Receptor
PDB id Resolution Class Description Source Keywords
2wa8 2.15 Å EC: 3.-.-.- STRUCTURAL BASIS OF N-END RULE SUBSTRATE RECOGNITION IN ESCHERICHIA COLI BY THE CLPAP ADAPTOR PROTEIN CLPS - THE P HE PEPTIDE STRUCTURE ESCHERICHIA COLI N-END RULE PHE PEPTIDE CLPS CLPA CLPP PEPTIDE-BINDING PROTEIN
Ref.: STRUCTURAL BASIS OF N-END RULE SUBSTRATE RECOGNITION IN ESCHERICHIA COLI BY THE CLPAP ADAPTOR PROTEIN CLPS. EMBO REP. V. 10 508 2009
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PHE ARG SER LYS GLY GLU GLU LEU PHE THR B:1;
D:107;
 Valid;
Valid;
 none;
none;
 Kd = 3.8 uM
580.711 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WA8 2.15 Å EC: 3.-.-.- STRUCTURAL BASIS OF N-END RULE SUBSTRATE RECOGNITION IN ESCHERICHIA COLI BY THE CLPAP ADAPTOR PROTEIN CLPS - THE P HE PEPTIDE STRUCTURE ESCHERICHIA COLI N-END RULE PHE PEPTIDE CLPS CLPA CLPP PEPTIDE-BINDING PROTEIN
Ref.: STRUCTURAL BASIS OF N-END RULE SUBSTRATE RECOGNITION IN ESCHERICHIA COLI BY THE CLPAP ADAPTOR PROTEIN CLPS. EMBO REP. V. 10 508 2009
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 312 families.
1 3O2B - PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
2 2WA8 Kd = 3.8 uM PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 261 families.
1 3O2B - PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
2 2WA8 Kd = 3.8 uM PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
50% Homology Family (7)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 214 families.
1 3O2B - PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
2 2WA8 Kd = 3.8 uM PHE ARG SER LYS GLY GLU GLU LEU PHE THR n/a n/a
3 3DNJ - TYR LEU PHE VAL GLN ARG ASP SER LYS GLU n/a n/a
4 3G1B - TRP LEU PHE VAL GLN ARG ASP SER LYS GLU n/a n/a
5 3GW1 - PHE GLY GLY n/a n/a
6 3G19 - LEU LEU LEU n/a n/a
7 3GQ1 - TRP LEU PHE VAL GLN ARG ASP SER LYS GLU n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PHE ARG SER LYS GLY GLU GLU LEU PHE THR; Similar ligands found: 62
No: Ligand ECFP6 Tc MDL keys Tc
1 PHE ARG SER LYS GLY GLU GLU LEU PHE THR 1 1
2 PHE GLU ASP LEU ARG LEU LEU SER PHE 0.551724 0.813559
3 PHE TYR ARG TYR GLY PHE VAL ALA ASN PHE 0.538462 0.754386
4 ALA THR ARG ASN PHE SER GLY 0.535088 0.875
5 LEU LYS SER MLZ LYS GLY GLN SER THR TYR 0.525253 0.711864
6 SER LEU ARG PHE LEU TYR GLU GLY 0.525 0.790323
7 PHE GLU ASP LEU ARG VAL SER SER PHE 0.507937 0.813559
8 PHE GLU ASP LEU ARG VAL LEU SER PHE 0.507937 0.813559
9 PHE ARG TYR LEU GLY 0.504425 0.725806
10 PAC DLY DLY DAR 0.5 0.884615
11 ILE LYS ARG SER LYS LYS ASN SER LEU ALA 0.5 0.884615
12 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.492188 0.746032
13 ARG SER MLZ SER ASP GLY 0.486239 0.813559
