Receptor
PDB id Resolution Class Description Source Keywords
2YNN 1.78 Å NON-ENZYME: OTHER YEAST BETAPRIME COP 1-304 WITH KTKTN MOTIF SACCHAROMYCES CEREVISIAE PROTEIN TRANSPORT PEPTIDE BINDING PROTEIN MEMBRANE TRAFFICCOPI-MEDIATED TRAFFICKING DILYSINE MOTIFS
Ref.: MOLECULAR BASIS FOR RECOGNITION OF DILYSINE TRAFFIC MOTIFS BY COPI. DEV.CELL V. 23 1255 2012
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CYS THR PHE LYS THR LYS THR ASN P:1;
Valid;
none;
submit data
944.122 n/a SCC([...
SO4 A:1302;
A:1303;
A:1304;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J73 1.44 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/P25 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL SIGNAL COATOMERECOGNITION PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1256 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1068 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 922 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
11 4J8B - LEU LYS THR LYS LEU LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: CYS THR PHE LYS THR LYS THR ASN; Similar ligands found: 98
No: Ligand ECFP6 Tc MDL keys Tc
1 CYS THR PHE LYS THR LYS THR ASN 1 1
2 THR PHE LYS LYS THR ASN 0.777778 0.96
3 GLY ALA PHE THR PHE ASN GLU ASP PHE 0.550459 0.792453
4 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.546219 0.890909
5 CYS VAL PHE MET 0.540816 0.672727
6 THR LYS CYS VAL PHE MET 0.531532 0.836364
7 LYS ALA VAL PHE ASN PHE ALA THR MET 0.525 0.842105
8 ASP PHE M3L THR ASP 0.522936 0.725806
9 SER ILE ILE ASN PHE GLU LYS LEU 0.516949 0.87037
10 THR LYS ASN TYR LYS GLN THR SER VAL 0.516949 0.890909
11 ALA ILE PHE GLN SER SER MET THR LYS 0.516393 0.875
12 LYS ALC LYS 0.505495 0.74
13 GLU ILE ILE ASN PHE GLU LYS LEU 0.504202 0.830189
14 ALA GLU THR PHE 0.5 0.8
15 CYS VAL ASN GLY SER CYS PHE THR VAL 0.5 0.867925
16 LYS VAL ILE THR PHE ILE ASP LEU 0.5 0.849057
17 GLU ASN GLN LYS GLU TYR PHE PHE 0.5 0.781818
18 LYS ALA VAL TYR ASN PHE ALA THR MET 0.496063 0.8
19 LYS MET ASN THR GLN PHE THR ALA VAL 0.496 0.890909
20 CYS THR GLU LEU LYS LEU SER ASP TYR 0.491935 0.839286
21 THR TYR LYS PHE PHE GLU GLN 0.491071 0.818182
22 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.491071 0.818182
23 LYS ALA LEU TYR ASN PHE ALA THR MET 0.488372 0.8
24 THR LYS ASN TYR LYS GLN PHE SER VAL 0.483051 0.842105
25 SER LEU PHE ASN THR VAL ALA THR LEU 0.483051 0.811321
26 ILE ASN PHE ASP PHE ASN THR ILE 0.481818 0.763636
27 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.481132 0.722222
28 GLU GLN TYR LYS PHE TYR SER VAL 0.474576 0.824561
29 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.472441 0.814815
30 CYS ASP PTR ALA ASN PHE LYS 0.46875 0.71875
31 THR ASN GLU TYR LYS VAL 0.468468 0.814815
32 ALA THR ARG ASN PHE SER GLY 0.466667 0.793103
33 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.465649 0.737705
34 SER LEU PHE ASN THR ILE ALA VAL LEU 0.463415 0.814815
35 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.456693 0.736842
36 ALA THR VAL ARG THR TYR SER CYS 0.454545 0.754098
37 SER ILE ILE GLY PHE GLU LYS LEU 0.448 0.8
38 PHE LEU ALA TYR LYS 0.447368 0.701754
39 LEU LYS THR LYS LEU LEU 0.445545 0.788462
