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Receptor
PDB id Resolution Class Description Source Keywords
2V0U 1.4 Å NON-ENZYME: OTHER N- AND C-TERMINAL HELICES OF OAT LOV2 (404-546) ARE INVOLVED IN LIGHT-INDUCED SIGNAL TRANSDUCTION (CRYO DARK S TRUCTURE OF LOV2 (404-546)) AVENA SATIVA LOV2 KINASE TRANSFERASE ATP-BINDING AVENA SATIVA SERINE/THREONINE-PROTEIN KINASE LIGHT-INDUCED SIGNAL TRANSPHOTOTROPIN1 NUCLEOTIDE-BINDING
Ref.: N- AND C-TERMINAL FLANKING REGIONS MODULATE LIGHT-I SIGNAL TRANSDUCTION IN THE LOV2 DOMAIN OF THE BLUE SENSOR PHOTOTROPIN 1 FROM AVENA SATIVA. BIOCHEMISTRY V. 46 14001 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FMN A:1547;
Valid;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
GOL A:1548;
A:1549;
A:1550;
A:1551;
A:1552;
A:1553;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2V0U 1.4 Å NON-ENZYME: OTHER N- AND C-TERMINAL HELICES OF OAT LOV2 (404-546) ARE INVOLVED IN LIGHT-INDUCED SIGNAL TRANSDUCTION (CRYO DARK S TRUCTURE OF LOV2 (404-546)) AVENA SATIVA LOV2 KINASE TRANSFERASE ATP-BINDING AVENA SATIVA SERINE/THREONINE-PROTEIN KINASE LIGHT-INDUCED SIGNAL TRANSPHOTOTROPIN1 NUCLEOTIDE-BINDING
Ref.: N- AND C-TERMINAL FLANKING REGIONS MODULATE LIGHT-I SIGNAL TRANSDUCTION IN THE LOV2 DOMAIN OF THE BLUE SENSOR PHOTOTROPIN 1 FROM AVENA SATIVA. BIOCHEMISTRY V. 46 14001 2007
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 2V1A - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 2V0U - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 4EES - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 4EET - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 4NXE - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 4EER - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 4NXG - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 4NXF - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 4EEP - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
8 4EEU - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 2V1A - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
10 2V0U - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 6GB3 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 6GAY - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 6GBV - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 6GBA - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 2PR5 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 1N9N - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
8 4EES - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 4EET - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
10 4NXE - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
11 4EER - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
12 4NXG - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
13 4NXF - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
14 4EEP - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
15 4EEU - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
16 2V1A - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
17 2V0U - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 5DKK - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
19 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
20 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2V0U; Ligand: FMN; Similar sites found with APoc: 320
This union binding pocket(no: 1) in the query (biounit: 2v0u.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 6GNO XDI None
