Receptor
PDB id Resolution Class Description Source Keywords
2ZEJ 2 Å EC: 2.7.11.1 STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSON'S DISEASE-ASS LEUCINE-RICH REPEAT KINASE 2 REVEALS A DIMERIC GTPASE HOMO SAPIENS PARKINSON-prime S DISEASE LRRK2 ROC GTPASE ROCO KINASE ATP-BDISEASE MUTATION GTP-BINDING GTPASE ACTIVATION LEUCINE-RREPEAT MEMBRANE NUCLEOTIDE-BINDING PARKINSON DISEASE SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSON'S DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REV DIMERIC GTPASE PROC.NATL.ACAD.SCI.USA V. 105 1499 2008
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GDP A:1;
B:2;
Valid;
Valid;
none;
none;
submit data
443.201 C10 H15 N5 O11 P2 c1nc2...
MG A:2;
B:1;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2ZEJ 2 Å EC: 2.7.11.1 STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSON'S DISEASE-ASS LEUCINE-RICH REPEAT KINASE 2 REVEALS A DIMERIC GTPASE HOMO SAPIENS PARKINSON-prime S DISEASE LRRK2 ROC GTPASE ROCO KINASE ATP-BDISEASE MUTATION GTP-BINDING GTPASE ACTIVATION LEUCINE-RREPEAT MEMBRANE NUCLEOTIDE-BINDING PARKINSON DISEASE SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: STRUCTURE OF THE ROC DOMAIN FROM THE PARKINSON'S DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 REV DIMERIC GTPASE PROC.NATL.ACAD.SCI.USA V. 105 1499 2008
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 107 families.
1 3D6T - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 2ZEJ - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 82 families.
1 3D6T - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 2ZEJ - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 55 families.
1 3D6T - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 2ZEJ - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: GDP; Similar ligands found: 153
No: Ligand ECFP6 Tc MDL keys Tc
1 GDP 1 1
2 GTP 0.909091 1
3 GP3 0.881579 0.973684
4 GNH 0.858974 0.986667
5 GNP 0.839506 0.973684
6 G 0.828947 0.986486
7 5GP 0.828947 0.986486
8 G1R 0.82716 0.986667
9 GCP 0.82716 0.973684
10 GSP 0.817073 0.948718
11 GAV 0.797619 0.961039
12 GMV 0.792683 0.973684
13 G2P 0.77381 0.961039
14 G2R 0.770115 0.961039
15 GDP MG 0.759036 0.923077
16 GP2 0.756098 0.961039
17 GDP BEF 0.75 0.9
18 GDD 0.747253 0.961039
19 GKE 0.747253 0.961039
20 GDC 0.747253 0.961039
21 GPG 0.741573 0.961039
22 G3D 0.732558 0.986486
23 ALF 5GP 0.729412 0.888889
24 Y9Z 0.728261 0.902439
25 GTP MG 0.724138 0.923077
26 BEF GDP 0.724138 0.888889
27 G5P 0.723404 0.973684
28 GFB 0.72043 0.961039
29 GTG 0.72043 0.936709
30 GDR 0.72043 0.961039
31 G4P 0.715909 0.986486
32 GCP G 0.715909 0.935065
33 6CK 0.712766 0.936709
34 G3A 0.712766 0.973684
35 GDP ALF 0.7 0.888889
36 GDP AF3 0.7 0.888889
37 YGP 0.698925 0.901235
38 JB2 0.697917 0.961039
39 GKD 0.697917 0.961039
40 GDX 0.690722 0.973684
41 GPD 0.690722 0.925
42 GMP 0.684211 0.88
43 0O2 0.666667 0.986486
44 G G 0.659574 0.935065
45 JB3 0.656863 0.948718
46 NGD 0.650485 0.961039
47 GDP 7MG 0.636364 0.911392
48 DGI 0.636364 0.923077
49 U2G 0.634615 0.936709
50 GPX 0.634409 0.946667
51 IDP 0.632184 0.972973
52 2MD 0.632075 0.891566
53 CAG 0.62963 0.880952
54 CG2 0.622642 0.936709
55 FEG 0.619048 0.879518
56 MGD 0.614679 0.891566
57 ZGP 0.613208 0.869048
58 GH3 0.612903 0.973333
59 3GP 0.611765 0.946667
60 MD1 0.607143 0.891566
