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Receptor
PDB id Resolution Class Description Source Keywords
2Z6D 2 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF LOV1 DOMAIN OF PHOTOTROPIN2 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA PAS-FOLD LOV-FOLD ALTERNATIVE SPLICING ATP-BINDING CHROMOPHORE FLAVOPROTEIN FMN KINASE MEMBRANE NUCLEOTIDE-BINDING PHOSPHORYLATION PHOTORECEPTOR PROTEINRECEPTOR SENSORY TRANSDUCTION SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURAL BASIS OF THE LOV1 DIMERIZATION OF ARABIDOPSIS PHOTOTROPINS 1 AND 2 J.MOL.BIOL. V. 381 718 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
FMN A:500;
B:500;
Valid;
Valid;
none;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Z6D 2 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF LOV1 DOMAIN OF PHOTOTROPIN2 FROM ARABIDOPSIS THALIANA ARABIDOPSIS THALIANA PAS-FOLD LOV-FOLD ALTERNATIVE SPLICING ATP-BINDING CHROMOPHORE FLAVOPROTEIN FMN KINASE MEMBRANE NUCLEOTIDE-BINDING PHOSPHORYLATION PHOTORECEPTOR PROTEINRECEPTOR SENSORY TRANSDUCTION SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURAL BASIS OF THE LOV1 DIMERIZATION OF ARABIDOPSIS PHOTOTROPINS 1 AND 2 J.MOL.BIOL. V. 381 718 2008
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
50% Homology Family (20)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 174 families.
1 6GB3 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 6GAY - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 6GBV - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 6GBA - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 2PR5 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 1N9N - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 2Z6C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
8 4EES - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 4EET - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
10 4NXE - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
11 4EER - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
12 4NXG - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
13 4NXF - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
14 4EEP - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
15 4EEU - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
16 2V1A - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
17 2V0U - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
18 5DKK - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
19 4R38 - RBF C17 H20 N4 O6 Cc1cc2c(cc....
20 2Z6D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Z6D; Ligand: FMN; Similar sites found with APoc: 382
This union binding pocket(no: 1) in the query (biounit: 2z6d.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 4WG0 CHD None
2 6EWZ APC None
3 6FA4 D1W None
4 3O5N BR0 None
5 1ECM TSA None
6 1TUK PGM None
7 1YRX FMN None
8 5HV0 AKG None
9 4AF5 CIT None
10 1ZEI CRS None
11 2IYG FMN None
12 2X32 OTP None
13 5D48 L96 None
14 4O4K 2PK None
15 3GD8 GOL None
16 6CAY ERG None
17 1L0I PSR None
18 1BWO LPC None