2 2ARC ARA None
3 6A0S NDP None
4 5TPV TYD None
5 4WVW SLT None
6 4Z3E GAL NGA GLA BGC GAL None
7 1UO5 PIH None
8 1YRX FMN None
9 1SWG BTN None
10 4WG0 CHD None
11 1CEB AMH None
12 1MDC PLM None
13 1LRI CLR None
14 2IYG FMN None
15 5LX9 OLB None
16 1ZEI CRS None
17 6HDT BTN None
18 1TUK PGM None
19 4EKV BTN None
20 1TT8 PHB None
21 4CPH LH4 None
22 2Z77 HE7 None
23 6AYI C3G None
24 2PEH LYS ARG LYS SER ARG TRP ASP GLU THR PRO None
25 1V1A KDG None
26 4OAS 2SW None
27 4F4S EFO None
28 4NAE 1GP None
29 1X8X TYR None
30 5LWY OLB None
31 1N5S ADL None
32 5T2Z 017 None
33 1W5T ADP None
34 1UO4 PIH None
35 1SDW IYT 1.36986
36 1M2Z BOG 1.36986
37 5H2U 1N1 1.36986
38 2P7Q GG6 1.50376
39 1UGY GLA GLC 1.50376
40 1OGZ EQU 1.6
41 1Y75 NAG 1.69492
42 2JBM SRT 2.05479
43 4D4U FUC NDG GAL FUC 2.05479
44 5UR1 YY9 2.05479
45 5X3R 7Y3 2.05479
46 4D52 GIV 2.05479
47 4D52 GXL 2.05479
48 2HFN FMN 2.05479
49 1URX AAL GAL AAL GLA 2.05479
50 1MFI FHC 2.63158
51 4YLZ LAT NAG GAL 2.73973
52 3VV5 SLZ 2.73973
53 2IUW AKG 2.73973
54 5MKG C2E 2.73973
55 1VJY 460 2.73973
56 4KQP GLN 2.73973
57 3PUR 2HG 3.42466
58 4QXB OGA 3.42466
59 3W54 RNB 3.42466
60 4RF7 ARG 3.42466
61 2GJ5 VD3 3.42466
62 5XVG 8FX 3.42466
63 3RGA LSB 3.42466
64 3KP6 SAL 3.42466
65 5A5W GUO 3.42466
66 4RD0 GDP 3.42466
67 5O9W AKG 3.42466
68 6FA4 D1W 3.42466
69 2HK9 SKM 3.42466
70 3D91 REM 3.42466
71 2JLD AG1 3.42466
72 4BPZ GLC BGC BGC 3.42466
73 1SGJ OAA 3.52113
74 3QLM PLM 4.03226
75 4XTX 590 4.10959
76 4L4J NAG NAG BMA MAN NAG 4.10959
77 2GBB CIT 4.10959
78 6F6D AKG 4.10959
79 5IM3 DTP 4.10959
80 2OVW CBI 4.10959
81 5DQ8 FLF 4.10959
82 3GE7 AFQ 4.10959
83 5LXB 7A9 4.10959
84 2RH4 EMO 4.10959
85 2CYC TYR 4.10959
86 5VAD 91Y 4.10959
87 5VAD PRO 4.10959
88 3E9I XAH 4.10959
89 5G48 1FL 4.10959
90 1A78 TDG 4.47761
91 1OGX EQU 4.58015
92 1ECM TSA 4.58716
93 5U9J GER 4.79452
94 2WA4 069 4.79452
95 2EAE FUC 4.79452
96 1U6R ADP 4.79452
97 4UAL 3FV 4.79452
98 1Z6K OAA 4.79452
99 2Z7I 742 4.79452
100 4XV1 904 4.79452
101 4QB6 GCU XYP 4.79452
102 6AYH C3G 4.79452
103 4NAO AKG 4.79452
104 4CQE CQE 4.79452
105 3CBC DBS 4.79452
106 2BCG GER 4.79452
107 3VRY B43 4.79452
108 5KD6 6C7 4.79452
109 5XIJ 873 4.79452
110 6GR0 F8W 4.79452
111 4YUS FMN 4.79452
112 5A0U CHT 4.79452
113 5HES 032 4.79452
114 1VRP ADP 4.79452
115 4QMN DB8 4.79452
116 6C0B PAM 4.79452
117 5XIJ ANP 4.79452
118 6G5J EM8 4.79452
119 4WOE ADP 4.79452
120 4BCS BTN 4.8
121 5H9P TD2 5.06329
122 1L0I PSR 5.12821
123 4TW7 37K 5.46875
124 6CB2 OLC 5.47945
125 3T4L ZEA 5.47945
126 3JU6 ANP 5.47945
127 5BVE 4VG 5.47945
128 3HP9 CF1 5.47945
129 1GQG DCD 5.47945
130 4G31 0WH 5.47945
131 2CHG ANP 5.47945
132 5VNF VAL THR SER VAL VAL 5.47945
133 4P8K 38C 5.47945
134 4P8K FAD 5.47945
135 3WV6 GAL BGC 5.47945
136 1NAA 6FA 5.47945
137 1NAA ABL 5.47945
138 1PS9 FAD 5.47945
139 5DRB 5FJ 5.47945
140 1JLX GAL A2G MBN 5.47945
141 2CYB TYR 5.47945
142 3TEG DAH 5.47945
143 1XAP TTB 5.47945
144 5FCF GLY GLY GLY 5.47945
145 5G3N X28 5.51181
146 4BJ8 BTN 5.55556
147 4JH6 FCN 5.7971
148 6BU0 IHP 6.10687
149 3KMZ EQO 6.16438
150 6MPT C30 6.16438
151 3AI3 SOL 6.16438
152 1ULE GLA GAL NAG 6.16438
153 5JSP DQY 6.16438
154 4DQ2 BTX 6.16438
155 3W5N RAM 6.16438
156 5D48 L96 6.16438
157 2DXU BT5 6.16438
158 2JIG PD2 6.16438
159 3AI3 SOE 6.16438
160 1WPY BTN 6.16438
161 5EK3 5PK 6.16438
162 2QZZ EMF 6.16438
163 5XHA FRU 6.16438
164 3SHZ 5CO 6.16438
