Receptor
PDB id Resolution Class Description Source Keywords
2XTZ 2.34 Å EC: 3.6.5.1 CRYSTAL STRUCTURE OF THE G ALPHA PROTEIN ATGPA1 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA HYDROLASE G-PROTEIN SIGNALING SELF-ACTIVATION RAS-LIKE DO
Ref.: THE CRYSTAL STRUCTURE OF A SELF-ACTIVATING G PROTEI SUBUNIT REVEALS ITS DISTINCT MECHANISM OF SIGNAL IN SCI.SIGNAL. V. 159 RA8 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:1383;
B:1380;
B:1382;
C:1386;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
35.453 Cl [Cl-]
GSP A:1382;
B:1379;
C:1382;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
539.246 C10 H16 N5 O13 P3 S c1nc2...
MG A:1381;
B:1378;
C:1381;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
submit data
24.305 Mg [Mg+2...
SO4 A:1384;
B:1381;
C:1383;
C:1384;
C:1385;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2XTZ 2.34 Å EC: 3.6.5.1 CRYSTAL STRUCTURE OF THE G ALPHA PROTEIN ATGPA1 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA HYDROLASE G-PROTEIN SIGNALING SELF-ACTIVATION RAS-LIKE DO
Ref.: THE CRYSTAL STRUCTURE OF A SELF-ACTIVATING G PROTEI SUBUNIT REVEALS ITS DISTINCT MECHANISM OF SIGNAL IN SCI.SIGNAL. V. 159 RA8 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2XTZ - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2XTZ - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
50% Homology Family (24)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1GFI - ALF GDP n/a n/a
2 4N0E - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4PAM - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
4 1AS0 - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
5 1GDD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
6 4PAO - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
7 1BOF - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
8 4N0D - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
9 1SVS Kd = 2.3 nM GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 1SVK Kd = 1.1 nM ALF GDP n/a n/a
11 1GIL - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
12 3FFA Kd = 0.69 uM GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
13 1CIP - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
14 1GIA - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
15 1AS3 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
16 4PAN - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
17 4PAQ - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
18 1TAG - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
19 1TND - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
20 1TAD - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
21 1AZT - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
22 1BH2 - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
23 2XTZ - GSP C10 H16 N5 O13 P3 S c1nc2c(n1[....
24 1ZCB - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GSP; Similar ligands found: 132
No: Ligand ECFP6 Tc MDL keys Tc
1 GSP 1 1
2 GP3 0.897436 0.925
3 GTP 0.853659 0.948718
4 GNH 0.829268 0.936709
5 GDP 0.817073 0.948718
6 G1R 0.8 0.936709
7 GCP 0.77907 0.925
8 GNP 0.770115 0.925
9 GMV 0.767442 0.925
10 5GP 0.756098 0.935897
11 G 0.756098 0.935897
12 G2R 0.747253 0.91358
13 GKE 0.744681 0.91358
14 GDD 0.744681 0.91358
15 GDC 0.744681 0.91358
16 GPG 0.73913 0.91358
17 GTG 0.736842 0.891566
18 G3A 0.729167 0.925
19 G5P 0.721649 0.925
20 GDR 0.71875 0.91358
21 GFB 0.71875 0.91358
22 GAV 0.714286 0.987179
23 GP2 0.712644 0.91358
24 6CK 0.71134 0.891566
25 Y9Z 0.708333 0.860465
26 JB2 0.69697 0.91358
27 GKD 0.69697 0.91358
28 GDP MG 0.696629 0.878049
29 G2P 0.692308 0.91358
30 GDX 0.69 0.925
31 GPD 0.69 0.880952
32 GDP BEF 0.688889 0.857143
33 GCP G 0.677419 0.888889
34 ALF 5GP 0.67033 0.847059
