-->
Receptor
PDB id Resolution Class Description Source Keywords
2XBJ 2.3 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CHK2 IN COMPLEX WITH AN INHIBITOR HOMO SAPIENS TRANSFERASE DNA REPAIR PARP
Ref.: STRUCTURE-BASED DESIGN OF POTENT AND SELECTIVE 2-(QUINAZOLIN-2-YL)PHENOL INHIBITORS OF CHECKPOINT KINASE 2. J.MED.CHEM. V. 54 580 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:1514;
Invalid;
none;
submit data
24.305 Mg [Mg+2...
NO3 A:1515;
A:1516;
Invalid;
Invalid;
none;
none;
submit data
62.005 N O3 [N+](...
XBJ A:1513;
Valid;
none;
ic50 = 0.86 uM
442.483 C23 H27 F N4 O4 CC(C)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2XK9 2.35 Å EC: 2.7.11.1 STRUCTURAL ANALYSIS OF CHECKPOINT KINASE 2 (CHK2) IN COMPLEX INHIBITOR PV1533 HOMO SAPIENS STRUCTURE-BASED DRUG DESIGN TRANSFERASE
Ref.: STRUCTURAL CHARACTERIZATION OF INHIBITOR COMPLEXES CHECKPOINT KINASE 2 (CHK2), A DRUG TARGET FOR CANCE THERAPY. J.STRUCT.BIOL. V. 176 292 2011
Members (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 2YCQ ic50 = 0.14 nM UPX C20 H17 N7 O3 C/C(=NNc1[....
2 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
3 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
4 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
5 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
6 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
7 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
8 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
9 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
10 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
11 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
12 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
13 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
14 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
15 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
16 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
17 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
18 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 2YCQ ic50 = 0.14 nM UPX C20 H17 N7 O3 C/C(=NNc1[....
2 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
3 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
4 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
5 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
6 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
7 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
8 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
9 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
10 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
11 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
12 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
13 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
14 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
15 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
16 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
17 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
18 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
50% Homology Family (420)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 3IGO - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
2 3NCG - BK1 C19 H19 N5 CC(C)n1c2c....
3 3MWU - BK3 C22 H24 N6 c1ccc2c(c1....
4 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
5 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
6 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
7 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
8 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
9 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
10 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
11 5OQ7 ic50 = 0.8743 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
12 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
13 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
14 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
15 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
16 5OP5 ic50 = 0.4964 uM 3FE C17 H15 N5 O c1cc(cc(c1....
17 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
18 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
19 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
20 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
21 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
22 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
23 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
24 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
25 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
26 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
27 5OPR ic50 = 5.8506 uM A3E C21 H26 N6 O CC(C)n1cc(....
28 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
29 5OQ5 ic50 = 0.052 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
30 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
31 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
32 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
33 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
34 5OQ8 ic50 = 4.0577 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
35 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
36 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
37 5OPS ic50 = 1.9827 uM A3Q C14 H9 N3 O c1cc(cc(c1....
38 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
39 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
40 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
41 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
42 5OP2 ic50 = 0.5543 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
43 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
44 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
45 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
46 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
47 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
48 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
49 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
50 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
51 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
52 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
53 3LFN Ki = 3160 nM A27 C23 H21 N3 O2 CCCC(=O)Nc....
54 3PY1 Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
55 2A4L ic50 = 0.4 uM RRC C19 H26 N6 O CC[C@H](CO....
56 1Y8Y ic50 = 2 uM CT7 C13 H11 Cl N4 O2 S CS(=O)(=O)....
57 6GUH Kd = 26 nM FB8 C18 H21 N5 O2 S Cc1ncc(n1C....
58 1OIR ic50 = 0.032 uM HDY C23 H26 N6 O2 Cc1c(n2ccc....
59 1PXJ - CK2 C9 H10 N4 S Cc1c(sc(n1....
60 2VTO ic50 = 0.14 uM LZ8 C17 H13 F N4 O2 c1ccc(cc1)....
61 2BTR ic50 = 95 nM U73 C13 H15 N3 O S CC(C)C1=CN....
62 2VTA ic50 = 185 uM LZ1 C7 H6 N2 c1ccc2c(c1....
63 3EZR - EZR C26 H27 N7 O CN1CCN(CC1....
64 3ULI ic50 = 0.07 uM 1N3 C21 H25 Br N6 O2 COc1ccc(cc....
65 2DS1 ic50 = 6.4 nM 1CD C22 H21 N5 O3 C[C@@H]1C[....
66 5FP5 - 1Y6 C7 H5 F O2 c1cc(ccc1C....
67 2VTH ic50 = 120 uM LZ2 C10 H9 N O3 S c1cc2c(ccc....
68 1KE5 ic50 = 560 nM LS1 C16 H15 N3 O3 S CNS(=O)(=O....
69 3FZ1 - B98 C13 H15 N3 O2 S COc1ccc2c(....
70 1WCC ic50 = 350 uM CIG C4 H4 Cl N3 c1c(nc(cn1....
71 1PXO Ki = 2 nM CK7 C14 H12 N6 O2 S Cc1c(sc(n1....
72 1H00 ic50 = 38 uM FAP C21 H23 F2 N5 O2 CN(C)C[C@@....
73 2R3R - 6SC C18 H14 Br N5 c1ccc(cc1)....
74 1B39 Kd = 0.12 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
75 3PXF Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
76 3TI1 - B49 C22 H27 F N4 O2 CCN(CC)CCN....
77 2R3G ic50 = 800 nM SC9 C18 H14 F N5 c1ccc(c(c1....
78 2C69 ic50 = 26 uM CT8 C17 H14 Br N6 c1cc(cc(c1....
79 2VTM ic50 ~ 1 mM LZM C7 H4 N4 c1cnc2c(cn....
80 4ERW - STU C28 H26 N4 O3 C[C@@]12[C....
81 1E1V Ki = 12 uM CMG C12 H17 N5 O c1[nH]c2c(....
82 2VV9 ic50 = 0.017 uM IM9 C23 H29 N7 O2 Cc1ncc(n1C....
83 5IEV - R0N C18 H23 F3 N4 O3 S C[C@H]([C@....
84 4D1X - ESJ C11 H8 N2 O3 S2 c1cc2c(cc1....
85 5MHQ - 8QT C19 H27 N7 O CC[C@@H]([....
86 2BTS ic50 = 20 nM U32 C12 H15 N3 O2 S2 CC(C)c1cnc....
