-->
Receptor
PDB id Resolution Class Description Source Keywords
2WA2 1.8 Å NON-ENZYME: STRUCTURAL STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV) MODOC VIRUS TRANSFERASE S-ADENOSYL-L- METHIONINE VIRION MEMBRANE FLAVIVIRUS MODOC VIRUS N7-METHYLTRANSFERASE 2-prime -O-METHYLTRANSFERASE TRANSMEMBRANE ENVELOPE PROTEIN METHYLTRANSFERASE
Ref.: STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM THE MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR. ACTA CRYSTALLOGR.,SECT.D V. 65 796 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SAM A:1248;
B:1267;
Valid;
Valid;
none;
none;
submit data
398.437 C15 H22 N6 O5 S C[S@@...
SO4 A:1249;
B:1268;
B:1269;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WA2 1.8 Å NON-ENZYME: STRUCTURAL STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR (NKV) MODOC VIRUS TRANSFERASE S-ADENOSYL-L- METHIONINE VIRION MEMBRANE FLAVIVIRUS MODOC VIRUS N7-METHYLTRANSFERASE 2-prime -O-METHYLTRANSFERASE TRANSMEMBRANE ENVELOPE PROTEIN METHYLTRANSFERASE
Ref.: STRUCTURE OF THE METHYLTRANSFERASE DOMAIN FROM THE MODOC VIRUS, A FLAVIVIRUS WITH NO KNOWN VECTOR. ACTA CRYSTALLOGR.,SECT.D V. 65 796 2009
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 2WA2 - SAM C15 H22 N6 O5 S C[S@@+](CC....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2WA2 - SAM C15 H22 N6 O5 S C[S@@+](CC....
50% Homology Family (47)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 3EVA - SAH C14 H20 N6 O5 S c1nc(c2c(n....
2 3EVC - SAH C14 H20 N6 O5 S c1nc(c2c(n....
3 3EVF - SAH C14 H20 N6 O5 S c1nc(c2c(n....
4 3EVB - SAH C14 H20 N6 O5 S c1nc(c2c(n....
5 3EVD - SAH C14 H20 N6 O5 S c1nc(c2c(n....
6 3EVE - SAH C14 H20 N6 O5 S c1nc(c2c(n....
7 3ELU - SAM C15 H22 N6 O5 S C[S@@+](CC....
8 3ELW - SAM C15 H22 N6 O5 S C[S@@+](CC....
9 3EMD - SFG C15 H23 N7 O5 c1nc(c2c(n....
10 3ELD - SFG C15 H23 N7 O5 c1nc(c2c(n....
11 3ELY - SAH C14 H20 N6 O5 S c1nc(c2c(n....
12 3EMB - SAM C15 H22 N6 O5 S C[S@@+](CC....
13 2P3L - G3A C20 H27 N10 O17 P3 c1nc(c2c(n....
14 2P41 - G1G C22 H32 N10 O18 P3 Cn1c[n+](c....
15 1L9K - SAH C14 H20 N6 O5 S c1nc(c2c(n....
16 5M5B - SAM C15 H22 N6 O5 S C[S@@+](CC....
17 5GOZ - GTP C10 H16 N5 O14 P3 c1nc2c(n1[....
18 5GP1 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
19 5KQR - SAM C15 H22 N6 O5 S C[S@@+](CC....
20 5NJU - SAH C14 H20 N6 O5 S c1nc(c2c(n....
21 5ULP Kd = 24.3 uM KB1 C21 H26 F N7 O5 c1cc(ccc1C....
22 5MRK - SFG C15 H23 N7 O5 c1nc(c2c(n....
23 5NJV - SAM C15 H22 N6 O5 S C[S@@+](CC....
24 5WXB - SAH C14 H20 N6 O5 S c1nc(c2c(n....
25 5KQS - SAM C15 H22 N6 O5 S C[S@@+](CC....
26 3LKZ - SFG C15 H23 N7 O5 c1nc(c2c(n....
27 3EVG - SAH C14 H20 N6 O5 S c1nc(c2c(n....
28 2PX5 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
29 2PXA - SAH C14 H20 N6 O5 S c1nc(c2c(n....
30 2PX8 - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
31 2PX2 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
32 2PX4 - SAH C14 H20 N6 O5 S c1nc(c2c(n....
33 5E9Q - SAM C15 H22 N6 O5 S C[S@@+](CC....
34 5EHG - 5O0 C20 H16 Cl N3 O6 S c1cc(cc(c1....
35 5EKX - 2CQ C7 H9 Cl N2 Cc1cc(c(cc....
36 4R8S - SFG C15 H23 N7 O5 c1nc(c2c(n....
37 4CTJ - 3A9 C9 H8 O3 c1cc2c(cc1....
38 4CTK - SAM C15 H22 N6 O5 S C[S@@+](CC....
39 5EC8 - 5LP C15 H14 Cl N3 O3 Cc1ccc(c(c....
40 5EIW - X0V C7 H7 F3 N2 c1cc(c(cc1....
41 3P8Z - SAH C14 H20 N6 O5 S c1nc(c2c(n....
42 5CUQ ic50 = 7.7 uM NSC C21 H20 N6 O Cc1cc(c2cc....
43 5EIF - 4M0 C8 H9 N O2 Cc1ccc(c(c....
44 5EHI - 5O3 C20 H17 Cl N4 O5 S c1cc(cc(c1....
45 3P97 - SAM C15 H22 N6 O5 S C[S@@+](CC....
46 3GCZ - SAM C15 H22 N6 O5 S C[S@@+](CC....