35 0O2 0.666667 0.935897
36 GTP MG 0.666667 0.878049
37 BEF GDP 0.666667 0.847059
38 YGP 0.663265 0.858824
39 JB3 0.657143 0.902439
40 GDP ALF 0.645833 0.847059
41 GDP AF3 0.645833 0.847059
42 G G 0.642857 0.888889
43 GMP 0.641975 0.835443
44 G3D 0.638298 0.935897
45 NGD 0.635514 0.91358
46 2MD 0.633027 0.894118
47 CAG 0.630631 0.840909
48 G4P 0.625 0.935897
49 U2G 0.62037 0.891566
50 FEG 0.62037 0.83908
51 MGD 0.616071 0.894118
52 ZGP 0.614679 0.872093
53 CG2 0.609091 0.891566
54 TPG 0.598291 0.804348
55 3GP 0.595506 0.898734
56 GDP 7MG 0.590476 0.86747
57 GH3 0.581633 0.924051
58 MD1 0.581197 0.894118
59 PGD 0.581197 0.926829
60 2GP 0.577778 0.911392
61 DGT 0.561224 0.878049
62 DBG 0.558333 0.902439
63 G1G 0.550847 0.880952
64 SAP 0.547368 0.924051
65 AGS 0.547368 0.924051
66 FE9 0.546219 0.8
67 G4M 0.539062 0.840909
68 U A G G 0.538462 0.888889
69 G A A A 0.529915 0.878049
70 MGP 0.525253 0.91358
71 GPX 0.524272 0.898734
72 BGO 0.521739 0.879518
73 DGI 0.520408 0.878049
74 6G0 0.52 0.91358
75 I2C FE2 CMO CMO 0.516667 0.774194
76 IDP 0.515464 0.923077
77 GGM 0.508475 0.858824
78 G1R G1R 0.508065 0.879518
79 PGD O 0.504 0.875
80 G G U 0.5 0.888889
81 GTA 0.486726 0.891566
82 P2G 0.484536 0.839506
83 GPC 0.483607 0.83908
84 G C 0.483333 0.857143
85 P1G 0.474747 0.829268
86 DG 0.474227 0.865854
87 DGP 0.474227 0.865854
88 BA3 0.46875 0.85
89 AP5 0.463918 0.85
90 B4P 0.463918 0.85
91 IMP 0.463918 0.910256
92 G2Q 0.462963 0.91358
93 G G G RPC 0.459016 0.833333
94 APC G U 0.456 0.843373
95 U G A 0.452555 0.847059
96 ATP 0.45 0.873418
97 G G G C 0.448819 0.869048
98 A2D 0.447917 0.85
99 5FA 0.445545 0.873418
100 AQP 0.445545 0.873418
101 A G C C 0.445312 0.86747
102 G7M 0.444444 0.901235
103 G U34 0.442623 0.847059
104 01G 0.442478 0.860465
105 ITT 0.44 0.825
106 SGP 0.44 0.876543
107 G C C C 0.431818 0.879518
108 AN2 0.43 0.8625
109 DG DG 0.428571 0.825581
110 A4P 0.42623 0.829545
111 UCG 0.424242 0.86747
112 C2E 0.423077 0.875
113 PCG 0.423077 0.886076
114 35G 0.423077 0.886076
115 MGO 0.420561 0.823529
116 ADP 0.42 0.873418
117 ANP 0.419048 0.851852
118 5GP 5GP 0.419048 0.839506
119 ADQ 0.418182 0.829268
120 APR 0.417476 0.85
121 AR6 0.417476 0.85
122 7DT 0.417476 0.860759
123 A G U 0.414286 0.847059
124 AD9 0.413462 0.851852
125 UP5 0.413223 0.831325
126 A22 0.412844 0.8625
127 25L 0.412281 0.8625
128 M33 0.411765 0.839506
129 JBT 0.410405 0.783505
130 ACP 0.407767 0.851852
131 ACQ 0.40566 0.851852
132 A1R 0.405405 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2XTZ; Ligand: GSP; Similar sites found: 526
This union binding pocket(no: 1) in the query (biounit: 2xtz.bio3) has 26 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3LN9 FLC 0.006646 0.41983 None
2 5C2N NAG 0.0214 0.4141 None
3 2RCN GDP 0.000000003755 0.54167 1.41243
4 1QHG ATP 0.009617 0.4094 1.41243
5 2ZL4 ALA ALA ALA ALA 0.03086 0.40359 1.53061
6 1SKQ GDP 0.00000000006596 0.83908 1.69492
7 1YQT ADP 0.00007826 0.54514 1.69492
8 1XMV ADP 0.00007456 0.4125 1.69492
9 3ITJ CIT 0.01238 0.42216 1.77515
10 1IG0 VIB 0.03525 0.40054 1.88088
11 4RD0 GDP 0.00000000007164 0.6829 1.9774
12 1JWY GDP 0.0000001888 0.62639 1.9774
13 2OG2 MLI 0.00009268 0.54919 1.9774
14 1JWY ADP 0.000058 0.52412 1.9774
15 4R43 GDP 0.0004294 0.48789 1.9774
16 3QOX SAH 0.0007895 0.42793 1.9774
17 2IYF UDP 0.01652 0.41349 1.9774
18 4B9E FAH 0.0287 0.41019 1.99336
19 1VBO MAN MAN MAN 0.02861 0.40621 2.01342
20 1CR1 TTP 0.001333 0.40264 2.02703
21 4LJ9 ACP 0.001831 0.45676 2.0649
22 2A5J GDP 0.00000001576 0.68582 2.09424
23 1L2T ATP 0.000995 0.431 2.12766
24 2CHG ANP 0.000776 0.45529 2.21239
25 3EZ2 ADP 0.00005224 0.54031 2.25989
26 5FTB ANP 0.0001073 0.50518 2.25989
27 3ZS9 ADP ALF 0.0000179 0.48918 2.25989
28 3FKQ ATP 0.0001553 0.4868 2.25989
29 2WOJ ADP ALF 0.00002313 0.48495 2.25989
30 5FHD ADP ALF 0.0001639 0.47601 2.25989
31 2BIF ANP 0.003697 0.41469 2.25989
32 2BIF SIN 0.006343 0.41469 2.25989
33 5M7P ADP 0.000564 0.4102 2.25989
34 3GDN FAD 0.01264 0.40363 2.25989
35 3GDN HBX 0.0186 0.40264 2.25989
36 2PW0 TRC 0.02924 0.40079 2.25989
37 1YRB GDP 0.00000000864 0.68812 2.29008
38 1Z0A GDP 0.000000005197 0.55956 2.29885
39 3B9Q MLI 0.00002759 0.56449 2.31788
40 3BFX A3P 0.001901 0.43375 2.36486
41 1UJ2 C5P 0.001136 0.42697 2.38095
42 1UJ2 ADP 0.001279 0.42488 2.38095
43 2ZTS ADP 0.001085 0.44451 2.39044
44 4WEI GLC GAL 0.003707 0.4578 2.52708
45 2ZFI ADP 0.00002436 0.54946 2.54237
46 4AG5 ADP 0.0001084 0.53654 2.54237
47 2PL3 ADP 0.0007055 0.48304 2.54237
48 4XGU ADP 0.000673 0.45808 2.54237
49 1Z6T ADP 0.001011 0.45012 2.54237
50 1W5T ADP 0.0031 0.42815 2.54237
51 1W5T ANP 0.002115 0.42796 2.54237
52 2X1L ADN 0.02002 0.40524 2.54237
53 3PQC GDP 0.000001301 0.59549 2.5641
54 2X7I CIT 0.01579 0.41038 2.5974
55 5BQ5 ADP BEF 0.0003457 0.48124 2.6455
56 2OZE AGS 0.0003028 0.46899 2.68456
57 2Z5F A3P 0.004361 0.41434 2.68456
58 1G6O ADP 0.0002299 0.48959 2.72727
59 5J1J ANP 0.00005828 0.46545 2.80702
60 4ZKD GDP 0.0000000002917 0.69211 2.82486
61 5M04 GDP 0.0000000001671 0.56487 2.82486
62 3EC1 GDP 0.00000001622 0.53671 2.82486
63 1QF5 RPL 0.007335 0.44503 2.82486
64 2GK6 ADP 0.005799 0.44162 2.82486
65 1PUJ GNP 0.0000000005095 0.60345 2.83688
66 2QEN ADP 0.00005433 0.4407 2.85714
67 4E03 ADP 0.000006718 0.45304 2.91262
68 5L3W GDP 0.0001728 0.41675 2.94118
69 5L3R GCP 0.0000106 0.51143 2.99003
70 1BG2 ADP 0.0000007304 0.40829 3.07692
71 5MVR ADP 0.00007079 0.4088 3.08642
72 4B47 GDP 0.0000000000493 0.84549 3.10734
73 3U6B GDP 0.0000000001246 0.82509 3.10734
74 2BVN GNP 0.00000000006361 0.78641 3.10734
75 4G5G GDP 0.0000000004626 0.78271 3.10734
76 3U6K GDP 0.000000001474 0.75785 3.10734
77 3LRE ADP 0.00000427 0.62021 3.10734
78 5JBQ GDP 0.0000000003674 0.57064 3.10734
79 1DAR GDP 0.000000000494 0.56712 3.10734
80 1D8T GDP 0.0000000005068 0.56647 3.10734
81 4IEE AGS 0.000826 0.47957 3.10734
82 2DPY ADP 0.00139 0.47392 3.10734
83 4YS0 ADP 0.003871 0.4238 3.10734
84 3IO3 ADP 0.00003632 0.45388 3.16092
85 4M6T SAM 0.03871 0.40436 3.27869
86 2HCJ GDP 0.0000000002609 0.56379 3.28358
87 1W7J ADP BEF 0.00004157 0.51261 3.31126
88 3VMF GTP 0.0000000001096 0.706 3.38983
89 2IS6 ADP 0.0002235 0.5019 3.38983
90 4OHY ANP 0.0002698 0.45411 3.38983
91 5I34 GDP 0.00001812 0.43993 3.38983
92 1X6V ADP 0.0006845 0.41579 3.38983
93 1U2Z SAH 0.001764 0.4144 3.38983
94 4QOS ADP 0.0007103 0.4665 3.39623
95 3A1S GDP 0.000003359 0.58379 3.48837
96 2BEK ATP 0.0001597 0.47193 3.50195
97 3H86 AP5 0.008651 0.40055 3.64583
98 2B8W ALF 5GP 0.000009722 0.51296 3.65854
99 1VHT BA3 0.0003701 0.47984 3.66972
100 2C78 GNP 0.00000000002007 0.76442 3.67232
101 2C77 GNP 0.000000000005879 0.70983 3.67232
102 1GOJ ADP 0.000003488 0.62736 3.67232
103 1MKY GDP 0.0000000002868 0.57174 3.67232
104 4ZG4 VO4 ADP 0.000004441 0.50837 3.67232
105 2FNA ADP 0.0002953 0.46062 3.67232
106 5FJJ MAN 0.02818 0.41116 3.67232
107 2CE7 ADP 0.0001993 0.40754 3.67232
108 3COB ADP 0.000007176 0.40167 3.67232
109 2GWH A3P 0.007758 0.41014 3.69128
110 1D5C GDP 0.00000002649 0.6567 3.7037
111 5KUT GDP 0.0000004519 0.49022 3.7037
112 1H65 GDP 0.0001803 0.4697 3.7037
113 3BOS CDP 0.00007407 0.5256 3.71901
114 3FYH ADP 0.003903 0.40677 3.72671
115 5X40 ACP 0.001395 0.41153 3.76712
116 1M7G ADX 0.0005267 0.44683 3.79147
117 1M7G ADP 0.0009392 0.43351 3.79147
118 1M7G AV2 0.000005038 0.4332 3.79147
119 5HCN GCP 0.0000001053 0.65631 3.83142
120 4GOX A3P 0.001598 0.426 3.83387