87 1URW ic50 < 0.003 uM I1P C21 H24 N8 O2 S CN(C)CCCNS....
88 5FP6 - MFZ C11 H7 Cl2 N O c1cc(c2c(c....
89 1CKP - PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
90 1KE6 ic50 = 5.7 nM LS2 C17 H15 N5 O3 S2 CNS(=O)(=O....
91 2C6K ic50 = 0.73 uM DT2 C17 H21 N7 O2 S c1cc(ccc1N....
92 2R3Q - 5SC C19 H16 Br N5 O Cc1ccccc1c....
93 1OIT ic50 < 0.003 uM HDT C17 H14 N6 O2 S c1ccn2c(c1....
94 3NS9 ic50 = 0.003 uM NS9 C20 H27 N5 O3 CC(C)c1cnn....
95 1H01 ic50 = 22 uM FAL C21 H23 Cl2 N5 O2 CN(C)C[C@H....
96 2EXM - ZIP C10 H13 N5 CC(=CCNc1c....
97 4BGH ic50 = 4 nM 3I6 C13 H16 Br N5 O3 S C[C@H](CO)....
98 2R3F ic50 = 500 nM SC8 C18 H13 Cl2 N5 c1cc(c(c(c....
99 1GII - 1PU C17 H16 N4 O2 c1ccnc(c1)....
100 2R64 ic50 = 0.03 uM 740 C23 H27 N5 O3 S c1cc(ccc1C....
101 5A14 - LQ5 C24 H26 F3 N7 O2 CN1CCN(CC1....
102 2C6L ic50 = 0.27 uM DT4 C17 H22 N8 O2 S c1cc(ccc1N....
103 2W06 - FRV C18 H20 N6 O2 S Cc1ncc(n1C....
104 4EZ7 - STU C28 H26 N4 O3 C[C@@]12[C....
105 5D1J ic50 = 48 nM 56H C17 H24 N4 O2 S2 CC(C)(C)c1....
106 5IEY - 6AE C14 H19 N5 O3 S C[C@H]([C@....
107 2VTT ic50 = 0.044 uM LZD C16 H17 F2 N5 O2 c1cc(c(c(c....
108 2VU3 ic50 = 0.047 uM LZE C16 H17 Cl2 N5 O2 c1cc(c(c(c....
109 2B54 - D05 C20 H15 Cl3 N4 O3 CCc1c2c(n(....
110 1GZ8 - MBP C10 H13 N5 O2 CC(C)C(=O)....
111 3PY0 ic50 = 0.13 uM SU9 C13 H11 N3 O2 COc1ccc2c(....
112 2VTR ic50 = 1.5 uM LZB C10 H10 Cl N5 CC(C)Nc1cc....
113 1E1X Ki = 1.3 uM NW1 C11 H17 N5 O2 C1CCC(CC1)....
114 3UNJ ic50 = 11 uM 0BX C17 H14 N4 O2 c1ccc(cc1)....
115 2A0C - CK9 C19 H26 N6 O2 CC[C@H](CO....
116 3TIY - TIY C11 H8 O5 c1c2c(c(c(....
117 2R3I ic50 = 1000 nM SCF C18 H14 F N5 c1ccc(c(c1....
118 1VYZ ic50 = 290 nM N5B C13 H13 N3 O c1ccc(cc1)....
119 3WBL ic50 = 23 uM PDY C20 H26 N6 O CCOc1ccc(c....
120 4RJ3 ic50 = 93 nM 3QS C22 H28 N6 O COC1CCN(CC....
121 2VTN ic50 = 0.85 uM LZ7 C12 H11 F N4 O2 CC(=O)Nc1c....
122 1AQ1 - STU C28 H26 N4 O3 C[C@@]12[C....
123 2C6M ic50 = 0.35 uM DT5 C17 H20 N6 O3 S c1cc(ccc1N....
124 2R3L ic50 = 100 nM SCW C18 H14 Br N5 c1ccc(cc1)....
125 1H08 - BYP BWP n/a n/a
126 1B38 Kd = 0.254 uM ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
127 2B52 ic50 = 8 nM D42 C21 H23 N7 O2 S Cc1c(sc(n1....
128 1PXL - CK4 C16 H13 F3 N4 S Cc1c(sc(n1....
129 3S2P ic50 = 0.068 uM PMU C17 H22 N4 O3 CC(C)c1cc(....
130 2R3O ic50 = 600 nM 2SC C19 H17 N5 O c1ccc(cc1)....
131 3IGG ic50 = 95 nM EFQ C16 H19 N3 O3 COc1ccc(cc....
132 1R78 ic50 = 3 nM FMD C20 H20 F N3 O4 C[C@H]([C@....
133 2FVD Ki = 0.003 uM LIA C18 H21 F2 N5 O4 S COc1ccc(c(....
134 2VTL ic50 = 97 uM LZ5 C10 H9 N3 O c1ccc(cc1)....
135 1KE9 ic50 = 660 nM LS5 C16 H15 N5 O3 S c1ccc2c(c1....
136 1PYE ic50 = 0.32 uM PM1 C21 H13 F2 N3 O2 c1ccc(cc1)....
137 4EZ3 - 0S0 C11 H10 N4 O4 S c1cc(ccc1/....
138 1H07 ic50 = 3 uM MFP C24 H27 Br N6 O2 Cc1ccc(c(c....
139 2B53 ic50 = 0.6 uM D23 C19 H19 F3 N4 CC(C)(C)Nc....
140 6GUK Kd = 725 nM FC8 C19 H24 Cl N7 CCn1cnc2c1....
141 2DUV ic50 = 0.087 uM 371 C19 H17 N O7 S Cc1cc2c(c(....
142 4D1Z - WG8 C13 H10 N2 O3 S c1cc2ccc(n....
143 4ACM Ki = 210 nM 7YG C20 H23 N7 O3 S CN(C)CCNS(....
144 2C5Y ic50 = 0.25 uM MTW C19 H15 N7 O2 c1cc(cc(c1....
145 2R3K ic50 = 100 nM SCQ C18 H14 Br N5 c1ccc(cc1)....
146 2V0D - C53 C9 H7 N3 O S [H]/N=C1/N....
147 2W1H ic50 = 0.052 uM L0F C17 H13 N5 O c1ccc(cc1)....
148 1Y91 ic50 = 0.059 uM CT9 C23 H33 N7 O2 S CC(C)c1cnn....
