Receptor
PDB id Resolution Class Description Source Keywords
2W2X 2.3 Å EC: 3.1.4.11 COMPLEX OF RAC2 AND PLCG2 SPPH DOMAIN HOMO SAPIENS HYDROLASE PHOSPHOLIPASE C PHOSPHOINOSITIDES RHO GTPASES RAC SH2 DOMAIN SH3 DOMAIN SIGNALING PROTEIN/HYDROLASE
Ref.: STRUCTURAL INSIGHTS INTO FORMATION OF AN ACTIVE SIGNALING COMPLEX BETWEEN RAC AND PHOSPHOLIPASE C GAMMA 2. MOL.CELL V. 34 223 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GSP A:1178;
B:1178;
Valid;
Valid;
none;
none;
submit data
539.246 C10 H16 N5 O13 P3 S c1nc2...
MG A:1179;
B:1179;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2W2X 2.3 Å EC: 3.1.4.11 COMPLEX OF RAC2 AND PLCG2 SPPH DOMAIN HOMO SAPIENS HYDROLASE PHOSPHOLIPASE C PHOSPHOINOSITIDES RHO GTPASES RAC SH2 DOMAIN SH3 DOMAIN SIGNALING PROTEIN/HYDROLASE
Ref.: STRUCTURAL INSIGHTS INTO FORMATION OF AN ACTIVE SIGNALING COMPLEX BETWEEN RAC AND PHOSPHOLIPASE C GAMMA 2. MOL.CELL V. 34 223 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2W2X - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2W2X - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 2W2X - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GSP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GSP 1 1
2 GP3 0.897436 0.925
3 GTP 0.853659 0.948718
4 GNH 0.829268 0.936709
5 GDP 0.817073 0.948718
6 G1R 0.8 0.936709
7 GCP 0.77907 0.925
8 GNP 0.770115 0.925
9 GMV 0.767442 0.925
10 5GP 0.756098 0.935897
11 G 0.756098 0.935897
12 G2R 0.747253 0.91358
13 GKE 0.744681 0.91358
14 GDD 0.744681 0.91358
15 GDC 0.744681 0.91358
16 GPG 0.73913 0.91358
17 GTG 0.736842 0.891566
18 G3A 0.729167 0.925
19 G5P 0.721649 0.925
20 GDR 0.71875 0.91358
21 GFB 0.71875 0.91358
22 GAV 0.714286 0.987179
23 GP2 0.712644 0.91358
24 6CK 0.71134 0.891566
25 Y9Z 0.708333 0.860465
26 JB2 0.69697 0.91358
27 GKD 0.69697 0.91358
28 GDP MG 0.696629 0.878049
29 G2P 0.692308 0.91358
30 GDX 0.69 0.925
31 GPD 0.69 0.880952
32 GDP BEF 0.688889 0.857143
33 GCP G 0.677419 0.888889
34 ALF 5GP 0.67033 0.847059
35 0O2 0.666667 0.935897
36 GTP MG 0.666667 0.878049
37 BEF GDP 0.666667 0.847059
38 YGP 0.663265 0.858824
39 JB3 0.657143 0.902439
40 GDP ALF 0.645833 0.847059
41 GDP AF3 0.645833 0.847059
42 G G 0.642857 0.888889
43 GMP 0.641975 0.835443
44 G3D 0.638298 0.935897
45 NGD 0.635514 0.91358
46 2MD 0.633027 0.894118
47 CAG 0.630631 0.840909
48 G4P 0.625 0.935897
49 U2G 0.62037 0.891566
50 FEG 0.62037 0.83908
51 MGD 0.616071 0.894118
52 ZGP 0.614679 0.872093
53 CG2 0.609091 0.891566
54 TPG 0.598291 0.804348
55 3GP 0.595506 0.898734
56 GDP 7MG 0.590476 0.86747
57 GH3 0.581633 0.924051
58 MD1 0.581197 0.894118
59 PGD 0.581197 0.926829
60 2GP 0.577778 0.911392
61 DGT 0.561224 0.878049
62 DBG 0.558333 0.902439
63 G1G 0.550847 0.880952
64 SAP 0.547368 0.924051
65 AGS 0.547368 0.924051
66 FE9 0.546219 0.8
67 G4M 0.539062 0.840909
68 U A G G 0.538462 0.888889
69 G A A A 0.529915 0.878049
70 MGP 0.525253 0.91358
71 GPX 0.524272 0.898734
72 BGO 0.521739 0.879518
73 DGI 0.520408 0.878049
74 6G0 0.52 0.91358
75 I2C FE2 CMO CMO 0.516667 0.774194
76 IDP 0.515464 0.923077
77 GGM 0.508475 0.858824
78 G1R G1R 0.508065 0.879518
79 PGD O 0.504 0.875
80 G G U 0.5 0.888889
81 GTA 0.486726 0.891566
82 P2G 0.484536 0.839506
83 GPC 0.483607 0.83908