121 2WKQ GTP 0.00000000129 0.67923 3.91566
122 1D2E GDP 0.000000005015 0.69901 3.9548
123 3TBK ANP 0.007021 0.43729 3.9548
124 5TSH ANP 0.00005296 0.41196 3.9548
125 1R18 SAH 0.00377 0.41048 3.96476
126 1WF3 GNP 0.000000002422 0.65512 3.98671
127 3ZQ6 ADP ALF 0.00002219 0.49574 4.01235
128 4P32 ADP 0.004605 0.41002 4.01606
129 4GBM A3P 0.004024 0.4093 4.02477
130 2FFQ GSP 0.00000000003376 0.72978 4.09357
131 5H56 ADP 0.00306 0.41407 4.10256
132 5H56 TYD 0.00306 0.41407 4.10256
133 1ION ADP 0.0000167 0.44365 4.11523
134 1FP6 ADP 0.0001171 0.49771 4.15225
135 3DEF GDP 0.000027 0.52708 4.19847
136 1G3Q ADP 0.00001077 0.55939 4.21941
137 5IRR GSP 0.0000002444 0.59126 4.22078
138 3WY9 GDP 0.00000000003827 0.85106 4.23729
139 3WYA GDP 0.00000000006427 0.82506 4.23729
140 4J0Q GDP 0.0000000001328 0.8237 4.23729
141 2WHX ADP 0.00008801 0.54253 4.23729
142 2FAH GDP 0.0004233 0.472 4.23729
143 2AL2 PEP 0.01569 0.40665 4.23729
144 3TK1 GDP 0.000000005246 0.75587 4.24242
145 4PPF FLC 0.000001987 0.64104 4.28571
146 2ZR9 DTP 0.00008872 0.52172 4.29799
147 2QN6 GDP 0.0000000002378 0.81087 4.30108
148 2C04 GCP 0.0000547 0.50724 4.3771
149 3BER AMP 0.02328 0.40197 4.41767
150 4R98 GNH 0.00000001892 0.52972 4.42804
151 1HTW ADP 0.00008763 0.41302 4.43038
152 1UKZ ADP 0.007295 0.40244 4.4335
153 2W58 ADP 0.000008595 0.61127 4.45545
154 2VOH CIT 0.01071 0.4166 4.4586
155 2F5X ASP 0.0293 0.40572 4.48718
156 2WIC GNP 0.0000000002359 0.78411 4.49438
157 1G41 ADP 0.0006444 0.46849 4.5045
158 1FNN ADP 0.0005468 0.45766 4.51977
159 4PFO ADP 0.0005413 0.43816 4.51977
160 1OS1 ATP 0.001732 0.4026 4.51977
161 4LPS GDP 0.0000003073 0.63388 4.54545
162 2GDJ ANP 0.0001372 0.51236 4.54545
163 4MKF AP5 0.003767 0.42237 4.60829
164 3BFV ADP 0.00001847 0.55539 4.79705
165 1XP8 AGS 0.000177 0.51346 4.80226
166 4IDN GNP 0.00004567 0.49498 4.80226
167 3FVQ ATP 0.0004567 0.45676 4.80226
168 2J5V PCA 0.01819 0.41825 4.80226
169 1WY7 SAH 0.001167 0.41706 4.83092
170 1I1N SAH 0.005421 0.40253 4.86726
171 5J1S ATP 0.003484 0.40879 4.87805
172 3CPJ GDP 0.00000008432 0.53817 4.93274
173 1JI0 ATP 0.00004414 0.55182 5
174 2F9L GDP 0.00000004638 0.61458 5.02513
175 5N69 ADP 0.00006932 0.4292 5.02513
176 4LC1 GDP 0.00000008955 0.66973 5.04451
177 1X1R GDP 0.00000002222 0.60306 5.05618
178 4DCT GDP 0.00000001085 0.70393 5.08475
179 4WZA ACP 0.0000762 0.51259 5.08475
180 4WZA ADP 0.0000762 0.51259 5.08475
181 1YTM ATP 0.0002535 0.46781 5.08475
182 5KSZ GCP 0.000008827 0.46415 5.08475
183 1B7T ADP 0.0002389 0.4888 5.12821
184 2IXE ATP 0.0006438 0.44627 5.16605
185 4DID GDP 0.0000002013 0.64274 5.18135
186 1KK8 BEF ADP 0.00006287 0.50451 5.19481
187 2NGR AF3 0.0000000098 0.74176 5.2356
188 2NGR GDP 0.00000002015 0.69096 5.2356
189 1GRN AF3 0.000000183 0.67568 5.2356
190 1GRN GDP 0.0000000528 0.64319 5.2356
191 1A4R GNH 0.0000003001 0.60917 5.2356
192 1A4R GDP 0.0000002543 0.60477 5.2356
193 1U0J ADP 0.0007544 0.48156 5.24345
194 1JJV ATP 0.0000116 0.58802 5.33981
195 2QJY UQ2 0.02674 0.40688 5.34759
196 3B5J 12D 0.00003772 0.55537 5.34979
197 5MZN ADP 0.003707 0.45175 5.36723
198 4PJ3 ANP 0.003969 0.42717 5.36723
199 1DNP MHF 0.01345 0.42491 5.36723
200 3QXC ATP 0.002115 0.41001 5.3719
201 1YZN GNP 0.0000000002361 0.67962 5.40541
202 4V03 ADP 0.00002697 0.43767 5.44747
203 4P3Y GDP 0.0000000001313 0.56961 5.49451
204 3UIE ANP 0.0001246 0.50213 5.5
205 1NRJ GTP 0.0000000002006 0.65617 5.50459
206 1W0J ADP 0.00004636 0.43565 5.51471
207 4YC7 GNP 0.000000002452 0.62861 5.52486
208 4XTR ATP 0.00004351 0.47041 5.52995
209 4XVU ATP 0.00004843 0.4687 5.52995
210 4XTR ADP 0.00003732 0.45354 5.52995
211 4DKX GDP 0.0000000009245 0.76786 5.55556
212 3NHB ADP 0.00004567 0.55781 5.55556
213 3FB4 AP5 0.004203 0.41929 5.55556