61 PGD 0.59292 0.925
62 DGT 0.591398 0.923077
63 BGO 0.588785 0.924051
64 TPG 0.582609 0.840909
65 DBG 0.582609 0.948718
66 2GP 0.574713 0.96
67 FE9 0.570175 0.776596
68 I2C FE2 CMO CMO 0.566372 0.808989
69 G A A A 0.553571 0.923077
70 MGP 0.553191 0.961039
71 U A G G 0.548673 0.935065
72 G4M 0.548387 0.880952
73 6G0 0.547368 0.961039
74 G1R G1R 0.542373 0.924051
75 P2G 0.527473 0.883117
76 PGD O 0.525 0.850575
77 ADP 0.522222 0.92
78 GGM 0.517544 0.901235
79 DG 0.516484 0.910256
80 DGP 0.516484 0.910256
81 P1G 0.516129 0.871795
82 G G U 0.509259 0.935065
83 G1G 0.508475 0.925
84 IMP 0.505495 0.959459
85 G C 0.504348 0.9
86 GPC 0.491525 0.879518
87 G7M 0.483871 0.948052
88 6AD 0.479592 0.841463
89 ATP 0.473684 0.92
90 G2Q 0.471154 0.961039
91 U G A 0.469697 0.888889
92 5FA 0.46875 0.92
93 AQP 0.46875 0.92
94 GTA 0.468468 0.936709
95 7DD 0.468085 0.906667
96 G G G RPC 0.466102 0.875
97 SGP 0.463158 0.82716
98 01G 0.462963 0.902439
99 B4P 0.457447 0.894737
100 AP5 0.457447 0.894737
101 A2D 0.456522 0.894737
102 G G G C 0.455285 0.9125
103 ACQ 0.454545 0.896104
104 5GP 5GP 0.454545 0.883117
105 ANP 0.454545 0.896104
106 A G C C 0.451613 0.911392
107 APC G U 0.45082 0.886076
108 G U34 0.449153 0.888889
109 DG DG 0.448598 0.865854
110 ITT 0.447917 0.868421
111 BA3 0.446809 0.894737
112 35G 0.444444 0.933333
113 C2E 0.444444 0.921053
114 PCG 0.444444 0.933333
115 MGO 0.441176 0.864198
116 AN2 0.4375 0.907895
117 G C C C 0.4375 0.924051
118 M33 0.43299 0.883117
119 UCG 0.429688 0.911392
120 A G U 0.42963 0.888889
121 ACP 0.428571 0.896104
122 MGQ 0.424528 0.935897
123 7DT 0.424242 0.906667
124 APR 0.424242 0.894737
125 AR6 0.424242 0.894737
126 93A 0.42268 0.833333
127 A4P 0.420168 0.869048
128 SAP 0.42 0.873418
129 AD9 0.42 0.896104
130 AGS 0.42 0.873418
131 G8D 0.42 0.875
132 CA0 0.418367 0.896104
133 ATF 0.417476 0.884615
134 AGO 0.414634 0.888889
135 NIA 0.413043 0.82716
136 MGV 0.412844 0.890244
137 TAT 0.411765 0.884615
138 A1R 0.411215 0.839506
139 ADQ 0.411215 0.871795
140 RGT 0.410714 0.909091
141 CGP 0.409836 0.86747
142 AMP 0.408602 0.893333
143 A 0.408602 0.893333
144 UP5 0.40678 0.873418
145 C2R 0.406593 0.906667
146 AMZ 0.406593 0.918919
147 JBT 0.405882 0.778947
148 A22 0.40566 0.907895
149 25L 0.405405 0.907895
150 ADX 0.40404 0.809524
151 8OD 0.401961 0.946667
152 4TC 0.4 0.851852
153 50T 0.4 0.883117
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2ZEJ; Ligand: GDP; Similar sites found: 505
This union binding pocket(no: 1) in the query (biounit: 2zej.bio1) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3MD0 GDP 0.000000004224 0.75045 None
2 3T12 GDP ALF 0.0000001148 0.60772 None
3 3T1O GDP 0.00000002976 0.53164 None
4 1GXU 2HP 0.0003422 0.50353 None
5 3VX3 ADP 0.0002616 0.47362 None
6 1NJF AGS 0.000425 0.41925 None
7 3PQC GDP 0.0000009358 0.60459 1.63043
8 3BOS CDP 0.0001455 0.51299 1.63043
9 3ZS9 ADP ALF 0.001155 0.42343 1.63043
10 2WOJ ADP ALF 0.001181 0.42305 1.63043
11 4R43 GDP 0.00006607 0.53 1.75719
12 3W5J GDP 0.0000007108 0.65474 2.17391
13 3Q9L ATP 0.0005203 0.46488 2.17391
14 2C9O ADP 0.0007107 0.45018 2.17391
15 1T3D CYS 0.00811 0.43331 2.17391
16 4IDN GNP 0.002309 0.42437 2.17391
17 2VOH CIT 0.01554 0.40386 2.54777
18 3WYA GDP 0.00000000155 0.75974 2.71739
19 2DPY ADP 0.00007114 0.54299 2.71739
20 4IEE AGS 0.0002682 0.50613 2.71739
