Receptor
PDB id Resolution Class Description Source Keywords
2W0Z 1.7 Å NON-ENZYME: SIGNAL_HORMONE GRB2 SH3C (3) HOMO SAPIENS SIGNALING PROTEIN POLYMORPHISM PHOSPHOPROTEIN GOLGI APPARATUS ALTERNATIVE SPLICING HOST-VIRUS INTERACTION SH3C GRB2 SIGNALING SH2 DOMAIN SH3 DOMAIN
Ref.: DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2. STRUCTURE V. 17 809 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ALA PRO PRO PRO ARG PRO PRO LYS PRO B:6;
 Valid;
 none;
 submit data
943.185 n/a O=C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2W0Z 1.7 Å NON-ENZYME: SIGNAL_HORMONE GRB2 SH3C (3) HOMO SAPIENS SIGNALING PROTEIN POLYMORPHISM PHOSPHOPROTEIN GOLGI APPARATUS ALTERNATIVE SPLICING HOST-VIRUS INTERACTION SH3C GRB2 SIGNALING SH2 DOMAIN SH3 DOMAIN
Ref.: DISTINCT BINDING MODES OF TWO EPITOPES IN GAB2 THAT INTERACT WITH THE SH3C DOMAIN OF GRB2. STRUCTURE V. 17 809 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 289 families.
1 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 214 families.
1 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
2 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 40 families.
1 6A9C - LYS VAL ALA PRO PRO ILE PRO HIS ARG n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKB Kd = 5.2 uM PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG n/a n/a
4 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
5 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
6 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 2D0N - PRO SER ILE ASP ARG SER THR LYS PRO n/a n/a
9 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
10 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
11 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
12 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
13 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
14 4HXJ Kd ~ 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ALA PRO PRO PRO ARG PRO PRO LYS PRO; Similar ligands found: 55
No: Ligand ECFP6 Tc MDL keys Tc
1 ALA PRO PRO PRO ARG PRO PRO LYS PRO 1 1
2 VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU 0.688679 0.948276
3 ARG PRO PRO LYS PRO ARG PRO ARG 0.654545 0.963636
4 GLY PRO ARG PRO 0.622449 0.946429
5 ARG PRO LYS PRO LEU VAL ASP PRO 0.533898 0.915254
6 ALA PRO ASP THR ARG PRO ALA PRO 0.5 0.846154
7 ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG 0.495652 0.948276
8 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.479675 0.931035
9 THR LYS PRO ARG 0.477064 0.894737
10 GLN PRO PRO VAL PRO PRO GLN ARG PRO MET 0.474453 0.818182
11 SER PRO LYS ARG ILE ALA 0.467742 0.8125
12 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.46087 0.827586
13 ASP LEU THR ARG PRO 0.459016 0.776119
14 ARG PRO LYS ARG ILE ALA 0.457364 0.868852
15 PRO PRO LYS LYS LYS ARG LYS VAL 0.456 0.913793
16 ACE SER LEU ARG PRO ALA PRO LPD 0.446154 0.846154
17 ARG GLU ARG SER PRO THR ARG 0.440678 0.825397
18 3BY PRO LYS ARG ILE ALA 0.440298 0.859375
19 ARG ARG ALA SEP ALA PRO LEU PRO 0.438849 0.797101
20 LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL 0.436508 0.915254
21 ALA PRO PRO ALA 0.43617 0.8
22 GLY ARG LEU LEU PRO 0.435897 0.85
23 LYS VAL ALA PRO PRO ILE PRO HIS ARG 0.431373 0.873016
24 5JP PRO LYS ARG ILE ALA 0.430769 0.787879
25 PRO PRO LYS ARG ILE ALA 0.42963 0.868852
26 ALA PRO THR MET PRO PRO PRO LEU PRO PRO 0.428571 0.685714
27 ACE PRO PRO PRO VAL IPG PRO ARG ARG 0.428571 0.932203
28 ARG GLN PRO ALA LYS ALA PRO LEU LEU 0.425532 0.887097
29 GLU ALA LYS PRO 0.424779 0.779661
30 GLY HIS ARG PRO NH2 0.422764 0.866667
31 GLY MET PRO ARG GLY ALA 0.421875 0.84127
32 TYR PRO LYS ARG ILE ALA 0.41844 0.791045
33 ILE ARG ALA ALA PRO PRO PRO LEU PHE 0.417808 0.859375
34 DPN PRO ARG 0.415254 0.847458
35 LEU ASP PRO ARG 0.414634 0.809524
36 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.413793 0.824561
37 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.413333 0.80597
38 LYS PRO VAL LEU ARG THR ALA 0.413043 0.787879
39 PRO GLN ILE ILE ASN ARG PRO GLN ASN 0.411765 0.84127
40 ARG PRO ARG PRO ASP ASP LEU GLU ILE 0.411348 0.84375
41 ARG LEU PRO ALA LYS ALA PRO LEU LEU 0.410072 0.901639
42 DPN PRO DAR ILE NH2 0.409449 0.836066
43 PRO PRO ARG PRO ILE TYR ASN ARG ASN 0.409396 0.771429
44 ARG PRO PRO ILE PHE ILE ARG ARG LEU 0.408163 0.84375
45 ARG PRO PRO GLY PHE SER PRO PHE ARG 0.407692 0.898305
46 ARG PRO PRO GLY PHE 0.407692 0.898305
47 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 0.407407 0.813559
48 SER ALA PRO ASP THR ARG PRO ALA 0.405797 0.833333
49 LYS PRO LYS 0.40566 0.789474
50 ASP GLN GLY ARG GLY ARG ARG ARG PRO 0.40458 0.866667
51 LYS THR PHE PRO PRO THR GLU PRO LYS 0.40411 0.716418
52 VAL MET LEU PRO GLY ARG GLY VAL PRO 0.402685 0.84375
53 PRO SER ILE ASP ARG SER THR LYS PRO 0.4 0.794118
54 ARG PRO PRO GLY PHE SER PRO PHE ALA 0.4 0.818182
55 PRO ALA ILE ILE ASN ARG PRO GLN ASN 0.4 0.84127
Similar Ligands (3D)
Ligand no: 1; Ligand: ALA PRO PRO PRO ARG PRO PRO LYS PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback