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Receptor
PDB id Resolution Class Description Source Keywords
2YM5 2.03 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CHECKPOINT KINASE 1 (CHK1) IN COMPLEX W INHIBITORS HOMO SAPIENS TRANSFERASE DNA REPAIR
Ref.: STRUCTURE-GUIDED EVOLUTION OF POTENT AND SELECTIVE INHIBITORS THROUGH SCAFFOLD MORPHING. J.MED.CHEM. V. 54 8328 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:1272;
Invalid;
none;
submit data
62.068 C2 H6 O2 C(CO)...
YM5 A:1271;
Valid;
none;
ic50 = 0.43 uM
339.392 C18 H21 N5 O2 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3TKI 1.6 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CHK1 IN COMPLEX WITH INHIBITOR S25 HOMO SAPIENS CHK1 KINASE CELL CHECKPOINT TRANSFERASE-TRANSFERASE INHIBCOMPLEX
Ref.: PYRIDYL AMINOTHIAZOLES AS POTENT INHIBITORS OF CHK1 SLOW DISSOCIATION RATES. BIOORG.MED.CHEM.LETT. V. 22 2609 2012
Members (85)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
38 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
39 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
40 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
41 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
42 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
43 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
44 5OQ7 ic50 = 0.8743 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
45 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
46 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
47 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
48 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
49 5OP5 ic50 = 0.4964 uM 3FE C17 H15 N5 O c1cc(cc(c1....
50 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
51 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
52 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
53 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
54 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
55 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
56 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
57 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
58 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
59 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
60 5OPR ic50 = 5.8506 uM A3E C21 H26 N6 O CC(C)n1cc(....
61 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
62 5OQ5 ic50 = 0.052 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
63 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
64 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
65 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
66 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
67 5OQ8 ic50 = 4.0577 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
68 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
69 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
70 5OPS ic50 = 1.9827 uM A3Q C14 H9 N3 O c1cc(cc(c1....
71 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
72 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
73 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
74 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
75 5OP2 ic50 = 0.5543 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
76 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
77 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
78 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
79 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
80 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
81 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
82 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
83 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
84 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
85 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
70% Homology Family (86)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 2XF0 ic50 = 30 uM 4UB C15 H11 N5 c1ccc(cc1)....
38 2YM6 ic50 = 0.88 uM YM6 C14 H16 N6 O c1cncc2c1c....
39 6FCK ic50 = 0.031 uM D4Z C20 H22 N4 O c1ccc(cc1)....
40 4QYG ic50 = 0.0041 uM 3DW C22 H21 N5 O2 CN1CCN(CC1....
41 3TKH ic50 = 47 nM 07S C23 H27 N7 O2 S c1cc(cnc1)....
42 2XEZ ic50 = 1.5 uM XEZ C12 H9 N7 c1c[nH]nc1....
43 2HXL ic50 = 12 nM 422 C23 H24 N6 c1cc2c(cc1....
44 5OQ7 ic50 = 0.8743 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
45 5F4N ic50 = 2.2 nM 5UY C17 H19 N7 O3 COC(=O)c1c....
46 2E9N ic50 = 6.2 nM 76A C29 H27 N3 O3 c1cc(ccc1c....
47 2YM3 ic50 = 1.2 uM YM3 C14 H19 N5 O3 CCOC(=O)c1....
48 2YDI - YDI C16 H20 N4 O3 S CN(C)CCOc1....
49 5OP5 ic50 = 0.4964 uM 3FE C17 H15 N5 O c1cc(cc(c1....
50 3NLB ic50 = 35 nM 5BE C21 H28 N6 O Cc1c(c([nH....
51 3JVR Ki = 1.89 uM AGX C16 H13 Cl2 N3 O2 C[C@@H](c1....
52 2WMX ic50 = 0.86 uM ZY6 C17 H19 N5 O c1ccc(cc1)....
53 2C3J Ki = 0.659 uM DBQ C11 H11 N5 O2 c1c[nH]c2c....
54 2YM7 ic50 = 0.13 uM YM7 C15 H18 N8 c1c(ncnc1N....
55 2X8I ic50 = 0.19 uM X8I C17 H13 N3 O2 CC1=CC2=NN....
56 2YDJ ic50 = 0.005 uM YDJ C17 H19 F N4 O2 S c1cc(cc(c1....
57 4QYE ic50 = 1.2 uM 3DL C17 H12 N2 O3 c1cc(cc(c1....
