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Receptor
PDB id Resolution Class Description Source Keywords
2Z6C 2.1 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF LOV1 DOMAIN OF PHOTOTROPIN1 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA PAS-FOLD LOV-FOLD ATP-BINDING CHROMOPHORE CYTOPLASM FLAVOPROTEIN FMN KINASE MEMBRANE NUCLEOTIDE-BINDING PHOSPHORYLATION PHOTORECEPTOR PROTEIN RECEPTOR SENSORY TRANSDUCTION SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURAL BASIS OF THE LOV1 DIMERIZATION OF ARABIDOPSIS PHOTOTROPINS 1 AND 2 J.MOL.BIOL. V. 381 718 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FMN A:500;
B:500;
Valid;
Valid;
none;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Z6C 2.1 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF LOV1 DOMAIN OF PHOTOTROPIN1 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA PAS-FOLD LOV-FOLD ATP-BINDING CHROMOPHORE CYTOPLASM FLAVOPROTEIN FMN KINASE MEMBRANE NUCLEOTIDE-BINDING PHOSPHORYLATION PHOTORECEPTOR PROTEIN RECEPTOR SENSORY TRANSDUCTION SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURAL BASIS OF THE LOV1 DIMERIZATION OF ARABIDOPSIS PHOTOTROPINS 1 AND 2 J.MOL.BIOL. V. 381 718 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 6GB3 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 6GAY - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 6GBV - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 6GBA - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 2PR5 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 1N9N - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
8 4EES - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 4EET - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
10 4NXE - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
11 4EER - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
12 4NXG - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
13 4NXF - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
14 4EEP - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
15 4EEU - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
16 2V1A - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
17 2V0U - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 5DKK - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
19 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
20 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Z6C; Ligand: FMN; Similar sites found with APoc: 378
This union binding pocket(no: 1) in the query (biounit: 2z6c.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 5TPV TYD None