19 3QPB URA None
20 2Z77 HE7 None
21 5AIG VPR None
22 2GJ5 VD3 None
23 5MWE TCE None
24 5U9J GER None
25 1ZNY GDP None
26 2YLD CMO None
27 5IXG OTP None
28 2GBB CIT None
29 5K21 6QF None
30 5ML3 DL3 None
31 1KAH HIS None
32 4CS4 ANP None
33 3E2M E2M None
34 4NS0 PIO None
35 2P7Q GG6 None
36 5EK3 5PK None
37 4E2J MOF None
38 2LBD REA None
39 4YUS FMN 1.53846
40 2X34 UQ8 1.53846
41 4O4Z N2O 1.53846
42 3EW2 BTN 1.53846
43 5IF4 6AK 1.53846
44 4D1J DGJ 1.53846
45 4GJ3 0XP 1.53846
46 3QLM PLM 1.6129
47 5ACM MBT 1.8018
48 2ARC ARA 2.30769
49 1XZ3 ICF 2.30769
50 3HP9 CF1 2.30769
51 4MGA 27L 2.30769
52 4MG8 27J 2.30769
53 1VJY 460 2.30769
54 1M5B BN1 2.30769
55 4Z28 BTN 2.30769
56 4TUZ 36J 2.30769
57 1D6H COA 2.30769
58 4MG9 27K 2.30769
59 5X80 SAL 2.30769
60 5AAV GW5 2.30769
61 3WCS MAN NAG GAL 2.30769
62 6AYI C3G 2.30769
63 4XAC AKG 2.30769
64 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 2.30769
65 3E8N ATP 2.30769
66 3E8N VRA 2.30769
67 4RQL SNE 2.30769
68 5GLT BGC GAL NAG GAL 2.30769
69 4NPL AKG 2.30769
70 6FOF LAT 2.30769
71 4TV1 36M 2.30769
72 4TW7 37K 2.34375
73 5B09 4MX 2.88462
74 3T4L ZEA 3.07692
75 2HZQ STR 3.07692
76 2AG4 OLA 3.07692
77 2AG4 LP3 3.07692
78 2AGC DAO 3.07692
79 5HCY 60D 3.07692
80 2JIG PD2 3.07692
81 4BG4 ADP 3.07692
82 1DZK PRZ 3.07692
83 1XAP TTB 3.07692
84 3QCP FAD 3.07692
85 3KU0 ADE 3.07692
86 5D9G GLU ASN LEU TYR PHE GLN 3.07692
87 4JNJ BTN 3.47826
88 6GNO XDI 3.84615
89 4XTX 590 3.84615
90 4GC1 MAN MAN 3.84615
91 4QXB OGA 3.84615
92 5FUI APY 3.84615
93 3BJC WAN 3.84615
94 1ELI PYC 3.84615
95 5CC2 CKA 3.84615
96 2VWT PYR 3.84615
97 1KC7 PPR 3.84615
98 5OF1 SAL 3.84615
99 4Y2B EPK 3.84615
100 4A38 BZS 3.84615
101 2EAE FUC 3.84615
102 4NG2 OHN 3.84615
103 2QZZ EMF 3.84615
104 3L24 GOA 3.84615
105 4CNO 9PY 3.84615
106 2OHV NHL 3.84615
107 2QZZ NAP 3.84615
108 3FXU TSU 3.84615
109 2J4D MHF 3.84615
110 1ERB ETR 3.84615
111 1MDC PLM 3.84615
112 5EOB 5QQ 3.84615
113 4FGC PQ0 3.84615
114 2F7A BEZ 3.84615
115 1R6B ADP 3.84615
116 6IIU A8X 3.84615
117 2Z9V PXM 3.84615
118 5OFI 9TQ 4.09836
119 5JSP DQY 4.61538
120 5INJ 6C7 4.61538
121 4MA6 28E 4.61538
122 4MRP GSH 4.61538
123 5VLC HSO 4.61538
124 1GT4 UNA 4.61538
125 4JH6 FCN 4.61538
126 5JPH COA 4.61538
127 5XHA FRU 4.61538
128 3VQ2 LP4 LP5 MYR DAO 4.61538
129 2WA4 069 4.61538
130 3SHZ 5CO 4.61538
131 2DXU BT5 4.61538
132 3E9I XAH 4.61538
133 1SR7 MOF 4.61538
134 1E1O LYS 4.61538
135 1NAA ABL 4.61538
136 5XDT ZI7 4.61538
137 3NZ1 3NY 4.61538
138 3SAO DBH 4.61538
139 2VAR KDG 4.61538
140 4JX1 CAM 4.61538
141 4JX1 CAH 4.61538
142 6HDT BTN 4.61538
143 1WPY BTN 4.61538
144 5NV9 SLB 4.61538
145 2C91 TLA 4.61538
146 5N7O 69Y 4.61538
147 3ACL 3F1 4.61538
148 3K5I AIR 4.61538
149 5KAU RHQ 4.61538
150 2G30 ALA ALA PHE 5.38462
151 1GQG DCD 5.38462
152 1ZOY UQ1 5.38462
153 2JBM SRT 5.38462
154 2GWH PCI 5.38462
155 3WV6 GAL GLC 5.38462
156 3WV6 GAL BGC 5.38462
157 4DQ2 BTX 5.38462
158 5MRH Q9Z 5.38462
159 4EKV BTN 5.38462
160 2XN5 FUN 5.38462
161 3LGG CFE 5.38462
162 3A16 PXO 5.38462
163 4Y85 499 5.38462