214 1Z0F GDP 0.00000001259 0.70081 5.58659
215 1NJF AGS 0.000671 0.4199 5.6
216 1NJF ADP 0.0005721 0.41183 5.6
217 3VX3 ADP 0.0005592 0.45723 5.64516
218 4NCN GTP 0.0000000001376 0.71963 5.64972
219 1TQ4 GDP 0.0000001121 0.61286 5.64972
220 2C9O ADP 0.0005679 0.45266 5.64972
221 5IRN ADP 0.00009327 0.42579 5.64972
222 5D9G GLU ASN LEU TYR PHE GLN 0.02811 0.40167 5.64972
223 4KFU ACP 0.00001137 0.40521 5.66038
224 4PC3 GDP 0.00000006865 0.64664 5.67376
225 4Q1A UDP 0.007446 0.45558 5.71429
226 4Q1A 2XZ 0.007446 0.45558 5.71429
227 4M7V RAR 0.01222 0.40426 5.71429
228 1OIX GDP 0.0000000001814 0.69724 5.75916
229 1OIV GDP 0.00000003901 0.60391 5.75916
230 3A4M ADP 0.00001235 0.58057 5.76923
231 2OFW ADX 0.000947 0.44556 5.76923
232 1VG8 GNP 0.00000000003469 0.72931 5.7971
233 4TMZ GSP 0.000000000268 0.7076 5.7971
234 1VG0 GDP 0.00000002587 0.55097 5.7971
235 2BCG GDP 0.0000001603 0.61362 5.82524
236 3IT6 ORN 0.03734 0.40119 5.85366
237 5UWP GNP 0.00000000002071 0.74157 5.90717
238 5UWI GNP 0.0000000000186 0.7402 5.90717
239 5DHF GNP 0.00000000002382 0.73587 5.90717
240 5DI9 GNP 0.00000000002913 0.73557 5.90717
241 5UWQ GNP 0.00000000001888 0.72195 5.90717
242 5UWW GNP 0.00000000002069 0.72043 5.90717
243 5UWJ GNP 0.00000000002185 0.71949 5.90717
244 5UWH GNP 0.00000000002274 0.71881 5.90717
245 5UWO GNP 0.00000000002377 0.71812 5.90717
246 2CBZ ATP 0.000003208 0.63848 5.90717
247 1YVD GNP 0.0000000008413 0.67058 5.91716
248 1KK1 GNP 0.0000000003674 0.8013 5.9322
249 1WDT GTP 0.000000001058 0.70988 5.9322
250 2NCD ADP 0.00002551 0.57053 5.9322
251 1IHU AF3 0.0001547 0.47252 5.9322
252 1IHU ADP 0.0001997 0.46354 5.9322
253 5VGR GDP 0.0006266 0.45948 5.9322
254 4A4Z ANP 0.005303 0.4339 5.9322
255 2EW1 GNP 0.0000000007558 0.65588 5.97015
256 2XTN GTP 0.00002224 0.50316 5.98291
257 4MKG AP5 0.003212 0.42425 5.99078
258 2WJH GDP 0.000000001234 0.57313 6.0241
259 2WJH FLC 0.0000006103 0.49618 6.0241
260 3E70 GDP 0.0000178 0.44053 6.09756
261 3CNL GNP 0.000000000716 0.78663 6.10687
262 2QZ4 ADP 0.0001587 0.49718 6.10687
263 3TKL GTP 0.0000000002729 0.69854 6.12245
264 1V8K ANP 0.0000005565 0.63054 6.21469
265 2ZJ5 ADP 0.02416 0.41159 6.21469
266 5G41 AP5 0.005875 0.41801 6.27803
267 3KJI ADP 0.0001755 0.42442 6.29921
268 4O48 ASP 0.03293 0.4038 6.3253
269 3GJ7 GDP 0.000000002505 0.74647 6.33484
270 3GJ5 GDP 0.000000001472 0.74577 6.33484
271 3GJ0 GDP 0.000000003313 0.74047 6.33484
272 3GJ4 GDP 0.000000003888 0.73704 6.33484
273 3GJ3 GDP 0.000000001521 0.55863 6.33484
274 3WYF GTP 0.00000000004588 0.72759 6.39269
275 1RYH GNP 0.000000004726 0.56943 6.40394
276 1EK0 GNP 0.0000000002995 0.68853 6.47059
277 1G16 GDP 0.0000004531 0.54149 6.47059
278 3CH5 GDP 0.00000000136 0.74742 6.48148
279 4HAT GNP 0.00000000001666 0.74538 6.48148
280 1IBR GNP 0.00000000002709 0.71597 6.48148
281 1VG1 GDP 0.000000003899 0.55378 6.48649
282 1VG9 GDP 0.000000009102 0.54373 6.48649
283 5GOE GDP 0.000000004357 0.71213 6.49718
284 3ZFD ANP 0.0000002232 0.50665 6.49718
285 3DZD ADP 0.0003997 0.47314 6.49718
286 5XDR ADP 0.001891 0.45111 6.49718
287 5IFS ADP 0.0002928 0.40302 6.49718
288 2H7C SIA 0.03665 0.40125 6.49718
289 3Q85 GNP 0.000000001237 0.55577 6.50888
290 3GJ8 GDP 0.000000001439 0.74624 6.52174
291 1M7B GTP 0.0000000005684 0.71211 6.52174
292 3MJH GTP 0.0000000002167 0.69416 6.54762
293 2D7C GTP 0.0000000001883 0.69659 6.58683
294 1D2N ANP 0.0008343 0.44543 6.61765
295 2PEZ DAT 0.0008713 0.4393 6.70391
296 2PEZ GGZ 0.0008713 0.4393 6.70391
297 2CJW GDP 0.000000002682 0.745 6.77083
298 4H1V GNP 0.000002389 0.56854 6.77507
299 4LX0 BEF GDP 0.0000000002112 0.69775 6.77966
300 5I0H ADP BEF 0.000002048 0.50703 6.77966
301 5L3V GDP 0.0000117 0.45366 6.77966