21 1IHU AF3 0.00004256 0.49827 2.71739
22 1IHU ADP 0.00006283 0.48637 2.71739
23 5J1J ANP 0.0001387 0.44437 2.71739
24 4V03 ADP 0.00005911 0.41978 2.71739
25 5CDH TLA 0.02545 0.41592 2.71739
26 4U60 SIA GAL NGA 0.04027 0.40529 2.71739
27 4U60 SIA 0.0463 0.4016 2.71739
28 2PL3 ADP 0.0000307 0.55402 3.26087
29 1G41 ADP 0.0001168 0.50535 3.26087
30 2GDJ ANP 0.0002727 0.49945 3.26087
31 3FKQ ATP 0.0002666 0.47804 3.26087
32 3ZQ6 ADP ALF 0.0002951 0.44685 3.26087
33 4E03 ADP 0.00001747 0.43112 3.26087
34 3FYH ADP 0.002592 0.41563 3.26087
35 5N69 ADP 0.0001628 0.40967 3.26087
36 3H86 AP5 0.00667 0.40258 3.26087
37 1T5C ADP 0.0000006483 0.40231 3.26087
38 2GJ8 ALF GDP 0.0000007593 0.54914 3.48837
39 1GOJ ADP 0.0000002253 0.69926 3.80435
40 4LC1 GDP 0.0000000273 0.69791 3.80435
41 2XT3 ADP 0.0000004304 0.67621 3.80435
42 1D2E GDP 0.0000000391 0.66056 3.80435
43 2NCD ADP 0.000002111 0.63086 3.80435
44 3DC4 ADP 0.000003153 0.61365 3.80435
45 3DKP ADP 0.00005869 0.53255 3.80435
46 1SVI GDP 0.000000008293 0.50999 3.80435
47 1XP8 AGS 0.0002966 0.50392 3.80435
48 3BER AMP 0.002638 0.45052 3.80435
49 3ZFD ANP 0.0000332 0.42516 3.80435
50 1F9V ADP 0.000001572 0.41756 3.80435
51 3COB ADP 0.0000005078 0.41747 3.80435
52 3H4S ADP 0.0000004751 0.41673 3.80435
53 4FRZ ADP 0.000001511 0.4166 3.80435
54 2VVG ADP 0.0000003063 0.41027 3.80435
55 4MKF AP5 0.006275 0.41022 3.80435
56 1UKZ ADP 0.004548 0.40815 3.80435
57 4MKG AP5 0.007753 0.40536 3.80435
58 2P3V SRT 0.032 0.40436 3.80435
59 1OFH ADP 0.0002783 0.40039 4.02299
60 3QXC ATP 0.003473 0.40453 4.13223
61 2W58 ADP 0.00000109 0.66536 4.34783
62 2IYL GDP 0.000000214 0.65354 4.34783
63 2FH5 GTP 0.0000004133 0.5908 4.34783
64 1TAD ALF 0.0000004997 0.56089 4.34783
65 1TAD GDP 0.0000004997 0.56089 4.34783
66 2ZFI ADP 0.00002508 0.55088 4.34783
67 1NRJ GTP 0.000001127 0.50957 4.34783
68 1DAR GDP 0.00000004212 0.50322 4.34783
69 2QZ4 ADP 0.000133 0.50268 4.34783
70 3EZ2 ADP 0.0003329 0.50136 4.34783
71 4RZ3 ADP 0.00007273 0.43289 4.34783
72 1OYY AGS 0.006399 0.43138 4.34783
73 1X6V ADP 0.0004515 0.42749 4.34783
74 2X7I CIT 0.01397 0.41447 4.34783
75 1BG2 ADP 0.0000003991 0.40641 4.34783
76 2Y65 ADP 0.000001565 0.40628 4.34783
77 3P13 RIP 0.04867 0.41005 4.86111
78 4J0Q GDP 0.0000000007049 0.79 4.8913
79 2X77 GDP 0.00000005656 0.67196 4.8913
80 4PPF FLC 0.000001137 0.66417 4.8913
81 1JJV ATP 0.00003251 0.5648 4.8913
82 2C04 GCP 0.000005428 0.55466 4.8913
83 4TTQ ATP 0.00004448 0.53853 4.8913
84 1AZT GSP 0.0000006332 0.53379 4.8913
85 2ZR9 DTP 0.00006255 0.53118 4.8913
86 5KUT GDP 0.0000000432 0.50759 4.8913
87 1YTM ATP 0.00009741 0.48769 4.8913
88 2CHG ANP 0.0007746 0.45705 4.8913
89 5VGR GDP 0.001009 0.45184 4.8913
90 3RC3 ANP 0.00454 0.44359 4.8913
91 1XKV ATP 0.00006069 0.41906 4.8913
92 2Q2Y ADP 0.004007 0.41733 4.8913
93 2Q2Y MKR 0.003862 0.41692 4.8913
94 1NN5 ANP 0.003323 0.41108 4.8913
95 1YXM ADE 0.03862 0.40144 4.8913
96 3U6B GDP 0.0000000005444 0.79571 5.07614
97 4G5G GDP 0.000000001319 0.76321 5.07614
98 3U6K GDP 0.000000002276 0.75145 5.07614
99 4PC3 GDP 0.00000002943 0.66627 5.07614
100 5JBQ GDP 0.0000000009417 0.54256 5.07614
101 4P3Y GDP 0.0000000004257 0.53999 5.07614
102 2BVN GNP 0.00000001218 0.68401 5.08906
103 1D8T GDP 0.0000000009945 0.54176 5.08906
104 3TK1 GDP 0.000000001302 0.79031 5.43478