47 2WA2 - SAM C15 H22 N6 O5 S C[S@@+](CC....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SAM; Similar ligands found: 202
No: Ligand ECFP6 Tc MDL keys Tc
1 SAM 1 1
2 SMM 0.792683 0.96
3 S4M 0.6875 0.909091
4 S7M 0.670455 0.945946
5 M2T 0.636364 0.878378
6 GEK 0.612903 0.931507
7 SAI 0.571429 0.878378
8 ADN 0.565789 0.773333
9 RAB 0.565789 0.773333
10 XYA 0.565789 0.773333
11 5CD 0.564103 0.783784
12 EP4 0.5625 0.826667
13 SA8 0.56044 0.945205
14 SFG 0.555556 0.875
15 5X8 0.555556 0.888889
16 5N5 0.551282 0.773333
17 A4D 0.544304 0.797297
18 EEM 0.542553 0.945946
19 SAH 0.537634 0.916667
20 DTA 0.536585 0.789474
21 62X 0.535354 0.884615
22 MTA 0.53012 0.875
23 3DH 0.517647 0.849315
24 5AL 0.510417 0.743902
25 54H 0.510204 0.673913
26 VMS 0.510204 0.673913
27 0UM 0.51 0.857143
28 AMP 0.505747 0.707317
29 LMS 0.505747 0.666667
30 A 0.505747 0.707317
31 ABM 0.505618 0.753086
32 A5A 0.505155 0.688889
33 SON 0.5 0.746988
34 SSA 0.5 0.684783
35 6RE 0.5 0.78481
36 K15 0.5 0.883117
37 5AD 0.5 0.75
38 SRP 0.5 0.746988
39 LSS 0.49505 0.706522
40 CA0 0.494624 0.714286
41 A12 0.494505 0.705882
42 AP2 0.494505 0.705882
43 ME8 0.490385 0.841463
44 TSB 0.49 0.681319
45 53H 0.49 0.666667
46 DAL AMP 0.49 0.765432
47 5CA 0.49 0.684783
48 ACP 0.489362 0.694118
49 ADP 0.48913 0.690476
50 5AS 0.48913 0.648936
51 J7C 0.488889 0.772152
52 A2D 0.488889 0.690476
53 ZAS 0.488636 0.769231
54 9ZD 0.485149 0.729412
55 9ZA 0.485149 0.729412
56 8QN 0.485149 0.743902
57 GAP 0.484536 0.73494
58 AN2 0.483871 0.682353
59 A3S 0.483871 0.813333
60 A7D 0.483871 0.851351
61 GJV 0.483516 0.775
62 SRA 0.483146 0.694118
63 LAD 0.480769 0.752941
64 KAA 0.480769 0.698925
65 GSU 0.480769 0.722222
66 AMO 0.480392 0.746988
67 DSZ 0.480392 0.703297
68 52H 0.48 0.666667
69 M33 0.478723 0.722892
70 BA3 0.478261 0.690476
71 MAO 0.478261 0.82716
72 NEC 0.477778 0.75
73 AOC 0.477778 0.776316
74 DSH 0.477778 0.842105
75 SXZ 0.47619 0.894737
76 AHX 0.475728 0.701149
77 NVA LMS 0.475728 0.736264
78 Y3J 0.47561 0.706667
79 G5A 0.474227 0.684783
80 A3T 0.473684 0.8
81 B4P 0.473118 0.690476
82 AP5 0.473118 0.690476
83 A3N 0.472527 0.766234
84 KB1 0.471698 0.833333
85 PRX 0.46875 0.73494
86 APC 0.46875 0.705882
87 AT4 0.468085 0.686047
88 PAJ 0.466019 0.712644
89 4AD 0.466019 0.759036
90 RBY 0.463918 0.72619
91 ADP PO3 0.463918 0.728395
92 ADV 0.463918 0.72619
93 ADX 0.463158 0.666667
94 MHZ 0.463158 0.82716
95 AU1 0.463158 0.674419
96 YAP 0.462963 0.738095
97 TXA 0.462264 0.72619
98 NB8 0.462264 0.72093
99 A3G 0.461538 0.802632
100 VRT 0.459184 0.842105
101 XAH 0.458716 0.715909
102 YSA 0.458716 0.684783
103 HEJ 0.458333 0.690476
104 50T 0.458333 0.682353
105 ATP 0.458333 0.690476
106 LEU LMS 0.457143 0.717391
107 7D7 0.45679 0.723684
108 KH3 0.455357 0.871795
109 ACQ 0.454545 0.694118
110 AR6 0.453608 0.710843
111 APR 0.453608 0.710843
112 AQP 0.453608 0.690476
113 5FA 0.453608 0.690476
114 NSS 0.451923 0.703297
115 FA5 0.449541 0.746988
116 A5D 0.44898 0.789474
117 AD9 0.44898 0.674419
118 AGS 0.44898 0.678161
119 SAP 0.44898 0.678161
120 PTJ 0.448598 0.72093
121 YLB 0.448276 0.758621
122 YLP 0.447368 0.738636
123 8X1 0.446602 0.680851
124 D3Y 0.446602 0.792208
125 ADP ALF 0.445545 0.678161
126 ALF ADP 0.445545 0.678161
127 3AM 0.444444 0.674699
128 MYR AMP 0.444444 0.776471
129 OAD 0.443396 0.73494
130 2VA 0.443299 0.779221
131 S8M 0.442308 0.831169
132 OOB 0.442308 0.722892
133 TYR AMP 0.441441 0.759036
134 6YZ 0.441176 0.694118
135 ADP VO4 0.441176 0.702381
