MYR None
13 2V5E SCR None
14 5X80 SAL None
15 3NV3 GAL NAG MAN None
16 4CCK OGA None
17 2QL9 CIT None
18 4CCN OGA None
19 1SBR VIB None
20 3T03 3T0 None
21 5IXK 6EW None
22 4Y3O OGA None
23 2GC0 PAN None
24 5JF2 SF7 None
25 1MT1 AG2 None
26 2XOC ADE None
27 4V2O CLQ None
28 4WG0 CHD None
29 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO None
30 5ICK FEZ None
31 3GN8 DEX None
32 5UNJ RJW None
33 6CB2 OLC None
34 2Z77 HE7 None
35 3I0O SMI None
36 4E2J MOF None
37 5Y02 HBX None
38 5TPV TYD None
39 2HFP NSI None
40 3VRV YSD None
41 3RY9 1CA None
42 2HFN FMN None
43 1DB1 VDX None
44 5OLK DTP None
45 3FUR Z12 None
46 3BEJ MUF None
47 4I94 ANP 1.8018
48 5DG2 GAL GLC 2.7027
49 4N14 WR7 2.7027
50 1NF8 BOG 2.7027
51 1GEG GLC 2.7027
52 1Y9Q MED 2.7027
53 5A8E XTK 2.7027
54 3G4Q MCH 2.7027
55 1S17 GNR 2.7027
56 4L77 CNL 2.7027
57 4P6X HCY 2.7027
58 3QP8 HL0 2.7027
59 6A46 DCM 2.7027
60 4TV1 36M 3.6036
61 4MGA 27L 3.6036
62 4TUZ 36J 3.6036
63 1A78 TDG 3.6036
64 1WMA AB3 3.6036
65 4MGD 27N 3.6036
66 2QA8 GEN 3.6036
67 4DK7 0KS 3.6036
68 1X0P FAD 3.6036
69 5DX3 EST 3.6036
70 2QZO KN1 3.6036
71 5DXE EST 3.6036
72 4MG8 27J 3.6036
73 5WGD EST 3.6036
74 4MGB XDH 3.6036
75 5HYR EST 3.6036
76 5J32 IPM 3.6036
77 4MG9 27K 3.6036
78 5AAV GW5 3.6036
79 5DXG EST 3.6036
80 4O4Z N2O 3.6036
81 3UUD EST 3.6036
82 1O6U PLM 3.6036
83 5WGQ EST 3.6036
84 3UUA 0CZ 3.6036
85 4WGF HX2 3.6036
86 2BJ4 OHT 3.6036
87 4MG7 27H 3.6036
88 5UGW GSH 4.5045
89 6A0S NDP 4.5045
90 4RW3 PLM 4.5045
91 4RW3 TDA 4.5045
92 4MRP GSH 4.5045
93 4DI8 0GZ 4.5045
94 4DI8 0GY 4.5045
95 3JQ9 AX1 4.5045
96 4DNJ ANN 4.5045
97 4JGP PYR 4.5045
98 2BHW NEX 4.5045
99 6FBA D48 4.5045
100 3G08 FEE 4.5045
101 4F4S EFO 5.26316
102 4BIX ADP 5.40541
103 5W7B MYR 5.40541
104 5UC4 83S 5.40541
105 1LQY BB2 5.40541
106 4BXF AKG 5.40541
107 5U9J GER 5.40541
108 1ZED PNP 5.40541
109 5OCA 9QZ 5.40541
110 4ZXA H8N 5.40541
111 1ZPD CIT 5.40541
112 2Q1H AS4 5.40541
113 3NB0 G6P 5.40541
114 2WTS ALA 5.40541
115 3G58 988 5.40541
116 4DOO DAO 5.40541
117 2YFB SIN 6.30631
118 1R6N 434 6.30631
119 1UUY PPI 6.30631
120 1Q1Y BB2 6.30631
121 1NRL SRL 6.30631
122 3CV2 COA 6.30631
123 3WUD GLC GAL 6.30631
124 4YUS FMN 6.30631
125 1WS1 BB2 6.30631
126 3KYQ DPV 6.30631
127 1A05 IPM 6.30631
128 5A86 D7E 6.30631
129 3AI3 SOE 6.30631
130 1G27 BB1 6.30631
131 1J3R 6PG 6.30631
132 5HCN DAO 6.30631
133 5LXB 7A9 6.30631
134 2E2R 2OH 6.30631
135 5JIB OIA 6.30631
136 6AYI C3G 6.30631
137 1NX4 AKG 6.30631
138 1ONI BEZ 7.20721
139 2XN3 ID8 7.20721
140 6BMS PLM 7.20721
141 1YC4 43P 7.20721
142 1RJW ETF 7.20721
143 5XJD 87L 7.20721
144 6GSG RCO 7.20721
145 5AG3 3EB 7.20721
146 6A5Y 9R0 7.20721
147 4B6C B5U 7.20721
148 2WH8 II2 7.20721
149 1DKF BMS 7.20721
150 1NU4 MLA 7.2165
151 2Y69 CHD 7.93651
152 2D5X L35 8.10811
153 2UW1 GVM 8.10811
154 6B9T 2HE 8.10811
155 1LPD ADE 8.10811
156 3V49 PK0 8.10811
157 5CX6 CDP 8.10811
158 3V1S 0LH 8.10811
159 5GLT BGC GAL NAG GAL 8.10811
160 5H9P TD2 8.10811
161 4J24 EST 9.00901
162 1YYE 196 9.00901
163 4J26 EST 9.00901
164 3OLL EST 9.00901
165 3B99 U51 9.00901
166 1U3R 338 9.00901
167 2OHV NHL 9.00901
168 2YJD YJD 9.00901
169 2H12 OAA 9.00901
170 3ETG GTP 9.00901
171 6B9R 2HE 9.00901
172 4UCC ZKW 9.00901
173 1EYQ NAR 9.00901
174 1RZM PEP 9.00901
175 3E70 GDP 9.90991
176 3G5K BB2 9.90991
177 2YMZ LAT 9.90991
178 6FOF LAT 9.90991
179 3R9C ECL 9.90991
180 3A51 VDY 9.90991
181 5OKT 9XK 9.90991
182 4DE3 DN8 9.90991
183 6CGN DA 9.90991
184 5KOR GDP 9.90991
185 1BYG STU 9.90991
186 2R5V HHH 9.90991
187 5IM3 DTP 9.90991
188 1YRX FMN 9.90991
189 3UG4 AHR 9.90991
190 2IYG FMN 9.90991
191 5Z84 CHD 10.6383
192 5W97 CHD 10.6383
193 5ZCO CHD 10.6383
194 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 10.8108
195 2HZL PYR 10.8108
196 6AYH C3G 10.8108
197 1Q3A NGH 10.8108
198 3ZDS OMD 10.8108
199 1VR0 3SL 10.8108
200 4W9F 3JU 11.5385
201 5FS0 5JC 11.7117
202 2RH1 CLR 11.7117
203 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 11.7117
204 5HCV 60R 11.7117
205 5U55 S0H 11.7117
206 2GWH PCI 12.6126
207 5M36 9SZ 12.6126
208 4JGX PLM 12.6126
209 3JZB 4HY 12.6126
210 2CFC KPC 12.6126
211 3TL1 JRO 12.6126
212 3RMK BML 12.6126
213 1IXE CIT 12.6126
214 4BKS X6C 13.4615
215 5CHR 4NC 13.5135
216 1M2Z BOG 13.5135
217 2OKL BB2 13.5135
218 3ET1 ET1 13.5135
219 1SO2 666 13.5135
220 1XI9 PLP 13.5135
221 1M2Z DEX 13.5135
222 3WG3 A2G GAL NAG FUC 14.4144
223 5WIU AQD 14.4144
224 1HBK MYR 15.7303
225 3W5N RAM 17.1171
226 4DR9 BB2 17.1171
227 1XMY ROL 17.1171
228 3E3U NVC 18.018