105 1G3Q ADP 0.00002581 0.54312 5.43478
106 1H65 GDP 0.000004024 0.54191 5.43478
107 5FJJ MAN 0.0001516 0.49941 5.43478
108 4QOS ADP 0.0002158 0.49272 5.43478
109 2FNA ADP 0.0005616 0.45054 5.43478
110 3KJI ADP 0.00003301 0.43659 5.43478
111 5H56 ADP 0.001347 0.42546 5.43478
112 5H56 TYD 0.001347 0.42546 5.43478
113 2BEK ATP 0.002664 0.42171 5.43478
114 5I0H ADP BEF 0.0002992 0.41908 5.43478
115 1K6M AGS 0.003097 0.41562 5.43478
116 1ION ADP 0.00009823 0.41561 5.43478
117 2CE7 ADP 0.0001 0.40934 5.43478
118 5IFS ADP 0.0001394 0.40707 5.43478
119 1HTW ADP 0.00001221 0.43839 5.6962
120 2HCJ GDP 0.0000000005034 0.53837 5.97015
121 4AG5 ADP 0.000003441 0.62016 5.97826
122 3BFV ADP 0.000007973 0.57557 5.97826
123 3B5J 12D 0.0000222 0.5694 5.97826
124 3UIE ANP 0.00001051 0.55487 5.97826
125 1FP6 ADP 0.00001784 0.53746 5.97826
126 5CK5 GDP 0.000000002232 0.52253 5.97826
127 5FTB ANP 0.0004444 0.47787 5.97826
128 3DZD ADP 0.0003747 0.47623 5.97826
129 1VHT BA3 0.0007592 0.46686 5.97826
130 5FHD ADP ALF 0.0007442 0.44931 5.97826
131 4PJ3 ANP 0.002073 0.44182 5.97826
132 4A4Z ANP 0.004322 0.43986 5.97826
133 1CR1 TTP 0.0006396 0.40808 5.97826
134 4OHY ANP 0.004343 0.40643 5.97826
135 4KFU ACP 0.000007608 0.40241 5.97826
136 2KIN ADP 0.0000004177 0.40562 6
137 5MVR ADP 0.00002189 0.42096 6.17284
138 1KK1 GNP 0.000000002207 0.76479 6.52174
139 2AWN ADP 0.00000009341 0.73786 6.52174
140 2WJG GDP 0.000000006305 0.72949 6.52174
141 5GOE GDP 0.000000007117 0.7049 6.52174
142 2CBZ ATP 0.000001535 0.65193 6.52174
143 2OG2 MLI 0.000007571 0.6068 6.52174
144 4M9Q GNP 0.0000001297 0.60546 6.52174
145 3B9Q MLI 0.00002555 0.57956 6.52174
146 4ZKD GDP 0.000001836 0.53399 6.52174
147 3VMF GTP 0.000003019 0.51929 6.52174
148 4HSE ADP 0.00008364 0.51838 6.52174
149 5XDR ADP 0.00008732 0.51747 6.52174
150 1G6O ADP 0.0000715 0.51544 6.52174
151 3WXM GTP 0.000005287 0.50993 6.52174
152 5L3V GDP 0.0000002066 0.49581 6.52174
153 3E70 GDP 0.0000001409 0.49177 6.52174
154 1IN4 ADP 0.0009426 0.44891 6.52174
155 2OFW ADX 0.0007014 0.44766 6.52174
156 1M7G ADX 0.0006053 0.44091 6.52174
157 1M7G AV2 0.000002368 0.4383 6.52174
158 1M7G ADP 0.001181 0.42623 6.52174
159 3RLF ANP 0.002497 0.41954 6.52174
160 4GOX A3P 0.003906 0.41141 6.52174
161 2VF7 ADP 0.00005842 0.40615 6.52174
162 2PEZ DAT 0.0004755 0.44662 6.70391
163 2PEZ GGZ 0.0004755 0.44662 6.70391
164 1KO8 6PG 0.00008391 0.43279 6.85714
165 1B0U ATP 0.00006246 0.51225 6.87023
166 3KTA AP5 0.0004309 0.47342 6.93642
167 4QM7 GTP 0.00001984 0.41331 7.01754
168 1B7T ADP 0.0002259 0.49178 7.05128
169 1SKQ GDP 0.000000003138 0.75701 7.06522
170 5HCN GCP 0.000000003546 0.73023 7.06522
171 1FQJ GDP 0.0000004222 0.57715 7.06522
172 1FQK GDP 0.0000006734 0.56867 7.06522
173 4LYA ATP 0.00001075 0.56154 7.06522
174 1ZCB GDP 0.0000004839 0.55035 7.06522
175 3CX8 GSP 0.000000255 0.54865 7.06522
176 4RD0 GDP 0.0000001444 0.54637 7.06522
177 3AB3 GDP 0.0000007713 0.51379 7.06522
178 3T34 GDP 0.00002923 0.50026 7.06522
179 4XGU ADP 0.0003596 0.47215 7.06522
180 1L2T ATP 0.002107 0.41933 7.06522
181 4Q1A UDP 0.03639 0.4193 7.06522
182 4Q1A 2XZ 0.03639 0.4193 7.06522
183 1UJ2 ADP 0.001915 0.41476 7.06522
184 1UJ2 C5P 0.002391 0.41094 7.06522
185 5LTJ ADP 0.00005193 0.40887 7.06522
186 2XAU ADP 0.0001299 0.40494 7.06522
187 3Q85 GNP 0.0000000002514 0.56091 7.10059