84 G C 0.483333 0.857143
85 P1G 0.474747 0.829268
86 DG 0.474227 0.865854
87 DGP 0.474227 0.865854
88 BA3 0.46875 0.85
89 AP5 0.463918 0.85
90 B4P 0.463918 0.85
91 IMP 0.463918 0.910256
92 G2Q 0.462963 0.91358
93 G G G RPC 0.459016 0.833333
94 APC G U 0.456 0.843373
95 U G A 0.452555 0.847059
96 ATP 0.45 0.873418
97 G G G C 0.448819 0.869048
98 A2D 0.447917 0.85
99 5FA 0.445545 0.873418
100 AQP 0.445545 0.873418
101 A G C C 0.445312 0.86747
102 G7M 0.444444 0.901235
103 G U34 0.442623 0.847059
104 01G 0.442478 0.860465
105 ITT 0.44 0.825
106 SGP 0.44 0.876543
107 G C C C 0.431818 0.879518
108 AN2 0.43 0.8625
109 DG DG 0.428571 0.825581
110 A4P 0.42623 0.829545
111 UCG 0.424242 0.86747
112 C2E 0.423077 0.875
113 PCG 0.423077 0.886076
114 35G 0.423077 0.886076
115 MGO 0.420561 0.823529
116 ADP 0.42 0.873418
117 ANP 0.419048 0.851852
118 5GP 5GP 0.419048 0.839506
119 ADQ 0.418182 0.829268
120 APR 0.417476 0.85
121 AR6 0.417476 0.85
122 7DT 0.417476 0.860759
123 A G U 0.414286 0.847059
124 AD9 0.413462 0.851852
125 UP5 0.413223 0.831325
126 A22 0.412844 0.8625
127 25L 0.412281 0.8625
128 M33 0.411765 0.839506
129 JBT 0.410405 0.783505
130 ACP 0.407767 0.851852
131 ACQ 0.40566 0.851852
132 A1R 0.405405 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2W2X; Ligand: GSP; Similar sites found: 495
This union binding pocket(no: 1) in the query (biounit: 2w2x.bio2) has 22 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4E03 ADP 0.0002343 0.48675 None
2 2IL4 COA 0.01023 0.40162 None
3 1G3Q ADP 0.000939 0.45825 2.16216
4 2OZE AGS 0.0004529 0.45343 2.16216
5 4QM7 GTP 0.000121 0.50668 2.92398
6 1P9B GDP 0.001917 0.43034 3.16742
7 3MD0 GDP 0.00000003128 0.69169 3.22581
8 4WOP CTP 0.00002773 0.50036 3.22581
9 1XP8 AGS 0.0005663 0.48012 3.22581
10 5WRJ A3P 0.007672 0.40051 3.24324
11 5MVR ADP 0.00004946 0.44432 3.7037
12 2DPY ADP 0.000138 0.51775 3.78378
13 2C04 GCP 0.0006568 0.45087 3.78378
14 2XAU ADP 0.001376 0.44558 3.78378
15 1RRC ADP 0.00003193 0.40708 3.78378
16 1SVI GDP 0.000000001332 0.75981 4.03226
17 1V8K ANP 0.000001424 0.60013 4.03226
18 2BEK ATP 0.0003009 0.44891 4.03226
19 1LVG ADP 0.00003364 0.42954 4.03226
20 2X7I CIT 0.008223 0.41783 4.03226
21 4RZ3 ADP 0.001586 0.41687 4.03226
22 2VOH CIT 0.01233 0.41399 4.03226
23 1L2T ATP 0.0009747 0.41314 4.03226
24 5GOE GDP 0.0000002287 0.62006 4.32432
25 4LYA ATP 0.00002526 0.53248 4.32432
26 3FVQ ATP 0.0004139 0.45072 4.32432
27 1NJF AGS 0.0006339 0.44494 4.32432
28 5TSH ANP 0.00004113 0.44431 4.32432
29 1NJF ADP 0.000792 0.433 4.32432
30 5TSH ADP 0.00006818 0.41386 4.32432
31 1VBO MAN MAN MAN 0.02798 0.40551 4.32432
32 1UJ2 C5P 0.0008492 0.40301 4.32432
33 4O48 ASP 0.02639 0.40294 4.32432
34 2WJH GDP 0.00000001164 0.5914 4.81928
35 2WJH FLC 0.000002429 0.51204 4.81928
36 2QZ4 ADP 0.0001207 0.49439 4.83871
37 5XDR ADP 0.0008587 0.46008 4.83871
38 1M7G ADX 0.0006671 0.45772 4.83871
39 1M7G ADP 0.0006535 0.45505 4.83871
40 1M7G AV2 0.00002361 0.44377 4.83871
41 2ZTS ADP 0.001679 0.42884 4.83871
42 4X1Z FUC GAL NDG 0.02068 0.41648 4.83871
43 1APZ ASP 0.01612 0.41207 4.83871
44 2WJG GDP 0.00000001975 0.69013 4.86486
45 2CBZ ATP 0.0000006102 0.66308 4.86486
46 1OXV ANP 0.00008474 0.52112 4.86486
47 2D2F ADP 0.0006302 0.48948 4.86486