58 5OP7 - A1K C19 H21 Cl N6 O3 CNc1c2c(c[....
59 5OOP - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
60 5OPR ic50 = 5.8506 uM A3E C21 H26 N6 O CC(C)n1cc(....
61 2BRG ic50 = 6.1 uM DFY C21 H19 N3 O2 CN(CCO)c1c....
62 5OQ5 ic50 = 0.052 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
63 2CGU ic50 = 13.4 uM 3A3 C17 H13 N O7 c1cc-2c(cc....
64 2WMR ic50 = 52 uM ZYR C10 H10 N2 O S C1CCc2c(c3....
65 3PA5 ic50 = 2 nM C73 C17 H19 Cl N4 O2 S c1cc(ccc1c....
66 2WMV ic50 = 9.2 uM ZYV C10 H14 N6 O c1[nH]c2c(....
67 5OQ8 ic50 = 4.0577 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
68 2CGX ic50 = 15.6 uM 3D3 C7 H8 N6 O S c1nc(c2c(n....
69 4QYF - 3DV C17 H13 N3 O3 c1cc(cc(c1....
70 5OPS ic50 = 1.9827 uM A3Q C14 H9 N3 O c1cc(cc(c1....
71 3JVS Ki = 0.146 uM AGY C22 H22 N4 O4 CC(C)(C)c1....
72 2WMW ic50 = 0.39 uM ZYW C11 H14 Br N5 O c1c2c(c(cn....
73 2BR1 Ki = 7.2 uM PFP C22 H21 N3 O4 COc1ccc(cc....
74 2C3L Ki = 0.026 uM IDZ C14 H10 N4 c1ccc2c(c1....
75 5OP2 ic50 = 0.5543 uM A0Q C24 H26 N4 O2 CN1CCN(CC1....
76 2X8E ic50 = 0.014 uM X8E C16 H12 N4 O CC1=CC2=NN....
77 2X8D ic50 = 0.8 uM X8D C11 H9 N3 O CC1=CC2=NN....
78 2YEX ic50 = 0.0001 uM YEX C15 H12 N4 O CC1=CC2=NN....
79 2BRM Ki = 1.3 uM DFZ C20 H18 N4 O c1ccc(cc1)....
80 1NVQ Ki = 5.6 nM UCN C28 H26 N4 O4 C[C@@]12[C....
81 5OOR - STU C28 H26 N4 O3 C[C@@]12[C....
82 3PA4 ic50 = 3 nM C72 C19 H19 Cl N4 O S c1cc(ccc1c....
83 4RVK ic50 = 13.5 nM 3XK C19 H13 N5 O CC(=O)Nc1c....
84 2HOG ic50 = 0.3 nM 710 C24 H25 N7 O c1cc2c(cc1....
85 6FC8 ic50 = 0.012 uM D4Q C19 H19 F N4 O S c1cc(cc(c1....
86 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
50% Homology Family (199)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
51 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
52 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
53 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
54 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
55 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
56 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
57 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
58 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
59 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
60 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
61 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
62 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
63 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
64 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
65 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
66 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
70 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
71 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
72 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
73 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
76 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
77 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
78 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
79 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
80 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
81 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
82 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
83 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
84 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
85 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
86 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
87 5ORY ic50 = 407 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
88 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
89 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
90 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
92 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
93 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
94 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
95 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
96 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
97 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
98 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
99 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
100 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
101 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
102 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
103 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
104 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
105 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
106 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
107 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
108 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
109 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
110 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
111 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
112 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
113 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
115 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
116 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
117 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
118 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
119 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
120 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
121 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
123 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
124 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
125 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
126 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
127 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
128 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
129 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
130 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
131 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
132 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
133 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
134 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
135 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
136 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
137 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
138 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
139 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
140 4QMX ic50 = 11 uM H8H C27 H32 Cl N5 O5 CN1CCN(CC1....
141 4QMT ic50 = 0.01 uM H1N C29 H32 N4 O3 S CCS(=O)(=O....
142 4QMM ic50 = 0.46 uM 35R C19 H23 N7 O2 c1cc2c(cc1....
143 4QMU ic50 = 1.3 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
144 4W8E - 3JB C20 H17 N7 O2 Cc1nc(no1)....