188 2WJH GDP 0.0000001109 0.50554 7.22892
189 2WJH FLC 0.000004937 0.46111 7.22892
190 1G7C 5GP 0.0000006868 0.62841 7.44681
191 2WIC GNP 0.000000002811 0.73512 7.6087
192 4LPS GDP 0.0000000341 0.6826 7.6087
193 4P4T GDP 0.00000009176 0.62689 7.6087
194 3DEF GDP 0.0000003416 0.61698 7.6087
195 4WZ6 ATP 0.00001204 0.59061 7.6087
196 4H1V GNP 0.000002082 0.57351 7.6087
197 1PUJ GNP 0.000000002821 0.56789 7.6087
198 1WDT GTP 0.000003472 0.55689 7.6087
199 1MKY GDP 0.0000000004956 0.55452 7.6087
200 1BH2 GSP 0.000001247 0.52313 7.6087
201 5FG3 GDP 0.000000004773 0.5159 7.6087
202 1SQ5 ADP 0.0002238 0.49767 7.6087
203 5L3S GNP 0.000008279 0.49554 7.6087
204 5L3W GDP 0.000001022 0.4752 7.6087
205 2IXE ATP 0.001255 0.43565 7.6087
206 4WEI GLC GAL 0.01068 0.43325 7.6087
207 5IRN ADP 0.00004307 0.42774 7.6087
208 5I34 GDP 0.00004118 0.42167 7.6087
209 4OI4 ATP 0.002841 0.4172 7.6087
210 3P4X ADP 0.00001709 0.41479 7.6087
211 1OXV ANP 0.00001611 0.40384 7.6087
212 1KK8 BEF ADP 0.0002606 0.47849 7.91367
213 1JJ7 ADP 0.0000004621 0.68668 8.15217
214 1YQT ADP 0.000007946 0.60074 8.15217
215 3B7G ANP 0.0002471 0.49559 8.15217
216 3FB4 AP5 0.0061 0.40971 8.15217
217 1ZUI SKM 0.002526 0.42106 8.33333
218 4P32 ADP 0.001487 0.43252 8.43373
219 1G6H ADP 0.0000004949 0.6853 8.69565
220 3LRE ADP 0.0000005295 0.67749 8.69565
221 3NHB ADP 0.000004279 0.61556 8.69565
222 2WHX ADP 0.00003094 0.56874 8.69565
223 5IRR GSP 0.00001195 0.52177 8.69565
224 5TSH ANP 0.00001257 0.42127 8.69565
225 1R6B ADP 0.0001582 0.40196 8.69565
226 2ZTS ADP 0.0003849 0.46618 9.16335
227 4B47 GDP 0.000000001532 0.77285 9.23913
228 1F6B GDP 0.00000004115 0.67865 9.23913
229 4YDS ATP 0.0000184 0.57365 9.23913
230 2RCN GDP 0.0000000009172 0.54624 9.23913
231 4R98 GNH 0.000000002675 0.53988 9.23913
232 5M04 GDP 0.0000000008997 0.53173 9.23913
233 3FWY ADP 0.00001522 0.45299 9.23913
234 3IO3 ADP 0.0002959 0.41647 9.23913
235 2FAH GDP 0.0002571 0.40924 9.23913
236 5K5Z ANP 0.002465 0.40226 9.23913
237 1D2N ANP 0.009469 0.40122 9.23913
238 1GOT GDP 0.0000006073 0.5769 9.58904
239 4HI0 GDP 0.0000005419 0.58568 9.78261
240 4ZG4 VO4 ADP 0.0004744 0.42268 9.78261
241 1YRB GDP 0.000000003663 0.70817 10.3261
242 1GP2 GDP 0.0000001381 0.59742 10.3261
243 5KDO GDP 0.0000003298 0.59506 10.3261
244 1Y63 ADP 0.000007703 0.57632 10.3261
245 1Y3A GDP 0.0000005651 0.57185 10.3261
246 1SVK ALF GDP 0.0000005263 0.56215 10.3261
247 2ODE ALF GDP 0.0000004978 0.56095 10.3261
248 1CS4 GSP 0.000002477 0.52014 10.3261
249 1P9B GDP 0.0002391 0.48018 10.3261
250 1G7S GDP 0.00000002063 0.69318 10.8696
251 5BQ5 ADP BEF 0.000189 0.49546 10.8696
252 5G41 AP5 0.01023 0.40506 10.8696
253 1XEX ATP 0.004621 0.40242 11.0465
254 1BO4 COA 0.009069 0.42384 11.3095
255 2C78 GNP 0.0000001698 0.60048 11.413
256 2XTN GTP 0.0000008215 0.56507 11.413
257 4NCN GTP 0.000001234 0.55768 11.413
258 4TMZ GSP 0.000001302 0.55671 11.413
259 2C77 GNP 0.0000001897 0.5355 11.413
260 5L3R GCP 0.000007563 0.51956 11.413
261 2OBM ADP 0.0005131 0.50428 11.413
262 4WZA ACP 0.002347 0.44326 11.413
263 4WZA ADP 0.002347 0.44326 11.413
264 3CNL GNP 0.00000003362 0.70463 11.9565
265 2HF9 GSP 0.000003997 0.56068 11.9565
266 2XTZ GSP 0.0000009498 0.53863 11.9565
267 4LJ9 ACP 0.0004684 0.48779 11.9565
268 4XTR ATP 0.0005312 0.42259 11.9565
269 4XVU ATP 0.000615 0.42046 11.9565
