Receptor
PDB id Resolution Class Description Source Keywords
2RL9 2.4 Å NON-ENZYME: SIGNAL_HORMONE CRYSTAL STRUCTURE CATION-DEPENDENT MANNOSE 6-PHOSPHATE RECEP 6.5 BOUND TO TRIMANNOSIDE BOS TAURUS P-TYPE LECTIN RECEPTOR MANNOSE 6-PHOSPHATE LECTIN GLYCOPLYSOSOME MEMBRANE TRANSMEMBRANE TRANSPORT PROTEIN TRANSSUGAR BINDING PROTEIN
Ref.: STRUCTURAL INSIGHTS INTO THE MECHANISM OF PH-DEPEND LIGAND BINDING AND RELEASE BY THE CATION-DEPENDENT 6-PHOSPHATE RECEPTOR. J.BIOL.CHEM. V. 283 10124 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MN A:3000;
B:3001;
Part of Protein;
Part of Protein;
none;
none;
submit data
54.938 Mn [Mn+2...
NAG A:501;
B:502;
Invalid;
Invalid;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
MAN MAN M6P C:1;
D:1;
Valid;
Valid;
none;
none;
submit data
582.401 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1M6P 1.8 Å NON-ENZYME: SIGNAL_HORMONE EXTRACYTOPLASMIC DOMAIN OF BOVINE CATION-DEPENDENT MANNOSE 6 RECEPTOR BOS TAURUS RECEPTOR CATION DEPENDENT MANNOSE 6-PHOSPHATE P-TYPE LECTITRANSPORT
Ref.: MOLECULAR BASIS OF LYSOSOMAL ENZYME RECOGNITION: THREE-DIMENSIONAL STRUCTURE OF THE CATION-DEPENDENT 6-PHOSPHATE RECEPTOR. CELL(CAMBRIDGE,MASS.) V. 93 639 1998
Members (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 289 families.
1 1C39 - MAN MAN M6P n/a n/a
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - MAN MAN M6P n/a n/a
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 214 families.
1 1C39 - MAN MAN M6P n/a n/a
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - MAN MAN M6P n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 181 families.
1 1C39 - MAN MAN M6P n/a n/a
2 2RLB - M6D C6 H13 O9 P C([C@@H]1[....
3 2RL7 - NAG NAG n/a n/a
4 3K41 Kd = 150 mM M6D C6 H13 O9 P C([C@@H]1[....
5 2RL8 - M6D C6 H13 O9 P C([C@@H]1[....
6 1M6P Kd = 8 uM M6P C6 H13 O9 P C([C@@H]1[....
7 2RL9 - MAN MAN M6P n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: MAN MAN M6P; Similar ligands found: 42
No: Ligand ECFP6 Tc MDL keys Tc
1 MAN MAN M6P 1 1
2 BGC BGC BGC BGC BGC BGC BGC 0.716667 0.785714
3 BGC BGC BGC 0.716667 0.785714
4 BGC BGC BGC BGC BGC BGC 0.716667 0.785714
5 GLC BGC BGC BGC 0.716667 0.785714
6 BGC BGC BGC BGC BGC 0.716667 0.785714
7 BGC BGC BGC BGC 0.671429 0.785714
8 GAL GLA 0.633333 0.785714
9 GLC G6P 0.603175 1
10 GAL SO4 GAL 0.541667 0.769231
11 BGC GAL GLA 0.528571 0.785714
12 BGC BGC BGC BGC BGC BGC BGC BGC 0.520548 0.785714
13 BMA MAN MAN 0.513889 0.785714
14 GAL NAG GAL 0.481481 0.611111
15 NAG GAL GAL 0.481013 0.611111
16 MAN MAN MAN GLC 0.473684 0.785714
17 MBG GAL 0.470588 0.75
18 MAN MAN MAN 0.469136 0.809524
19 BMA MAN NAG 0.457831 0.611111
20 GCU BGC 0.452055 0.767442
21 BGC GAL NAG GAL 0.44186 0.611111
22 GAL NAG FUC GAL 0.438202 0.6
23 BGC GAL GLA NGA GAL 0.438202 0.611111
24 BGC XGP 0.432432 1
25 MAN IPD MAN 0.430556 1
26 BGC GAL GLA NGA 0.426966 0.611111
27 IPD MAN 0.424658 0.952381
28 A2G GAL 0.421053 0.611111
29 GAL AAL GAL AAL GAL AAL 0.420455 0.717391
30 GAL AAL GAL AAL 0.420455 0.717391
31 BGC GAL NAG 0.418605 0.611111
32 FUC GAL 0.416667 0.744186
33 MAN MAN MAN MAN MAN MAN MAN 0.41573 0.785714
34 BQZ 0.415385 0.714286
35 MGF G6P 0.414286 0.8125
36 BGC FUC GAL NAG GAL 0.408163 0.6
37 GLA NAG GAL FUC 0.406593 0.6
38 NAG BMA MAN MAN MAN MAN 0.40625 0.611111
39 G16 0.405797 0.844444
40 MMA MAN MAN 0.405063 0.75
41 BGC FUC GAL NAG 0.404255 0.6
42 AHR FUB 0.4 0.681818
Similar Ligands (3D)
Ligand no: 1; Ligand: MAN MAN M6P; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1m6p.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 1M6P; Ligand: M6P; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 1m6p.bio1) has 16 residues
No: Leader PDB Ligand Sequence Similarity
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