3 3M3E GAL A2G NPO None
4 1UO5 PIH None
5 2JIG PD2 None
6 1IS3 LAT None
7 1QY1 PRZ None
8 2YLD CMO None
9 1TUK PGM None
10 5FUI APY None
11 1TT8 PHB None
12 3L5R 47X None
13 1MID LAP None
14 1UO4 PIH None
15 5A5W GUO None
16 1D6H COA None
17 4CS4 AXZ None
18 1VJY 460 None
19 2X32 OTP None
20 5MZI FYK None
21 5MZI FAD None
22 6FOF LAT None
23 5Y02 MXN None
24 1I06 TZL None
25 5NFB 8VT None
26 2P7Q GG6 None
27 1U29 I3P None
28 1LRI CLR None
29 2GJ5 VD3 None
30 1KAH HIS None
31 1ZZ7 S0H None
32 1BWO LPC None
33 4JD3 COA None
34 4JD3 PLM None
35 2QX0 PH2 None
36 3A6T 8OG None
37 2I5F 5IP None
38 1OGX EQU None
39 2HPL ASP ASP LEU TYR GLY None
40 4CS4 ANP None
41 2HFN FMN None
42 5NLD LBT None
43 5Y02 HBX None
44 1L0I PSR None
45 5N17 8FK None
46 5H9P TD2 None
47 5HV0 AKG None
48 5UR6 8KM None
49 3GQT UFO None
50 3NNF AKG 1.55039
51 4Z3E GAL NGA GLA BGC GAL 1.55039
52 3KU0 ADE 1.55039
53 5AIG VPR 1.6
54 3ZW2 NAG GAL FUC 2.29885
55 3VV1 GAL FUC 2.32558
56 4RQL SNE 2.32558
57 5OSW DIU 2.32558
58 1MDC PLM 2.32558
59 3E8N VRA 2.32558
60 3E8N ATP 2.32558
61 1EWF PC1 2.32558
62 4OIV XX9 2.32558
63 3GE7 AFQ 2.32558
64 6HDT BTN 2.32558
65 5IXH OTP 2.32558
66 3EW2 BTN 2.32558
67 1C9K 5GP 2.32558
68 2GBB CIT 2.32558
69 5OWC AYZ 2.45902
70 4WN5 MVC 2.6087
71 6GNO XDI 3.10078
72 1WW5 SGA BGC 3.10078
73 4MG8 27J 3.10078
74 4TV1 36M 3.10078
75 5VM6 9EG 3.10078
76 3VRY B43 3.10078
77 4TUZ 36J 3.10078
78 4MGA 27L 3.10078
79 2QE4 JJ3 3.10078
80 3NZ1 3NY 3.10078
81 5WGQ EST 3.10078
82 1M5W DXP 3.10078
83 5BVE 4VG 3.10078
84 5HYR EST 3.10078
85 2IUW AKG 3.10078
86 1Y7P RIP 3.10078
87 2G30 ALA ALA PHE 3.87597
88 4N14 WR7 3.87597
89 4XTX 590 3.87597
90 5OCG 9R5 3.87597
91 5L2R MLA 3.87597
92 6CB2 OLC 3.87597
93 6FA4 D1W 3.87597
94 1F9V ADP 3.87597
95 4WOE ADP 3.87597
96 5JSP DQY 3.87597
97 1M2Z BOG 3.87597
98 1DZK PRZ 3.87597
99 4LIT AKG 3.87597
100 2F7A BEZ 3.87597
101 2VWT PYR 3.87597
102 5TFZ 7BC 3.87597
103 1BHX ASP PHE GLU GLU ILE 3.87597
104 3SAO NKN 3.87597
105 5EOB 5QQ 3.87597
106 3E85 BSU 3.87597
107 1GT4 UNA 3.87597
108 4JWK CTN 3.87597
109 3SAO DBH 3.87597
110 5HES 032 3.87597
111 1PNF NDG NAG 3.87597
112 4IAW LIZ 3.87597
113 4KBA 1QM 3.87597
114 1X8X TYR 3.87597
115 4E2J MOF 3.87597
116 6IIU A8X 3.87597
117 1B4U DHB 3.87597
118 1GPM AMP 3.87597
119 5N9T 8QQ 3.87597
120 2OVW CBI 4.65116
121 1ULE GLA GAL NAG 4.65116
122 4GC1 MAN MAN 4.65116
123 1W6P NDG GAL 4.65116
124 5O9W AKG 4.65116
125 5F6U 5VK 4.65116
126 5XHA FRU 4.65116
127 5F1R 42O 4.65116