270 4XTR ADP 0.000259 0.41804 11.9565
271 1QHG ATP 0.006811 0.41785 11.9565
272 1QHH ATP 0.01149 0.41467 11.9565
273 2GK6 ADP 0.001691 0.47114 12.5
274 3ZIA ADP 0.00009986 0.41805 12.6984
275 3ZIA ATP 0.00004235 0.41671 12.6984
276 3QKT ANP 0.002435 0.41675 13.0435
277 4CVN ADP 0.000003149 0.61367 13.587
278 1JI0 ATP 0.00001547 0.57758 13.587
279 3EC1 GDP 0.000000008819 0.53362 13.587
280 1M2O GNP 0.000008537 0.50173 13.587
281 1Z6T ADP 0.0004338 0.46846 13.587
282 4U00 ADP 0.0000003003 0.40395 13.587
283 1V8K ANP 0.00002017 0.55558 14.1304
284 1W7J ADP BEF 0.0002847 0.47675 14.1304
285 2ZJ5 ADP 0.03973 0.40171 14.1304
286 2QTV GNP 0.000004547 0.50629 14.2857
287 3A1S GDP 0.0000001798 0.64762 14.6739
288 1W5T ADP 0.004749 0.42133 14.6739
289 1W5T ANP 0.007112 0.40664 14.6739
290 3IIJ ADP 0.00001227 0.4231 15
291 1TQ4 GDP 0.00000001394 0.65477 15.2174
292 2V7Q ATP 0.00003388 0.5308 15.2174
293 2V7Q ADP 0.0004104 0.49064 15.2174
294 5MZN ADP 0.001133 0.48022 15.2174
295 2CK3 ANP 0.00213 0.4332 15.2174
296 1W0J ADP 0.00005217 0.42727 15.2174
297 4PX9 ADP 0.000008067 0.41745 15.2174
298 2I4I AMP 0.00585 0.41722 15.2174
299 2CK3 ADP 0.004202 0.41008 15.2174
300 3A4M ADP 0.000001664 0.62813 16.3043
301 1F5N GNP 0.00384 0.4028 16.3043
302 2OM2 GDP 0.0000003369 0.59466 16.6667
303 4YS0 ADP 0.001434 0.44492 16.8478
304 3FVQ ATP 0.001403 0.43733 16.8478
305 1JWY GDP 0.0000004503 0.61142 17.3913
306 1JWY ADP 0.00009517 0.51566 17.3913
307 4V0K GDP 0.0000001044 0.5958 17.7515
308 1FZQ GDP 0.000000001637 0.75855 17.9348
309 4GOJ GNP 0.0000001146 0.54981 17.9348
310 4ZI2 GNP 0.0000001145 0.54928 17.9348
311 1KSH GDP 0.00000007345 0.54873 17.9348
312 1LVG ADP 0.00000117 0.43395 17.9348
313 4BQS ADP 0.000009405 0.57201 18.1818
314 4BQS K2Q 0.001513 0.4302 18.1818
315 2QN6 GDP 0.000000003316 0.7558 18.2796
316 1FNN ADP 0.0007926 0.45226 18.4783
317 3T5G GDP 0.0000000677 0.51372 18.7845
318 3AQ4 GDP 0.0000000001942 0.79134 19.0217
319 4PFO ADP 0.003176 0.40133 19.0217
320 2VB6 ADP BEF 0.001763 0.40087 19.0217
321 5DI3 GNP 0.00000008562 0.61315 19.5652
322 1MR3 G3D 0.0000000001351 0.58414 20.442
323 5EE5 GTP 0.0000000671 0.55832 20.4678
324 1UPT GTP 0.0000003538 0.53235 20.4678
325 1O3Y GTP 0.00000008148 0.60699 20.4819
326 2J59 GTP 0.0000001107 0.60143 20.4819
327 1J2J GTP 0.0000003392 0.58111 20.4819
328 2J0V GDP 0.0000001484 0.49091 20.6522
329 4U5X GNP 0.000001334 0.49823 20.7865
330 1S9D GDP 0.0000000005117 0.77096 21.3415
331 1RE0 GDP 0.0000000002918 0.54818 21.3415
332 2IS6 ADP 0.0001176 0.51757 21.7391
333 2QEN ADP 0.0003208 0.40493 21.7391
334 1R4A GNP 0.00000004432 0.61105 21.8182
335 3WY9 GDP 0.0000000076 0.73747 21.875
336 4YLG GDP 0.000000005232 0.56935 21.9653
337 1ZJ6 G3D 0.0000000002705 0.78437 22.2826
338 2A5F GTP 0.00000007341 0.57409 22.2857
339 4KAX GTP 0.00000005241 0.56245 22.4852
340 4BAS GNP 0.0000002116 0.5415 22.8261
341 1YZG GDP 0.0000000003737 0.57114 22.905
342 2W83 GTP 0.0000001425 0.59686 23.0303
343 3PCR GTP 0.00000006437 0.61127 23.4568
344 3N5C GDP 0.000000001028 0.76858 24.0741
345 4YMU ATP 0.000009732 0.41008 25
346 1WF3 GNP 0.000002066 0.53196 27.1739
347 5KSP GDP 0.000008338 0.56689 27.8947
348 5KSZ GCP 0.00001372 0.44583 28.2609
349 3Q72 GNP 0.00000001242 0.50941 28.3133
350 2CJW GDP 0.0000000001883 0.80515 29.3478
351 1M7B GTP 0.000002955 0.55367 29.3478