302 3QBT GNP 0.00000000009641 0.70823 6.89655
303 3TNF GNP 0.0000000001552 0.70619 6.89655
304 2OBM ADP 0.001531 0.47946 6.91643
305 3SBD GNP 0.0000000009687 0.66813 6.95187
306 1MH1 GNP 0.0000000007298 0.67608 6.98925
307 1G6H ADP 0.000004481 0.6259 7.00389
308 1P9B GDP 0.00003767 0.51454 7.06215
309 1G4U GDP 0.000001566 0.56992 7.06522
310 1G4U AF3 0.00005913 0.55094 7.06522
311 3RAB GNP 0.0000000001304 0.70298 7.10059
312 1Z2A GDP 0.0000000405 0.61703 7.14286
313 1KY3 GDP 0.00000006579 0.53836 7.14286
314 1B0U ATP 0.001605 0.44531 7.25191
315 4ITR GDP 0.000001442 0.50746 7.27848
316 1DS6 GDP 0.00000006807 0.51129 7.29167
317 2FJU GSP 0.0000000009247 0.63621 7.30337
318 1G7S GDP 0.0000000003637 0.77504 7.34463
319 5FG3 GDP 0.0000000001243 0.56778 7.34463
320 3DKP ADP 0.001187 0.46606 7.34694
321 3W5J GDP 0.0000001307 0.69485 7.35294
322 1G8S MET 0.0154 0.42184 7.3913
323 4YDS ATP 0.00007305 0.54045 7.45614
324 2BME GNP 0.00000000005736 0.71725 7.52688
325 3DC4 ADP 0.000006179 0.59621 7.55814
326 4WZ6 ATP 0.00002343 0.57424 7.58621
327 4QM7 GTP 0.0001808 0.50645 7.60234
328 5JCP GDP ALF 0.000000006135 0.68534 7.62712
329 1K6M AGS 0.004857 0.4059 7.62712
330 1Z0J GTP 0.0000000006421 0.66257 7.64706
331 4OI4 ATP 0.0003776 0.45204 7.82609
332 3Q72 GNP 0.000000001165 0.54352 7.83133
333 4U5X GNP 0.00000001414 0.57955 7.86517
334 5BXQ GDP 0.000000002442 0.56568 7.87402
335 3MD0 GDP 0.00000000167 0.768 7.9096
336 2WMO GTP 0.000000004556 0.71122 7.9096
337 4LYA ATP 0.00008482 0.51616 7.9096
338 5CK5 GDP 0.0000000585 0.50294 7.91139
339 2WJG GDP 0.000000000924 0.76787 7.97872
340 4WOP CTP 0.0007176 0.4141 8
341 4ZNL BEF ADP 0.00005297 0.41766 8.0292
342 4HI0 GDP 0.0000004383 0.58726 8.0402
343 4LHW GNP 0.0000000003354 0.68656 8.04598
344 2HT6 GDP 0.0000000001338 0.56435 8.04598
345 5L3S GNP 0.00003718 0.47937 8.05369
346 2G77 GDP 0.000000002482 0.70306 8.08081
347 2G77 AF3 0.0000004372 0.66377 8.08081
348 1LVG ADP 0.000002789 0.42649 8.08081
349 1IN4 ADP 0.0006684 0.45381 8.08383
350 4PU6 ASP 0.02485 0.40855 8.12183
351 2GJ8 ALF GDP 0.000000003256 0.6346 8.13953
352 3T34 GDP 0.000003351 0.53732 8.19209
353 4IOK ADP 0.0005944 0.43996 8.19209
354 4IOK XPO 0.0004463 0.43695 8.19209
355 2Q2Y ADP 0.001926 0.43367 8.19209
356 2Q2Y MKR 0.002129 0.4307 8.19209
357 1R2Q GNP 0.0000000002817 0.60177 8.23529
358 3FWY ADP 0.00002819 0.45255 8.28025
359 4TTQ ATP 0.0000981 0.51957 8.37209
360 2HF9 GSP 0.00000004211 0.64762 8.40708
361 2AWN ADP 0.0000043 0.63222 8.47458
362 3GJX GTP 0.00000000006691 0.71783 8.49315
363 3B7G ANP 0.001756 0.45266 8.69565
364 4P4T GDP 0.000002351 0.56213 8.75706
365 3RC3 ANP 0.002341 0.45663 8.75706
366 1D8C SOR 0.01643 0.42463 8.75706
367 1Z08 GNP 0.000000001968 0.67161 8.82353
368 2W2X GSP 0.000000001186 0.62994 8.87097
369 1HE1 AF3 0.000007227 0.59268 8.88889
370 1HE1 GDP 0.0000009968 0.57183 8.88889
371 1U8Z GDP 0.00000001892 0.63076 8.92857
372 4HSE ADP 0.0004378 0.48177 9.03955
373 2FH5 GTP 0.00000000004408 0.76013 9.18919
374 3RWO GDP 0.000000004603 0.64105 9.18919
375 1CXZ GSP 0.000000000209 0.6672 9.30233
376 2Y8E GNP 0.00000000005727 0.71728 9.49721
377 3E5H GNP 0.0000000002669 0.69053 9.55056
378 1KAO GDP 0.000000002449 0.70332 9.58084
379 1S8F GDP 0.000000002457 0.62846 9.60452
380 3RLF ANP 0.000887 0.43662 9.60452
381 5SZH GNP 0.0000000001042 0.71008 9.80392
382 1I4D GDP 0.00000009012 0.68026 9.82143
383 1GXU 2HP 0.002203 0.45025 9.89011
384 5E5U MLI 0.005716 0.41408 10.0503
385 4DSU GDP 0.000000002903 0.63721 10.0529
386 5JCZ GDP 0.00000001844 0.65507 10.0559
387 2VB6 ADP BEF 0.0001462 0.44989 10.0671
388 3T1O GDP 0.0000000004166 0.59253 10.101
389 1BO4 COA 0.005656 0.43252 10.119
390 4D0G GTP 0.000000003239 0.62231 10.1449