145 4QMZ ic50 = 0.21 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
146 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
147 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
148 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
149 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
150 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
151 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
152 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
153 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
154 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
155 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
156 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
157 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
158 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
159 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
160 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
161 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
162 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
163 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
164 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
165 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
166 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
167 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
168 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
169 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
170 5DH3 ic50 = 38.1 nM 5BS C17 H16 N6 O3 S2 CN1c2ccsc2....
171 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
172 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
173 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
174 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
175 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
176 6CQF ic50 = 0.0045 uM F97 C21 H26 F2 N8 CC(C)n1c2c....
177 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
178 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
179 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
180 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
181 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
182 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
183 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
184 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
185 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
186 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
187 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
188 6C0T ic50 = 43 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
189 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
190 3DV3 - MEK C18 H18 F3 I N2 O5 c1cc(c(cc1....
191 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
192 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
193 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
194 5DBX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
196 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
197 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
198 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
199 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: YM5; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 YM5 1 1
2 3FE 0.489362 0.793103
3 3JB 0.477064 0.705882
4 YM6 0.42 0.946429
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 3TKI; Ligand: S25; Similar sites found with APoc: 421
This union binding pocket(no: 1) in the query (biounit: 3tki.bio1) has 50 residues
No: Leader PDB Ligand Sequence Similarity
1 6E2B PT7 None
2 4O4F ATP 1.20968
3 4O4F IHP 1.20968
4 5TT6 ATP 1.23839
5 1GSA ADP 1.26582
6 1M3U KPL 1.51515
7 3V4S ATP 1.54799
8 5FPE 3TR 1.54799
9 4GCZ FMN 1.54799
10 3X01 AMP 1.85759
11 2IF8 ADP 1.85759
12 3VOT ADP 1.85759
13 5COU ATP 1.85759
14 4PZ6 GMP 1.85759
15 5FS0 5JC 1.89573
16 1I7L ATP 1.94175
17 3VPC ADP 2.12766
18 2PUL ACP 2.16718
19 5HV7 RBL 2.16718
20 1EHI ADP 2.16718
21 4MOB ADP 2.16718
22 1MLY ACZ PLP 2.16718
23 1ONI BEZ 2.17391
24 2PHN GDP 2.3622
25 2GND MAN MMA 2.38095
26 2PHX MAN MAN MAN MAN 2.38095
27 1Q8V MAN MAN MAN 2.38095
28 1Q8P MAN MMA 2.38095
29 1S68 AMP 2.40964
30 3W0O ADP 2.47678
31 3W0O HY0 2.47678
32 2CFM AMP 2.47678
33 5JBE MAL 2.47678
34 1PK8 ATP 2.47678
35 1IZC PYR 2.47678
36 6EAC ANP 2.47678
37 1ZDQ MSM 2.47678
38 3VPD ANP 2.4911
39 1AUX AGS 2.57235
40 4ZS4 ATP 2.60586
41 4XZ3 ACP 2.6087
42 1OIJ AKG 2.65781
43 4OFG PCG 2.77778
44 2YRX AMP 2.78638
45 4XYM A12 2.78638
46 4OCJ NDG 2.78638
47 2Q7D ANP 2.78638
48 4GYS MLI 2.78638
49 1SDW IYT 2.86624
50 5CGE 51F 2.88809
51 3PDT ADP 2.90909
52 5K2M ADP 2.9304
53 5ZCT ANP 2.94118
54 2W14 WR2 2.9703
55 4LOC OXM 3.00633
56 3NZ1 3NY 3.06513
57 3DGY 2GP 3.09278
58 4OCV ANP 3.09598
59 2VPQ ANP 3.09598
60 5XLS URA 3.09598
61 1E4E ADP 3.09598
62 4FE2 ADP 3.13725
63 3PN1 IVH 3.14465
64 1IA9 ANP 3.21429
65 4XMF HSM 3.26087
66 6AR9 3L4 3.30882
67 4R78 AMP 3.40557
68 4CYI ATP 3.40557
69 3TII ANP 3.40557
70 2HGS ADP 3.40557
71 2XG5 EC2 3.46821
72 2XG5 EC5 3.46821
73 2VQ5 HBA 3.48259
74 1ZTH ADP 3.48837
75 1ZP9 ATP 3.48837
76 5Z46 8XL 3.55987
77 1A8R GTP 3.61991
78 1TZD ADP 3.63636
79 5TDF ADP 3.71517
80 2WKQ FMN 3.71517
81 2IDO TMP 3.76344
82 1W2D ADP 3.77358
83 2PR5 FMN 3.78788
84 5C1P ADP 3.92157
85 4YNM SAM 3.9823
86 3I0O ADP 4.02477
87 5A96 GTP 4.02477
88 5YJS SAL 4.02477
89 5T96 79J 4.02477
90 2B6N ALA PRO THR 4.31655
91 2PYW ADP 4.33437
92 5YK1 ANP 4.33437
93 1M0W ANP 4.33437
94 2VQD AP2 4.33437
95 5W75 SUC 4.33437
96 2RDE C2E 4.33437
97 4EIL CB3 4.33437
98 3K5I ADP 4.4665
99 3E3U NVC 4.56853
100 1OKE BOG 4.64396
101 5G48 1FL 4.64396
102 1MJT ITU 4.64396
103 5JM8 ATP 4.64396
104 3T50 FMN 4.6875
105 4WUJ FMN 4.7619
106 5DJU FMN 4.82759
107 5MW8 ATP 4.95356
108 2QK4 ATP 4.95356
109 5AE9 OKO 4.95356
110 5VLQ ANP 4.95356
111 3ETH ATP 4.95356
112 6EZ6 C5Z 4.95356
113 4G5H UD7 4.95356
114 4RRG A3T 4.96454
115 3HAV ATP 5.01672
116 5YW5 ADE 5.02793
117 2QX0 PH2 5.03145
118 3CBC DBS 5.05051
119 6BMN PAP 5.08475
120 5I35 ANP 5.26316
121 5MRH Q9Z 5.26316
122 4UWH JXM 5.26316
123 3DNT ATP 5.26316
124 5X7Q GLC GLC GLC GLC 5.26316
125 1TQP ATP 5.31915
126 2CBT TH2 5.35714
127 3VKX T3 5.36398
128 2W5P CL8 5.36913
129 5HWV MBN 5.38462
130 6GBV FMN 5.47945