48 5VGR GDP 0.0006452 0.45121 4.86486
49 3IO3 ADP 0.0007117 0.43479 4.86486
50 4WZ6 ATP 0.00003324 0.55611 5.40541
51 3EZ2 ADP 0.0002851 0.49494 5.40541
52 1R6B ADP 0.0002973 0.48187 5.40541
53 2FAH GDP 0.0002282 0.47624 5.40541
54 5J1J ANP 0.0002703 0.46275 5.40541
55 2VVG ADP 0.0000009595 0.44077 5.40541
56 1XX6 ADP 0.0003822 0.40733 5.40541
57 4U00 ADP 0.00001241 0.40496 5.40541
58 1G7S GDP 0.00000007689 0.65144 5.64516
59 3W5J GDP 0.000001984 0.6263 5.64516
60 2ZFI ADP 0.000009541 0.56011 5.64516
61 4YDS ATP 0.00002392 0.55659 5.64516
62 1JI0 ATP 0.00007218 0.53211 5.64516
63 3T1O GDP 0.000001157 0.52742 5.64516
64 1G6O ADP 0.0003017 0.47601 5.64516
65 1ION ADP 0.0008031 0.45638 5.64516
66 5MZN ADP 0.002215 0.45622 5.64516
67 4LJ9 ACP 0.005114 0.42786 5.64516
68 1OYY AGS 0.005438 0.42656 5.64516
69 1KO8 6PG 0.001238 0.42466 5.64516
70 3EWA ANP 0.0001519 0.4234 5.64516
71 4NZ6 DGL 0.0216 0.40746 5.64516
72 4P32 ADP 0.003227 0.40596 5.64516
73 4FCW ADP 0.001559 0.40133 5.64516
74 3TK1 GDP 0.00000001932 0.71439 5.94595
75 4NON GDP 0.00000002733 0.55424 5.94595
76 1SQ5 ADP 0.00005764 0.51554 5.94595
77 2QEN ADP 0.0001122 0.46113 5.94595
78 1U0J ADP 0.001626 0.45735 5.94595
79 1QHG ATP 0.008254 0.40585 5.94595
80 1UPT GTP 0.0000000005321 0.68298 6.45161
81 4M9Q GNP 0.0000000005999 0.6814 6.45161
82 4LC1 GDP 0.00000006901 0.66381 6.45161
83 2AWN ADP 0.000001572 0.64734 6.45161
84 4IHQ ADP 0.0001072 0.51605 6.45161
85 4PFO ADP 0.0000733 0.49112 6.45161
86 4XGU ADP 0.0004443 0.45836 6.45161
87 3KTA AP5 0.0008011 0.45162 6.45161
88 1F9V ADP 0.00000773 0.44254 6.45161
89 5G41 AP5 0.003242 0.44203 6.45161
90 2ZPA ADP 0.0005995 0.43783 6.45161
91 1D2N ANP 0.001715 0.42461 6.45161
92 5LTJ ADP 0.0002638 0.42449 6.45161
93 1NHX FTB 0.007521 0.42416 6.45161
94 1NHX PEP 0.007783 0.42253 6.45161
95 2PZE ATP 0.00001089 0.41875 6.45161
96 3QIN P1Y 0.01771 0.41026 6.45161
97 4RLQ 3SK 0.01781 0.40984 6.45161
98 2RCN GDP 0.000000001195 0.74915 6.48649
99 4QRH 0O2 0.002018 0.42161 6.48649
100 3KJI ADP 0.0009835 0.42044 6.48649
101 5I34 GDP 0.0006049 0.41951 6.48649
102 5E58 CPZ 0.01433 0.41695 6.48649
103 1G8S MET 0.02717 0.4015 6.95652
104 1HTW ADP 0.00003664 0.45819 6.96203
105 3DC4 ADP 0.000002146 0.61001 7.02703
106 5FTB ANP 0.000151 0.4899 7.02703
107 5BQ5 ADP BEF 0.000231 0.48137 7.02703
108 5FHD ADP ALF 0.0005083 0.44695 7.02703
109 1OFH ADP 0.0002569 0.43287 7.02703
110 4ZNL BEF ADP 0.0001491 0.43226 7.02703
111 4V03 ADP 0.0006821 0.41633 7.02703
112 3WYA GDP 0.000000004532 0.7211 7.25806
113 1WDT GTP 0.00000003121 0.63314 7.25806
114 2GJ8 ALF GDP 0.000000001062 0.61516 7.25806
115 4HSE ADP 0.00005057 0.51823 7.25806
116 3BOS CDP 0.0000812 0.51506 7.25806
117 3BFV ADP 0.0001271 0.50563 7.25806
118 3Q9L ATP 0.00006655 0.49475 7.25806
119 3DZD ADP 0.0002418 0.4751 7.25806
120 4KBF AMP 0.001487 0.45928 7.25806
121 5GJC ATP 0.00007028 0.43553 7.25806
122 4YMU ATP 0.00006269 0.42841 7.25806
123 3BER AMP 0.009418 0.41496 7.25806
124 5HWK BEZ 0.01756 0.41218 7.25806
125 3U6B GDP 0.000000002224 0.74875 7.56757
126 2BVN GNP 0.0000000003447 0.73886 7.56757
127 3U6K GDP 0.000000005494 0.71705 7.56757
128 4G5G GDP 0.000000006903 0.71225 7.56757
129 1D8T GDP 0.000000007759 0.70979 7.56757