136 VO4 ADP 0.441176 0.702381
137 T99 0.44 0.686047
138 TAT 0.44 0.686047
139 ANP 0.44 0.674419
140 WAQ 0.439252 0.75
141 B5Y 0.436364 0.717647
142 8PZ 0.436364 0.684783
143 F0P 0.435897 0.844156
144 YLC 0.435897 0.755814
145 AAT 0.435644 0.797468
146 1ZZ 0.435185 0.755814
147 9K8 0.435185 0.663158
148 3OD 0.435185 0.73494
149 NVA 2AD 0.434343 0.855263
150 00A 0.433962 0.689655
151 DLL 0.433962 0.722892
152 ARG AMP 0.433628 0.727273
153 7MD 0.433628 0.715909
154 ATF 0.431373 0.666667
155 SO8 0.43 0.792208
156 3UK 0.429907 0.714286
157 A6D 0.429907 0.72619
158 9X8 0.429907 0.717647
159 F2R 0.429752 0.7
160 5SV 0.428571 0.741176
161 AMP DBH 0.428571 0.714286
162 TYM 0.42735 0.746988
163 WSA 0.42735 0.692308
164 9SN 0.427273 0.681818
165 AHZ 0.426087 0.755814
166 P5A 0.425926 0.691489
167 B5V 0.425926 0.705882
168 PR8 0.425926 0.744186
169 A A 0.425926 0.710843
170 3NZ 0.425926 0.807692
171 A1R 0.424528 0.709302
172 2A5 0.424242 0.674419
173 7MC 0.423729 0.719101
174 B5M 0.423423 0.717647
175 7D5 0.422222 0.658824
176 JB6 0.422018 0.709302
177 FYA 0.422018 0.722892
178 AYB 0.421488 0.75
179 A22 0.419048 0.682353
180 MAP 0.419048 0.659091
181 2AM 0.417582 0.666667
182 TAD 0.417391 0.712644
183 A3P 0.416667 0.686747
184 ADP BMA 0.416667 0.714286
185 25A 0.415094 0.690476
186 YLA 0.413223 0.719101
187 8Q2 0.411765 0.663158
188 A3R 0.411215 0.709302
189 ADQ 0.411215 0.694118
190 48N 0.410256 0.72093
191 0XU 0.41 0.824324
192 GA7 0.408696 0.72619
193 7D3 0.40625 0.643678
194 PAP 0.405941 0.678571
195 DQV 0.405172 0.702381
196 OVE 0.404255 0.662791
197 4UV 0.403509 0.697674
198 AF3 ADP 3PG 0.403361 0.712644
199 3AD 0.402299 0.783784
200 CMP 0.402062 0.691358
201 2BA 0.402062 0.682927
202 7C5 0.4 0.731707
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WA2; Ligand: SAM; Similar sites found with APoc: 739
This union binding pocket(no: 1) in the query (biounit: 2wa2.bio2) has 20 residues
No: Leader PDB Ligand Sequence Similarity
1 1WMA NDP None
2 1WMA AB3 None
3 1MXH DHF 1.08696
4 1MXH NAP 1.08696
5 3LCV SAM 1.08696
6 3PFG TLO 1.14068
7 3PFG SAM 1.14068
8 5N0J FAD 1.44928
9 4FC7 COA 1.44928
10 4FC7 NAP 1.44928
11 1LLU NAD 1.44928
12 2DTX BMA 1.51515
13 1V35 NAI 1.51976
14 4U00 ADP 1.63934
15 2YX1 SFG 1.81159
16 4ONQ SFG 1.81159
17 4DMG SAM 1.81159
18 3HDY FAD 1.81159
19 3HDY FDA 1.81159
20 3HDY GDU 1.81159
21 5DNK SAH 1.81159
22 1RLZ NAD 1.81159
23 2CDU FAD 1.81159
24 4OHU 2TK 1.81159
25 4OHU NAD 1.81159
26 5L4S 6KX 1.81159
27 5L4S NAP 1.81159
28 2XT3 ADP 1.81159
29 2PZM UDP 1.81159
30 2PZM NAD 1.81159
31 1GET FAD 1.81159
32 1GET NAP 1.81159
33 3AYI HCI 1.81159
34 3AYI FAD 1.81159
35 4JNA FAD 1.81159
36 3QWI NAP 1.81159
37 3QWI CUE 1.81159
38 1BDB NAD 1.81159
39 3OZ2 FAD 1.81159
40 4BV6 FAD 1.82556
41 1AE1 NAP 1.8315
42 4XUC SAM 1.83486
43 4XUC 43G 1.83486
44 1NFQ NAI 1.92308
45 1Q0S SAH 1.9305
46 1JJV ATP 1.94175
47 2BD0 NAP 2.04918
48 3G2O SAM 2.17391
49 2DPM SAM 2.17391
50 5KVA SAM 2.17391
51 6D6Y SAH 2.17391
52 5F8F SFG 2.17391
53 4RPL 3UC 2.17391
54 4RPL FAD 2.17391
55 3U4C NDP 2.17391
56 5EJ2 NAD 2.17391
57 1EK6 NAI 2.17391
58 1RKX NAD 2.17391
59 3WXB NDP 2.17391
60 5YF1 SFG 2.17391
61 5YF1 8V0 2.17391
62 6B92 SAH 2.17391
63 1GOJ ADP 2.17391
64 2VVL FAD 2.17391
65 6F97 FAD 2.17391
66 1QO8 FAD 2.17391
67 1D7O TCL 2.17391
68 1D7O NAD 2.17391
69 2GMH FAD 2.17391
70 2VVM FAD 2.17391
71 2PK3 A2R 2.17391
72 1EK6 UPG 2.17391
73 3JQF NAP 2.17391
74 2GN4 UD1 2.17391
75 3JQG NAP 2.17391
76 1E1M FAD 2.17391
77 1E1M NAP 2.17391
