Receptor
PDB id Resolution Class Description Source Keywords
2Y0I 2.28 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (T FRAGMENT PEPTIDE (21-MER) HOMO SAPIENS OXIDOREDUCTASE-PEPTIDE COMPLEX DIOXYGENASE HELIX-LOOP-HELIFACIAL TRIAD ASPARAGINYL/ASPARTYL HYDROXYLASE ANKYRIN REPDOMAIN
Ref.: FACTOR-INHIBITING HYPOXIA-INDUCIBLE FACTOR (FIH) CA THE POST-TRANSLATIONAL HYDROXYLATION OF HISTIDINYL WITHIN ANKYRIN REPEAT DOMAINS. FEBS J. V. 278 1086 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
AKG A:1351;
Valid;
none;
submit data
146.098 C5 H6 O5 C(CC(...
FE2 A:1350;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
GOL A:1355;
A:1356;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SO4 A:1352;
A:1353;
A:1354;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Y0I 2.28 Å EC: 1.14.11.16 FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH TANKYRASE-2 (T FRAGMENT PEPTIDE (21-MER) HOMO SAPIENS OXIDOREDUCTASE-PEPTIDE COMPLEX DIOXYGENASE HELIX-LOOP-HELIFACIAL TRIAD ASPARAGINYL/ASPARTYL HYDROXYLASE ANKYRIN REPDOMAIN
Ref.: FACTOR-INHIBITING HYPOXIA-INDUCIBLE FACTOR (FIH) CA THE POST-TRANSLATIONAL HYDROXYLATION OF HISTIDINYL WITHIN ANKYRIN REPEAT DOMAINS. FEBS J. V. 278 1086 2011
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2Y0I - AKG C5 H6 O5 C(CC(=O)O)....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4B7E - OGA C4 H5 N O5 C(C(=O)O)N....
2 2Y0I - AKG C5 H6 O5 C(CC(=O)O)....
3 2XUM - OGA C4 H5 N O5 C(C(=O)O)N....
4 4B7K - OGA C4 H5 N O5 C(C(=O)O)N....
50% Homology Family (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 3P3N - AKG C5 H6 O5 C(CC(=O)O)....
2 4B7E - OGA C4 H5 N O5 C(C(=O)O)N....
3 2Y0I - AKG C5 H6 O5 C(CC(=O)O)....
4 2XUM - OGA C4 H5 N O5 C(C(=O)O)N....
5 4B7K - OGA C4 H5 N O5 C(C(=O)O)N....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: AKG; Similar ligands found: 7
No: Ligand ECFP6 Tc MDL keys Tc
1 AKG 1 1
2 SIN 0.526316 0.833333
3 OOG 0.5 0.947368
4 69O 0.458333 0.714286
5 2IT 0.423077 0.615385
6 SHF 0.416667 0.666667
7 3PY 0.409091 0.652174
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Y0I; Ligand: AKG; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 2y0i.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
1 6F4T OGA 46.2745
Pocket No.: 2; Query (leader) PDB : 2Y0I; Ligand: AKG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2y0i.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
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