130 1PUJ GNP 0.00000000201 0.70432 7.56757
131 4PC3 GDP 0.0000003211 0.6049 7.56757
132 5JBQ GDP 0.000000005913 0.58338 7.56757
133 4P3Y GDP 0.000000004837 0.57545 7.56757
134 4P4T GDP 0.000003652 0.54383 7.56757
135 4HI0 GDP 0.000003865 0.53655 7.56757
136 4OHY ANP 0.00001792 0.48006 7.56757
137 4IEE AGS 0.0006006 0.47885 7.56757
138 1G41 ADP 0.0003597 0.47249 7.56757
139 3H4S ADP 0.000002891 0.44195 7.56757
140 4FRZ ADP 0.00001289 0.43632 7.56757
141 2HCJ GDP 0.000000001314 0.59086 7.76119
142 2FH5 GTP 0.00000000004883 0.74366 8.06452
143 1Y63 ADP 0.0001253 0.50594 8.06452
144 3FWY ADP 0.0001561 0.47841 8.06452
145 2GK6 ADP 0.002113 0.45726 8.06452
146 2VF7 ADP 0.001161 0.45388 8.06452
147 2C9O ADP 0.0007168 0.44064 8.06452
148 5V4R MGT 0.03295 0.40062 8.06452
149 2WIC GNP 0.00000002654 0.67327 8.10811
150 3B5J 12D 0.00008433 0.52866 8.10811
151 3FKQ ATP 0.00007268 0.49306 8.10811
152 2PL3 ADP 0.0003389 0.49121 8.10811
153 5K5Z ANP 0.0002201 0.46855 8.10811
154 3CV2 OXL 0.03242 0.40635 8.10811
155 4KFU ACP 0.000008919 0.58414 8.64865
156 2OBM ADP 0.0002548 0.51355 8.64865
157 3E70 GDP 0.00006421 0.51333 8.64865
158 4Q1A UDP 0.001909 0.49829 8.64865
159 4Q1A 2XZ 0.001909 0.49829 8.64865
160 4R2I ANP 0.0015 0.46486 8.64865
161 1NX9 AIC 0.01363 0.42136 8.64865
162 4KVA GTP 0.00000912 0.40391 8.64865
163 3T12 GDP ALF 0.00000001336 0.62715 8.82353
164 1DAR GDP 0.00000006104 0.66639 8.87097
165 2W58 ADP 0.0000009925 0.65277 8.87097
166 2XTZ GSP 0.000000001186 0.62994 8.87097
167 2HF9 GSP 0.0000002599 0.60102 8.87097
168 4WZA ACP 0.00009287 0.52664 8.87097
169 4WZA ADP 0.00009287 0.52664 8.87097
170 1W7J ADP BEF 0.00001716 0.52072 8.87097
171 1FP6 ADP 0.0003186 0.4697 8.87097
172 5L3W GDP 0.0000535 0.46145 8.87097
173 1FNN ADP 0.0005318 0.45042 8.87097
174 1YTM ATP 0.0004501 0.44918 8.87097
175 1IN4 ADP 0.001092 0.43691 8.87097
176 5M7P ADP 0.0009855 0.42973 8.87097
177 3BFX A3P 0.004303 0.41117 8.87097
178 2C77 GNP 0.0000000001327 0.7253 9.18919
179 2C78 GNP 0.0000000000816 0.71568 9.18919
180 1JJ7 ADP 0.00000703 0.60491 9.18919
181 3COB ADP 0.000003631 0.44079 9.18919
182 3VX3 ADP 0.0009377 0.43977 9.18919
183 3R7F CP 0.00596 0.43686 9.18919
184 1IHU AF3 0.000611 0.43568 9.18919
185 1IHU ADP 0.0006033 0.42863 9.18919
186 4OI4 ATP 0.0006034 0.42829 9.18919
187 2IXE ATP 0.001158 0.42425 9.18919
188 3IIJ ADP 0.00005966 0.52155 9.44444
189 1KK1 GNP 0.00000001661 0.70535 9.67742
190 3CX8 GSP 0.000000002318 0.5882 9.67742
191 1ZCB GDP 0.000001544 0.56361 9.67742
192 3AB3 GDP 0.0000008955 0.5634 9.67742
193 4R43 GDP 0.0002699 0.48979 9.67742
194 1XMV ADP 0.0002183 0.4882 9.67742
195 1H65 GDP 0.00005703 0.47833 9.67742
196 3DKP ADP 0.0009344 0.46366 9.67742
197 2CE7 ADP 0.0002106 0.43567 9.67742
198 1XPJ TLA 0.03353 0.40826 9.67742
199 2GWH A3P 0.006306 0.40747 9.67742
200 1ITU CIL 0.02285 0.40009 9.67742
201 5HCN GCP 0.00000001238 0.68893 9.72973
202 1JWY GDP 0.000003989 0.55553 9.72973
203 1JWY ADP 0.00001967 0.53762 9.72973
204 2IS6 ADP 0.0002108 0.49499 9.72973
205 4YS0 ADP 0.0006559 0.4509 9.72973
206 4A4Z ANP 0.004182 0.43209 9.72973
207 4J0Q GDP 0.00000000884 0.71897 10.2703
208 2B8W ALF 5GP 0.000001839 0.51789 10.2703
209 4R98 GNH 0.0000008016 0.5171 10.2703