149 4FII - ARG PRO LYS PRO LEU VAL ASP PRO n/a n/a
150 4NJD ic50 = 0.79 uM NJD C21 H20 N8 O COc1nc(nc(....
151 4JDK - ARG ARG ARG ARG SER TRP TYR n/a n/a
152 5XVG Ki = 0.009 uM 8FX C20 H22 Cl N7 O C[C@@H]1CN....
153 2ZV2 - 609 C19 H10 N2 O3 c1ccc2c(c1....
154 4ONA ic50 = 0.002 uM UW1 C19 H23 N5 O2 CCOc1ccc2c....
155 4JBV ic50 = 0.003 uM V68 C26 H32 N6 O CC(C)COc1c....
156 3NYV - DTQ C16 H15 N3 O3 COc1cc2c(c....
157 3T3U Ki = 0.0025 uM BK6 C22 H24 N6 O COc1ccc2cc....
158 3KU2 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
159 4M84 ic50 = 0.049 uM 21E C17 H19 N5 O CC(C)(C)n1....
160 3HX4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
161 3UPX Ki = 0.0075 uM B6A C20 H22 N4 O c1ccc(cc1)....
162 3SXF Ki = 0.0025 uM BK5 C20 H21 N5 O CCOc1ccc2c....
163 3T3V Ki = 0.003 uM BK4 C19 H19 N5 O CC(C)n1c2c....
164 3I7B ic50 = 0.066 uM BK1 C19 H19 N5 CC(C)n1c2c....
165 3V5P Ki = 0.011 uM C88 C19 H24 N6 O Cc1cc(ccc1....
166 3V51 - I76 C25 H22 Cl N5 O CC(C)n1c2c....
167 3UPZ - B5A C11 H16 N6 c1c2c(ncnc....
168 3I7C ic50 = 0.018 uM BK2 C19 H19 N5 CC(C)(C)n1....
169 3V5T - UW9 C24 H30 N6 O CCOc1ccc2c....
170 3N51 - BK3 C22 H24 N6 c1ccc2c(c1....
171 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
172 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
173 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
174 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
175 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
176 5H8E ic50 < 0.003 uM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
177 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
178 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
179 5MOE Kd = 500 uM OQC C11 H10 Cl N O c1cc(c(cc1....
180 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
181 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
182 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
183 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
184 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
185 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
186 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
187 5N9N Ki = 0.4 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
188 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
189 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
190 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
191 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
192 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
193 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
194 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
196 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
197 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
198 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
199 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
200 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
201 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
202 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
203 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
204 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
205 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
206 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
207 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
208 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
209 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
210 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
211 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
212 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
213 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
214 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
215 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
216 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
217 3PE1 Ki = 0.38 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
218 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
219 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
220 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
221 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
222 2ZJW ic50 = 0.04 uM REF C14 H6 O8 c1c2c-3c(c....
223 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
224 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
225 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
226 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
227 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
228 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
229 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
230 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
231 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
232 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
233 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
234 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
235 3SHE - I85 C24 H22 F3 N5 O2 c1cc(cc(c1....
236 5IZJ - 6J9 C10 H13 N5 c1c[nH]c2c....
237 3AG9 Ki = 9 nM A02 C40 H70 N18 O9 [H]/N=C(N)....
238 5IZF Kd = 1.7 nM 6J9 AZ1 DAR ACA DAR NH2 n/a n/a
239 2VZ6 - FEF C20 H19 N3 O4 c1ccc2c(c1....
240 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 C[C@@]12[C....
241 4J8M ic50 = 48 nM CJ5 C26 H25 F3 N8 O c1cc(cc(c1....
242 5ORO - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
243 5OS4 Kd = 1665 uM A8H C14 H15 N O2 c1ccc(cc1)....
244 6HJJ ic50 = 1.7 uM G7T C26 H24 F4 N6 O2 Cc1cc(ccc1....
245 5ORS - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
246 5ORL - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
247 5DR9 - 5E2 C16 H9 Br Cl N O2 c1cc(cc(c1....
248 4DEA ic50 = 256 nM NHI C18 H14 N4 O4 c1cc(ccc1C....
249 5DN3 Kd = 3.77 uM 5DN C16 H9 Br F N O2 c1cc(cc(c1....
250 5ORP - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
251 4DEE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
252 5OSE Kd = 681 uM A98 C6 H9 N3 O2 S2 CCSc1nnc(s....
253 5DNR - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
254 3UOD Kd = 49 nM 0C3 C18 H13 F3 N4 O2 c1ccc(c(c1....
255 3EFW - AK8 C25 H21 F3 N6 O2 Cc1cc(ccc1....
256 5DT0 - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
257 3UO4 Kd = 299 nM 0C0 C23 H18 N4 O2 c1ccc(cc1)....
258 3UP2 Kd = 40 nM 0C8 C18 H13 F3 N4 O3 c1ccc(c(c1....
259 5ORX ic50 = 308 uM A6H C11 H8 Cl2 N2 O c1cc(c(c(c....
260 5ORN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
261 5OS5 ic50 = 108 uM A8K C12 H10 O2 S c1cc(ccc1O....
262 5DR2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
263 3DJ5 - AK5 C21 H20 Br N5 O3 S COc1ccc(cc....
264 3UOL ic50 = 3.1 nM 0C7 C17 H13 Cl N8 c1ccc(c(c1....
265 3D14 ic50 = 22 nM AK1 C19 H15 F3 N6 O S2 c1cc(cc(c1....
266 5OSD - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
267 5OS2 Kd = 1821 uM A7K C13 H21 N2 O c1ccc(c(c1....
268 4BN1 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
269 2NP8 ic50 = 42 nM CC3 C21 H18 F3 N5 O c1cc(cc(c1....
270 5ORR ic50 = 899 uM A5Q C9 H6 F3 N3 S c1cc(ccc1c....
271 4JBQ - VX6 C23 H28 N8 O S Cc1cc([nH]....
272 5OS3 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
273 5DRD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
274 5DPV - SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
275 5ORZ ic50 = 245 uM A6W C10 H9 N O2 S2 COC(=O)c1c....
276 4UYN ic50 = 2 nM Y3M C25 H22 N4 O4 S CCOC(=O)c1....
277 5DT3 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
278 2WTV Ki = 1.8 nM ZZL C25 H15 Cl F2 N4 O2 c1cc(c(c(c....
279 6HJK ic50 = 25 nM G7W C25 H20 F4 N6 O2 CC(C)n1c2c....