128 3ACL 3F1 4.65116
129 3JQ3 ADP 4.65116
130 4YZC STU 4.65116
131 1Y42 TYR 4.65116
132 4EWH T77 4.65116
133 3W68 VIV 4.65116
134 5ZUN 9JX 4.65116
135 5XDT ZI7 4.65116
136 2VYT MLZ 4.65116
137 5FXD H7Y 4.65116
138 2JBM SRT 4.65116
139 4B9K TG0 4.65116
140 4BKS X6C 4.65116
141 6F6D AKG 4.65116
142 5APK 76E 4.65116
143 4W9H 3JF 4.65116
144 4W9F 3JU 4.65116
145 5IXK 6EW 4.65116
146 1W6O LAT 4.65116
147 2AIB ERG 5.10204
148 3O5N BR0 5.35714
149 4LED XXR 5.42636
150 5KJW 53C 5.42636
151 1OCU PIB 5.42636
152 5YJS SAL 5.42636
153 3AI3 SOE 5.42636
154 2AG4 OLA 5.42636
155 2AG4 LP3 5.42636
156 6CAY ERG 5.42636
157 1SW1 PBE 5.42636
158 5MBC FMN 5.42636
159 4MA6 28E 5.42636
160 1WUB OTP 5.42636
161 3GFZ FMN 5.42636
162 4A38 BZS 5.42636
163 3T58 FAD 5.42636
164 4KYS VIB 5.42636
165 3IES M24 5.42636
166 1AUA BOG 5.42636
167 4KJG 4NP 5.42636
168 5U83 ZN8 5.42636
169 2DW7 SRT 5.42636
170 3KC1 2T6 5.42636
171 3FXU TSU 5.42636
172 4DXJ 0M9 5.42636
173 5CDH TLA 5.42636
174 4EKV BTN 5.42636
175 5XIO HFG 5.42636
176 1ZED PNP 5.42636
177 2HFK E4H 5.42636
178 6GPC ARG 5.55556
179 3RGA LSB 6.20155
180 3KP6 SAL 6.20155
181 5D48 L96 6.20155
182 1ZOY UQ1 6.20155
183 2C9O ADP 6.20155
184 4RD0 GDP 6.20155
185 5IXG OTP 6.20155
186 1ZHX HC3 6.20155
187 2F2G HMH 6.20155
188 5BYK A3P 6.20155
189 5BYK OAQ 6.20155
190 5WP4 PC 6.20155
191 2P4Y C03 6.20155
192 4HEE 14R 6.20155
193 1HV9 UD1 6.20155
194 3QPB URA 6.20155
195 4OIT MAN 6.20155
196 5OFI 9TQ 6.55738
197 6E1Q CFA 6.97674
198 6D61 4AA 6.97674
199 3KMZ EQO 6.97674
200 2ARC ARA 6.97674
201 1ERB ETR 6.97674
202 5GLT BGC GAL NAG GAL 6.97674
203 1KC7 PPR 6.97674
204 5K13 6Q7 6.97674
205 5VAD 91Y 6.97674
206 6EWZ APC 6.97674
207 6CAM BGC 6.97674
208 4JUI EGR 6.97674
209 1M5B BN1 6.97674
210 4NG2 OHN 6.97674
211 4QCK ASD 6.97674
212 3GD9 GLC BGC BGC BGC 6.97674
213 3LGG CFE 6.97674
214 4YVN EBS 6.97674
215 5FLJ QUE 6.97674
216 5VAD PRO 6.97674
217 4RF7 ARG 7.75194
218 2BYC FMN 7.75194
219 1GQG DCD 7.75194
220 5W75 SUC 7.75194
221 3KV5 OGA 7.75194
222 4MRP GSH 7.75194
223 4XCB AKG 7.75194
224 2Z77 HE7 7.75194
225 1SR7 MOF 7.75194
226 1T0S BML 7.75194
227 2HZQ STR 7.75194
228 2J8R MSL 7.75194
229 2XMY CDK 7.75194
230 1G5N UAP SGN IDS SGN 7.75194
231 1F76 ORO 7.75194
232 2R09 4IP 7.75194
233 4J4H NAI 7.75194
234 6FWH 5LD 7.75194
235 4YUS FMN 7.75194
236 2R0D 4IP 7.75194
237 4IRX INS 7.75194
238 4KAX 4IP 7.75194
239 4JNJ BTN 7.82609
240 1WAP TRP 8
241 1Y75 NAG 8.47458
242 5DYO FLU 8.52713
243 4WHZ 3NL 8.52713
244 4JH6 FCN 8.52713
245 5KOD IAC 8.52713
246 4UMX VVS 8.52713