210 1F5N GNP 0.000001851 0.49874 10.2703
211 1VHT BA3 0.0005735 0.46313 10.2703
212 3H86 AP5 0.001913 0.44147 10.2703
213 3A1S GDP 0.00000005823 0.65714 10.4839
214 1D2E GDP 0.00000003721 0.64713 10.4839
215 1G6H ADP 0.00001121 0.5915 10.4839
216 5FG3 GDP 0.000000001945 0.58581 10.4839
217 3ZFD ANP 0.0000002723 0.54763 10.4839
218 3NHB ADP 0.0000521 0.54527 10.4839
219 5LB3 ADP 0.00006458 0.52698 10.4839
220 5N69 ADP 0.00002 0.52394 10.4839
221 3DEF GDP 0.00002807 0.5173 10.4839
222 3TBK ANP 0.0006517 0.48334 10.4839
223 2FNA ADP 0.0006783 0.43407 10.4839
224 3CNL GNP 0.00000006059 0.67743 10.8108
225 2ZR9 DTP 0.0001798 0.49834 10.8108
226 2ZE7 DST 0.006383 0.40869 10.8108
227 2ZE7 AMP 0.005887 0.40869 10.8108
228 1NRJ GTP 0.00000001463 0.63895 11.0092
229 4ZKD GDP 0.0000000002499 0.73068 11.2903
230 1AZT GSP 0.000000003204 0.58285 11.2903
231 2OG2 MLI 0.00006586 0.5331 11.2903
232 2IYL GDP 0.00006464 0.51986 11.2903
233 1KK8 BEF ADP 0.00002267 0.51539 11.2903
234 1B7T ADP 0.0001268 0.4934 11.2903
235 4IDN GNP 0.00003596 0.48573 11.2903
236 3B7G ANP 0.0002847 0.48275 11.2903
237 1Z6T ADP 0.0001393 0.4806 11.2903
238 1NY5 ADP 0.0004559 0.45787 11.2903
239 5IRN ADP 0.0002215 0.44138 11.2903
240 4WEI GLC GAL 0.007339 0.43421 11.2903
241 1UKZ ADP 0.005527 0.41958 11.2903
242 1QHH ATP 0.01581 0.40014 11.3043
243 4PPF FLC 0.000003999 0.61023 11.3514
244 3A4M ADP 0.00001798 0.56291 11.3514
245 2Y65 ADP 0.000003696 0.44044 11.3514
246 3JUC PCA 0.02504 0.40446 11.7647
247 1YRB GDP 0.0000000207 0.65862 11.8919
248 5HR5 ADP 0.0003322 0.44144 11.8919
249 3RC3 ANP 0.01054 0.41691 11.8919
250 2Q2Y ADP 0.0004311 0.47692 12.0968
251 2Q2Y MKR 0.0004232 0.47607 12.0968
252 3ZQ6 ADP ALF 0.00008958 0.44088 12.0968
253 1W5T ADP 0.002034 0.42919 12.0968
254 1W5T ANP 0.001422 0.42805 12.0968
255 1R0X ATP 0.0002049 0.41493 12.0968
256 4LPS GDP 0.00000004756 0.6613 12.4324
257 5CK5 GDP 0.00000001959 0.55665 12.4324
258 2V7Q ADP 0.0000553 0.52314 12.4324
259 2V7Q ATP 0.00003277 0.52052 12.4324
260 1W0J ADP 0.00005346 0.46616 12.4324
261 2CK3 ANP 0.0003977 0.45586 12.4324
262 2OFW ADX 0.001429 0.45205 12.4324
263 1W0J ADP BEF 0.0004413 0.44342 12.4324
264 2ZJ5 ADP 0.004704 0.4428 12.4324
265 2CK3 ADP 0.0004164 0.43521 12.4324
266 1BO4 COA 0.01316 0.40788 12.5
267 2PEZ DAT 0.001354 0.44552 12.8492
268 2PEZ GGZ 0.001354 0.44552 12.8492
269 5EE5 GTP 0.0000000002053 0.721 12.8655
270 4B47 GDP 0.000000006231 0.72652 12.9032
271 2WHX ADP 0.00004712 0.54836 12.9032
272 3B9Q MLI 0.0001616 0.51486 12.9032
273 3T34 GDP 0.00003799 0.47864 12.9032
274 2JLR ANP 0.0004215 0.46421 12.9032
275 5IFS ADP 0.0002653 0.4329 12.9032
276 4D81 ADP 0.0004109 0.43145 12.9032
277 4GOX A3P 0.002287 0.40763 12.9032
278 1TQ4 GDP 0.0000003399 0.58119 12.973
279 5IRR GSP 0.000000008195 0.63443 13.5135
280 5L3V GDP 0.000029 0.52297 13.5135
281 5L3S GNP 0.00001637 0.51711 13.5135
282 3QKT ANP 0.0008559 0.41655 13.5135
283 4TTQ ATP 0.00005461 0.52341 13.7097
284 4AF0 IMP 0.006719 0.40298 13.7097
285 2X77 GDP 0.00000001264 0.6885 13.7566
286 5M04 GDP 0.00000007058 0.54062 14.0541
287 1K6M AGS 0.0009239 0.4213 14.0541
288 1T5C ADP 0.000002186 0.62565 14.5161
289 1CS4 GSP 0.000000003521 0.59175 14.5161
290 3RLF ANP 0.0004579 0.43297 14.5161