280 3O50 - LJE C24 H17 F3 N4 O2 Cc1cc(ccc1....
281 2J4Z ic50 = 65 nM 626 C23 H24 N6 O2 S CN1CCN(CC1....
282 3LAU ic50 = 0.044 uM OFI C17 H17 N3 O2 CCCC(=O)Nc....
283 3DAJ ic50 = 2.9 uM FXG C22 H29 N7 O2 CCCCNC(=O)....
284 4JBO ic50 = 24 nM WPH C31 H32 N6 O3 CN(C)CCOc1....
285 5ORW Kd = 796 uM A6E C13 H16 F N O2 S c1cc(ccc1O....
286 2C6D - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
287 5OS0 Kd = 2792 uM A6Z C12 H15 Cl N3 c1cc(cc(c1....
288 3K5U ic50 = 309 nM PFQ C20 H17 N3 O2 c1ccc(cc1)....
289 4KS7 - X4Z C25 H28 N8 O S Cc1nc2ccsc....
290 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
291 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
292 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
293 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
294 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
295 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
296 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
297 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
298 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
299 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
300 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
301 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
302 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
303 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
304 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
305 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
306 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
307 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
308 3EH9 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
309 1IG1 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
310 5AUW ic50 = 8.9 uM QUE C15 H10 O7 c1cc(c(cc1....
311 5AV2 - KMP C15 H10 O6 c1cc(ccc1C....
312 5AUU ic50 = 21 uM LU2 C15 H10 O6 c1cc(c(cc1....
313 3EHA - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
314 5AV3 - KMP C15 H10 O6 c1cc(ccc1C....
315 5AUT Kd = 6.7 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
316 5AV0 ic50 = 280 uM 47X C15 H10 O5 c1cc(c(cc1....
317 1JKK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
318 3F5U - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
319 5AV4 - GEN C15 H10 O5 c1cc(ccc1C....
320 5AUX ic50 = 10 uM KMP C15 H10 O6 c1cc(ccc1C....
321 5AUV ic50 = 31 uM AGI C15 H10 O5 c1cc(ccc1C....
322 2XK6 - EQH C18 H21 N3 O2 S c1csc(c1C2....
323 2W5A - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
324 5M55 ic50 = 0.24 uM 7GG C17 H20 N6 CCN(CC)/C=....
325 2XNM ic50 = 0.16 uM WGZ C27 H27 F3 N4 O3 S C[C@H](c1c....
326 2XKF ic50 = 0.87 uM BX1 C19 H24 N4 O5 COc1cc(cc(....
327 2JAV ic50 ~ 8 uM 5Z5 C17 H16 Cl N3 O2 Cc1c([nH]c....
328 5M53 ic50 = 0.62 uM 7GJ C21 H26 N6 O2 CN(C)C(=O)....
329 2XK8 ic50 = 2.4 uM 5R1 C21 H21 N3 O6 COc1cc(ccc....
330 2WQO - VGK C21 H20 N2 O5 COc1cc(cc(....
331 2XKE ic50 = 4.2 uM WI2 C17 H20 N4 O3 COc1cccc(c....
332 2XNN - 430 C21 H16 F3 N3 O2 S C[C@H](c1c....
333 2XK7 ic50 = 1.5 uM 30E C21 H28 N4 O5 CC[C@H]1C[....
334 1Z5M ic50 = 30 nM LI8 C23 H31 Br N8 O3 CC(C)(C(=O....
335 5HKM ic50 = 0.013 uM 61Y C16 H15 N7 CCc1cc(nc(....
336 3QD0 ic50 = 0.00000001 M 3Q4 C24 H26 N8 O C[C@@H]1CC....
337 3ORZ - BI4 C27 H26 N4 O2 C[N@]1CCC[....
338 5LVN Kd = 20 uM ADN C10 H13 N5 O4 c1nc(c2c(n....
339 2XCH ic50 = 374 nM CKG C22 H25 N7 O c1c2c(nc(n....
340 4AW0 - MJF C18 H15 Cl O5 c1ccc(cc1)....
341 3OTU - BI4 C27 H26 N4 O2 C[N@]1CCC[....
342 3QCX ic50 = 0.00000001 M 3Q2 C16 H19 N7 O C[C@@H]1CO....
343 1UU3 ic50 = 0.75 uM LY4 C28 H28 N4 O3 CN(C)C[C@@....
344 5LVL Kd = 1.25 uM 537 C14 H8 N2 O c1ccc2c(c1....
345 3QC4 ic50 = 0.002 uM MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
346 3QCY ic50 = 0.00000001 M 3Q3 C22 H22 N8 O2 c1ccc(cc1)....
347 1UU8 ic50 = 9 uM BI1 C25 H24 N4 O2 CN(C)CCCn1....
348 4CT1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
349 4A07 - AZ7 C17 H13 Cl3 N2 O2 c1cc(ccc1[....
350 2X39 ic50 = 30 nM X39 C19 H21 Cl N6 O c1cc(ccc1C....
351 3E87 - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
352 4QNA ic50 = 0.023 uM X11 C9 H9 N5 O c1ccc(c(c1....
353 4QMO ic50 = 0.019 uM 34L C13 H8 N4 O S c1cc2c(c3c....
354 4QMW ic50 = 0.086 uM KS1 C17 H17 N7 c1c[nH]c2c....
355 3A7H - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
356 4QML - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
357 4QO9 ic50 = 0.16 uM 627 C26 H30 N6 O3 CN1CCN(CC1....
358 4QMQ ic50 = 0.26 uM 34U C24 H27 N5 O2 COCCOc1ccc....
359 4EL9 - AFE C21 H20 O10 C[C@H]1[C@....
360 5D9L ic50 = 0.024 uM 583 C15 H12 N2 O2 c1cc(ccc1c....
361 2XK9 ic50 = 0.03 nM XK9 C18 H17 N7 O4 C/C(=NNC(=....
362 2YCS ic50 = 1.36 nM NXP C18 H18 N6 O C/C(=NNC(=....
363 2WTI ic50 = 0.092 uM WTI C18 H15 N3 O3 S c1cc(ccc1c....
364 2YIR ic50 = 0.17 nM YIR C20 H19 N7 O3 [H]/N=C(N)....
365 2XBJ ic50 = 0.86 uM XBJ C23 H27 F N4 O4 CC(C)([C@@....
366 2XM9 ic50 = 0.009 uM LWH C21 H20 N6 O c1ccc2c(c1....