247 5HCY 60D 8.52713
248 4REI 3MV 8.52713
249 2E56 MYR 8.52713
250 5AZC PGT 8.52713
251 3E2M E2M 8.52713
252 2E2R 2OH 8.52713
253 4I3G BGC 8.52713
254 4POS NAG SIA GAL 8.52713
255 4GID 0GH 8.52713
256 5MKG C2E 8.52713
257 3FAL REA 8.52713
258 4Z28 BTN 8.52713
259 4BJ8 BTN 8.73016
260 1KJ1 MAN 9.17431
261 2GU8 796 9.30233
262 3W54 RNB 9.30233
263 5IHE D5M 9.30233
264 5KOH HCA 9.30233
265 3H0L ADP 9.30233
266 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 9.30233
267 5KWY C3S 9.30233
268 5G48 1FL 9.30233
269 3HQP OXL 9.30233
270 5ACM MBT 9.90991
271 3H5N ATP 10.0775
272 3I27 SID 10.0775
273 2WA4 069 10.0775
274 2GC0 PAN 10.0775
275 2WL9 MBD 10.0775
276 4P8K FAD 10.0775
277 4P8K 38C 10.0775
278 2B9I ADP 10.0775
279 4CNO 9PY 10.0775
280 1NQ7 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 10.0775
281 4QXB OGA 10.2941
282 1YRX FMN 10.7438
283 1MO9 KPC 10.8527
284 1MO9 FAD 10.8527
285 2YNE YNE 10.8527
286 2YNE NHW 10.8527
287 3A16 PXO 10.8527
288 4FFG LBS 10.8527
289 3O01 DXC 10.8527
290 4K55 H6P 11.2903
291 5W1E PHB 11.6279
292 4O4K 2PK 11.6279
293 3ZXE PGZ 11.6279
294 5H9Q TD2 11.6279
295 2BCG GER 11.6279
296 5MJA 7O3 11.6279
297 1PS9 FAD 11.6279
298 5LXT GTP 11.6279
299 1VRP ADP 11.6279
300 5U8U FAD 11.6279
301 5EYP LOC 11.6279
302 1QAW TRP 12.1622
303 4YRD 3IT 12.4031
304 4D52 GXL 12.4031
305 5VNF VAL THR SER VAL VAL 12.4031
306 4BG4 ADP 12.4031
307 5MRH Q9Z 12.4031
308 4D4U FUC GAL NAG 12.4031
309 4JGP PYR 13.1783
310 5LUN OGA 13.1783
311 1LNX URI 13.5802
312 3MG9 GHP 3MY 3FG GHP GHP OMY 3FG 13.9535
313 5VLC HSO 13.9535
314 2UW1 GVM 13.9535
315 2WEL K88 13.9535
316 4QDF 30Q 13.9535
317 2B3B BGC 13.9535
318 3M0J OAF 13.9535
319 2B3B GLC 13.9535
320 5LIA 6XN 13.9535
321 5LX9 OLB 13.9535
322 3PUR 2HG 14.7287
323 3N9O OGA 14.7287
324 3N9P OGA 14.7287
325 3N9Q OGA 14.7287
326 4GNC ASO 14.7287
327 4L4J NAG NAG BMA MAN NAG 14.7287
328 1X0P FAD 14.7287
329 5C1M OLC 14.7287
330 5TSH ANP 14.7287
331 1M15 ADP 15.5039
332 1M15 ARG 15.5039
333 4CSD MFU 15.5039
334 2Z7I 742 15.5039
335 3E9I XAH 15.5039
336 3WYJ H78 16.2791
337 4JX1 CAH 16.2791
338 1NE7 16G 16.2791
339 4JX1 CAM 16.2791
340 3VQ2 LP4 LP5 MYR DAO 17.0543
341 2W5P CL8 17.0543
342 1B7Y FYA 17.8295
343 1LOX RS7 17.8295
344 3T4L ZEA 18.6047
345 3G5D 1N1 18.6047
346 4NS3 NAD 18.6047
347 4BVA T3 19.3798
348 4F06 PHB 19.3798
349 4P25 FUC GAL NAG FUC 19.3798
350 4KRI 1SH 19.3798
351 3B12 FAH 19.3798
352 5INJ 6C7 20.155
353 2J3M PRI 20.155
354 4DQ2 BTX 20.155
355 2J3M ATP 20.155
356 3LXI CAM 20.155
357 5XIJ ANP 21.7054