291 5E5U MLI 0.01263 0.43179 14.5161
292 2ODE ALF GDP 0.000000007116 0.6728 14.5946
293 2W8Q SIN 0.02357 0.40678 14.5946
294 1M2O GNP 0.0000000004419 0.71684 15.1351
295 2QTV GNP 0.000000001782 0.68759 15.1351
296 3WXM GTP 0.0000000002108 0.73074 15.3226
297 3VMF GTP 0.000000000272 0.72595 15.3226
298 1GOJ ADP 0.000000915 0.64369 15.3226
299 2VB6 ADP BEF 0.00004893 0.49451 15.4362
300 1WF3 GNP 0.0000000008666 0.7072 16.129
301 4CVN ADP 0.00001835 0.56245 16.129
302 2BIF ANP 0.0006348 0.46156 16.129
303 2BIF SIN 0.001107 0.46156 16.129
304 1XKV ATP 0.0007254 0.45842 16.129
305 5X40 ACP 0.001003 0.43838 16.129
306 3P4X ADP 0.00009248 0.43004 16.129
307 1OE0 TTP 0.007127 0.4066 16.129
308 2QN6 GDP 0.000000001734 0.75412 16.2162
309 1KSH GDP 0.0000000002833 0.71138 16.2162
310 1SKQ GDP 0.00000002665 0.69515 16.2162
311 3DOE GTP 0.0000000006068 0.66645 16.2162
312 1GXU 2HP 0.000314 0.49965 16.4835
313 4RD0 GDP 0.00000000003119 0.75582 16.7568
314 4DCT GDP 0.00000000147 0.73266 16.9355
315 4AG5 ADP 0.00003533 0.55397 16.9355
316 1P4V GLY 0.01399 0.41652 16.9355
317 1G7C 5GP 0.000001109 0.60539 17.0213
318 4MKG AP5 0.002564 0.44161 17.0507
319 3PQC GDP 0.000000009433 0.68398 17.2973
320 3ZIA ATP 0.00003143 0.528 17.4603
321 3ZIA ADP 0.0001046 0.49151 17.4603
322 1R4A GNP 0.000000000277 0.6646 17.5758
323 4ZG4 VO4 ADP 0.0000007734 0.57156 17.7419
324 4BQS ADP 0.0001791 0.49842 17.7419
325 4BQS K2Q 0.003349 0.43178 17.7419
326 2WZF BGC 0.01541 0.41432 17.7419
327 2J5V PCA 0.04615 0.40379 17.7419
328 3PCR GTP 0.000000004053 0.63505 17.9012
329 4PU6 ASP 0.01337 0.41625 18.3206
330 1YZG GDP 0.00000008863 0.64852 18.4358
331 3AQ4 GDP 0.0000001141 0.64333 18.4783
332 1JJV ATP 0.00003267 0.5559 18.5484
333 4H1V GNP 0.000005368 0.543 18.5484
334 5DI3 GNP 0.000000001287 0.66846 18.9189
335 1F6B GDP 0.000000528 0.61188 18.9189
336 1CR1 TTP 0.0009008 0.43644 18.9189
337 5H56 TYD 0.001937 0.4358 18.9189
338 5H56 ADP 0.001937 0.4358 18.9189
339 3N5C GDP 0.00000005674 0.66793 19.1358
340 1MR3 G3D 0.0000001807 0.54681 19.337
341 3LRE ADP 0.000005281 0.59904 19.3548
342 4MKF AP5 0.003118 0.4388 19.3548
343 2A5F GTP 0.0000000009831 0.64438 19.4286
344 1J2J GTP 0.0000000001396 0.69025 19.8795
345 2J59 GTP 0.0000000005188 0.6688 19.8795
346 1O3Y GTP 0.000000001244 0.65481 19.8795
347 2CHG ANP 0.000783 0.4475 20
348 1S9D GDP 0.0000003064 0.62306 20.122
349 1RE0 GDP 0.00000004009 0.54837 20.122
350 1YQT ADP 0.0001417 0.52264 20.1613
351 3UIE ANP 0.00005007 0.51202 20.1613
352 2XTN GTP 0.000006499 0.50793 20.1613
353 5L3R GCP 0.000003918 0.50686 20.1613
354 4YLG GDP 0.00000006976 0.59144 20.2312
355 2NCD ADP 0.00001335 0.57516 20.9677
356 4PJ3 ANP 0.00195 0.43418 20.9677
357 2XT3 ADP 0.000002995 0.61429 22.5806
358 1BG2 ADP 0.0000007025 0.44339 22.5806
359 3QF7 ANP 0.002089 0.41532 22.5806
360 4TMZ GSP 0.00000000001994 0.72174 23.2432
361 2KIN ADP 0.000000701 0.44326 24
362 1B0U ATP 0.001744 0.43638 24.3243
363 5I0H ADP BEF 0.0000008148 0.56513 25
364 1GOT GDP 0.000003882 0.52662 25.4054
365 2GDJ ANP 0.0001875 0.49746 25.8065
366 4QOS ADP 0.0003706 0.47189 25.8065
367 1FQJ ALF 0.00000006568 0.69737 25.9459
368 1FQK ALF 0.0000001317 0.69248 25.9459
369 5KUT GDP 0.00000000497 0.59846 25.9459