229 4OGQ 2WD 18.018
230 6FFI D8B 19.8198
231 2BCG GER 19.8198
232 4OB0 PBC 19.8198
233 3WV6 GAL GLC 21.6216
234 2BMR 3NT 22.5225
235 6FS8 E4Z 22.5225
236 5LWY OLB 25.2252
237 5LX9 OLB 25.2252
238 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA 25.2252
239 6D5H FV7 27.027
240 5C1M OLC 33.3333
241 3SAO NKN 33.3333
242 3SQP 3J8 33.3333
243 5C1M CLR 33.3333
244 4YSX E23 34.2342
Pocket No.: 2; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found with APoc: 37
This union binding pocket(no: 2) in the query (biounit: 2qzt.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 3BEO UD1 None
2 2O4J VD4 None
3 3RUU 37G None
4 5YF9 NIO None
5 1FK5 OLA None
6 5E7V M7E 4.5045
7 5K13 6Q7 4.5045
8 3KMR EQN 4.5045
9 1HG4 LPP 5.40541
10 3PF7 MLA 5.40541
11 3UP3 XCA 6.30631
12 3FC4 EDO 7.20721
13 1Y0G 8PP 7.20721
14 3GUZ PAF 7.20721
15 1SR7 MOF 8.10811
16 2R40 EPH 8.10811
17 1ML4 PAL 9.00901
18 5FTW SAH 9.90991
19 1T9D FAD 10.8108
20 1T9D PYD 10.8108
21 1T9D P25 10.8108
22 1T9D 1MM 10.8108
23 2Q0L FAD 10.8108
24 3WCA FPS 10.8108
25 3OU2 SAH 11.7117
26 3F8D FAD 12.6126
27 1FFU FAD 14.4144
28 5ZZO FLC 14.4144
29 4ZOH FAD 15.3153
30 1T3Q FAD 15.3153
31 1N83 CLR 16.2162
32 4S15 4D8 16.2162
33 1FL2 FAD 18.018
34 6DEN FAD 21.6216
35 6DEN G8A 21.6216
36 6DEN TP9 21.6216
37 3B8X G4M 26.1261
Pocket No.: 3; Query (leader) PDB : 2QZT; Ligand: PLM; Similar sites found with APoc: 35
This union binding pocket(no: 3) in the query (biounit: 2qzt.bio1) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 3KPE TM3 None
2 1TV5 N8E None
3 5EW9 5VC None
4 5C8W PCG None
5 1SLT NDG GAL None
6 4CCO OGA None
7 3W54 RNB None
8 5OWC AYZ None
9 5X3R 7Y3 None
10 3B8I OXL 2.7027
11 1UOU CMU 3.6036
12 2BHW XAT 4.5045
13 2GJ5 VD3 5.40541
14 3BGD PM6 6.30631
15 6C0B PAM 6.30631
16 5MBC FMN 6.30631
17 4P3H 25G 6.30631
18 6MVU K4V 7.20721
19 6BMS POV 7.20721
20 2XN5 FUN 7.20721
21 4AQL TXC 8.10811
22 3TDC 0EU 9.00901
23 6F6D AKG 9.00901
24 5A1S FLC 9.90991
25 4RC8 STE 9.90991
26 2HHP FLC 10.8108
27 5VNF VAL THR SER VAL VAL 10.8108
28 1YKJ PHB 10.8108
29 3N7S 3N7 12.5
30 3SP6 IL2 13.5135
31 2YIV NBN 15.3153
32 4OGQ 7PH 18.018
33 5FQK 6NT 18.018
34 3WW2 SF9 18.9189
35 3KCG NTP 25.2252
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