358 5XIJ 873 21.7054
359 5TBM 79A 21.7391
360 5W97 CHD 21.7391
361 5ZCO PGV 21.7391
362 5Z84 CHD 21.7391
363 5ZCO CHD 21.7391
364 1XZ3 ICF 22.4806
365 5KD6 LBU 23.2558
366 5KD6 6C7 23.2558
367 3BJE URA 25.5814
368 5LXB 7A9 25.5814
369 4D1J DGJ 26.3566
370 4ONA UW1 34.1085
371 5C3R HMU 36.4341
372 5C3R AKG 36.4341
373 3EWK FAD 40.3101
374 4HIA FMN 41.0853
375 2GJ3 FAD 43.3333
376 3IS2 FAD 48.062
377 3D72 FAD 48.062
378 3P7N FMN 49.6124
Pocket No.: 2; Query (leader) PDB : 2Z6C; Ligand: FMN; Similar sites found with APoc: 89
This union binding pocket(no: 2) in the query (biounit: 2z6c.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 1Y2F WAI None
2 1TDF FAD None
3 4F4S EFO None
4 3RET SAL None
5 1SBR VIB None
6 1Z6K OAA 1.55039
7 1RDL MMA 1.76991
8 3ZW2 GAL FUC 2.29885
9 1J3R 6PG 2.32558
10 2YIV NBN 2.32558
11 4MNP SLB 2.32558
12 1DTL BEP 2.32558
13 1SWG BTN 2.34375
14 5DG2 GAL GLC 3.10078
15 2D6M LBT 3.10078
16 5Z2L NDP 3.10078
17 5N0L ILE 3.10078
18 3RV5 DXC 3.37079
19 3WG3 A2G GAL NAG FUC 3.87597
20 2R8Q IBM 3.87597
21 1NWW HPN 3.87597
22 2ADA HPR 3.87597
23 2J5B TYE 3.87597
24 5KEW 6SB 4.25532
25 1QKQ MAN 4.65116
26 3UNG ADP 4.65116
27 3WXL ADP 4.65116
28 6GMN F4E 4.65116
29 1VAY AZA 4.65116
30 5NTP 98E 4.65116
31 2AK3 AMP 4.65116
32 2OX9 GAL NAG FUC 4.65116
33 3OYW TDG 4.65116
34 5UR1 YY9 5.42636
35 3JU6 ANP 5.42636
36 4NAE 1GP 5.42636
37 4DXJ IPE 5.42636
38 1K7L 544 5.42636
39 4HSE ADP 5.42636
40 1U6R ADP 6.20155
41 2P1C GG3 6.20155
42 2F9W PAU 6.20155
43 2CHG ANP 6.20155
44 4X9X OLA 6.20155
45 5HWV MBN 6.20155
46 4GGZ BTN 6.95652
47 1T36 ADP 6.97674
48 2GQS C2R 6.97674
49 1YKD CMP 6.97674
50 2H6B 3C4 6.97674
51 5U9J GER 7.75194
52 4RW3 PLM 7.75194
53 5OD2 GLC 7.75194
54 4OAR 2S0 7.75194
55 3HQ9 OXL 7.75194
56 1YFS ALA 7.75194
57 4QMN DB8 8.52713
58 3QLM PLM 8.87097
59 3HP9 CF1 9.30233
60 1NJF AGS 9.30233
61 1NJF ADP 9.30233
62 2FCU AKG 9.30233
63 4MNS 2AX 9.30233
64 5H2U 1N1 10.0775
65 4IA6 EIC 10.0775
66 2ZMF CMP 10.0775
67 3F70 MLZ 10.0775
68 2ZL4 ALA ALA ALA ALA 10.0775
69 2B9J ADP 10.0775
70 4LHD GLY 10.8527
71 4RDN 6MD 11.6279
72 2Y6Q I7T 11.6279
73 3E5P PPI 11.6279
74 1E1O LYS 11.6279
75 4D4U FUC 12.4031
76 4D4U FUC NDG GAL FUC 12.4031
77 3W5N RAM 12.4031
78 2RDG NDG FUC SIA GAL 13.1783
79 4WVO 3UZ 13.9535
80 5NC1 NAG 14.7287
81 4GJ3 0XP 14.7287
82 3WV6 GAL BGC 15.5039
83 3NNT DQA 15.5039
84 3NV3 GAL NAG MAN 16.2791
85 5LWY OLB 16.8224
86 4F4P 0SB 17.0543
87 2Y69 CHD 17.5
88 2BS5 BGC GAL FUC 17.7778
89 3PGU OLA 20.9302
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