367 2YIQ ic50 = 12.67 nM YIQ C20 H19 N7 O C/C(=NNC(=....
368 2CN5 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
369 3HZT - J60 C22 H27 Cl N4 O2 CCN(CC)CCN....
370 4FG8 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
371 5L2S - 6ZV C27 H32 F2 N8 CCN1CCN(CC....
372 4AUA ic50 = 7.2 uM 4AU C12 H9 N3 O c1ccc2c(c1....
373 5K00 ic50 = 7.1 nM 6PV C32 H34 N6 O4 COc1cccc(c....
374 5MAG - 7KC C25 H30 N8 O S Cc1nc2ccsc....
375 5IHC ic50 = 0.013 uM 6BB C20 H21 F N4 O c1ccc(c(c1....
376 6BUU - GLY ARG PRO ARG THR THR ZXW PHE ALA GLU n/a n/a
377 3QKM ic50 = 0.038 uM SM9 C31 H43 N5 O4 S CCOCCN(C[C....
378 3CQU ic50 = 151 nM CQU C15 H13 N7 Cc1[nH]c(n....
379 2WEI ic50 = 3.4 nM VGG C17 H21 N5 Cc1cccc(c1....
380 3C0G - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
381 3MFR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
382 4OTI ic50 = 43 nM MI1 C16 H20 N6 O C[C@@H]1CC....
383 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
384 5YF9 - NIO C6 H5 N O2 c1cc(cnc1)....
385 5ONI - 9YE C23 H25 N O3 CC(C)n1c2c....
386 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
387 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
388 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
389 4AU8 ic50 = 551 nM Z3R C11 H8 N2 O2 S3 c1ccc2c(c1....
390 6B16 Ki = 32 nM C7Y C19 H20 N8 C[C@@H](c1....
391 5DFP Ki = 22 nM 59U C28 H32 Cl N7 O CCN1c2c(cn....
392 3FXZ ic50 = 130 nM FLL C30 H18 Cl F N5 O4 Ru c1ccc(cc1)....
393 5IME Ki = 4.6 nM 6BZ C22 H22 Cl N7 O2 CC1=NC=CN(....
394 4ZY6 Ki = 5 nM 4T6 C18 H17 Cl N8 c1cc2c(c(c....
395 3Q53 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
396 4EQC ic50 = 0.008 uM XR1 C29 H28 Cl N7 O S CCN1c2c(cn....
397 5JZJ - AN2 C10 H16 N6 O9 P2 c1nc(c2c(n....
398 5AX9 ic50 = 8 nM 4KT C24 H24 N4 O3 COc1ccc(cc....
399 2J7T - 274 C28 H30 Cl N5 O4 S Cc1c([nH]c....
400 4JQE - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
401 4MWH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
402 4LFI - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
403 3GGF - GVD C22 H19 N7 c1ccc2c(c1....
404 4U44 ic50 = 0.008 uM 3D9 C17 H13 N5 c1ccc(cc1)....
405 3DAK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
406 1QL6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
407 1PHK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
408 3M2W ic50 < 0.003 uM L8I C23 H21 F N4 O CN1CC2(C1)....
409 3BHY - 7CP C18 H18 Cl2 N4 O Cn1c2c(ccc....
410 2J90 - IZA C18 H16 F N3 O CC(C)(C)c1....
411 5VJA - DUK C14 H12 Cl N5 O2 S C[C@H](C(=....
412 5A6N ic50 = 2.1 uM U7E C7 H7 N5 O2 S c1cc(cc(c1....
413 6CMJ ic50 = 5 nM F6J C24 H22 N2 O2 CC(C)Cc1cc....
414 2VN9 - GVD C22 H19 N7 c1ccc2c(c1....
415 4EJN ic50 = 0.005 uM 0R4 C33 H26 F N7 O2 CC(=O)Nc1c....
416 4WNO ic50 = 160 nM 3RF C20 H19 N7 c1ccc2c(c1....
417 4WNP ic50 = 8 nM 3RJ C22 H20 N8 c1ccc2c(c1....
418 5CI7 ic50 = 120 nM 51W C18 H24 I N7 O c1cc(cc(c1....
419 2V7O - DRN C25 H23 N5 O2 S [H]/N=C(/N....
420 3AQV - TAK C24 H25 N5 O c1cc(ccc1c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: XBJ; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 XBJ 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2XK9; Ligand: XK9; Similar sites found with APoc: 588
This union binding pocket(no: 1) in the query (biounit: 2xk9.bio1) has 36 residues
No: Leader PDB Ligand Sequence Similarity
1 5H9Q TD2 None
2 1OGX EQU None
3 5AIG VPR None
4 3ZXE PGZ None
5 1RDS GPC None
6 1FHW I5P None
7 5DKK FMN None
8 5NLD LBT None
9 4BJ8 BTN None
10 2RIF AMP None
11 1NBU PH2 None
12 4RJD TFP None
13 3ORQ ADP 0.931677
14 5VLQ ANP 1.24224
15 4CCK OGA 1.24224
16 5K21 6QF 1.41844
17 4CSD MFU 1.47059
18 2QK4 ATP 1.5528
19 1OFL NGK GCD 1.5528
20 5T96 79J 1.5528
21 1GSA ADP 1.58228
22 5C1P ADP 1.63399