352 3REF GDP 0.000005459 0.53627 29.3478
353 1GWN GTP 0.000004061 0.48938 29.3478
354 1E96 GTP 0.00001685 0.50054 30.9783
355 2W2X GSP 0.000002799 0.49593 30.9783
356 2HT6 GDP 0.0000000006153 0.54075 31.0345
357 1DS6 GDP 0.00000007107 0.49272 31.5217
358 1XTQ GDP 0.000001454 0.51812 31.6384
359 2G77 GDP 0.00000005889 0.64367 32.0652
360 4NON GDP 0.00000356 0.51413 32.0652
361 2G77 AF3 0.005736 0.44775 32.0652
362 1Z06 GNP 0.0000003178 0.57598 32.6087
363 2A9K GDP 0.0000002224 0.51495 32.6087
364 4KVG GTP 0.000001398 0.53212 33.3333
365 4HDO GNP 0.000002551 0.52835 33.5329
366 3X1Z GNP 0.000003235 0.52643 33.5329
367 4HDQ GNP 0.000004083 0.52028 33.5329
368 4DKX GDP 0.000000003425 0.74264 33.6957
369 2F9L GDP 0.0000006645 0.56892 33.6957
370 1ZC3 GNP 0.0000004799 0.55701 33.7143
371 2A5J GDP 0.000000007081 0.70501 34.2391
372 5JCP GDP ALF 0.000001525 0.57965 34.2391
373 2BME GNP 0.0000004528 0.55103 34.2391
374 3RWO GDP 0.0000007796 0.54191 34.2391
375 3CPJ GDP 0.00000002899 0.53357 34.2391
376 2GCN GDP 0.000004123 0.49581 34.2391
377 2GCO GNP 0.000001442 0.49232 34.2391
378 1KMQ GNP 0.00001016 0.48758 34.2391
379 1UAD GNP 0.000001788 0.52807 34.2857
380 1S8F GDP 0.00000124 0.53148 34.4633
381 1Z08 GNP 0.000001426 0.55506 34.7059
382 3LXR GDP 0.0000002606 0.63087 34.7826
383 3DOE GTP 0.0000001523 0.59564 34.7826
384 4D0N GDP 0.0000001024 0.49009 34.7826
385 1OW3 GDP 0.000004057 0.47501 34.7826
386 5HPY GDP 0.000003828 0.47492 34.7826
387 5IRC GDP 0.000008043 0.45094 34.7826
388 4XOI GTP 0.00001446 0.48749 35
389 5WDR GNP 0.000003185 0.52454 35.0877
390 1CXZ GSP 0.000008689 0.48468 35.1648
391 5TAR GDP 0.00000003231 0.6644 35.3261
392 1VG8 GNP 0.0000004694 0.55739 35.3261
393 1VG1 GDP 0.000000001348 0.55224 35.3261
394 1VG0 GDP 0.00000001019 0.548 35.3261
395 4DSU GDP 0.000001146 0.54207 35.3261
396 1VG9 GDP 0.000000003703 0.54181 35.3261
397 5UQW GDP 0.000000627 0.53828 35.3261
398 5TB5 GDP 0.00000001559 0.53228 35.3261
399 1KAO GDP 0.0000001973 0.5167 35.3293
400 1U8Z GDP 0.0000002104 0.58978 35.7143
401 2Y8E GNP 0.000001146 0.54751 35.7542
402 4XSH GSP 0.000002453 0.49074 35.7542
403 1ZD9 GDP 0.000000341 0.60159 35.8696
404 1X1R GDP 0.000002067 0.53196 35.9551
405 1Z0K GTP 0.0000001594 0.59481 36.0465
406 1TX4 ALF GDP 0.00001078 0.51836 36.1582
407 1D5C GDP 0.00000005388 0.64542 36.4198
408 1Z0A GDP 0.000000009672 0.54013 36.7816
409 3TKL GTP 0.0000001692 0.58721 36.9565
410 3SFV GDP 0.0000001365 0.53807 37.0166
411 1Z0J GTP 0.0000004932 0.55654 37.0588
412 1KY3 GDP 0.00000004884 0.5251 37.3626
413 2FFQ GSP 0.000002129 0.53145 37.4269
414 1Z0F GDP 0.000000002704 0.73593 37.4302
415 5SZH GNP 0.0000003554 0.56216 37.5
416 2EFE GNH 0.00000005565 0.65347 37.5691
417 1YZQ GNP 0.000001176 0.54164 37.6471
418 4D0G GTP 0.0000000851 0.55513 37.7143
419 1YVD GNP 0.0000003822 0.56669 37.8698
420 1TU3 GNP 0.0000003129 0.55709 38.0117
421 5XCO GDP 0.00000005107 0.52594 38.0117
422 4DID GDP 0.0000003149 0.63583 38.0435
423 1OIX GDP 0.0000004561 0.55097 38.0435
424 1NF3 GNP 0.00001979 0.49773 38.0435
425 3MJH GTP 0.0000006119 0.55847 38.0952
426 2C5L GTP 0.000001459 0.53794 38.1503
427 1R2Q GNP 0.0000002119 0.51102 38.2353
428 5O2T GSP 0.000001737 0.53494 38.4615
429 2WMO GTP 0.0000003435 0.6252 38.587
430 1A4R GNH 0.000001174 0.58479 38.587