164 6AYH C3G 5.38462
165 3T58 FAD 5.38462
166 2XN3 ID8 5.38462
167 4WVW SLT 5.38462
168 1PNF NDG NAG 5.38462
169 3T1A 5MA 5.38462
170 3RMK BML 5.38462
171 4KBA 1QM 5.38462
172 1MID LAP 5.49451
173 4BJ8 BTN 5.55556
174 1JIF CU BLM 5.7377
175 5OWC AYZ 5.7377
176 3AI3 SOE 6.15385
177 6D61 4AA 6.15385
178 5DYO FLU 6.15385
179 3RGA LSB 6.15385
180 2CYB TYR 6.15385
181 2CHG ANP 6.15385
182 1M2Z BOG 6.15385
183 5KJW 53C 6.15385
184 4JWK CTN 6.15385
185 4YRD 3IT 6.15385
186 4HEE 14R 6.15385
187 4HSJ 6PC 6.15385
188 5ECP MET 6.15385
189 5ECP JAA 6.15385
190 2A9G ARG 6.15385
191 3BRN SRO 6.15385
192 1NHZ 486 6.15385
193 1U29 I3P 6.20155
194 1KGI T4A 6.29921
195 5TVI MYR 6.52174
196 3ZW2 NAG GAL FUC 6.89655
197 6A0S NDP 6.92308
198 4RF7 ARG 6.92308
199 5LNW RP5 6.92308
200 3KMZ EQO 6.92308
201 2BCG GER 6.92308
202 2GC0 PAN 6.92308
203 1M15 ADP 6.92308
204 1M15 ARG 6.92308
205 3W54 RNB 6.92308
206 4C01 QY9 6.92308
207 5W75 SUC 6.92308
208 1B7Y FYA 6.92308
209 6F8A HIS 6.92308
210 1YQZ FAD 6.92308
211 1SWG BTN 7.03125
212 4CPH LH4 7.08661
213 1LRI CLR 7.14286
214 1Y75 NAG 7.62712
215 4F06 PHB 7.69231
216 5TPV TYD 7.69231
217 5A5W GUO 7.69231
218 1J3R 6PG 7.69231
219 4XCB AKG 7.69231
220 2W5P CL8 7.69231
221 2HFK E4H 7.69231
222 1QY1 PRZ 7.69231
223 3W5N RAM 7.69231
224 5CX6 CDP 7.69231
225 1R37 ETX 7.69231
226 1I06 TZL 7.69231
227 1VA6 P2S 7.69231
228 4FFG LBS 7.69231
229 1VA6 ADP 7.69231
230 1X0P FAD 7.69231
231 1R6N 434 7.69231
232 5Z3I ADE 7.69231
233 4OAS 2SW 8.33333
234 6E1Q CFA 8.46154
235 1OCU PIB 8.46154
236 4D4U FUC NDG GAL FUC 8.46154
237 5C1M OLC 8.46154
238 4WHZ 3NL 8.46154
239 2C9O ADP 8.46154
240 3X01 AMP 8.46154
241 1RQH PYR 8.46154
242 4IA6 EIC 8.46154
243 4D4U FUC 8.46154
244 1X8X TYR 8.46154
245 4D52 GIV 8.46154
246 3ANY 2A3 8.46154
247 1ZHX HC3 8.46154
248 1LNX URI 8.64198
249 4OIT BMA 8.84956
250 4OIT MAN 8.84956
251 3PUR 2HG 9.23077
252 3N9O OGA 9.23077
253 5NM7 GLY 9.23077
254 4N14 WR7 9.23077
255 4YVN EBS 9.23077
256 1C9K 5GP 9.23077
257 5APK 76E 9.23077
258 3UNG ADP 9.23077
259 2A1L PCW 9.23077
260 5UR1 YY9 9.23077
261 4QCK ASD 9.23077
262 2Z7I 742 9.23077
263 5NTW 98N 9.23077
264 2HK5 1BM 9.23077
265 6FS0 E4W 9.63303
266 3KP6 SAL 10
267 2CYC TYR 10
268 3FAL REA 10
269 5MJA 7O3 10
270 2HFN FMN 10
271 6F6D AKG 10
272 4YZC STU 10
273 5UFN SAH 10
274 4P8K FAD 10
275 4P8K 38C 10
276 3W68 VIV 10
277 2IUW AKG 10
278 5KD6 6C7 10
279 1KJ1 MAN 10.0917
280 4YLZ LAT NAG GAL 10.7692
281 1F9V ADP 10.7692
282 1OGX EQU 10.7692
283 5LX9 OLB 10.7692
284 5IKI A9H 10.7692
285 1W6P NDG GAL 10.7692
286 1T36 ADP 10.7692
287 1URX AAL GAL AAL GLA 10.7692
288 5OD2 GLC 10.7692
289 5LWY OLB 10.7692
290 5WL1 D3D 10.7692
291 5WL1 CUY 10.7692
292 3GFZ FMN 10.7692
293 3RDO BTN 10.7692
294 2AIB ERG 11.2245
295 4K55 H6P 11.2903
296 4LED XXR 11.5385
297 4URX FK1 11.5385
298 5MKG C2E 11.5385
299 4WGF HX2 11.5385
300 1KOL NAD 11.5385
301 5CJ3 52G 11.5385
302 4URX HXY 11.5385
303 2IV2 MGD 11.5385
304 6BVM EBV 11.5385
305 6BVK EAV 11.5385
306 1JLX GAL A2G MBN 11.5385
307 4IAW LIZ 12.3077
