Receptor
PDB id Resolution Class Description Source Keywords
2VJ0 1.6 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF P EPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SY NAPTOJANIN P170 MUS MUSCULUS PROTEIN TRANSPORT CYTOPLASMIC VESICLE ALTERNATIVE SPLICING TRANSPORT COATED PIT SH3 DOMAIN ENDOCYTOSIS ALPHA-ADAPTIN GOLGI APPARATUS PHOSPHORYLATION AP2 SYNAPSE MEMBRANE CYTOPLASM COILED COIL AMPHIPHYSIN CYTOSKELETON SYNAPTOJANIN LIPID-BINDING CELL JUNCTION
Ref.: SOLITARY AND REPETITIVE BINDING MOTIFS FOR THE AP2 COMPLEX {ALPHA}-APPENDAGE IN AMPHIPHYSIN AND OTHER ACCESSORY PROTEINS. J.BIOL.CHEM. V. 283 5099 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BEN A:1939;
 Invalid;
 none;
 submit data
120.152 C7 H8 N2 [H]/N...
CL A:1944;
 Invalid;
 none;
 submit data
35.453 Cl [Cl-]
DTD A:1940;
 Invalid;
 none;
 submit data
152.235 C4 H8 O2 S2 C1[C@...
PHE GLU ASP ASN PHE VAL PRO Q:1;
 Valid;
 none;
 Kd = 21 uM
778.864 n/a O=C(N...
SO4 A:1941;
A:1942;
A:1943;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2VJ0 1.6 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE ALPHA-ADAPTIN APPENDAGE DOMAIN, FROM THE AP2 ADAPTOR COMPLEX, IN COMPLEX WITH AN FXDNF P EPTIDE FROM AMPHIPHYSIN1 AND A WVXF PEPTIDE FROM SY NAPTOJANIN P170 MUS MUSCULUS PROTEIN TRANSPORT CYTOPLASMIC VESICLE ALTERNATIVE SPLICING TRANSPORT COATED PIT SH3 DOMAIN ENDOCYTOSIS ALPHA-ADAPTIN GOLGI APPARATUS PHOSPHORYLATION AP2 SYNAPSE MEMBRANE CYTOPLASM COILED COIL AMPHIPHYSIN CYTOSKELETON SYNAPTOJANIN LIPID-BINDING CELL JUNCTION
Ref.: SOLITARY AND REPETITIVE BINDING MOTIFS FOR THE AP2 COMPLEX {ALPHA}-APPENDAGE IN AMPHIPHYSIN AND OTHER ACCESSORY PROTEINS. J.BIOL.CHEM. V. 283 5099 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 2VJ0 Kd = 21 uM PHE GLU ASP ASN PHE VAL PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 2VJ0 Kd = 21 uM PHE GLU ASP ASN PHE VAL PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 2VJ0 Kd = 21 uM PHE GLU ASP ASN PHE VAL PRO n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PHE GLU ASP ASN PHE VAL PRO; Similar ligands found: 39
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE GLU ASP ASN PHE VAL PRO 1 1
2 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.689076 0.952381
3 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.52518 0.904762
4 ARG VAL ILE PTR PHE VAL PRO LEU ASN ARG 0.519685 0.75
5 ACE GLY ASN CYS PHE SER LYS PRO ARG 0.507353 0.818182
6 ALA VAL ALA PHE TYR ILE PRO ASP GLN ALA 0.48855 0.80303
7 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.469697 0.787879
8 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.467626 0.907692
9 LEU GLY TYR GLY PHE VAL ASN TYR ILE 0.466667 0.69697
10 PHE ASN ARG PRO VAL 0.441176 0.848485
11 PHE ASN PHE PRO GLN ILE THR 0.439716 0.876923
12 ILE ASN PHE ASP PHE ASN THR ILE 0.439024 0.646154
13 ILE THR ASP GLN VAL PRO PHE SER VAL 0.437086 0.848485
14 ASP PHE GLU GLU ILE PRO GLY GLU PTR 0.436709 0.780822
15 LEU LEU TYR GLY PHE VAL ASN TYR ILE 0.435714 0.69697
16 ASP ASP LEU ASP VAL PRO SER PHE LEU GLN 0.434483 0.890625
17 CYS VAL ASN GLY SER CYS PHE THR VAL 0.430657 0.676923
18 SER PRO ILE VAL PRO SER PHE ASP MET 0.430464 0.814286
19 ASP PHE ALA ASN THR PHE LEU PRO 0.429577 0.921875
20 TYR ASP LEU SEP LEU PRO PHE PRO 0.428571 0.76
21 LEU LEU TYR GLY PHE VAL ASN TYR VAL 0.427536 0.707692
22 ARG PRO GLY ASN PHE PHE GLN ASN ARG PRO 0.427419 0.721311
23 PHE ALA PRO GLY ASN TYI PRO ALA LEU 0.425806 0.833333
24 LYS PRO PHE PTR VAL ASN VAL NH2 0.423841 0.830986
25 PHE GLU ALA ASN GLY ASN LEU ILE 0.417266 0.741935
26 ILE MET ASP GLN VAL PRO PHE SER VAL 0.416667 0.811594
27 PHE ALA PRO GLY ASN TYR PRO ALA LEU 0.415584 0.895522
28 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.414286 0.876923
29 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.4125 0.850746
30 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.409938 0.895522
31 LEU PHE GLY TYR PRO VAL TYR VAL 0.405405 0.861538
32 ALA ASP PBF PTR LEU ILE PRO 0.404908 0.77027
33 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.403974 0.846154
34 ACE GLU HIS PHE ILE VAL PRO ASP LEU TYR 0.403846 0.861538
35 LEU ASN PHE PRO ILE SER PRO 0.402878 0.878788
36 ACE GLY PHE GLY VAL VAL PRO SER PHE TYR 0.401408 0.873016
37 ILE GLY PRO GLY ARG ALA PHE TYR VAL 0.401235 0.777778
38 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.401235 0.850746
39 ARG GLN ALA ASN PHE LEU GLY LYS 0.4 0.693548
Similar Ligands (3D)
Ligand no: 1; Ligand: PHE GLU ASP ASN PHE VAL PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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