391 5K5Z ANP 0.00005568 0.47231 10.1911
392 2XT3 ADP 0.000009551 0.59894 10.4651
393 2EFE GNH 0.0000001176 0.63587 10.4972
394 5WDR GNP 0.00000000004725 0.72391 10.5263
395 1GWN GTP 0.0000000002289 0.65565 10.7317
396 1F5N GNP 0.00001974 0.48777 10.7345
397 1Y63 ADP 0.00001277 0.56331 10.8696
398 4D81 ADP 0.0002627 0.40916 10.9541
399 1OYY AGS 0.004444 0.43771 11.0169
400 3SFV GDP 0.00000008463 0.55978 11.0497
401 2QG6 NMN 0.002394 0.40137 11.0553
402 5XCO GDP 0.00000003103 0.55094 11.1111
403 2D2F ADP 0.0002301 0.53441 11.2
404 2IYL GDP 0.00004252 0.53751 11.2676
405 3WXM GTP 0.0000000001508 0.70045 11.2994
406 1F2U ATP 0.002943 0.40313 11.4094
407 2UZI GTP 0.0000000002206 0.69384 11.4458
408 5UFQ GNP 0.00000001458 0.62101 11.4458
409 1CLU DBG 0.0000001565 0.61023 11.4458
410 3Q9L ATP 0.0000693 0.5026 11.5385
411 5UQW GDP 0.00000002186 0.60678 11.6402
412 3WYG GTP 0.00000000003706 0.69685 11.8421
413 5E95 GDP 0.00000004804 0.64504 11.9048
414 2ZEJ GDP 0.0000009498 0.53863 11.9565
415 1LFD GNP 0.00000000007804 0.7119 11.976
416 1WQ1 AF3 0.00000005683 0.71773 12.0482
417 3KUD GDP 0.000000001152 0.69885 12.0482
418 1WQ1 GDP 0.00000002083 0.62903 12.0482
419 1SVI GDP 0.00000007663 0.68383 12.3077
420 1NF3 GNP 0.000000001091 0.66606 12.3077
421 1T5C ADP 0.00000266 0.63645 12.3209
422 3QKT ANP 0.001778 0.42071 12.3894
423 1XKV ATP 0.0001924 0.41468 12.4294
424 1OW3 GDP 0.0000000512 0.55277 12.4352
425 3NKV GNP 0.0000000004689 0.68074 12.5714
426 1R0X ATP 0.0001105 0.40009 12.5874
427 5KSP GDP 0.00000128 0.60401 12.6316
428 3DDC GNP 0.00000000007202 0.69973 12.6506
429 2C5L GTP 0.0000000001113 0.69231 12.7168
430 1QHH ATP 0.008532 0.41948 12.8205
431 4RZ3 ADP 0.0005892 0.41183 12.8814
432 5O2T GSP 0.0000000004865 0.66774 13.0178
433 4XOI GTP 0.0000000002788 0.68112 13.3333
434 5TB5 GDP 0.000000007502 0.55754 13.3333
435 4XSH GSP 0.00000001417 0.58258 13.4078
436 4NON GDP 0.0000004449 0.54236 13.4615
437 5TAR GDP 0.00000001455 0.67768 13.5135
438 4D0N GDP 0.0000000433 0.51517 13.5135
439 3BC1 GNP 0.0000000002611 0.69091 13.5593
440 1TX4 ALF GDP 0.000000000681 0.69077 13.5593
441 3M1I GTP 0.0000000000363 0.72851 13.6126
442 4M9Q GNP 0.000000000001365 0.8139 13.6564
443 1G7C 5GP 0.0000000952 0.66842 13.8298
444 1WA5 GTP 0.00000000004823 0.65711 13.8418
445 1SQ5 ADP 0.000166 0.50209 13.961
446 4K81 GTP 0.000000001307 0.66877 14.0351
447 3REF GDP 0.0000001269 0.60333 14.433
448 5HPY GDP 0.00000006584 0.55004 14.5946
449 1UPT GTP 0.000000000009803 0.71345 14.6199
450 2GCO GNP 0.00000000377 0.59258 14.9254
451 2GCN GDP 0.0000003713 0.54551 14.9254
452 5UWU GNP 0.00000000001953 0.73935 15
453 2KIN ADP 0.000001422 0.40093 15
454 3KTA AP5 0.0005292 0.46753 15.0289
455 1NVU GTP 0.00000000004091 0.72642 15.2542
456 1NVV GNP 0.00000000003699 0.71082 15.2542
457 2HV8 GTP 0.0000000007927 0.67161 15.625
458 3LXR GDP 0.0000003504 0.62234 15.6757
459 2J0V GDP 0.0000004199 0.49724 16.0377
460 5IRC GDP 0.0000001588 0.52127 16.129
461 1KMQ GNP 0.000000000249 0.70893 16.3043
462 1M2O GNP 0.00000000007937 0.71161 16.3158
463 3ZIA ATP 0.00002196 0.43071 17.4603
464 3ZIA ADP 0.000075 0.42837 17.4603
465 1ZJ6 G3D 0.0000000001461 0.79415 17.6471
466 3T12 GDP ALF 0.000000000005607 0.78789 17.6471
467 1F6B GDP 0.0000000008198 0.75802 17.6768
468 3T5G GDP 0.000000008188 0.55641 17.6796
469 4ZI2 GNP 0.00000000000334 0.73279 17.8947
470 4GOJ GNP 0.000000000001131 0.74949 17.9894
471 2X77 GDP 0.00000001155 0.70262 17.9894
472 1XTQ GDP 0.00000000487 0.62449 18.0791
473 4BAS GNP 0.000000000006924 0.71873 18.0905
474 3DOE GTP 0.000000000002321 0.79332 18.2292
475 4CVN ADP 0.00007483 0.5399 18.2482
476 1ZC3 GNP 0.000000000103 0.7103 18.2857
477 1UAD GNP 0.0000000001196 0.70448 18.2857