78 4WZ6 ATP 2.17391
79 4O1M NAD 2.17391
80 4GKV NAD 2.17391
81 3LZW NAP 2.17391
82 3LZW FAD 2.17391
83 4X7Y SAH 2.18978
84 6F9Q NAD 2.20588
85 2VZ0 D64 2.23881
86 2VZ0 NAP 2.23881
87 2WD7 NAP 2.23881
88 1O5O U5P 2.26244
89 3GD4 NAD 2.34834
90 3GD4 FAD 2.34834
91 6GFK SAH 2.39044
92 6FDF SAH 2.39521
93 1QAN SAH 2.45902
94 3GDH SAH 2.48963
95 5O98 NAP 2.52366
96 4N49 SAM 2.53623
97 3GU3 SAH 2.53623
98 6ECW SAH 2.53623
99 4KRG SAH 2.53623
100 4M73 M72 2.53623
101 4M73 SAH 2.53623
102 4KIB SAH 2.53623
103 3VYW SAM 2.53623
104 5W7M SAH 2.53623
105 1WG8 SAM 2.53623
106 4EUE NAI 2.53623
107 4HXY NDP 2.53623
108 1O97 FAD 2.53623
109 2AWN ADP 2.53623
110 4PIO AVI 2.53623
111 4PIO SAH 2.53623
112 1O97 AMP 2.53623
113 3THR C2F 2.53623
114 4A6D SAM 2.53623
115 1XKQ NDP 2.53623
116 1UWK URO 2.53623
117 1UWK NAD 2.53623
118 1XHL NDP 2.53623
119 3H4V DVP 2.53623
120 3H4V NAP 2.53623
121 3O03 NAP 2.53623
122 5OC1 FAD 2.53623
123 1YQZ FAD 2.53623
124 1PS9 FAD 2.53623
125 3QVP FAD 2.53623
126 5CG1 NAD BBN 2.53623
127 2GKS ADP 2.53623
128 5I7S E9P 2.53623
129 5I7S NAD 2.53623
130 3O26 NDP 2.53623
131 2XVE FAD 2.53623
132 1G0N NDP 2.53623
133 1G0N PHH 2.53623
134 2Q7V FAD 2.53623
135 5NA1 FAD 2.53623
136 5MBX SP5 2.53623
137 5MBX FAD 2.53623
138 1H5Q NAP 2.53623
139 3LRE ADP 2.53623
140 2XVF FAD 2.53623
141 2WET FAD 2.53623
142 5FJN FAD 2.53623
143 5FJN BE2 2.53623
144 5GSN NAP 2.53623
145 5GSN FAD 2.53623
146 3RUV ANP 2.53623
147 5TS5 FAD 2.53623
148 1XCL SAH 2.55319
149 3A4T SFG 2.55474
150 3FUU ADN 2.58303
151 1H9A NAP 2.68041
152 4R6W PC 2.71318
153 4R6W SAH 2.71318
154 3VZS CAA 2.72374
155 1GEG NAD 2.73438
156 2WSB NAD 2.75591
157 2NXE SAM 2.75591
158 3G89 SAM 2.81124
159 3NUG NAD 2.83401
160 1C3V PDC 2.85714
161 1NV8 SAM 2.89855
162 2JHP SAH 2.89855
163 4YUW 4JU 2.89855
164 3FPF TNA 2.89855
165 3FPF MTA 2.89855
166 5JGL SAM 2.89855
167 5F2K OCA 2.89855
168 5F2K SAH 2.89855
169 4YUW S4M 2.89855
170 4YAC NAI 2.89855
171 5GWT NAD 2.89855
172 1RJD SAM 2.89855
173 5GWT SIN 2.89855
174 3GDN HBX 2.89855
175 3GDN FAD 2.89855
176 4MIG G3F 2.89855
177 3Q9T FAY 2.89855
178 5WGR FAD 2.89855
179 2Z3Y F2N 2.89855
180 3I53 SAH 2.89855
181 1I8T FAD 2.89855
182 6EL3 NAP 2.89855
183 2V6G NAP 2.89855
184 1SB8 UD2 2.89855
185 1SB8 NAD 2.89855
186 2VVG ADP 2.89855
187 4ZRN NAD 2.89855
188 4NTC FAD 2.89855
189 4ZRN UPG 2.89855
190 5WC2 ADP 2.89855
191 5BRT FAD 2.89855
192 3AXB FAD 2.89855
193 3AXB PRO 2.89855
194 6GAS FAD 2.89855
195 1NV8 MEQ 2.89855
196 5NII FAD 2.89855
197 4IEE AGS 2.89855
198 4O0L NDP 2.90909
199 3EGI ADP 2.91262
200 3T7S SAM 2.98507
201 3OIG NAD 3.00752
202 1P1C SAH 3.01508
203 1ZEM NAD 3.05344
204 1B0U ATP 3.05344
205 2PZE ATP 3.05677
206 1NNU TCT 3.05677
207 1NNU NAD 3.05677
208 1R18 SAH 3.0837
209 6CI9 NAP 3.0888
210 5N5D SAM 3.09735
211 3AFN NAP 3.10078
212 5ZW3 SAH 3.11111
213 4NBW NAD 3.11284
214 1E6E FAD 3.125
215 3FRH SAH 3.16206
216 4URF NAD 3.22581
217 5JE0 SAH 3.23887
218 5JE0 AZ8 3.23887
219 2ZIF SAM 3.26087
220 1G55 SAH 3.26087
221 3TLJ SAH 3.26087
222 5HJM MTA 3.26087
223 3C6K SPD 3.26087
224 3C6K MTA 3.26087
225 5ICE SAH 3.26087
226 5ICE 2H4 3.26087
227 3TKA SAM 3.26087
228 3M6W SAM 3.26087
229 3GWZ SAH 3.26087
230 1FP2 SAH 3.26087
231 4KRI SAH 3.26087
232 5X62 SAH 3.26087
233 3GXO SAH 3.26087
234 1V59 NAD 3.26087
235 1V59 FAD 3.26087
236 3GF4 FAD 3.26087
237 4D5G TPP 3.26087
238 2WHX ADP 3.26087
239 1FP2 HMO 3.26087
240 3GF4 UPG 3.26087
241 1XSE NDP 3.26087
242 2C7G FAD 3.26087
243 2C7G ODP 3.26087