308 3A51 VDY 12.3077
309 5X3R 7Y3 12.3077
310 3HPY MCT 12.3077
311 5LIA 6XN 12.3077
312 3T03 3T0 12.3077
313 5DQ8 FLF 12.5
314 2HRL SIA GAL SIA BGC NGA CEQ 12.5984
315 4KAX 4IP 13.0769
316 2R09 4IP 13.0769
317 2R0D 4IP 13.0769
318 4X9X OLA 13.0769
319 3DOO SKM 13.0769
320 5I0U DCY 13.0769
321 1YFS ALA 13.0769
322 4UCC ZKW 13.0769
323 1FAO 4IP 14.2857
324 2BYC FMN 14.6154
325 5LXT GTP 14.6154
326 1SGJ OAA 14.6154
327 5YJS SAL 15.3846
328 5BVE 4VG 15.3846
329 1PS9 FAD 15.3846
330 1TT8 PHB 15.3846
331 1VR0 3SL 15.3846
332 5TSH ANP 16.1538
333 4BVA T3 16.1538
334 3GE7 AFQ 16.1538
335 2FCU AKG 16.1538
336 2YJD YJD 16.1538
337 2OVW CBI 16.1538
338 4YMU ARG 16.1538
339 4REI 3MV 16.9231
340 5F1R 42O 17.6923
341 4GNC ASO 17.6923
342 4P25 FUC GAL NAG FUC 17.6923
343 3O01 DXC 17.6923
344 5L2R MLA 17.6923
345 5KEW 6SB 18.0851
346 4GGZ BTN 18.2609
347 5AZC PGT 18.4615
348 4CQB MLI 18.4615
349 5OSW DIU 19.2308
350 3H0L ADP 19.2308
351 1UGY GLA GLC 19.2308
352 4TS1 TYR 19.2308
353 5W97 CHD 20
354 3H5N ATP 20
355 5ZCO CHD 20
356 5ZCO PGV 20
357 5Z84 CHD 20
358 5Z84 PGV 20
359 2Y69 CHD 20
360 2VYT MLZ 20
361 2DYR PGV 20
362 5TBM 79A 20.8696
363 1QKQ MAN 22.3077
364 3G5D 1N1 22.3077
365 1UO5 PIH 23.5294
366 1UO4 PIH 23.5294
367 2VPY PCI 23.8462
368 3B99 U51 24.6154
369 2J3M PRI 29.2308
370 2J3M ATP 29.2308
371 4L4J NAG NAG BMA MAN NAG 30.7692
372 4WN5 MVC 32.1739
373 5MBC FMN 33.8462
374 1UWK NAD 33.8462
375 1UWK URO 33.8462
376 4HIA FMN 42.3077
377 3EWK FAD 44.6154
378 3IS2 FAD 45.3846
379 3D72 FAD 45.3846
380 3P7N FMN 45.3846
381 3T50 FMN 46.875
382 2GJ3 FAD 47.5
Pocket No.: 2; Query (leader) PDB : 2Z6D; Ligand: FMN; Similar sites found with APoc: 57
This union binding pocket(no: 2) in the query (biounit: 2z6d.bio1) has 21 residues
No: Leader PDB Ligand Sequence Similarity
1 6CB2 OLC None
2 1TW4 CHD None
3 5WSY 7UC None
4 4DXJ 0M9 1.53846
5 4IN9 SER TRP PHE PRO 1.53846
6 1SDW IYT 2.30769
7 1XDY MTE 2.30769
8 3JU6 ANP 3.07692
9 5TZ6 7OD 3.07692
10 2WBV SIA 3.07692
11 5U8U FAD 3.07692
12 3UB7 ACM 3.07692
13 5HA0 LTD 3.07692
14 4RD0 GDP 3.84615
15 6MPT C30 3.84615
16 2EAE FUL 3.84615
17 4NAE 1GP 3.84615
18 5LXB 7A9 4.61538
19 3A7R LAQ 4.61538
20 4RW3 PLM 4.61538
21 1Y42 TYR 4.61538
22 4LUT DCS 4.61538
23 3ITA AIC 5.38462
24 3G9E RO7 6.15385
25 3AI3 SOL 6.15385
26 1K7L 544 6.15385
27 2CIX CEJ 6.15385
28 5OLK DTP 6.92308
29 5XFV FMN 6.92308
30 3OID TCL 6.92308
31 5K13 6Q7 6.92308
32 5X7Q GLC GLC GLC GLC GLC 6.92308
33 4OYA 1VE 7.69231
34 2XMY CDK 7.69231
35 3JRS A8S 7.69231
36 3KV5 OGA 8.46154
37 3WG3 A2G GAL NAG FUC 8.46154
38 2AX9 BHM 8.46154
39 4M26 AKG 8.46154
40 1WBI BTN 8.52713
41 1CEB AMH 9.09091
42 3BJE URA 9.23077
43 2OS2 OGA 9.23077
44 2P5B OGA 9.23077
45 2E56 MYR 9.23077
46 4XYM A12 9.23077
47 5U6C 7YS 10
48 3STK PLM 10.7692
49 2R5A MLZ 10.7692
50 4B0T ADP 11.5385
51 3VV5 SLZ 12.3077
52 3GON PMV 12.3077
53 4Z3E GAL NGA GLA BGC GAL 13.0769
54 1FHX 4IP 13.1783
55 2ALG DAO 15.2174
56 5V3Y 5V8 16.9231
57 3KO0 TFP 18.8119
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