370 1FQJ GDP 0.0000007329 0.54616 25.9459
371 1FQK GDP 0.000001925 0.53025 25.9459
372 4V0K GDP 0.000001417 0.52318 27.2189
373 5KSP GDP 0.000000009653 0.69403 27.3684
374 3EC1 GDP 0.0000001533 0.54806 27.4194
375 4NCN GTP 0.00000000001811 0.72347 28.1081
376 5KSZ GCP 0.00000001117 0.68059 29.1892
377 1ZD9 GDP 0.00000004279 0.62722 30.2703
378 1TAD ALF 0.00000001167 0.56613 30.6452
379 1TAD GDP 0.00000001167 0.56613 30.6452
380 2W83 GTP 0.0000000008115 0.66166 30.9091
381 2ZEJ GDP 0.000002799 0.49593 30.9783
382 4KAX GTP 0.0000000006692 0.69918 31.9527
383 4BAS GNP 0.00000001182 0.64613 32.2581
384 3E5H GNP 0.00000000005702 0.676 32.5843
385 2G77 GDP 0.0000000002904 0.73127 32.973
386 2G77 AF3 0.00000009782 0.68789 32.973
387 1ZJ6 G3D 0.00000004622 0.66188 32.973
388 5KDO GDP 0.00000591 0.52875 33.0645
389 3GJX GTP 0.000000000008755 0.79393 33.5135
390 3GJ4 GDP 0.000000005344 0.71763 33.5135
391 3GJ7 GDP 0.00000000603 0.71509 33.5135
392 3GJ8 GDP 0.00000001628 0.68331 33.5135
393 3GJ5 GDP 0.00000001807 0.68116 33.5135
394 5UWP GNP 0.000000000005776 0.80515 34.0541
395 5UWI GNP 0.000000000005446 0.8029 34.0541
396 5UWU GNP 0.000000000005452 0.80287 34.0541
397 5UWR GNP 0.000000000005648 0.80221 34.0541
398 5UWT GNP 0.000000000006387 0.79989 34.0541
399 5DI9 GNP 0.00000000000765 0.79981 34.0541
400 3M1I GTP 0.00000000000924 0.79292 34.0541
401 3WYF GTP 0.00000000002433 0.77787 34.0541
402 3GJ0 GDP 0.000000007927 0.70934 34.0541
403 3GJ3 GDP 0.0000000112 0.70207 34.0541
404 5DIF GNP 0.000000000004044 0.7001 34.0541
405 5UWQ GNP 0.000000000004966 0.69734 34.0541
406 5UWO GNP 0.000000000005388 0.69614 34.0541
407 5UWW GNP 0.000000000005393 0.69604 34.0541
408 5UWJ GNP 0.000000000005622 0.6956 34.0541
409 5DHF GNP 0.000000000005671 0.69539 34.0541
410 1IBR GNP 0.000000000006499 0.69353 34.0541
411 5UWH GNP 0.000000000006596 0.69332 34.0541
412 4HAT GNP 0.00000000000627 0.67951 34.0541
413 3CH5 GDP 0.00000002469 0.67476 34.0541
414 5UWS GNP 0.000000000009116 0.67464 34.0541
415 5BXQ GDP 0.00000000799 0.59201 34.0541
416 5SZH GNP 0.000000000001359 0.8291 34.5946
417 3TKL GTP 0.00000000000006273 0.79817 34.5946
418 3WYG GTP 0.00000000002562 0.66075 34.6154
419 4XTR ATP 0.0002068 0.46772 34.6774
420 4XVU ATP 0.000236 0.46527 34.6774
421 4XTR ADP 0.0002232 0.45587 34.6774
422 3ZS9 ADP ALF 0.00006487 0.44665 34.6774
423 2WOJ ADP ALF 0.00009503 0.44087 34.6774
424 3SFV GDP 0.000000002158 0.6741 34.8066
425 1WA5 GTP 0.00000000001039 0.6345 35.7955
426 4ZI2 GNP 0.0000000002911 0.71455 36.2162
427 4GOJ GNP 0.0000000003153 0.71308 36.2162
428 3NKV GNP 0.0000000000003899 0.75086 36.5714
429 3WY9 GDP 0.00000000337 0.73978 37.5
430 1Z2A GDP 0.00000001226 0.61365 37.5
431 1FZQ GDP 0.00000002151 0.68833 37.5691
432 1SVK ALF GDP 0.000000006125 0.6782 38.7097
433 1BH2 GSP 0.000000009832 0.56733 38.7097
434 2OM2 GDP 0.000009457 0.52012 38.7097
435 1GP2 GDP 0.000005645 0.51113 38.7097
436 1Y3A GDP 0.000007801 0.50616 38.7097
437 1Z0J GTP 0.000000000002614 0.70712 38.8235
438 3BC1 GNP 0.000000000004887 0.71394 38.9189
439 1YVD GNP 0.000000000001924 0.7276 40.2367
440 1Z06 GNP 0.000000000002289 0.7419 40.5405
441 1MKY GDP 0.000000001715 0.74154 40.5405
442 2CJW GDP 0.000000001661 0.74221 41.0811
