Receptor
PDB id Resolution Class Description Source Keywords
2WMC 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E FROM PI SATIVUM PISUM SATIVUM BIOSYNTHETIC PROTEIN INITIATION FACTOR PROTEIN BIOSYNTHESISBM1 GENE RNA-BINDING PISUM SATIVUM
Ref.: STRUCTURE-BASED MUTATIONAL ANALYSIS OF EIF4E IN REL SBM1 RESISTANCE TO PEA SEED-BORNE MOSAIC VIRUS IN P PLOS ONE V. 6 E873 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MGP A:500;
B:500;
C:500;
D:500;
E:500;
F:500;
G:500;
H:500;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
538.215 C11 H19 N5 O14 P3 C[n+]...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WMC 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF EUKARYOTIC INITIATION FACTOR 4E FROM PI SATIVUM PISUM SATIVUM BIOSYNTHETIC PROTEIN INITIATION FACTOR PROTEIN BIOSYNTHESISBM1 GENE RNA-BINDING PISUM SATIVUM
Ref.: STRUCTURE-BASED MUTATIONAL ANALYSIS OF EIF4E IN REL SBM1 RESISTANCE TO PEA SEED-BORNE MOSAIC VIRUS IN P PLOS ONE V. 6 E873 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 291 families.
1 2WMC - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 247 families.
1 2WMC - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
2 2IDV - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
50% Homology Family (12)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 1IPB - GTA C21 H30 N10 O17 P3 C[n+]1cn(c....
2 1IPC - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
3 2WMC - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
4 5OSX ic50 = 0.285 uM AKW C21 H30 N10 O16 P3 S2 C[n+]1cn(c....
5 1L8B Kd = 0.14 uM MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
6 5J5Y Ka = 82.8 M^-1 6G6 C13 H21 Cl2 N5 O16 P4 C[n+]1cn(c....
7 4TPW Kd = 19.5 uM 33R C18 H12 Cl2 N4 O4 S c1ccc(c(c1....
8 4TQB - MGT C11 H20 N5 O14 P3 CN1CN(C2=C....
9 1EJ1 - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
10 4TQC - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
11 5J5O Ka = 102.8 M^-1 6G0 C11 H20 N5 O17 P4 C[n+]1cn(c....
12 2IDV - M7G C11 H19 N5 O11 P2 CN1CN(C2=C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MGP; Similar ligands found: 81
No: Ligand ECFP6 Tc MDL keys Tc
1 MGP 1 1
2 6G0 0.986667 1
3 G7M 0.794872 0.987013
4 GTG 0.741935 0.974684
5 GTA 0.71875 0.974684
6 MG7 0.653846 0.884615
7 GTP 0.619565 0.961039
8 MGO 0.619565 0.901235
9 GDP 7MG 0.592233 0.949367
10 GP3 0.55914 0.936709
11 GDP 0.553191 0.961039
12 GSP 0.525253 0.91358
13 MGQ 0.514852 0.925
14 G1R 0.5 0.948718
15 MGV 0.5 0.880952
16 GAV 0.5 0.925
17 GNH 0.5 0.948718
18 01G 0.495327 0.870588
19 9GM 0.49505 0.936709
20 GNP 0.49505 0.936709
21 HFD 0.494845 0.841463
22 HEJ 0.494737 0.884615
23 ATP 0.494737 0.884615
24 AQP 0.489583 0.884615
25 5FA 0.489583 0.884615
26 GCP 0.485149 0.936709
27 G5P 0.477477 0.936709
28 7DT 0.474227 0.871795
29 G2R 0.471698 0.925
30 5GP 0.46875 0.948052
31 G 0.46875 0.948052
32 ITT 0.46875 0.835443
33 G3A 0.468468 0.936709
34 0O2 0.46729 0.948052
35 AJQ 0.466102 0.926829
36 GKE 0.463636 0.925
37 GDC 0.463636 0.925
38 GDD 0.463636 0.925
39 Y9Z 0.463636 0.892857
40 GMV 0.460784 0.936709
41 GFB 0.459459 0.949367
42 GDR 0.459459 0.949367
43 DGT 0.456311 0.888889
44 GPD 0.45614 0.914634
45 6CK 0.455357 0.902439
46 G2P 0.451923 0.925
47 AP5 0.447917 0.860759
48 B4P 0.447917 0.860759
49 GKD 0.447368 0.925
50 JB2 0.447368 0.949367
51 8GT 0.445545 0.843373
52 NGD 0.445378 0.949367
53 GPG 0.440367 0.925
54 BA3 0.4375 0.860759
55 GH3 0.433962 0.935897
56 ADP 0.43299 0.884615
57 6YZ 0.432692 0.8625
58 GP2 0.431373 0.925
59 GDX 0.431034 0.936709
60 YGP 0.428571 0.891566
61 MGT 0.428571 0.837209
62 RGT 0.428571 0.875
63 IDP 0.425743 0.935065
64 JB3 0.425 0.9375
65 A4P 0.425 0.83908
66 CAG 0.424 0.894118
67 25L 0.423423 0.873418
68 A2D 0.416667 0.860759
69 7DD 0.414141 0.871795
70 6AD 0.413462 0.855422
71 SAP 0.411765 0.841463
72 AGS 0.411765 0.841463
73 G3D 0.411215 0.948052
74 G2Q 0.409091 0.925
75 ALF 5GP 0.40566 0.879518
76 TPG 0.40458 0.853933
77 ACQ 0.403846 0.8625
78 ANP 0.403846 0.8625
79 G4P 0.40367 0.948052
80 C1Z 0.401786 0.948052
81 2MD 0.4 0.860465
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2wmc.bio4) has 8 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2wmc.bio6) has 9 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2wmc.bio7) has 7 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2wmc.bio2) has 7 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 2wmc.bio3) has 7 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 2wmc.bio8) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 2wmc.bio5) has 8 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 2WMC; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 2wmc.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
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