131 4U98 ACP 5.50661
132 1TL2 NDG 5.50847
133 3TDV GDP 5.55556
134 1OBD ATP 5.55556
135 4GYI ADP 5.57276
136 4U8P UDP 5.57276
137 3B6R CRN 5.57276
138 3AB4 THR 5.61798
139 3ZW2 NAG GAL FUC 5.74713
140 4Y24 TD2 5.84416
141 4JLS 3ZE 5.92105
142 1IHU ADP 5.94228
143 1IHU AF3 5.94228
144 2AJH MET 6.12245
145 2IO8 ADP 6.19195
146 2VL1 GLY GLY 6.19195
147 5L2R MLA 6.19195
148 1T36 ADP 6.19195
149 5DKK FMN 6.2069
150 3R51 MMA 6.25
151 1RGE 2GP 6.25
152 1U6R IOM 6.50155
153 1FWV SGA MAG FUC 6.71642
154 2AGC DAO 6.79012
155 6C1S EFV 6.81115
156 5KJW 53C 6.81115
157 3E7S AT2 6.81115
158 2FB3 MET 6.81115
159 2FB3 5AD 6.81115
160 3SAO DBH 6.875
161 4GLW 0XT 6.88525
162 3ZJX BOG 6.92042
163 5VZ0 ADP 7.12074
164 1KDK DHT 7.34463
165 5DZT AMP 7.43034
166 4IPN 1FT 7.43034
167 2BKK ADP 7.57576
168 3TM0 ANP 7.60456
169 3TM0 B31 7.60456
170 5MY8 RXZ 7.73994
171 3UDZ ADP 7.73994
172 4PU5 ANP 7.73994
173 1NY5 ADP 7.73994
174 6FL8 ADP 7.73994
175 6FL8 TIY 7.73994
176 1F5F DHT 7.80488
177 2GQS ADP 8.01688
178 2GQR ADP 8.01688
179 2GQS C2R 8.01688
180 1VDN ACE ALA ALA PRO ALA MCM 8.02469
181 1RV1 IMZ 8.23529
182 3BRN SRO 8.28025
183 2GJ3 FAD 8.33333
184 5OES ADP 8.35913
185 3WVR AMP 8.35913
186 4RF7 ARG 8.35913
187 5IM3 DTP 8.35913
188 2XOC ADP 8.42912
189 3NOJ PYR 8.82353
190 4LI4 AMP 8.82353
191 3HCH RSM 8.90411
192 4IX4 ADP 8.97833
193 2YW2 ATP 8.97833
194 2GCG DGY 9.09091
195 5LXT ACP 9.09091
196 6CGD GNP 9.18033
197 6CGD AKN 9.18033
198 4LH7 1X8 9.28793
199 2G30 ALA ALA PHE 10.2167
200 3ORQ ADP 10.2167
201 5DXT 5H5 10.2167
202 5FI4 5XV 10.2167
203 5C8W PCG 10.4895
204 3S6X SIA GAL BGC 10.5263
205 4FFG 0U8 10.5263
206 4AZW ATP 10.8359
207 1NU4 MLA 11.3402
208 3KIH GDL 11.3402
209 5CKW ANP 11.4551
210 5DJT FMN 11.4754
211 4WW7 AMP 11.4943
212 2V0U FMN 11.6438
213 5EFW FMN 11.6667
214 2UV4 AMP 11.8421
215 5H9P TD2 12.6582
216 3WG3 A2G GAL NAG FUC 13.4831
217 4DFU QUE 14.2857
218 4R38 RBF 14.2857
219 5C4L 4XR 14.3302
220 5C4L SIS 14.3302
221 4B52 RDF 14.4737
222 4OAV ACP 14.5511
223 3VHE 42Q 15.1703
224 3VPB ADP 16.0714
225 2AQX ATP 16.263
226 1CBK ROI 16.875
227 5NM7 GLY 16.9173
228 2V5E SCR 17.8218
229 4O1P ANP 17.9567
230 1T0S BML 18.6047
231 4Q5H ANP 18.9655
232 5GZ9 ANP 19.0164
233 2QHV OC9 22.8571
234 6FHQ DE5 25.8621
235 3KMW ATP 26.9373
236 1OPK P16 27.5542
237 4FL3 ANP 28.1734
238 3PP0 03Q 28.483
239 5HCY 60D 28.483
240 3PTG 932 28.7926
241 2H8H H8H 28.7926
242 1Y57 MPZ 28.7926
243 5C03 AGS 28.7926
244 4WHZ 3NL 28.7926
245 3TTI KBI 28.7926
246 3EKK GS2 28.9902
247 3BU5 ATP 29.085
248 1IR3 ANP 29.085
249 3H9R TAK 29.1022
250 4IZY 1J2 29.1022
251 3UIM ANP 29.1022
252 3C1X CKK 29.1022
253 4CRL C1I 29.1022
254 5EOB 5QQ 29.1536
255 4WOV 3SM 29.3375
256 4UX9 ANP 29.4118
257 4XH0 ADP 29.4118
258 4ASE AV9 29.4118
259 1OUK 084 29.4118
260 2XVD AS6 29.4702
261 5U6C 7YS 29.5238
262 3PLS ANP 29.5302
263 3NW7 LGV 29.6417
264 5AWM ANP 29.7214
265 3E7O 35F 29.7214
266 3E8N VRA 29.7214
267 3E8N ATP 29.7214
268 3KRL KRL 29.7214
269 4AG8 AXI 29.7468
270 6GWR FEW 29.8413
271 3LXN MI1 29.8742
272 3LXK MI1 30.031
273 4P5Z Q7M 30.031
274 2B9J ADP 30.3406
275 2B9I ADP 30.3406