165 2QZZ NAP 6.16438
166 4S00 AKR 6.16438
167 5K13 6Q7 6.16438
168 1YFS ALA 6.16438
169 3GD9 GLC BGC BGC BGC 6.16438
170 4RQL SNE 6.16438
171 4D1J DGJ 6.16438
172 5B09 4MX 6.73077
173 6EWZ APC 6.84932
174 1DZK PRZ 6.84932
175 1QY1 PRZ 6.84932
176 4BVA T3 6.84932
177 4FGC PQ0 6.84932
178 3H0L ADP 6.84932
179 2R8Q IBM 6.84932
180 4O4Z N2O 6.84932
181 5W4W 9WG 6.84932
182 1ERB ETR 6.84932
183 4GJ3 0XP 6.84932
184 2W5P CL8 6.84932
185 6DAM PQQ 6.84932
186 5EEH P9P 6.84932
187 4KBA 1QM 6.84932
188 3EW2 BTN 7.40741
189 3BJC WAN 7.53425
190 3CMJ SRT 7.53425
191 5LOF 70R 7.53425
192 5WL1 D3D 8.08081
193 5WL1 CUY 8.08081
194 1F9V ADP 8.21918
195 5OLK DTP 8.21918
196 5VLC HSO 8.21918
197 5AZC PGT 8.21918
198 1AUA BOG 8.21918
199 3A51 VDY 8.21918
200 6D6L FY4 8.21918
201 1WBI BTN 8.52713
202 5C1M OLC 8.8
203 4BG4 ADP 8.90411
204 4MRP GSH 8.90411
205 4RW3 PLM 8.90411
206 3M3E GAL A2G NPO 8.90411
207 4URX HXY 8.90411
208 4OIT MAN 8.90411
209 4IA6 EIC 8.90411
210 2AGC DAO 8.90411
211 4O4K 2PK 8.90411
212 4RW3 IPD 8.90411
213 2CIX CEJ 8.90411
214 2ADA HPR 8.90411
215 4WHZ 3NL 9.58904
216 1M15 ADP 9.58904
217 1M15 ARG 9.58904
218 1B7Y FYA 9.58904
219 3T58 FAD 9.58904
220 3B99 U51 9.58904
221 5H9Q TD2 9.58904
222 5XIO HFG 9.58904
223 5TSH ANP 9.58904
224 3LGG CFE 9.58904
225 2C9O ADP 9.58904
226 5V3Y 5V8 9.58904
227 4YDQ ANP 9.58904
228 4YDQ HFG 9.58904
229 4M26 AKG 9.58904
230 1LNX URI 9.87654
231 2V57 PRL 10
232 2AG4 LP3 10.274
233 2AG4 OLA 10.274
234 1J3R 6PG 10.274
235 2GWH PCI 10.274
236 4ONA UW1 10.274
237 4CNO 9PY 10.274
238 3GST GPR 10.274
239 4YZC STU 10.274
240 3V66 D3A 10.274
241 4GGZ BTN 10.4348
242 3ZXE PGZ 10.5263
243 4F06 PHB 10.9589
244 3SAO DBH 10.9589
245 2YBP 2HG 10.9589
246 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 10.9589
247 1MV8 GDX 10.9589
248 2Q8E OGA 10.9589
249 2OS2 OGA 10.9589
250 5LY2 OGA 10.9589
251 5U97 PIT 10.9589
252 1MID LAP 10.989
253 4JNJ BTN 11.3043
254 5MBC FMN 11.6438
255 3TKI S25 11.6438
256 3KU0 ADE 11.6438
257 3M2W L8I 11.6438
258 4CS4 AXZ 11.6438
259 3PPQ CHT 11.6438
260 2J3M ATP 11.6438
261 2J3M PRI 11.6438
262 3WG3 A2G GAL NAG FUC 11.6438
263 4OCT AKG 11.6438
264 6E1Q CFA 12.3288
265 2GC0 PAN 12.3288
266 2LBD REA 12.3288
267 5KJW 53C 12.3288
268 4OYA 1VE 12.3288
269 1FCZ 156 12.3288
270 2XMY CDK 12.3288
271 4LIT AKG 12.3288
272 4MGA 27L 13.0137
273 1SR7 MOF 13.0137
274 2IID PHE 13.0137
275 2IID FAD 13.0137
276 4KYS VIB 13.0137
277 3E7O 35F 13.0137
278 1X0P FAD 13.2867
279 5MJA 7O3 13.6986
280 1TE2 PGA 13.6986
281 5EOB 5QQ 13.6986
282 6BXL SAM 13.6986
283 1KGI T4A 14.1732
284 4FFG LBS 14.3836
285 1GT4 UNA 14.3836
286 5HV0 AKG 14.3836
287 3FAL REA 14.3836
288 5ZCO PGV 14.6789
289 5ZCO CHD 14.6789
290 5Z84 CHD 14.6789
291 5Z84 PGV 14.6789
292 2DYR PGV 14.6789
293 5W97 CHD 14.6789
294 5HCY 60D 15.0685
295 2XVD AS6 15.0685
296 3WUD GLC GAL 15.4412
297 4QCK ASD 15.7534
298 4CSD MFU 15.7534
299 5INJ 6C7 16.4384
300 2YIP YIO 16.6667
301 2FCU AKG 17.1233
302 5DEY 59T 17.1233
303 4Z28 BTN 17.1642
304 1W6P NDG GAL 17.1642
305 1ZOY UQ1 17.8082
306 5GLT BGC GAL NAG GAL 17.8082
307 1RQH PYR 17.8082
308 3JQ3 ADP 18.4932
309 2Z3U CRR 19.1781
310 2I4O ATP 21.2329
311 1XZ3 ICF 21.9178
312 2HFK E4H 21.9178
313 6F7X MFU 23.3333
314 3RMK BML 25.3012
315 2Y69 CHD 30
316 3G9E RO7 30.137
317 3EWK FAD 31.5068
318 3P7N FMN 41.0959
319 4WUJ FMN 41.7808
320 2GJ3 FAD 45
321 4GCZ FMN 50
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