23 5LXB 7A9 1.65289
24 5LHT TIH 1.70068
25 5GLT BGC GAL NAG GAL 1.76056
26 1CKM GTP 1.86335
27 1CKN GTP 1.86335
28 1MXG ACR 1.86335
29 6F6D AKG 1.86335
30 4D52 GXL 1.90476
31 4D52 GIV 1.90476
32 4D4U FUC NDG GAL FUC 1.90476
33 4D4U FUC GAL NAG 1.90476
34 2QHV OC9 1.90476
35 5KJZ PCG 2
36 2XEM SSV 2
37 5O96 SAM 2.04082
38 3THR C2F 2.04778
39 4WVW SLT 2.08333
40 2ZMF CMP 2.1164
41 4D06 NAR 2.12014
42 5VZ0 ADP 2.17391
43 5AE9 OKO 2.17391
44 5FI4 5XV 2.17391
45 6EZ6 C5Z 2.17391
46 4TQK NAG 2.17391
47 4QDF 30Q 2.17391
48 4OCJ NDG 2.17391
49 2ZBA ZBA 2.17391
50 1TZD ADP 2.18182
51 3WUC GLC GAL 2.18978
52 3EW2 BTN 2.22222
53 5ZCT ANP 2.28758
54 4RFR RHN 2.46305
55 2IF8 ADP 2.48447
56 5IM3 DTP 2.48447
57 5YJS SAL 2.48447
58 1EU1 GLC 2.48447
59 3TII ANP 2.48447
60 3K5I ADP 2.48447
61 5LUN OGA 2.48447
62 5OLK DTP 2.48447
63 2V58 LZJ 2.48447
64 3PGU OLA 2.48447
65 3G5N PB2 2.48447
66 3HPY MCT 2.589
67 5XEG AKG 2.5974
68 5TZ6 7OD 2.5974
69 5FQK 6NT 2.60223
70 1Y9Q MED 2.60417
71 1KHT AMP 2.60417
72 5T9C G3P 2.61194
73 6BOX SAH 2.64026
74 4OCT AKG 2.7027
75 3E2M E2M 2.7027
76 4OJ8 AKG 2.73038
77 1HGX 5GP 2.73224
78 2AQX ATP 2.76817
79 4OCV ANP 2.79503
80 2R5V HHH 2.79503
81 1CT9 GLN 2.79503
82 3TY5 ADP 2.79503
83 4IE6 UN9 2.79503
84 1VRP IOM 2.79503
85 1OS7 AKG 2.82686
86 3VPC ADP 2.83688
87 1UMZ BGC BGC XYS BGC XYS GAL 2.8777
88 4R78 AMP 2.91262
89 4RDL FUC GAL NDG FUC 2.92208
90 1NX4 AKG 2.9304
91 4NFE BEN 2.95359
92 1MZV AMP 2.97872
93 4P25 FUC GAL NAG FUC 2.98013
94 2C3H GLC GLC 3.06122
95 5C5T AKG 3.07018
96 2HKA C3S 3.07692
97 2UYN 2KT 3.10078
98 3UDZ ADP 3.10559
99 2VPQ ANP 3.10559
100 5MRH Q9Z 3.10559
101 5UQD AKG 3.10559
102 6FL8 ADP 3.10559
103 6FL8 TIY 3.10559
104 6EAC ANP 3.10559
105 5TDF ADP 3.10559
106 2CFM AMP 3.10559
107 3HQP OXL 3.10559
108 3VV1 GAL FUC 3.125
109 1SGJ OAA 3.16901
110 1SDW IYT 3.18471
111 5AEW BNL 3.19149
112 1OFZ FUC 3.20513
113 1IA9 ANP 3.21429
114 3PNA CMP 3.24675
115 6GW4 CHO 3.25733
116 2P69 PLP 3.26797
117 3O94 NCA 3.31754
118 1ZX5 LFR 3.33333
119 3K7S R52 3.35196
120 2ED4 NAD 3.3557
121 2GQR ADP 3.37553
122 2FT0 ACO 3.40426
123 3A76 SPD 3.40909
124 5J75 6GQ 3.40909
125 5OES ADP 3.41615
126 6A5K SAM 3.41615
127 5VNF VAL THR SER VAL VAL 3.41615
128 2XN5 FUN 3.41615
129 2WA4 069 3.41615
130 3ZGJ RMN 3.41615
131 3A16 PXO 3.41615
132 2XN3 ID8 3.41615
133 1EHI ADP 3.41615
134 2XOC ADP 3.44828
135 5ZZO FLC 3.48259
136 1ZTH ADP 3.48837
137 1ZP9 ATP 3.48837
138 5OCQ CIT 3.50877
139 4FE2 AIR 3.52941
140 4FE2 ADP 3.52941
141 3RGA LSB 3.53357
142 5EO8 TFU 3.53698
143 6E8I PTR 3.5503
144 2JBH 5GP 3.55556
145 3OZG SSI 3.6
146 3NV3 GAL NAG MAN 3.62319
147 5DYO FLU 3.66972
148 3I0O ADP 3.72671
149 3X01 AMP 3.72671
150 1PK8 ATP 3.72671
151 5COU ATP 3.72671
152 1E4E ADP 3.72671
153 3TKY N7I 3.72671
154 3IB1 IMN 3.72671
155 3AYI HCI 3.72671
156 3AYI FAD 3.72671
157 3SK2 GRI 3.78788
158 5XQW 8EU 3.79147
159 2GQS ADP 3.79747
160 2GQS C2R 3.79747
161 1AUX AGS 3.85852
162 4RYV ZEA 3.87097
163 1V1A KDG 3.8835
164 3PGL RZX 3.88889
165 4MMP SLB 3.8961
166 1F5F DHT 3.90244
167 4XZ3 ACP 3.91304
168 5TPV TYD 3.92157
169 3WG3 A2G GAL NAG FUC 3.93258
170 3AB4 THR 3.93258
171 5NFB 8VT 3.97727
172 4BCS BTN 4
173 2HZQ STR 4.02299
174 5MW8 ATP 4.03727
175 3VOT ADP 4.03727
176 2ZL7 FUC GAL NGA 4.0678
177 4ZSI GLP 4.09357
178 6D61 4AA 4.10256
179 3HX3 RET 4.11392
180 2BKK ADP 4.14201
181 4DE0 0JB 4.18251
182 1I7L ATP 4.20712
183 2ZSC BTN 4.25532
184 5GZ9 ANP 4.2623
185 6GVZ CHO 4.2623
186 5UMY TNN 4.28571
187 5JLB SAH 4.30108
188 1U6R IOM 4.34783
189 4RF7 ARG 4.34783
190 3ETH ATP 4.34783
191 3OKA GDD 4.34783
192 2HGS ADP 4.34783
193 5H9P TD2 4.43038
194 1IS3 LAT 4.44444
195 6GNO XDI 4.44444
196 6HDT BTN 4.51128