244 3GRU AMP 3.26087
245 2C9O ADP 3.26087
246 4YAG NAI 3.26087
247 3EYA FAD 3.26087
248 4J7U YTZ 3.26087
249 4J7U NAP 3.26087
250 1TZD ADP 3.27273
251 1PR9 NAP 3.27869
252 3D3W NAP 3.27869
253 4NBT NAD 3.33333
254 2GDZ NAD 3.37079
255 3RFV 15L 3.37079
256 3RFV NAI 3.37079
257 1T57 FMN 3.39806
258 5LOG SAH 3.43348
259 2BZG SAH 3.44828
260 3BGD PM6 3.46154
261 3BGD SAH 3.46154
262 3TN7 NJP 3.50195
263 5FTW SAH 3.51562
264 4LJ9 ACP 3.53982
265 3P2E SAH 3.55556
266 2JBH 5GP 3.55556
267 6DUB SAH 3.6036
268 3HVJ 705 3.61991
269 5E9W SAH 3.62319
270 1SQF SAM 3.62319
271 1I9G SAM 3.62319
272 5THY SAH 3.62319
273 5U19 827 3.62319
274 5U19 SAH 3.62319
275 1FP1 SAH 3.62319
276 4BLW AMP 3.62319
277 2O07 MTA 3.62319
278 2O07 SPD 3.62319
279 1MO9 KPC 3.62319
280 1MO9 FAD 3.62319
281 2FR1 NDP 3.62319
282 1U2Z SAH 3.62319
283 5VN0 FAD 3.62319
284 2AOT SAH 3.62319
285 3LAD FAD 3.62319
286 2GV8 FAD 3.62319
287 5VN0 NAI 3.62319
288 3ABI NAD 3.62319
289 2JB2 FAD 3.62319
290 2JB2 PHE 3.62319
291 2GVC FAD 3.62319
292 1VL0 NAI 3.62319
293 1JQD SAH 3.62319
294 3CTY FAD 3.62319
295 1VQW FAD 3.62319
296 2IVD FAD 3.62319
297 1JQD HSM 3.62319
298 4BLW SAH 3.62319
299 5MLR GRQ 3.62319
300 5MLR NAP 3.62319
301 1Z3C SA8 3.62319
302 2IID PHE 3.62319
303 2IID FAD 3.62319
304 6DNT NAD 3.62319
305 3LU1 NAD 3.62319
306 1VL8 NAP 3.74532
307 3BXO SAM 3.76569
308 2CUL FAD 3.87931
309 1G6H ADP 3.89105
310 1FK8 NAD 3.89105
311 2W58 ADP 3.9604
312 1I1N SAH 3.98551
313 6ECU SAH 3.98551
314 5YJI 8WO 3.98551
315 5YJI SAH 3.98551
316 5FUB SAH 3.98551
317 3LST SAH 3.98551
318 3V1U NAD 3.98551
319 3QOX SAH 3.98551
320 1ZGA SAH 3.98551
321 1UDB UFG 3.98551
322 1UDB NAD 3.98551
323 5K4W THR 3.98551
324 5K4W NAI 3.98551
325 1QG6 NAD 3.98551
326 2Q0L FAD 3.98551
327 1QG6 TCL 3.98551
328 5K0A FAD 3.98551
329 1ZK7 FAD 3.98551
330 4CNK FAD 3.98551
331 4AP3 NAP 3.98551
332 4AP3 FAD 3.98551
333 4EIP FAD 3.98551
334 1D1T NAD 3.98551
335 1CDO NAD 3.98551
336 4IV9 FAD 3.98551
337 4USR FAD 3.98551
338 1E5Q NDP 3.98551
339 4BFW ZVW 3.98551
340 1GZ6 NAI 3.98551
341 5J60 FAD 3.98551
342 5EEH P9P 3.98936
343 5EEH SAH 3.98936
344 4POO SAM 4
345 2EWM NAD 4.01606
346 3A27 SAM 4.04412
347 3GEG NAD 4.04858
348 5Z2L NDP 4.08163
349 5BTX CMP 4.10959
350 2A14 SAH 4.18251
351 1XX6 ADP 4.18848
352 5UFN SAH 4.20168
353 5MGZ SAH 4.23729
354 3OID NDP 4.26357
355 5GVR LMR 4.2735
356 3CBG SAH 4.31034
357 4GQB 0XU 4.34783
358 5MW4 5JU 4.34783
359 4X60 3XV 4.34783
360 4X60 SFG 4.34783
361 5YJF SAH 4.34783
362 5YJF 8WO 4.34783
363 5M58 SAH 4.34783
364 1F3L SAH 4.34783
365 5FA5 MTA 4.34783
366 1Y8Q ATP 4.34783
367 5JCM NAD 4.34783
368 5JCM ISD 4.34783
369 5JCM FAD 4.34783
370 4ITU NAI 4.34783
371 4ITU 1HS 4.34783
372 4ZA2 NAD 4.34783
373 5WS9 AMP 4.34783
374 4GLL NAD 4.34783
375 1GTE FAD 4.34783
376 4D42 NAP 4.34783
377 4D42 W0I 4.34783
378 1GPE FAD 4.34783
379 1ZBQ NAD 4.34783
380 3RNM FAD 4.34783
381 2WK1 SAH 4.34783
382 3U31 NAD 4.34783
383 1JA9 NDP 4.37956
384 5T2U NAP 4.43548
385 3AY6 NAI 4.46097
386 3AY6 BGC 4.46097
387 1UAY ADN 4.54545
388 5E1M SAH 4.56432
389 5E1M PRO PRO LYS ARG ILE ALA 4.56432
390 3DXY SAM 4.58716
391 3JWH SAH 4.60829
392 3C3Y SAH 4.64135
393 3A4V NAD 4.71014
394 3A4V PYR 4.71014
395 5O42 NAD 4.71014
396 5O42 9JW 4.71014
397 5O42 BGC 4.71014
398 4AZW SAM 4.71014
399 5DLY SAH 4.71014
400 5DLY 5D7 4.71014
401 2Q1S NAI 4.71014
402 4O48 ASP 4.71014
403 5XWV 8H6 4.71014
404 5BJX NAD 4.71014
405 5BJX UDP 4.71014
406 4HA6 FAD 4.71014
407 5DF1 NAP 4.71014
408 5DF1 58X 4.71014