443 2EW1 GNP 0.000000000001019 0.82315 42.1622
444 2A5J GDP 0.0000000001049 0.77418 42.1622
445 3CPJ GDP 0.000000002363 0.63793 42.1622
446 3RWO GDP 0.000000002447 0.61558 42.1622
447 1OIX GDP 0.00000000001651 0.77857 42.7027
448 1OIV GDP 0.000000002231 0.68643 43.2432
449 1VG8 GNP 0.000000000002867 0.815 43.7838
450 2BME GNP 0.000000000001198 0.73379 43.7838
451 1VG0 GDP 0.000000001575 0.64354 43.7838
452 1VG9 GDP 0.0000000003435 0.64176 43.7838
453 1VG1 GDP 0.0000000003825 0.63937 43.7838
454 1X1R GDP 0.0000000002577 0.63659 43.8202
455 2HT6 GDP 0.0000000007451 0.60003 44.2529
456 3Q72 GNP 0.0000000002787 0.6106 44.5783
457 5JCZ GDP 0.000000002785 0.67846 44.6927
458 5TAR GDP 0.000000004011 0.69077 44.8649
459 5TB5 GDP 0.00000000163 0.62939 44.8649
460 4LX0 BEF GDP 0.000000000001101 0.83308 45.1977
461 2HV8 GTP 0.00000000004221 0.76095 45.9302
462 4DSU GDP 0.0000000001049 0.65187 45.9459
463 2F9L GDP 0.000000004974 0.62925 45.9459
464 1TU3 GNP 0.000000000003271 0.71955 46.1988
465 4C4P GNP 0.00000000008026 0.75212 46.2428
466 3MJH GTP 0.0000000000005062 0.74684 46.4286
467 1EK0 GNP 0.000000000007304 0.70585 46.4706
468 1R2Q GNP 0.000000000004001 0.613 46.4706
469 4DKX GDP 0.000000000064 0.81072 46.4865
470 1Z0K GTP 0.000000000002328 0.75924 46.5116
471 5UQW GDP 0.0000000002445 0.7247 46.5608
472 2Y8E GNP 0.00000000000144 0.73222 46.9274
473 2BCG GDP 0.0000000009192 0.69925 47.027
474 1G16 GDP 0.000000006299 0.63879 47.0588
475 1KY3 GDP 0.000000001222 0.64778 47.2527
476 2D7C GTP 0.00000000006489 0.67476 47.3054
477 3Q85 GNP 0.000000001467 0.74483 47.3373
478 1Z0A GDP 0.0000000001859 0.76271 47.7011
479 2EFE GNH 0.000000003098 0.69583 48.0663
480 1YZN GNP 0.0000000000006022 0.72851 48.1081
481 3TNF GNP 0.000000000000877 0.8409 48.2759
482 3QBT GNP 0.0000000000007991 0.74006 48.2759
483 4LHW GNP 0.000000000007395 0.70767 48.2759
484 1ZC3 GNP 0.00000000000597 0.80116 48.5714
485 3T5G GDP 0.000000001067 0.63649 48.6188
486 1YZQ GNP 0.000000000002964 0.70596 48.8235
487 5XCO GDP 0.000000001051 0.64968 49.1228
488 1UAD GNP 0.0000000000005037 0.74652 49.1429
489 1Z0F GDP 0.0000000001463 0.78003 49.162
490 2A9K GDP 0.00000000223 0.64948 49.1979
491 1D5C GDP 0.0000000012 0.70408 49.3827
492 3RAB GNP 0.000000000000559 0.84216 49.7041
493 5O2T GSP 0.0000000000009746 0.72181 49.7041
494 4D0G GTP 0.00000000007338 0.74001 49.7143
495 1XTQ GDP 0.00000000009553 0.73877 49.7175
496 5UFQ GNP 0.00000000002589 0.77012 50
Pocket No.: 2; Query (leader) PDB : 2W2X; Ligand: GSP; Similar sites found: 14
This union binding pocket(no: 2) in the query (biounit: 2w2x.bio1) has 23 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 1PTR PRB 0.03054 0.4004 None
2 4CR6 MAN 0.0211 0.40348 3.78378
3 1VBO MAN 0.02421 0.40232 4.32432
4 3BP1 GUN 0.01156 0.43068 5.64516
5 3PA8 621 0.02622 0.40282 7.02703
6 4IOK XPO 0.003103 0.40109 7.25806
7 3BD9 A3P 0.01014 0.41104 8.06452
8 3B2Q AES 0.008091 0.40841 8.87097
9 1I1N SAH 0.006484 0.4081 8.87097
10 1O8B ABF 0.02427 0.40041 9.72973
11 4U60 SIA GAL NGA 0.004924 0.44023 10.4839
12 4U60 SIA 0.006224 0.43318 10.4839
13 1XVB BBX 0.03301 0.40836 12.0968
14 1JT1 MCO 0.03754 0.40084 18.9189
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