197 4Y24 TD2 4.54545
198 1P0Z FLC 4.58015
199 6FA4 D1W 4.62428
200 2VT3 ATP 4.65116
201 3P7N FMN 4.65116
202 5YK1 ANP 4.65839
203 6EOM ALA LYS 4.65839
204 2YRX AMP 4.65839
205 3FW9 SLX 4.65839
206 1SWG BTN 4.6875
207 1BKC INN 4.6875
208 4M1U A2G MBG 4.7138
209 3PN1 IVH 4.71698
210 5K2M ADP 4.7619
211 4CS9 AMP 4.7619
212 1RNT 2GP 4.80769
213 4O4F ATP 4.83871
214 4O4F IHP 4.83871
215 5KWY C3S 4.8583
216 5C8W PCG 4.8951
217 4U98 ACP 4.96894
218 5W0N UPU 4.96894
219 3M3E GAL A2G NPO 4.96894
220 4QCK ASD 4.96894
221 5L2R MLA 4.96894
222 4YZ5 SLT 4.96894
223 5VSM 5AD 4.96894
224 2VQ5 HBA 4.97512
225 3VPD ANP 4.98221
226 1CBK ROI 5
227 6DW2 HD4 5.06329
228 5ODY 9SK 5.07246
229 3QRC SCR 5.09554
230 5T7I LAT NAG GAL 5.16129
231 4XYM A12 5.21739
232 3OYW TDG 5.22388
233 4JLS 3ZE 5.26316
234 2VQD AP2 5.2795
235 5I35 ANP 5.2795
236 1UF5 CDT 5.28053
237 1W2D ADP 5.28302
238 1W2D 4IP 5.28302
239 1G2N EPH 5.30303
240 4AVV CD 5.39216
241 2ZHL NAG GAL GAL NAG 5.40541
242 4Z4P SAH 5.42169
243 5WBF LAC 5.55556
244 4LIT AKG 5.59006
245 5KR7 6X9 5.59006
246 5EZU MYR 5.61798
247 3SAO DBH 5.625
248 3SAO NKN 5.625
249 2C49 ADN 5.62914
250 2QX0 PH2 5.66038
251 3KIF GDL 5.66038
252 4J25 OGA 5.67686
253 3HAV ATP 5.68562
254 3HQR OGA 5.69106
255 3NZ1 3NY 5.74713
256 3OCP CMP 5.7554
257 1J3R 6PG 5.78947
258 1C1L GAL BGC 5.83942
259 4YLZ LAT NAG GAL 5.88235
260 4O1P ANP 5.90062
261 2IO8 ADP 5.90062
262 4NPL AKG 6
263 3DCJ THH 6.04651
264 3DGY 2GP 6.18557
265 4ZS4 ATP 6.18893
266 3TDV GDP 6.20915
267 4GYI ADP 6.21118
268 3WVR AMP 6.21118
269 4UWH JXM 6.21118
270 6CGD AKN 6.22951
271 6CGD GNP 6.22951
272 1RGE 2GP 6.25
273 3ZO7 K6H 6.38298
274 1KR3 113 6.46552
275 4OAV ACP 6.52174
276 4UDK NDG 6.52174
277 4XMF HSM 6.52174
278 3QP8 HL0 6.52174
279 4KYK IMN 6.52174
280 1FTH A3P 6.55738
281 4GLW 0XT 6.55738
282 1ZZ7 S0H 6.56566
283 2PTM CMP 6.56566
284 2YKL NLD 6.60377
285 5TQZ GLC 6.66667
286 2W5P CL8 6.71141
287 4ZGP ADP 6.82594
288 4M26 AKG 6.8323
289 4K37 SAM 6.8323
290 4K39 SAM 6.8323
291 4K38 SAM 6.8323
292 3ZW2 NAG GAL FUC 6.89655
293 3PDT ADP 6.90909
294 3KCC CMP 6.92308
295 4NPT 017 7.07071
296 4WOE 3S5 7.14286
297 2IUW AKG 7.14286
298 2XSB GDL 7.14286
299 4WOE ADP 7.14286
300 1NU4 MLA 7.2165
301 1I06 TZL 7.22222
302 5SVV FMN 7.29927
303 1KDK DHT 7.34463
304 1NKI PPF 7.40741
305 5KBE IPH 7.42358
306 1QFT HSM 7.42857
307 2PUL ACP 7.45342
308 1RPN GDP 7.45342
309 3ZS9 ADP ALF 7.45342
310 5KJW 53C 7.45342
311 1QY1 PRZ 7.47126
312 3ZJX BOG 7.61246
313 5KEW 6SB 7.63889
314 5HWV MBN 7.69231
315 4U0W 16G 7.72358
316 3QMN A3P 7.75194
317 1YKD CMP 7.76398
318 5I8T LAC 7.82123
319 3AHW 2AM 7.89474
320 5NC1 NAG 8.01688
321 2AGC DAO 8.02469
322 2CBT TH2 8.03571
323 5GP0 GPP 8.05369
324 4CYI ATP 8.07453
325 5X7Q ACR 8.07453
326 5X7Q GLC GLC GLC GLC GLC 8.07453
327 2QL9 CIT 8.09249
328 4XTR ADP 8.10811
329 4XTR ATP 8.10811
330 5LX9 OLB 8.14332
331 1DZK PRZ 8.28025
332 4MA6 28E 8.28025
333 3ACC 5GP 8.28729
334 5HV0 AKG 8.29493
335 5KBF CMP 8.30565
336 4DVR 0LY 8.30671
337 1JS8 MAN MAN BMA 8.38509
338 2GC0 PAN 8.51064
339 1Y7P RIP 8.52018
340 5B09 4MX 8.65385
341 1ULE GLA GAL NAG 8.66667
342 1OBD ATP 8.82353
343 5LJB RTL 8.88889
344 4COQ SAN 8.90688
345 1M0W ANP 9.00621
346 4IAW LIZ 9.04255
347 4WW7 AMP 9.1954
348 4Q5H ANP 9.21053
349 5EQY 5RA 9.31677
350 1F52 ADP 9.31677
351 6BYM HC3 9.35961
352 2ET1 GLV 9.45274
353 1B55 4IP 9.46746
354 3WUD GLC GAL 9.55882
355 2PYW ADP 9.62733
356 1IZC PYR 9.93789
357 4IX4 ADP 10.2484
358 5JSP DQY 10.4478
359 4K79 GAL A2G 10.4545
360 2P7Q GG6 10.5263
361 4MUV PCG 10.5634
362 4B9K TG0 10.5769
363 1I82 BGC BGC 10.582
364 4DFU QUE 10.8696
365 5C4L 4XR 10.9034
366 5C9J STE 11.1111
367 5NVX 4YY 11.1111
368 1P19 IMP 11.3122
369 1FUT 2GP 11.3208