14 LYS ARG ARG ARG HIS PRO SER GLY 0.469231 0.769231
15 TYR GLN SER LYS LEU 0.46789 0.716667
16 PHE LEU SER THR LYS 0.459459 0.736842
17 VAL ALA PHE ARG SER 0.459459 0.833333
18 ALA LYS PHE ARG HIS ASP 0.459016 0.754098
19 LYS LEU PHE SER PHE GLY GLY 0.458716 0.724138
20 LYS ARG LYS 0.457447 0.788462
21 PHE LEU SER TYR LYS 0.45614 0.677419
22 LYS ALA ALA ARG M3L SER ALA 0.452174 0.707692
23 ARG ARG LEU ILE PHE NH2 0.451327 0.719298
24 LEU ARG ASN GLN SER VAL PHE ASN PHE 0.445312 0.786885
25 ALA GLN PHE SER ALA SER ALA SER ARG 0.444444 0.872727
26 PHE ALN ARG ARG ARG ARG SLL ARG 00S 0.443396 0.830189
27 GLU GLU PHE GLY ARG ALA PHE SER PHE 0.44186 0.890909
28 GLY ASN CYS PHE SER LYS ARG ARG ALA ALA 0.440945 0.875
29 PHE TYR ARG ALA LEU MET 0.440945 0.651515
30 DPN PRO DAR CYS NH2 0.439655 0.709677
31 PHE LEU GLU LYS 0.439252 0.678571
32 LYS ARG LYS ARG LYS ARG LYS ARG LYS ARG 0.435644 0.769231
33 ACE PHE LYS PHE TA2 ALA LEU ARG NH2 0.435115 0.770492
34 ILE LEU GLY LYS PHE LEU HIS ARG LEU 0.433824 0.707692
35 LYS LYS ARG LEU SER VAL GLU 0.432432 0.836364
36 GLY ASN PHE LEU GLN SER ARG 0.432 0.844828
37 ILE LEU ALA LYS PHE LEU HIS ARG LEU 0.430657 0.671875
38 ASP ALA GLU PHE ARG HIS ASP 0.425 0.814815
39 ARG ILE PHE SER 0.424779 0.818182
40 ILE LYS ARG SER MLZ LYS ASN SER LEU ALA 0.424528 0.793103
41 ARG HIS LYS ALY LEU MET PHE LYS 0.42446 0.632353
42 PHE GLY GLY 0.423529 0.627451
43 PHE LEU ARG GLY ARG ALA TYR GLY LEU 0.423077 0.714286
44 GLN THR ALA ARG M3L SER THR GLY 0.420635 0.712121
45 GLU THR VAL ARG PHE GLN SER ASP 0.416667 0.857143
46 GLU GLN TYR LYS PHE TYR SER VAL 0.416 0.721311
47 LEU GLU PHE GLN GLY 0.414414 0.678571
48 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.414286 0.810345
49 LYS GLN THR ALA ARG M3L SER THR GLY 0.411765 0.712121
50 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.409449 0.821429
51 GLY ASP GLU VAL LYS VAL PHE ARG 0.409091 0.854545
52 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.408451 0.735294
53 PHE SER GLN HIS LYS THR SER TPO ILE 0.408163 0.638889
54 SER GLU LEU GLU ILE LYS ARG TYR 0.406015 0.819672
55 THR PHE ALY SER ILE MET LYS 0.404412 0.693548
56 SER SER LEU GLU ASN PHE ARG ALA TYR VAL 0.40411 0.75
57 THR ALA ARG MYK SER THR GLY 0.403101 0.813559
58 SER SER ILE GLU PHE ALA ARG LEU 0.402985 0.827586
59 PHE LEU ARG GLY ARG ALA TYR VAL LEU 0.402878 0.714286
60 ASP PHE GLU LYS GLU GLY TYR SER LEU 0.40146 0.714286
61 LEU GLU LYS ALA ARG GLY SER THR TYR 0.4 0.836066
62 ARG SER ARG 0.4 0.830189
Similar Ligands (3D)
Ligand no: 1; Ligand: PHE ARG SER LYS GLY GLU GLU LEU PHE THR; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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