478 1JJ7 ADP 0.000002851 0.63911 18.4615
479 5UWR GNP 0.00000000002153 0.73764 18.5185
480 4BQS ADP 0.00005479 0.53207 18.75
481 4BQS K2Q 0.001983 0.42845 18.75
482 1FZQ GDP 0.0000000001521 0.80657 18.7845
483 1KSH GDP 0.000000000004575 0.71521 18.8172
484 1Z0K GTP 0.0000000002327 0.71015 18.8406
485 1TU3 GNP 0.0000000006013 0.67642 18.9873
486 1YZG GDP 0.0000000001635 0.59143 18.9944
487 4HDO GNP 0.00000000006659 0.70085 19.1617
488 1GUA GNP 0.0000000001173 0.69128 19.1617
489 4HDQ GNP 0.0000000003237 0.69029 19.1617
490 1ZD9 GDP 0.000000001308 0.7058 19.6809
491 2QTV GNP 0.00000000003244 0.7166 19.7605
492 3X1Z GNP 0.00000000009659 0.71452 19.7605
493 5EE5 GTP 0.000000000003782 0.72919 19.883
494 3QF7 ANP 0.002317 0.42042 20
495 1E96 GTP 0.000000001168 0.66487 20.197
496 4KVG GTP 0.0000000001849 0.69691 20.2381
497 1MR3 G3D 0.000000002191 0.55841 20.442
498 4YLG GDP 0.000000003879 0.58562 20.8092
499 2A9K GDP 0.00000001014 0.57416 21.0762
500 5DI3 GNP 0.000000000003075 0.79895 21.0811
501 1Z06 GNP 0.0000000002106 0.70313 21.164
502 3AQ4 GDP 0.0000000002605 0.78204 21.1957
503 1R4A GNP 0.00000000002597 0.74018 21.2121
504 4V0K GDP 0.00000006372 0.60198 21.3018
505 2J59 GTP 0.000000000001302 0.80375 21.6867
506 1O3Y GTP 0.00000000000178 0.79811 21.6867
507 2A5F GTP 0.000000000005586 0.74657 22.2857
508 1YZQ GNP 0.00000000005958 0.7024 22.3529
509 4KAX GTP 0.000000000001167 0.74774 22.4852
510 1S9D GDP 0.0000000002632 0.78182 22.561
511 1RE0 GDP 0.00000000001914 0.58323 22.561
512 2V7Q ATP 0.00004037 0.52519 22.6027
513 2V7Q ADP 0.0002498 0.49951 22.6027
514 2CK3 ANP 0.001405 0.43956 22.6027
515 2CK3 ADP 0.002419 0.4185 22.6027
516 2W83 GTP 0.000000000001387 0.8026 23.0303
517 3PCR GTP 0.000000000004599 0.78097 23.4568
518 3N5C GDP 0.0000000000388 0.83589 24.0741
519 1J2J GTP 0.00000000001081 0.76555 24.4444
520 4C4P GNP 0.0000000001485 0.7039 25.2336
521 2Y65 ADP 0.000003627 0.40645 30
522 5DIF GNP 0.00000000002129 0.71996 31.5789
523 5UWS GNP 0.00000000003169 0.73409 40.9091
524 3IIJ ADP 0.00005504 0.53197 42.2222
525 5UWT GNP 0.00000000002257 0.73682 47.8261
526 1CS4 GSP 6.661e-16 0.8709 49.435
Pocket No.: 2; Query (leader) PDB : 2XTZ; Ligand: GSP; Similar sites found: 15
This union binding pocket(no: 2) in the query (biounit: 2xtz.bio1) has 26 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4UP4 NDG 0.01994 0.41137 2.25989
2 4IHQ ADP 0.00004812 0.40724 2.82486
3 2V2G BEZ 0.02582 0.40925 3.00429
4 3R7F CP 0.02453 0.41045 3.28947
5 4JD0 1KH 0.03127 0.40418 4.38247
6 1OS1 PYR 0.001542 0.40065 4.51977
7 3BP1 GUN 0.02598 0.41823 5.17241
8 1SQL GUN 0.03965 0.40003 5.47945
9 1W0J ADP BEF 0.001558 0.40013 5.51471
10 1YXM ADE 0.01218 0.41669 7.26073
11 3PA8 621 0.01854 0.41524 7.48031
12 4UXM BE7 0.005327 0.42166 9.09091
13 3LL5 IP8 0.03324 0.4023 9.23695
14 3P4X ADP 0.00009049 0.40134 9.60452
15 1DCP HBI 0.03508 0.40969 30.7692
Pocket No.: 3; Query (leader) PDB : 2XTZ; Ligand: GSP; Similar sites found: 16
This union binding pocket(no: 3) in the query (biounit: 2xtz.bio2) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 2QQC AG2 0.03043 0.40599 None
2 3CV2 OXL 0.007663 0.43992 2.82486
3 5JBE MAL 0.01753 0.41449 3.10734
4 2YY8 MTA 0.01798 0.4052 3.9801
5 4B2D FBP 0.01117 0.40786 4.51977
6 2GMP NAG MAN 0.04055 0.40332 5.55556
7 3MB5 SAM 0.004023 0.4078 6.27451
8 4IP7 FBP 0.0121 0.40625 6.49718
9 2Q37 3AL 0.02335 0.41393 7.18232
10 4WGF HX2 0.02493 0.40961 7.80488
11 1D8C GLV 0.009212 0.4309 8.75706
12 1P4V GLY 0.02764 0.4084 8.81356
13 4IXH IMP 0.00483 0.40454 10.452
14 1N13 AG2 0.0353 0.40208 12.3894
15 1A5Z FBP 0.02387 0.41062 17.2414
16 1JAC AMG 0.04607 0.40133 30
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