Receptor
PDB id Resolution Class Description Source Keywords
2Z9C 2.3 Å EC: 1.7.1.6 THE CRYSTAL STRUCTURE OF AZOR (AZOREDUCTASE) FROM ESCHERICHI AZOR IN COMPLEX WITH DICOUMAROL ESCHERICHIA COLI AZOREDUCTASE FLAVOPROTEIN FMN NAD OXIDOREDUCTASE
Ref.: EXPANSION OF SUBSTRATE SPECIFICITY AND CATALYTIC ME OF AZOREDUCTASE BY X-RAY CRYSTALLOGRAPHY AND SITE-D MUTAGENESIS J.BIOL.CHEM. V. 283 13889 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DTC A:202;
Valid;
none;
submit data
336.295 C19 H12 O6 c1ccc...
FMN A:201;
Valid;
none;
submit data
456.344 C17 H21 N4 O9 P Cc1cc...
GOL A:203;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Z9C 2.3 Å EC: 1.7.1.6 THE CRYSTAL STRUCTURE OF AZOR (AZOREDUCTASE) FROM ESCHERICHI AZOR IN COMPLEX WITH DICOUMAROL ESCHERICHIA COLI AZOREDUCTASE FLAVOPROTEIN FMN NAD OXIDOREDUCTASE
Ref.: EXPANSION OF SUBSTRATE SPECIFICITY AND CATALYTIC ME OF AZOREDUCTASE BY X-RAY CRYSTALLOGRAPHY AND SITE-D MUTAGENESIS J.BIOL.CHEM. V. 283 13889 2008
Members (6)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2Z9C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 2Z9D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 2D5I - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 2Z98 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 1V4B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 2Z9B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
70% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 1T5B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 2Z9C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
3 2Z9D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
4 2D5I - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 2Z98 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 1V4B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 2Z9B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
50% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 4C0W - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
2 4C0X - AQN C14 H8 O5 S c1ccc2c(c1....
3 4C14 - FD5 C42 H54 N9 O21 P S4 Cc1cc2c(cc....
4 1T5B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
5 2Z9C - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
6 2Z9D - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
7 2D5I - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
8 2Z98 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
9 1V4B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
10 2Z9B - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
11 3KEG - MRE C15 H15 N3 O2 CN(C)c1ccc....
12 3LT5 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
13 4N9Q - UQ1 C14 H18 O4 CC1=C(C(=O....
14 2V9C - MRE C15 H15 N3 O2 CN(C)c1ccc....
15 4N65 - FMN C17 H21 N4 O9 P Cc1cc2c(cc....
16 3R6W - NFZ C6 H6 N4 O4 c1cc(oc1C=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: DTC; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 DTC 1 1
Ligand no: 2; Ligand: FMN; Similar ligands found: 15
No: Ligand ECFP6 Tc MDL keys Tc
1 FMN 1 1
2 RBF 0.75641 0.876712
3 RS3 0.571429 0.831169
4 FAD 0.543307 0.876543
5 FAS 0.543307 0.876543
6 FAE 0.539062 0.865854
7 LFN 0.475 0.643836
8 C3F 0.473684 0.74359
9 CF4 0.463918 0.734177
10 FAY 0.446043 0.864198
11 FNR 0.444444 0.909091
12 RFL 0.442857 0.845238
13 4LS 0.411215 0.875
14 1VY 0.406593 0.769231
15 DLZ 0.404494 0.782051
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Z9C; Ligand: DTC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2z9c.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2Z9C; Ligand: DTC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2z9c.bio1) has 30 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2Z9C; Ligand: FMN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2z9c.bio1) has 43 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2Z9C; Ligand: FMN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2z9c.bio1) has 43 residues
No: Leader PDB Ligand Sequence Similarity
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