370 5ML3 DL3 11.4094
371 2HVW DDN 11.9565
372 2YFO GAL 12.4224
373 2YFO GLA 12.4224
374 1RZ1 NAD 12.4224
375 3PH4 AOS 12.426
376 4LI4 AMP 12.5
377 3OF1 CMP 12.6016
378 5CKW ANP 12.7329
379 5DZT AMP 12.7329
380 3VPB ADP 14.2857
381 1OIJ AKG 14.2857
382 2BS5 BGC GAL FUC 14.4444
383 4JH6 FCN 14.4928
384 5C03 AGS 14.5963
385 3KMW ATP 14.7601
386 4WOV 3SM 14.8265
387 5V3D FCN 15.1724
388 3VHE 42Q 15.2174
389 4AZW ATP 15.2174
390 4JGX PLM 15.5039
391 4WUJ FMN 15.6463
392 4Z28 BTN 15.6716
393 6C1S EFV 16.1491
394 4QXB OGA 16.1765
395 5FPX GLY SER SER HIS HIS HIS HIS HIS 16.8142
396 3ZIA ADP 17.4603
397 4K55 H6P 17.7419
398 4OFG PCG 18.0556
399 1GT4 UNA 18.239
400 1MID LAP 18.6813
401 4ZU4 4TG 19.5946
402 5TBM 79A 19.6581
403 1TQP ATP 20.2128
404 2QLU ADE 20.7006
405 4U0I 0LI 21.2698
406 2D6M LBT 22.0126
407 5QIN J2V 23.1013
408 3GNI ATP 23.2919
409 5USZ SKE 23.8754
410 3PLS ANP 24.1611
411 3C1X CKK 24.2236
412 5EOB 5QQ 24.4514
413 4E1Z 0MX 25.0859
414 3H9R TAK 27.3292
415 5KO1 6UY 27.5618
416 4YZC STU 28.882
417 5BV6 35G 28.9474
418 3LXK MI1 29.1925
419 3UIM ANP 29.1925
420 6GIN IR2 29.2359
421 6GWR FEW 29.8413
422 1VJY 460 30.033
423 4BTK DTQ 30.1242
424 5LPZ ADP 30.4348
425 3LXN MI1 30.5031
426 4XH0 ADP 30.7453
427 4KBA 1QM 30.7453
428 4K33 ACP 31.0559
429 4Y85 499 31.0559
430 4FL3 ANP 31.3665
431 3VRY B43 31.3665
432 5U6C 7YS 31.4286
433 5T8O 76Z 31.677
434 1OPK P16 31.677
435 6ES0 BW8 31.8612
436 3NW7 LGV 31.9218
437 3GQI ACP 31.9876
438 4E93 GUI 31.9876
439 4ASE AV9 31.9876
440 5WO4 B7V 32.1192
441 4GJ3 0XP 32.1192
442 5OKT 9XK 32.1656
443 2PVF ACP 32.2981
444 4CLI 5P8 32.2981
445 4Y93 746 32.2981
446 2CSN CKI 32.3232
447 5JGA 6KC 32.381
448 4AG8 AXI 32.5949
449 3KRL KRL 32.6087
450 4FF8 14S 32.6087
451 3E8N VRA 32.6087
452 3E8N ATP 32.6087
453 4EWH T77 32.7273
454 5LPB ADP 32.7703
455 1K3A ACP 32.7759
456 4AT3 LTI 32.7759
457 5JKG 6LF 32.7974
458 4P5Z Q7M 32.9193
459 5UR1 YY9 33.119
460 2OO8 RAJ 33.123
461 6C7Y ADP 33.2168
462 5HES 032 33.2248
463 3RI1 3RH 33.5463
464 5NKB 8ZT 33.6601
465 1JPA ANP 33.9744
466 5JFS 6K0 34.0909
467 2X2M X2M 34.3949
468 5WNL STU 34.472
469 2H8H H8H 34.472
470 1Y57 MPZ 34.472
471 6A1G 9OL 34.472
472 5MJA 7O3 34.7541
473 5DBX ANP 35.0932
474 4IDT T28 35.4037
475 3PP0 03Q 35.7143
476 5UKL SIX 35.7143
477 3PVW QRX 35.7143
478 1BYG STU 35.9712
479 4CSV STI 36
480 2XVD AS6 36.0927
481 2OFV 242 36.1011
482 5CEO 50D 36.3333
483 2HK5 1BM 36.6667
484 2Y6O 1N1 36.7698
485 1U59 STU 36.9338
486 4UXL 5P8 36.9565
487 4CRL C1I 36.9565
488 3BZ3 YAM 36.9565
489 3SLS ANP 37.1711
490 3SLS 77D 37.1711
491 2BMB PMM 37.2671
492 6GQM F8H 37.5776
493 3ALN ANP 37.8882
494 4TWP AXI 38.0074
495 5H2U 1N1 38.2022
496 3SRV S19 38.2671
497 5TO8 7FM 38.2979
498 6CZ3 FLJ 38.6364
499 1U5R ATP 38.8199
500 4F4P 0SB 38.8278
501 5HCY 60D 39.1304
502 5FBN 5WF 39.4834
503 3G5D 1N1 39.8601
504 3GC0 AMP 40.1216
505 4QMN DB8 40.3226
506 3FC2 IBI 40.3727
507 5TA6 79D 40.3727
508 5MY8 RXZ 40.6832
509 5Y86 HRM 40.6832
510 3HMO STU 40.9938
511 4BHN BH9 40.9938
512 4OTH DRN 41.3043
513 4RFM 3P6 41.3534
514 4YMJ 4EJ 41.4474
515 3EKK GS2 41.6938
516 5N87 N66 41.853
517 2A19 ANP 41.9014
518 5ZTN CUR 41.9255
519 1IR3 ANP 42.1569
520 4I6H 1C8 42.2078
521 2WU6 DKI 42.8571
522 5EFQ ADP 42.8571
523 5LI9 ACP 43.1677
524 1V0O INR 43.4028
525 6FYV 3NG 43.4783
526 4H3P ANP 43.4783
527 4H3Q ANP 43.4783
528 4DC2 ADE 43.4783
529 6E2O S0L 44.0678
530 6FYL 3NG 44.0994
531 3GC8 B45 44.0994
532 4PNI KQQ 44.0994
533 4WNK 453 44.0994
534 5BVE 4VG 44.0994
535 4L9I 8PR 44.0994
536 5VC5 96M 44.2907
537 4NST ADP 44.4099
538 3TXO 07U 44.4099
539 1UNH IXM 44.5205
540 3O0G 3O0 44.5205
541 2BPM 529 44.6602
542 6G33 5ID 44.7205
543 5X8I SQZ 44.7205
544 2F57 23D