40 ALA VAL TYR ASN PHE ALA THR MET 0.444444 0.733333
41 LEU PRO PHE ASP LYS THR THR ILE MET 0.443662 0.701493
42 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.443548 0.789474
43 ASP PHE GLU GLU ILE 0.443396 0.711538
44 LEU THR THR LYS LEU THR ASN THR ASN ILE 0.441441 0.814815
45 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.440678 0.783333
46 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.440559 0.714286
47 LYS THR LYS LEU LEU 0.44 0.788462
48 GLU THR VAL ARG PHE GLN SER ASP 0.439394 0.793103
49 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.439024 0.763636
50 GLU THR PHE TYR VAL ASP GLY 0.438017 0.77193
51 ALA GLU THR PHE TYR VAL ASP GLY 0.436975 0.732143
52 PHE LEU SER TYR LYS 0.434783 0.758621
53 ACE ASN TRP GLU THR PHE 0.434109 0.716667
54 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.431655 0.688525
55 LYS THR LYS 0.428571 0.8
56 TYR SER THR CYS TYR PHE ILE MET 0.428571 0.688525
57 ARG ABA GLN ILE PHE ALA ASN ILE 0.428571 0.826923
58 LYS ALA VAL TYR ASN LEU ALA THR MET 0.428571 0.827586
59 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.427419 0.849057
60 ALA LYS PHE ARG HIS ASP 0.42623 0.68254
61 ALA PHE THR SER 0.425743 0.745098
62 LEU SER SER PRO VAL THR LYS SER PHE 0.425373 0.71875
63 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.425 0.803571
64 TYS ILE TYS THR GLN 0.422414 0.614286
65 THR ASN GLU PHE TYR PHE 0.422018 0.690909
66 GLY ASP GLU VAL LYS VAL PHE ARG 0.421875 0.741379
67 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.420561 0.678571
68 ASP PHE SER ILE 0.419048 0.754717
69 THR ASN GLU PHE TYR ALA 0.418803 0.781818
70 LYS TYR LYS 0.418367 0.735849
71 PHE LEU GLU LYS 0.416667 0.75
72 LEU VAL THR LEU VAL PHE VAL 0.415929 0.692308
73 GLU ASN LEU TYR PHE GLN 0.415254 0.736842
74 LYS VAL LEU PHE LEU ASP GLY 0.415254 0.773585
75 SER THR SEP PRO THR PHE ASN LYS 0.413793 0.695652
76 LEU PRO PHE ASP LYS SER THR ILE MET 0.413333 0.705882
77 GLN VAL ASN PHE LEU GLY LYS 0.412698 0.849057
78 PHE LEU SER THR LYS 0.412281 0.830189
79 SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.411765 0.859649
80 ARG PRO MET THR PHE LYS GLY ALA LEU 0.411765 0.657534
81 GLY ILE LEU GLY PHE VAL PHE THR LEU 0.41129 0.75
82 FME TYR PHE ILE ASN ILE LEU THR LEU 0.410448 0.737705
83 THR ASN GLU PHE ALA PHE 0.409091 0.711538
84 ASN LYS PTR GLY ASN CA 0.408333 0.676923
85 GLY ILE LEU GLY LEU VAL PHE THR LEU 0.408 0.777778
86 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.407407 0.730159
87 TRP ASN TRP PHE ASP ILE THR ASN LYS 0.407143 0.704918
88 ASP GLU ASP LYS TRP ASP ASP PHE 0.404959 0.661017
89 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.40458 0.758621
90 LYS PHE LYS 0.40404 0.68
91 THR PHE ALY SER ILE MET LYS 0.403361 0.8
92 SER PTR VAL ASN VAL GLN ASN 0.401639 0.714286
93 LEU PRO PHE GLU LYS SER THR VAL MET 0.401361 0.716418
94 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.4 0.711864
95 GLU ASP GLU ASP PHE GLU ILE LEU SER LEU 0.4 0.781818
96 LYS HPE LYS 0.4 0.74
97 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.4 0.704918
98 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.4 0.709677
Similar Binding Sites (Proteins are less than 50% similar to leader)
Feedback