409 4FWE FAD 4.71014
410 3UOY FAD 4.71014
411 3UOY NAP 4.71014
412 5XWV NDP 4.71014
413 2Q28 ADP 4.71014
414 2HMT NAI 4.86111
415 5DM1 SAH 4.86891
416 5DM1 5D7 4.86891
417 2VDV SAM 4.87805
418 6F5Z SAH 4.91803
419 3A4M ADP 5
420 1LSS NAD 5
421 2HQM FAD 5.01044
422 3LN9 FLC 5.03597
423 3A28 NAD 5.03876
424 2JJQ SAH 5.07246
425 2EG5 SAH 5.07246
426 1N2X SAM 5.07246
427 5WP5 SAH 5.07246
428 2PT9 2MH 5.07246
429 2XYQ SAH 5.07246
430 5THZ SAH 5.07246
431 2I7C AAT 5.07246
432 6ECT SAM 5.07246
433 6ER9 FAD 5.07246
434 6ER9 NAP 5.07246
435 2C5A GDC 5.07246
436 2C5A NAD 5.07246
437 6C5B SAH 5.07246
438 4MOP 2H5 5.07246
439 1Z45 NAD 5.07246
440 2A8X FAD 5.07246
441 2PT9 S4M 5.07246
442 5JWC FAD 5.07246
443 4M52 FAD 5.07246
444 1FEC FAD 5.07246
445 4NTD FAD 5.07246
446 4EMI FAD 5.07246
447 1X87 NAD 5.07246
448 2ZFU SAH 5.11628
449 1XTP SAI 5.11811
450 4QED NAP 5.24194
451 1VE3 SAM 5.28634
452 3DUW SAH 5.38117
453 4UCI SAM 5.43478
454 6C8R EQV 5.43478
455 5IL1 SAM 5.43478
456 5WP4 SAH 5.43478
457 6C8R SAH 5.43478
458 5OCQ CIT 5.43478
459 1BZL FAD 5.43478
460 5JAQ NAI 5.43478
461 5Z75 NAD 5.43478
462 6GAR FAD 5.43478
463 5NMX FAD 5.43478
464 4D7E FAD 5.43478
465 5NMX NAP 5.43478
466 3H8V ATP 5.47945
467 3MB5 SAM 5.4902
468 5Z2F PDC 5.66038
469 5K7U SAM 5.73066
470 4CQM NAP 5.7377
471 2EFJ SAH 5.7971
472 3O7W SAM 5.7971
473 5GM1 SAH 5.7971
474 1WVG APR 5.7971
475 5TTJ FAD 5.7971
476 3NKS FAD 5.7971
477 1N5D NDP 5.7971
478 3ICT FAD 5.7971
479 3ICR FAD 5.7971
480 5XLX SAH 5.7971
481 3ICS FAD 5.7971
482 1RP0 AHZ 5.7971
483 4FN4 NAD 5.90551
484 3RJ5 NAD 5.90551
485 2CFC NAD 6
486 2XVM SAH 6.03015
487 2JAH NDP 6.07287
488 4DDY DN6 6.08365
489 4BUZ OAD 6.09756
490 4BUZ OCZ 6.09756
491 1YC5 NCA 6.09756
492 3PT9 SAH 6.15942
493 4LWP SAH 6.15942
494 3TKY SAH 6.15942
495 5GWX SAR 6.15942
496 5GWX SAM 6.15942
497 1W8D NAP 6.15942
498 3BMN NAP 6.15942
499 3JQ9 NAP 6.15942
500 4CM9 NAP 6.15942
501 2YY7 NAD 6.15942
502 1W73 NAP 6.15942
503 4CMI NAP 6.15942
504 4CLR NAP 6.15942
505 5JDC NAP 6.15942
506 4REP FAD 6.15942
507 5FEU NAP 6.15942
508 5JCJ NAP 6.15942
509 5K6A NAP 6.15942
510 3JQB NAP 6.15942
511 1GY8 NAD 6.15942
512 4LHD GLY 6.15942
513 3JQA NAP 6.15942
514 4II2 ATP 6.15942
515 5JDI NAP 6.15942
516 4CME NAP 6.15942
517 3COB ADP 6.15942
518 4CM4 NAP 6.15942
519 3JQ8 NAP 6.15942
520 3BMO NAP 6.15942
521 3BMQ NAP 6.15942
522 3JQ7 NAP 6.15942
523 4L2I FAD 6.15942
524 4CM8 NAP 6.15942
525 1I2B USQ 6.15942
526 1I2B NAD 6.15942
527 1I2B UPG 6.15942
528 4CLO NAP 6.15942
529 1KYQ NAD 6.20438
530 4OBW SAM 6.22568
531 4BQS ADP 6.25
532 2HNK SAH 6.27615
533 4NEC SAH 6.43939
534 3OFK SAH 6.48148
535 1XTT U5P 6.48148
536 1E3W NAD 6.51341
537 1GEE NAD 6.51341
538 5KOK SAH 6.52174
539 4C4A SAH 6.52174
540 3DMH SAM 6.52174
541 4Q9N NAI 6.52174
542 5KOK S9T 6.52174
543 5KOK R9T 6.52174
544 3DMH GMP 6.52174
545 5OVL NAP 6.52174
546 1YBH FAD 6.52174
547 1REO FAD 6.52174
548 1E6W NAD 6.53846
549 1YQD NAP 6.55738
550 2PWY SAH 6.58915
551 4P83 U5P 6.59341
552 5FFF 5XC 6.61479
553 5FFF NAP 6.61479
554 1EJ0 SAM 6.66667
555 1JNR FAD 6.66667
556 1JG3 ADN 6.80851
557 2BGM NAJ 6.83453
558 1YXM ADE 6.88406
559 5MPT SAH 6.88406
560 5E72 SAM 6.88406
561 3P9C SAH 6.88406
562 2EJU SAH 6.88406
563 4PNE SAH 6.88406
564 4YNU FAD 6.88406
565 2ZWA SAH 6.88406
566 1L1E SAH 6.88406
567 2FK8 SAM 6.88406
568 1U3U BNF 6.88406
569 1U3U NAD 6.88406
570 3H2B SAH 6.89655
571 1IM8 SAI 6.96721
572 5THQ NDP 6.98529
573 5OVK NDP 7.03125
574 4YSX FAD 7.05128
575 2UYQ SAM 7.09677
576 1O5I NAD 7.22892