431 1A4R GDP 0.00000136 0.57494 38.587
432 1GRN GDP 0.000002735 0.56815 38.587
433 1OIV GDP 0.0000007381 0.54286 38.587
434 2NGR GDP 0.0000003676 0.48317 38.587
435 4ITR GDP 0.000004837 0.47808 38.587
436 1GRN AF3 0.0213 0.41349 38.587
437 4K81 GTP 0.000001088 0.54522 38.5965
438 4YC7 GNP 0.000004157 0.49501 38.674
439 1G16 GDP 0.000001005 0.51545 38.8235
440 1LFD GNP 0.000001299 0.53329 38.9222
441 3QBT GNP 0.0000004632 0.56333 39.0805
442 4LHW GNP 0.0000004878 0.56243 39.0805
443 3TNF GNP 0.0000006775 0.55339 39.0805
444 5UFQ GNP 0.0000008707 0.53998 39.1566
445 1NVU GTP 0.000002015 0.5324 39.1566
446 5E95 GDP 0.00000004541 0.64878 39.2857
447 1EK0 GNP 0.000003893 0.52614 39.4118
448 3NKV GNP 0.0000003871 0.56647 39.4286
449 5JCZ GDP 0.0000004384 0.59675 39.6648
450 4DCT GDP 0.00000002457 0.6895 39.6739
451 1WQ1 GDP 0.000001181 0.55848 39.759
452 1CLU DBG 0.000003551 0.54735 39.759
453 1NVV GNP 0.00000176 0.53472 39.759
454 2UZI GTP 0.000001204 0.53459 39.759
455 3DDC GNP 0.000002126 0.53148 39.759
456 1WQ1 AF3 0.007411 0.445 39.759
457 1Z2A GDP 0.00000109 0.55994 39.881
458 4LX0 BEF GDP 0.0000009666 0.545 40.113
459 2HV8 GTP 0.0000004315 0.55194 40.6977
460 3M1I GTP 0.0000006953 0.55065 40.7609
461 3WYF GTP 0.0000008301 0.54989 40.7609
462 4C4P GNP 0.0000004057 0.55989 41.0405
463 3WYG GTP 0.000001429 0.52921 41.2088
464 1G4U GDP 0.000004788 0.5507 41.3043
465 2WKQ GTP 0.000006346 0.52797 41.3043
466 3SBD GNP 0.0000169 0.50049 41.3043
467 3GJX GTP 0.000001078 0.54313 41.8478
468 1MH1 GNP 0.00001036 0.5043 41.8478
469 2D7C GTP 0.0000003524 0.55525 41.9162
470 3GJ0 GDP 0.0000000006334 0.77901 42.3913
471 3CH5 GDP 0.0000000009357 0.75826 42.3913
472 1I4D GDP 0.00000005391 0.69419 42.3913
473 5BXQ GDP 0.0000000008983 0.55625 42.3913
474 5UWQ GNP 0.0000005751 0.5539 42.3913
475 5UWO GNP 0.0000005912 0.55343 42.3913
476 5UWR GNP 0.0000006482 0.55185 42.3913
477 5UWT GNP 0.0000006627 0.55147 42.3913
478 5UWS GNP 0.0000007667 0.55126 42.3913
479 5UWJ GNP 0.0000006751 0.55115 42.3913
480 5UWP GNP 0.0000007883 0.55078 42.3913
481 5UWH GNP 0.0000006906 0.55077 42.3913
482 5UWI GNP 0.0000006954 0.55065 42.3913
483 5UWU GNP 0.0000006963 0.55062 42.3913
484 1IBR GNP 0.0000007114 0.55026 42.3913
485 4HAT GNP 0.000000821 0.55008 42.3913
486 5DHF GNP 0.0000007228 0.54998 42.3913
487 5UWW GNP 0.0000007537 0.54926 42.3913
488 5DI9 GNP 0.000000862 0.54924 42.3913
489 5DIF GNP 0.0000007733 0.54882 42.3913
490 3GJ3 GDP 0.0000000008238 0.54685 42.3913
491 1RYH GNP 0.0000001063 0.50945 42.3913
492 3RAB GNP 0.0000004846 0.54986 42.6035
493 2FJU GSP 0.00000288 0.49451 43.2584
494 1HE1 GDP 0.000004458 0.54591 43.75
495 1HE1 AF3 0.02387 0.41087 43.75
496 3E5H GNP 0.000003273 0.52918 43.8202
497 3GJ4 GDP 0.0000000009368 0.77058 44.0217
498 3GJ7 GDP 0.00000000102 0.76874 44.0217
499 3GJ8 GDP 0.00000000122 0.75267 44.0217
500 3GJ5 GDP 0.000000001565 0.74744 44.0217
501 2BCG GDP 0.0000000732 0.63124 44.0217
502 1YZN GNP 0.0000008164 0.54789 44.0217
503 1WA5 GTP 0.000001374 0.50469 44.3182
504 3BC1 GNP 0.0000002927 0.57136 45.1087
505 2EW1 GNP 0.0000002122 0.54865 47.2826
Pocket No.: 2; Query (leader) PDB : 2ZEJ; Ligand: GDP; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2zej.bio1) has 27 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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