276 2B9H ADP 30.3406
277 5T8O 76Z 30.3406
278 6GQM F8H 30.3406
279 3VRY B43 30.3406
280 2B9F ADP 30.3406
281 5NKB 8ZT 30.3922
282 1K3A ACP 30.4348
283 2OO8 RAJ 30.5994
284 4IDT T28 30.6502
285 4BTK DTQ 30.6502
286 3GC8 B45 30.6502
287 5QIN J2V 30.6962
288 2X2M X2M 30.8917
289 3GC0 AMP 30.9598
290 5LPZ ADP 30.9598
291 4FF8 14S 30.9598
292 4LOO SB4 31.0345
293 5WNL STU 31.2694
294 2PVF ACP 31.2694
295 4Y93 746 31.2694
296 3RI1 3RH 31.3099
297 4GJ3 0XP 31.457
298 6GIN IR2 31.5615
299 2WU6 DKI 31.5789
300 3GQI ACP 31.5789
301 4NST ADP 31.5789
302 3PVW QRX 31.5789
303 3GNI ATP 31.5789
304 5UKL SIX 31.5789
305 4TWP AXI 31.7343
306 6FYL 3NG 31.8885
307 3HMO STU 31.8885
308 4K33 ACP 31.8885
309 4KBA 1QM 31.8885
310 2Y6O 1N1 31.9588
311 5JGA 6KC 32.0635
312 5WO4 B7V 32.1192
313 2QLU ADE 32.1656
314 6ES0 BW8 32.1767
315 5USZ SKE 32.1799
316 5Y86 HRM 32.1981
317 5EFQ ADP 32.1981
318 5JKG 6LF 32.4759
319 4WNK 453 32.5077
320 5EKO N17 32.5077
321 5N87 N66 32.5879
322 5OKT 9XK 32.8025
323 6FYV 3NG 32.8173
324 5X8I SQZ 32.8173
325 6A1G 9OL 32.8173
326 6G33 5ID 32.8173
327 3G5D 1N1 32.8671
328 3BZ3 YAM 32.971
329 4E1Z 0MX 32.9897
330 5MJA 7O3 33.1148
331 5KO1 6UY 33.2155
332 4CLI 5P8 33.3333
333 5ZTN CUR 33.4365
334 5UR1 YY9 33.4405
335 1U59 STU 33.4495
336 2BPM 529 33.657
337 2CSN CKI 33.67
338 5TO8 7FM 33.6879
339 5LPB ADP 33.7838
340 5VC5 96M 33.91
341 4AUA 4AU 34.202
342 6C7Y ADP 34.2657
343 4E93 GUI 34.3653
344 5HES 032 34.5277
345 4BCM T7Z 34.5515
346 4BCQ TJF 34.5515
347 4CFU 2WC 34.6535
348 3SRV S19 34.657
349 2OFV 242 34.657
350 4BCN T9N 34.6667
351 6GUE FB8 34.7682
352 4AU8 Z3R 34.7973
353 4CSV STI 34.9091
354 5LMK 6ZK 35.0168
355 4QMN DB8 35.1613
356 4F4P 0SB 35.1648
357 1JPA ANP 35.2564
358 4EWH T77 35.2727
359 4AT3 LTI 35.4515
360 4YMJ 4EJ 35.5263
361 3O0G 3O0 35.6164
362 1UNH IXM 35.6164
363 4YZC STU 35.9133
364 4UXL 5P8 36.0248
365 5JFS 6K0 36.039
366 4DC2 ADE 36.2229
367 5LI1 ANP 36.2229
368 2HK5 1BM 36.2963
369 1BYG STU 36.3309
370 4RFM 3P6 36.4662
371 4WB6 ATP 36.5325
372 4Y85 499 36.8421
373 3FHI ANP 36.8421
374 4WB7 ATP 36.8421
375 3IDB ANP 37.1517
376 2QCS ANP 37.1517
377 2GU8 796 37.1517
378 1ZY5 ANP 37.2937
379 5FBN 5WF 37.6384
380 4U0I 0LI 37.7778
381 5H2U 1N1 37.8277
382 1PHK ATP 37.9195
383 6CZ3 FLJ 38.2576
384 4H3P ANP 38.3901
385 4H3Q ANP 38.3901
386 5BVE 4VG 38.3901
387 3SLS ANP 38.4868
388 3SLS 77D 38.4868
389 1CM8 ANP 38.6997
390 2F57 23D 38.8013
391 3SXS PP2 38.806
392 4NM5 ADP 39.0093
393 3F7Z 34O 39.0093
394 3ZRM ZRM 39.0093
395 2JLD AG1 39.0093
396 5EH0 5NW 39.5349
397 1O9U ADZ 39.9381
398 4QTB 38Z 39.9381
399 4BHN BH9 40.5573
400 3ALN ANP 40.8669
401 1VJY 460 42.5743
402 3HZT J60 43.0341
403 2WEL K88 43.3437
404 3FC2 IBI 43.3437
405 5TA6 79D 43.3437
406 6E2O S0L 43.3898
407 2V7O DRN 43.6533
408 6CMJ F6J 43.9252
409 4FG8 ATP 44.127
410 4ONA UW1 44.582
411 5HQ0 LZ9 44.702
412 6GU6 1QK 44.702
413 2A19 ANP 44.7183
414 4I6H 1C8 44.8052
415 2VZ6 FEF 45.0479
416 3IGO ANP 45.8204
417 5CEO 50D 46
418 2VN9 GVD 46.5116
419 4PNI KQQ 46.7492
420 4L9I 8PR 46.7492
421 2ZV2 609 47.3154
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