Receptor
PDB id Resolution Class Description Source Keywords
2ig0 1.7 Å NON-ENZYME: BINDING STRUCTURE OF 53BP1/METHYLATED HISTONE PEPTIDE COMPLEX HOMO SAPIENS TANDEM TUDOR DOMAINS DIMETHYLATED HISTONE H4 DNA REPAIR CELL CYCLE REGULATION
Ref.: STRUCTURAL BASIS FOR THE METHYLATION STATE-SPECIFIC RECOGNITION OF HISTONE H4-K20 BY 53BP1 AND CRB2 IN DNA REPAIR. CELL(CAMBRIDGE,MASS.) V. 127 1361 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN B:19;
 Valid;
 none;
 submit data
302.467 n/a O=C(N...
SO4 A:201;
 Invalid;
 none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
3LGF 1.5 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF THE 53BP1 TANDEM TUDOR DOMAIN IN COMPLE P53K370ME2 HOMO SAPIENS TANDEM TUDOR DOMAINS DIMETHYLATED P53 PEPTIDE DNA REPAIR CYCLE DNA DAMAGE DNA-BINDING METHYLATION TRANSCRIPTIONTRANSCRIPTION REGULATION
Ref.: STRUCTURAL INSIGHT INTO P53 RECOGNITION BY THE 53BP TUDOR DOMAIN. J.MOL.BIOL. V. 398 489 2010
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 552 families.
1 3LGF - SER SER HIS LEU MLY SER LYS LYS GLY GLN n/a n/a
2 2IG0 - LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 426 families.
1 3LGF - SER SER HIS LEU MLY SER LYS LYS GLY GLN n/a n/a
2 2IG0 - LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 322 families.
1 3LGF - SER SER HIS LEU MLY SER LYS LYS GLY GLN n/a n/a
2 2IG0 - LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN 1 1
2 ARG VAL 0.533333 0.711538
3 AAR 0.471698 0.702128
4 ARG GLU 0.469697 0.62963
5 ARG ASP 0.454545 0.618182
6 ARG ARG ARG ARG ARG ARG ARG ARG 0.438356 0.673077
7 ARG ARG ARG ARG ARG ARG ARG ARG ARG ARG 0.438356 0.673077
8 THR ALA ARG M3L SER THR 0.425 0.810345
9 BEZ NLE LYS ARG OAR 0.416667 0.68
10 LYS ARG LYS ARG LYS ARG LYS ARG LYS ARG 0.407407 0.692308
Similar Ligands (3D)
Ligand no: 1; Ligand: LYS ARG HIS ARG MLY VAL LEU ARG ASP ASN; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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