577 4M38 SAH 7.24638
578 4M37 SAH 7.24638
579 2WPF FAD 7.24638
580 4J1Q NDP 7.24638
581 3UCL CYH 7.24638
582 3UCL NAP 7.24638
583 3UCL FAD 7.24638
584 1IY8 NAD 7.24638
585 2WPF WPF 7.24638
586 2RH4 EMO 7.24638
587 3S5W FAD 7.24638
588 6A20 ADP 7.24638
589 4HSU FAD 7.25806
590 4GUS FAD 7.25806
591 4GUT FAD 7.25806
592 1UZN NAP 7.28745
593 2AE2 NAP 7.30769
594 2AE2 PTO 7.30769
595 3MQ2 SAH 7.33945
596 3OJF NDP 7.393
597 3OJF IMJ 7.393
598 4Y9D NAI 7.54098
599 2CBZ ATP 7.59494
600 2D2F ADP 7.6
601 4QM7 GTP 7.60234
602 4FZV SAM 7.6087
603 6BQ6 TER 7.6087
604 5W7R 9Z7 7.6087
605 1W6U NAP 7.6087
606 5W7R SAH 7.6087
607 3ITJ FAD 7.6087
608 2NVK FAD 7.6087
609 4FRZ ADP 7.6087
610 6FP4 FAD 7.6087
611 2WYV NAD 7.66284
612 4JLS 3ZE 7.89474
613 2GAG NAD 7.97101
614 3WMX NAD 7.97101
615 3FPZ AHZ 7.97101
616 5CDH TLA 7.97101
617 2B4Q NAP 7.97101
618 3AB1 FAD 7.97101
619 2PD4 NAD 8
620 2PD4 DCN 8
621 1XDS SAM 8.02139
622 5FA8 SAM 8.07453
623 1JJ7 ADP 8.07692
624 2GUC MAN 8.19672
625 3Q87 SAM 8.23529
626 3L9W AMP 8.33333
627 3S1S SAH 8.33333
628 4YMH SAH 8.33333
629 1EFV FAD 8.33333
630 1EFV AMP 8.33333
631 3L9W GSH 8.33333
632 5BW4 SAM 8.33333
633 4TM3 FAD 8.33333
634 5TWB FAD 8.33333
635 2ZXI FAD 8.33333
636 4EMJ FAD 8.41121
637 1Q7B NAP 8.60656
638 5W7K SAH 8.69565
639 2OBF SAH 8.69565
640 2OBF F83 8.69565
641 1RJW ETF 8.69565
642 1RSG FAD 8.69565
643 1YY5 FAD 8.69565
644 5FWA J7C 8.69565
645 1GXU 2HP 8.79121
646 2P3V SRT 8.98438
647 4E70 N7I 9.05797
648 6BWL NAD 9.05797
649 3AD8 NAD 9.05797
650 3SSO SAH 9.05797
651 4Z24 FAD 9.05797
652 1KPH SAH 9.05797
653 1KPG SAH 9.05797
654 1U7T TDT 9.1954
655 3MCT SAH 9.42029
656 3MAG SAH 9.42029
657 4MO2 FDA 9.42029
658 3HB5 NAP 9.42029
659 4MO2 FAD 9.42029
660 1ORR NAD 9.42029
661 1TPY SAH 9.42029
662 1RRC ADP 9.42029
663 1A27 NAP 9.42029
664 5LXB 7A9 9.50413
665 5BSZ SAH 9.6
666 4J56 FAD 9.64912
667 1WY7 SAH 9.66184
668 3SJU NDP 9.67742
669 2AG5 NAD 9.7561
670 1ZQ9 SAM 9.78261
671 1BXK NAD 9.85915
672 3RKR NAP 9.92366
673 1RZ1 NAD 9.93789
674 1ZK4 NAP 9.96016
675 5JCA FAD 10.2113
676 5JCA NDP 10.2113
677 5ZYN FAD 10.5072
678 5HSA FAS 10.5072
679 1NAA 6FA 10.5072
680 3A25 SAM 10.6312
681 1G60 SAM 10.7692
682 1NW5 SAM 10.8696
683 1QZZ SAM 10.8696
684 1KYZ FER 10.8696
685 1KYZ SAH 10.8696
686 6GKV SAH 10.8696
687 1W5T ADP 10.8696
688 2JAP NDP 10.9312
689 1OAA OAA 11.1969
690 5ERG SAM 11.2319
691 2PS1 ORO 11.5044
692 5YV5 ADP 11.5942
693 4QTU SAM 11.8519
694 3VSE SAH 11.9565
695 4USQ FAD 11.9565
696 4TQG NDP 11.9565
697 2C31 ADP 11.9565
698 2C31 TZD 11.9565
699 1R37 NAD 12.3188
700 2F5Z FAD 12.5
701 3H4S ADP 12.5926
702 6ARJ BW4 12.6812
703 6ARJ SAH 12.6812
704 4DCM SAM 12.6812
705 5DX8 SFG 12.6812
706 5DX1 SFG 12.6812
707 5DXA SFG 12.6812
708 5DX0 SFG 12.6812
709 5Y1G AKB 12.6812
710 5Y1G NAD 12.6812
711 5DWQ SFG 12.6812
712 1PN0 FAD 12.6812
713 1PN0 IPH 12.6812
714 3VC1 GST 13.0435
715 3VC1 SAH 13.0435
716 5TVI O8N 13.0435
717 1RM6 FAD 13.0435
718 4U8P FDA 13.2554
719 4U8P UDP 13.2554
720 3KO8 NAD 13.4058
721 1XG5 NAP 13.9785
722 1L3I SAH 14.0625
723 2RAB NAD 14.4928
724 3OU2 SAH 14.6789
725 1JQ3 AAT 14.8551
726 3SJ7 NDP 15.4762
727 5E8J SAH 15.9091
728 4Y30 49L 16.3043
729 4Y30 SAH 16.3043
730 2DKN NAI 16.8627
731 5L95 AMP 18.75
732 3X0D SAH 19.5652
733 4NBU NAI 20.2899
734 2PXX SAH 21.3953
735 4IWN GEK 22.2707
736 1DL5 SAH 24.6377
737 3LCC SAH 26.8085
738 5EB4 FAD 30.7971
739 2V7Q ADP 32
Pocket No.: 2; Query (leader) PDB : 2WA2; Ligand: SAM; Similar sites found with APoc: 165
