Receptor
PDB id Resolution Class Description Source Keywords
2W7J 1.68 Å EC: 2.1.2.1 CRYSTAL STRUCTURE OF Y61ABSSHMT GLYCINE EXTERNAL ALDIMINE GEOBACILLUS STEAROTHERMOPHILUS ONE-CARBON METABOLISM PLP-DEPENDENT ENZYMES TRANSFERASE
Ref.: IMPORTANCE OF TYROSINE RESIDUES OF BACILLUS STEAROTHERMOPHILUS SERINE HYDROXYMETHYLTRANSFERASE COFACTOR BINDING AND L-ALLO-THR CLEAVAGE. FEBS J. V. 275 4606 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GLY PLP A:601;
Valid;
none;
submit data n/a n/a n/a n/a
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2VMQ 1.67 Å EC: 2.1.2.1 STRUCTURE OF N341ABSSHMT CRYSTALLIZED IN THE PRESENCE OF L- ALLO-THR BACILLUS STEAROTHERMOPHILUS PLP-DEPENDENT ENZYMES SERINE HYDROXYMETHYLTRANSFERASE SHMT N341A TRANSFERASE FOLATE BINDING PYRIDOXAL PHOSPHATE ONE-CARBON METABOLISM
Ref.: STRUCTURAL AND FUNCTIONAL STUDIES OF BACILLUS STEAROTHERMOPHILUS SERINE HYDROXYMETHYLTRANSFERASE: THE ROLE OF ASN(341), TYR(60) AND PHE(351) IN TETRAHYDROFOLATE BINDING. BIOCHEM.J. V. 418 635 2009
Members (17)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2VMO - GLY PLP n/a n/a
2 2VMQ - GLY PLP n/a n/a
3 2W7F - SER PLP n/a n/a
4 2W7L - PLP ALO n/a n/a
5 1KKP - PLP SER n/a n/a
6 2VMP - SER PLP n/a n/a
7 1YJY - PLP SER n/a n/a
8 2VMW - SER PLP n/a n/a
9 2W7K - SER PLP n/a n/a
10 1KL1 - PLP GLY n/a n/a
11 2W7J - GLY PLP n/a n/a
12 2W7M - GLY PLP n/a n/a
13 2VMX - PLP ALO n/a n/a
14 1YJZ - PLP C8 H10 N O6 P Cc1c(c(c(c....
15 2VMT - SER PLP n/a n/a
16 2W7G - PLP ALO n/a n/a
17 1YJS - PLP GLY n/a n/a
70% Homology Family (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2VMO - GLY PLP n/a n/a
2 2VMQ - GLY PLP n/a n/a
3 2W7F - SER PLP n/a n/a
4 2W7L - PLP ALO n/a n/a
5 1KKP - PLP SER n/a n/a
6 2VMP - SER PLP n/a n/a
7 1YJY - PLP SER n/a n/a
8 2VMW - SER PLP n/a n/a
9 2W7K - SER PLP n/a n/a
10 1KL1 - PLP GLY n/a n/a
11 2W7J - GLY PLP n/a n/a
12 2W7M - GLY PLP n/a n/a
13 2VMX - PLP ALO n/a n/a
14 1YJZ - PLP C8 H10 N O6 P Cc1c(c(c(c....
15 2VMT - SER PLP n/a n/a
16 2W7G - PLP ALO n/a n/a
17 1YJS - PLP GLY n/a n/a
18 4WXG - 2BO C12 H19 N2 O8 P Cc1c(c(c(c....
19 4WXB - CIT C6 H8 O7 C(C(=O)O)C....
20 4WXF - PLG C10 H15 N2 O7 P Cc1c(c(c(c....
21 1DFO - PLG C10 H15 N2 O7 P Cc1c(c(c(c....
50% Homology Family (37)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2VMO - GLY PLP n/a n/a
2 2VMQ - GLY PLP n/a n/a
3 2W7F - SER PLP n/a n/a
4 2W7L - PLP ALO n/a n/a
5 1KKP - PLP SER n/a n/a
6 2VMP - SER PLP n/a n/a
7 1YJY - PLP SER n/a n/a
8 2VMW - SER PLP n/a n/a
9 2W7K - SER PLP n/a n/a
10 1KL1 - PLP GLY n/a n/a
11 2W7J - GLY PLP n/a n/a
12 2W7M - GLY PLP n/a n/a
13 2VMX - PLP ALO n/a n/a
14 1YJZ - PLP C8 H10 N O6 P Cc1c(c(c(c....
15 2VMT - SER PLP n/a n/a
16 2W7G - PLP ALO n/a n/a
17 1YJS - PLP GLY n/a n/a
18 4WXG - 2BO C12 H19 N2 O8 P Cc1c(c(c(c....
19 4WXB - CIT C6 H8 O7 C(C(=O)O)C....
20 4WXF - PLG C10 H15 N2 O7 P Cc1c(c(c(c....
21 5GVN ic50 = 90 nM G6F C26 H25 F N4 O3 Cc1c2c(n[n....
22 5XMV - 8AU C24 H20 Cl F3 N4 O Cc1c2c(n[n....
23 5YFZ - 8UO C24 H28 F N5 O3 Cc1c2c(n[n....
24 5XMQ - 8A6 C32 H30 F3 N5 O3 S Cc1c2c(n[n....
25 4TN4 - 33G C25 H20 F N5 O Cc1c2c(n[n....
26 5GVL ic50 = 42 nM GI8 C24 H23 N5 O2 S Cc1c2c(n[n....
27 5XMP - 8A3 C27 H25 F6 N5 O3 S Cc1c2c(n[n....
28 5GVM ic50 = 186 nM G57 C26 H23 F3 N4 O3 Cc1c2c(n[n....
29 5XMS - 8B3 C24 H20 F4 N4 O Cc1c2c(n[n....
30 5YG4 - 8UF C25 H28 F N5 O3 Cc1c2c(n[n....
31 5XMU - 8A0 C25 H23 F3 N4 O Cc1ccccc1c....
32 5YG3 - 8UC C23 H20 F N5 O Cc1c2c(n[n....
33 5GVK Kd = 99 nM G45 C24 H24 N6 O3 S2 Cc1c2c(n[n....
34 5YG2 - N05 C25 H30 F N5 O3 Cc1c2c(n[n....
35 5GVP ic50 = 165 nM GCF C27 H25 F3 N4 O3 Cc1c2c(n[n....
36 5V7I - GLY C2 H5 N O2 C(C(=O)O)N
37 1DFO - PLG C10 H15 N2 O7 P Cc1c(c(c(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GLY PLP; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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