This union binding pocket(no: 2) in the query (biounit: 2wa2.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 4WOH 4NP None
2 3FXU TSU 1.08696
3 3ZF8 GDP 1.63934
4 5I39 FAD 1.81159
5 2RGJ FAD 1.81159
6 4X9M FAD 1.81159
7 2Q1W NAD 2.17391
8 1LVL NAD 2.17391
9 4YRY NAD 2.17391
10 3ZV6 4HB 2.17391
11 3ZV6 NAD 2.17391
12 4YRY FAD 2.17391
13 4K5S FAD 2.17391
14 4K5S PM0 2.17391
15 5EZ7 FAD 2.17391
16 1LVL FAD 2.17391
17 6IS0 SAH 2.17391
18 3L8H FX1 2.23464
19 5OJI ISN 2.30769
20 5OJI NAP 2.30769
21 1YKJ FAD 2.53623
22 1YKJ PHB 2.53623
23 5GSN MMZ 2.53623
24 6AA8 NAD 2.53623
25 5YEC ATP 2.53623
26 2NPX FAD 2.53623
27 4KWI NAP 2.6616
28 4KWI 1TJ 2.6616
29 3VZS NAP 2.72374
30 3ICC NAP 2.7451
31 4IF4 BEF 2.88462
32 6GNA FAD 2.89855
33 5BRT CH9 2.89855
34 1R6D NAD 2.89855
35 5BUK FAD 2.89855
36 3QJ4 FAD 2.89855
37 1R6D DAU 2.89855
38 4D04 FAD 2.89855
39 4D04 NAP 2.89855
40 4C3Y FAD 2.89855
41 1KNR FAD 2.89855
42 2E5V FAD 2.89855
43 4U7W NDP 2.89855
44 4C3Y ANB 2.89855
45 5J7X FAD 2.89855
46 2Q46 NAP 3.16206
47 4D5G FAD 3.26087
48 1D4D FAD 3.26087
49 1RYI FAD 3.26087
50 4OSP NAP 3.42205
51 1X1T NAD 3.46154
52 2Q2V NAD 3.52941
53 1Q9I FAD 3.62319
54 1Q9I TEO 3.62319
55 4RVG TYD 3.62319
56 4RVG SAM 3.62319
57 1Z6Z NAP 3.62319
58 1TAD ALF 3.62319
59 1TAD GDP 3.62319
60 4K26 SFF 3.62319
61 4JDR FAD 3.62319
62 4K26 NDP 3.62319
63 1FQK GDP 3.62319
64 1EDO NAP 3.68852
65 1HE1 GDP 3.97727
66 2B9W FAD 3.98551
67 1H82 GZZ 3.98551
68 4CJX NAP 3.98551
69 2RGO FAD 3.98551
70 1H82 FAD 3.98551
71 3RC1 NAP 3.98551
72 3RC1 TLO 3.98551
73 2B5W NAP 3.98551
74 5J5Z FAD 4.34783
75 6CUZ FEV 4.34783
76 4UP3 FAD 4.34783
77 5ZBC FAD 4.43459
78 4B63 ORN 4.71014
79 4B63 NAP 4.71014
80 4B63 FAD 4.71014
81 1E7S NAP 4.71014
82 1KEW NAD 4.71014
83 1KEW TYD 4.71014
84 1Q1R FAD 4.71014
85 5G3U FDA 4.72813
86 5G3U ITW 4.72813
87 4M52 M52 5.07246
88 2Q4W FAD 5.07246
89 5GT9 NAP 5.07246
90 5XNC MTA 5.07246
91 1BZL GCG 5.43478
92 3KLJ FAD 5.43478
93 5KOX RFP 5.43478
94 5KOX FAD 5.43478
95 1DJN ADP 5.43478
96 2GJP MAL 5.43478
97 5B4T 3HR 5.43478
98 5B4T NAD 5.43478
99 5UAO FAD 5.54529
100 5YW5 ADE 5.58659
101 3ZNN FAD 5.7971
102 3ZNN 4WL 5.7971
103 3CH6 311 5.7971
104 3CH6 NAP 5.7971
105 4D81 ADP 5.7971
106 4BUZ NAD 6.09756
107 1COY FAD 6.15942
108 3X0V FAD 6.15942
109 5CGE 51F 6.15942
110 2HK9 ATR 6.18182
111 5KMS FAD 6.52174
112 2ODE ALF GDP 6.52174
113 6HOY AR6 6.52174
114 6HOY TSN 6.52174
115 4ZCC FAD 6.54762
116 4YNU LGC 6.88406
117 3WGT QSC 6.88406
118 3WGT FAD 6.88406
119 5L53 NAP 7.24638
120 1VDC FAD 7.24638
121 4J36 1HR 7.24638
122 4J36 FAD 7.24638
123 5KVS 6XR 7.24638
124 2BQP GLC 7.26496
125 1BC5 SAH 7.43494
126 6F7L FAD 7.6087
127 6FP4 E1T 7.6087
128 1XHC FAD 7.62943
129 2GAG FOA 7.97101
130 2GAG FAD 7.97101
131 6H3O FAD 7.97101
132 2GUE NAG 8.19672
133 2GUD MAN 8.19672
134 1LVK MNT BEF 8.33333
135 5YU3 PRO 8.69565
136 5YU3 NAD 8.69565
137 3AD8 PYC 9.05797
138 3AD8 FAD 9.05797
139 3NTA FAD 9.05797
140 3NT6 FAD 9.05797
141 1U7T NAD 9.1954
142 3NTD FAD 9.42029
143 5ODQ FAD 9.78261
144 1ZK4 AC0 9.96016
145 6FHO FAD 10.1449
146 1LDN NAD 10.443
147 1NAA ABL 10.5072
148 3E1T FAD 10.5072
149 2BRY FAD 10.8696
150 5OJ7 AR6 11.5942
151 3CGB FAD 11.5942
152 1ELI PYC 11.9565
153 1HYH NAD 11.9565
154 2YG3 FAD 14.1304
155 5OCM NAP 14.4928
156 2RAB FAD 14.4928
157 5WUW NAP 17.0732
158 4KGD TDP 17.7536
159 4KGD FAD 17.7536
160 1E8G FAD 20.2899
161 1E8G FCR 20.2899
162 2YVJ FAD 25.7246
163 2YVF NAD 25.7246
164 2YVF FAD 25.7246
165 3QF7 ANP 42
APoc FAQ
Feedback